Construct validity and reliability of a real-time multidimensional smartphone app to assess pain in children and adolescents with cancer.

abstract：:The TRPA1 and TRPV1 receptors are important pharmaceutical targets for antipruritic and analgesic therapy. Obtaining further knowledge on their roles and interrelationship in humans is therefore crucial. Preclinical results are contradictory concerning coexpression and functional interdependency of TRPV1 and TRPA1, bu...

journal_title：Pain

authors： Nielsen TA,Eriksen MA,Gazerani P,Andersen HH

更新日期：2018-10-01 00:00:00

abstract：:Recent evidence indicates that pain-related fear can be acquired through associative learning. In the clinic, however, spreading of fear and avoidance is observed beyond movements/activities that were associated with pain during the original pain episode. One mechanism accounting for this spreading of fear is stimulus...

journal_title：Pain

authors： Meulders A,Vlaeyen JWS

更新日期：2013-02-01 00:00:00

abstract：:Patients with chronic pain in one limb, who experienced pain reduction with transcutaneous neurostimulation, were examined for sensory perception in that limb before and during electrical analgesia. Contralateral limbs and normal subjects served as controls. Sensory stimuli were quantified, a range of stimuli were pre...

journal_title：Pain

authors： Callaghan M,Sternbach RA,Nyquist JK,Timmermans G

更新日期：1978-08-01 00:00:00

abstract：:Two classes of neurons with distinct responses to opioids have been identified in the rostral ventromedial medulla (RVM), a region with a well-documented role in nociceptive modulation. 'On-cells' are directly inhibited by opioids, and opioids can thus gain access to the modulatory circuitry of the RVM by an action on...

journal_title：Pain

authors： Heinricher MM,McGaraughty S

更新日期：1998-04-01 00:00:00

abstract：:The aim of this study was to investigate the postnatal development of mu-(MOR) and delta-opioid receptor (DOR) immunoreactivity in rat dorsal root ganglia. Lumbar dorsal root ganglia (DRG) from postnatal day (P) 0, 3, 7 and 21 rat pups were immunostained for MOR and DOR. Proportions of MOR +ve and DOR +ve cells were c...

journal_title：Pain

authors： Beland B,Fitzgerald M

更新日期：2001-02-01 00:00:00

abstract：:The primary purpose of this study was to examine the extent to which specific patient attitudes and beliefs about medical care and self-care for back pain predict future healthcare use. An automated database allowed examination of the predictive relationships in two primary care patient samples. In general, beliefs th...

journal_title：Pain

authors： Saunders KW,Von Korff M,Pruitt SD,Moore JE

更新日期：1999-11-01 00:00:00

abstract：:A systematic review and meta-analysis of population-based epidemiological studies was undertaken to determine the prevalence of foot and ankle pain in middle and old age. Searches were conducted in the following electronic databases from inception to October 2010: PubMed, EMBASE, AMED, CINAHL, Cochrane, PEDro, and Spo...

journal_title：Pain

authors： Thomas MJ,Roddy E,Zhang W,Menz HB,Hannan MT,Peat GM

更新日期：2011-12-01 00:00:00

abstract：:Electrophysiological evidence has been obtained suggesting the presence of reciprocal excitation between descending pathways from the nucleus raphe magnus (NRM) and adjacent reticular formation (Ret.F) and spinal cord neurones projecting to these brain stem areas. In decerebrate and decerebellate cats, 40 spinal cord ...

journal_title：Pain

authors： Cervero F,Wolstencroft JH

更新日期：1984-10-01 00:00:00

abstract：:Coeliac plexus block (CPB) is one of the few neurolytic procedures that is still considered very useful in managing chronic cancer pain. We describe what we believe to be the fifth case in the literature of paraplegia following coeliac plexus block with ethyl alcohol. Clinical and neurophysiological examination confir...

journal_title：Pain

authors： De Conno F,Caraceni A,Aldrighetti L,Magnani G,Ferla G,Comi G,Ventafridda V

更新日期：1993-12-01 00:00:00

abstract：:Anti-nociceptive tolerance to opioids is a well-described phenomenon, which severely limits the clinical efficacy of opioids for the treatment of chronic pain syndromes. The mechanisms that drive anti-nociceptive tolerance, however, are less well understood. We have previously shown that glia have a central role in th...

journal_title：Pain

authors： Horvath RJ,Romero-Sandoval AE,De Leo JA

更新日期：2010-09-01 00:00:00

abstract：:Clinical observations and recent studies suggest that arthritis patients vary considerably in their involvement in self-management efforts. In the literature on health promotion, there is growing recognition that patients may be at different stages of change with respect to the adoption of self-management strategies. ...

