Paraplegia following coeliac plexus block.

abstract：:The capsaicin receptor in nociceptive neurons is a target for the sensitizing actions of algogenic inflammatory mediators. Capsaicin and potential endogenous ligands are thought not to gate this heat-activated ion channel but to sensitize it so profoundly that even room temperature can open it. We investigated the tem...

journal_title：Pain

authors： Kichko TI,Reeh PW

更新日期：2004-07-01 00:00:00

abstract：:To investigate the pathways of noxious information in the spinal cord in humans, we recorded cortical potentials following the stimulation of A-delta fibers using a YAG laser applied to two cutaneous points on the back at the C7 and Th10 level, 4cm to the right of the vertebral spinous process. A multiple source analy...

journal_title：Pain

authors： Tsuji T,Inui K,Kojima S,Kakigi R

更新日期：2006-08-01 00:00:00

abstract：:Effect of weight bearing of the hindlimbs on the assessment of mechanically-induced hindlimb withdrawal threshold was determined in intact rats and in rats with various pathophysiological conditions causing allodynia or hyperalgesia. Hindlimb withdrawal was elicited by applying a series of calibrated monofilaments to ...

journal_title：Pain

authors： Kauppila T,Kontinen VK,Pertovaara A

更新日期：1998-01-01 00:00:00

abstract：:Activation of supraspinal gamma-aminobutyric acid-A (GABAA) receptors is known to result in antagonism of opioid analgesia. Since benzodiazepines enhance the action of GABA at GABAA receptors, we hypothesized that administration of these agents for preoperative sedation might antagonize the analgesic effects of opioid...

journal_title：Pain

authors： Gear RW,Miaskowski C,Heller PH,Paul SM,Gordon NC,Levine JD

更新日期：1997-05-01 00:00:00

abstract：:Chronic widespread pain (CWP) is associated with poor health-related quality of life (HRQoL). It is unclear whether pain itself is the cause of poor HRQoL or other factors play a role. We hypothesised that new onset of CWP was associated with poor physical and mental HRQoL but that psychosocial risk markers for CWP on...

journal_title：Pain

authors： Nicholl BI,Macfarlane GJ,Davies KA,Morriss R,Dickens C,McBeth J

更新日期：2009-01-01 00:00:00

abstract：:Central antinociceptive effects of cannabinoids have been well documented. However, relatively little is known about the peripheral effects of the cannabinoids on inflammation. In the present study, we evaluated the effects of peripherally administered cannabinoids on three indices of inflammation: carrageenan-induced...

journal_title：Pain

authors： Richardson JD,Kilo S,Hargreaves KM

更新日期：1998-03-01 00:00:00

abstract：:Plasticity in inhibitory receptors, neurotransmission, and networks is an important mechanism for nociceptive signal amplification in the spinal dorsal horn. We studied potential changes in GABAergic pharmacology and its underlying mechanisms in hyperalgesic priming, a model of the transition from acute to chronic pai...

journal_title：Pain

authors： Kim JV,Megat S,Moy JK,Asiedu MN,Mejia GL,Vagner J,Price TJ

更新日期：2016-06-01 00:00:00

abstract：:We report findings from clinical examination and cutaneous laser stimulation in a 57-year-old male, who suffered from a right-sided postcentral stroke. In this patient, we were able to demonstrate (i) a dissociation of discriminative and affective components of pain perception and, for the first time in humans, (ii) t...

journal_title：Pain

authors： Ploner M,Freund HJ,Schnitzler A

更新日期：1999-05-01 00:00:00

abstract：:Endogenous pain inhibition is less efficient in chronic pain patients. Diffuse noxious inhibitory control (DNIC), a form of endogenous pain inhibition, is compromised in women and older people, making them more vulnerable to chronic pain. However, the underlying mechanisms remain unclear. Here, we used a capsaicin-ind...

journal_title：Pain

authors： Da Silva JT,Tricou C,Zhang Y,Seminowicz DA,Ro JY

更新日期：2020-06-01 00:00:00

abstract：:Data on comparative safety of opioid analgesics are limited, but some reports suggest disproportionate mortality risk associated with methadone. Our objective was to compare mortality rates among patients who received prescribed methadone or long-acting morphine for pain. This is a retrospective observational cohort d...

journal_title：Pain

authors： Krebs EE,Becker WC,Zerzan J,Bair MJ,McCoy K,Hui S

更新日期：2011-08-01 00:00:00

abstract：:Preventing and treating opioid dependence and withdrawal is a major clinical challenge, and the underlying mechanisms of opioid dependence and withdrawal remain elusive. We hypothesized that prolonged morphine exposure or chronic inflammation-induced μ-opioid receptor activity serves as a severe stress that elicits ne...

journal_title：Pain

authors： Wu M,Li Z,Liang L,Ma P,Cui D,Chen P,Wu G,Song XJ

更新日期：2020-03-01 00:00:00

abstract：:Postherpetic neuralgia (PHN) is a debilitating chronic pain condition, yet there is a lack of knowledge regarding underlying brain activity. Here we identify brain regions involved in spontaneous pain of PHN (n=11) and determine its modulation with Lidoderm therapy (patches of 5% lidocaine applied to the PHN affected ...

journal_title：Pain

authors： Geha PY,Baliki MN,Chialvo DR,Harden RN,Paice JA,Apkarian AV

更新日期：2007-03-01 00:00:00

abstract：:Caffeine is frequently added to mild analgesic preparations but its effect when used alone on pain has never been studied in humans. Using a double-blind placebo-controlled multiple crossover design, 53 patients with non-migrainous headaches were given placebo, acetaminophen, 2 doses of caffeine and 2 combinations of ...

journal_title：Pain

authors： Ward N,Whitney C,Avery D,Dunner D

更新日期：1991-02-01 00:00:00

abstract：:Substance P (SP) plays a central role in the transduction of second messenger signals from primary afferent nociceptive terminals to second-order neurons in the spinal cord. We have tested a recombinant engineered diphtheria toxin/SP fusion protein (DAB389SP) in acute and chronic pain models in the rat. DAB389SP binds...

journal_title：Pain

authors： Benoliel R,Eliav E,Mannes AJ,Caudle RM,Leeman S,Iadarola MJ

更新日期：1999-02-01 00:00:00

abstract：:The objective of this study was to examine which factors during pregnancy and postpartum predict pelvic girdle pain (PGP) at 12 weeks postpartum among working women. A total of 548 Dutch pregnant employees were recruited in 15 companies, mainly health care, child care, and supermarkets. The definition of PGP was any p...

journal_title：Pain

authors： Stomp-van den Berg SGM,Hendriksen IJM,Bruinvels DJ,Twisk JWR,van Mechelen W,van Poppel MNM

更新日期：2012-12-01 00:00:00

abstract：:Pain has the capacity to interfere with daily tasks. Although task interference by pain is largely unintentional, it can be controlled to a certain extent. Such top-down control over pain has been believed to be reduced in patients with fibromyalgia (FM). In this study, we investigated task interference and distractio...

journal_title：Pain

authors： Van Ryckeghem DML,Rost S,Kissi A,Vögele C,