journal_title：Pain

authors： Keefe FJ,Lefebvre JC,Kerns RD,Rosenberg R,Beaupre P,Prochaska J,Prochaska JO,Caldwell DS

更新日期：2000-09-01 00:00:00

abstract：:Individuals diagnosed with fibromyalgia syndrome (FMS) report chronic pain that is frequently worsened by physical activity and improved by rest. Palpation of muscle and tendinous structures suggests that nociceptors in deep tissues are abnormally sensitive in FMS, but methods of controlled mechanical stimulation of m...

journal_title：Pain

authors： Staud R,Cannon RC,Mauderli AP,Robinson ME,Price DD,Vierck CJ Jr

更新日期：2003-03-01 00:00:00

abstract：:The purpose of this study was to determine if some commonly used admission variables could predict treatment outcome on a multidisciplinary pain center. Specifically, it was designed as a prospective study of an index proposed by Maruta et al. The subjects were 104 patients. The 4 outcome measures used were staff judg...

journal_title：Pain

authors： Aronoff GM,Evans WO

更新日期：1982-09-01 00:00:00

abstract：:Though it is clear that genomic variability plays an integral role in accounting for pain sensitivity, controversy exists over which genes are involved. While recent data suggest a "protective" (i.e., less pain) haplotype in the GTP cyclohydrolase (GCH1) gene, other research has failed to confirm this association. Pos...

journal_title：Pain

authors： Campbell CM,Edwards RR,Carmona C,Uhart M,Wand G,Carteret A,Kim YK,Frost J,Campbell JN

更新日期：2009-01-01 00:00:00

abstract：:Physical and psychosocial disability in patients with chronic pain have been shown to be associated with patients' pain-related beliefs, tendency to catastrophize, and pain coping strategy use. However, little is known about whether beliefs, catastrophizing, and coping strategies are independently associated with pati...

journal_title：Pain

authors： Turner JA,Jensen MP,Romano JM

更新日期：2000-03-01 00:00:00

abstract：:Pain can be endogenously modulated by heterotopic noxious conditioning stimulation (HNCS) through a mechanism which is known as diffuse noxious inhibitory control (DNIC). Since DNIC can be impaired in patients suffering from chronic pain, a comparable impaired itch inhibition may exist in patients suffering from chron...

journal_title：Pain

authors： van Laarhoven AIM,Kraaimaat FW,Wilder-Smith OH,van de Kerkhof PCM,Evers AWM

更新日期：2010-05-01 00:00:00

abstract：:Fibromyalgia (FM) is a prevalent and disabling chronic disease. Recent studies have found elevated levels of glutamate in several brain regions, leading to hypotheses about the usefulness of glutamate-blocking drugs such as memantine in the treatment of FM. The aim of this study was to evaluate the efficacy of memanti...

journal_title：Pain

authors： Olivan-Blázquez B,Herrera-Mercadal P,Puebla-Guedea M,Pérez-Yus MC,Andrés E,Fayed N,López-Del-Hoyo Y,Magallon R,Roca M,Garcia-Campayo J

更新日期：2014-12-01 00:00:00

abstract：:Thirty subjects were given a placebo (intravenous saline), which was described as a known pain killer, once a week for 3 consecutive weeks. Experimental ischemic arm pain was produced prior to the placebo and again 1 h later. In a double blind procedure, half of the subjects received 10 mg of naloxone after placebo; t...

journal_title：Pain

authors： Grevert P,Albert LH,Goldstein A

更新日期：1983-06-01 00:00:00

abstract：:Do contrasting neuropathic pain diagnoses share common pathophysiological mechanisms? Selective breeding was used to derive rat lines with a common genetic background but a striking difference in the degree of spontaneous pain behavior expressed in the neuroma model of neuropathic pain (HA rats (high autotomy) and LA ...

journal_title：Pain

authors： Ziv-Sefer S,Raber P,Barbash S,Devor M

更新日期：2009-11-01 00:00:00

abstract：:Previous evidence suggests that, in adult animals, nerve growth factor (NGF) can induce hyperalgesia, and may be an endogenous mediator in some persistent pain states. Here we have studied the effects of single intradermal injections of 50-500 ng of human recombinant NGF into the plantar skin of adult rat hindpaws. We...

journal_title：Pain

authors： Andreev NY,Dimitrieva N,Koltzenburg M,McMahon SB

更新日期：1995-10-01 00:00:00

abstract：:Diffuse burning dysesthetic sensations distal to the level of spinal injury are the most common and disabling painful sequelae of traumatic spinal cord injury (SCI). In a cross-sectional study of 19 SCI patients, clinical characteristics and results of 3 validated pain measurement instruments (McGill Pain Questionnair...

journal_title：Pain

authors： Davidoff G,Roth E,Guarracini M,Sliwa J,Yarkony G

更新日期：1987-04-01 00:00:00

abstract：:The spinal ascending pathways responsible for neuronal ventrobasal (VB) thalamic responses elicited by joint stimulation of the posterior paw were determined in arthritic rats used as a model of experimental pain. Responses of a same neurone to mechanical (movement--pressure--brushing) or thermal stimulation (50 degre...

journal_title：Pain

authors： Guilbaud G,Peschanski M,Briand A,Gautron M

更新日期：1986-09-01 00:00:00

abstract：:Endogenous TRPV1 agonists such as oxidized linoleic acid metabolites (OLAMs) and the enzymes releasing them [eg, cytochrome P450 (CYP)] are up-regulated after inflammation in the rat. However, it is not known whether such agonists are elevated in human inflammatory pain conditions. Because TRPV1 is expressed in human ...

journal_title：Pain

authors： Ruparel S,Hargreaves KM,Eskander M,Rowan S,de Almeida JFA,Roman L,Henry MA

更新日期：2013-11-01 00:00:00

abstract：:Mounting evidence suggests that the spinal dorsal horn (SDH) contains multiple subpopulations of inhibitory interneurons that play distinct roles in somatosensory processing, as exemplified by the importance of spinal dynorphin-expressing neurons for the suppression of mechanical pain and chemical itch. Although it is...

journal_title：Pain

authors： Serafin EK,Chamessian A,Li J,Zhang X,McGann A,Brewer CL,Berta T,Baccei M

更新日期：2019-10-01 00:00:00

abstract：:Clinical trial participants often require additional instruction to prevent idiosyncratic interpretations regarding completion of patient-reported outcomes. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership developed a tr...

journal_title：Pain

authors： Smith SM,Amtmann D,Askew RL,Gewandter JS,Hunsinger M,Jensen MP,McDermott MP,Patel KV,Williams M,Bacci ED,Burke LB,Chambers CT,Cooper SA,Cowan P,Desjardins P,Etropolski M,Farrar JT,Gilron I,Huang IZ,Katz M,Kerns RD

更新日期：2016-05-01 00:00:00

abstract：:VGF (nonacronymic) is a granin-like protein that is packaged and proteolytically processed within the regulated secretory pathway. VGF and peptides derived from its processing have been implicated in neuroplasticity associated with learning, memory, depression, and chronic pain. In sensory neurons, VGF is rapidly incr...

journal_title：Pain

authors： Fairbanks CA,Peterson CD,Speltz RH,Riedl MS,Kitto KF,Dykstra JA,Braun PD,Sadahiro M,Salton SR,Vulchanova L

更新日期：2014-07-01 00:00:00

abstract：:The responses of primate spinothalamic tract (STT) neurons to innocuous and noxious mechanical stimuli applied to the skin can be enhanced for more than an hour following prolonged noxious stimulation. This increased responsiveness is thought to reflect sensitization of dorsal horn neurons and may help account for sec...

journal_title：Pain

authors： Paleček J,Palečková V,Dougherty PM,Willis WD

更新日期：1994-03-01 00:00:00

abstract：:Since a number of patients with Parkinson's Disease (PD) complain of painful sensations, we studied whether the central processing of nociceptive inputs is abnormal in PD. To test this hypothesis, we recorded scalp CO(2) laser evoked potentials (LEPs) to hand skin stimulation in 18 pain-free PD patients with unilatera...

journal_title：Pain

authors： Tinazzi M,Del Vesco C,Defazio G,Fincati E,Smania N,Moretto G,Fiaschi A,Le Pera D,Valeriani M

更新日期：2008-05-01 00:00:00

abstract：:Evidence has been accumulated suggesting that a dysfunction in pain inhibitory systems, i.e. in 'diffuse noxious inhibitory controls' (DNIC)-like mechanisms, might be-amongst other factors-responsible for the development of anatomically generalized chronic pain like fibromyalgia. The aim of the present study was to lo...

journal_title：Pain

authors： Pielsticker A,Haag G,Zaudig M,Lautenbacher S

更新日期：2005-11-01 00:00:00

abstract：:Anti-nerve growth factor (anti-NGF) therapy has shown significant promise in attenuating several types of skeletal pain. However, whether anti-NGF therapy changes the level of physical activity in individuals with or without skeletal pain is largely unknown. Here, automated day/night activity boxes monitored the effec...

journal_title：Pain

authors： Majuta LA,Mitchell SAT,Kuskowski MA,Mantyh PW

更新日期：2018-11-01 00:00:00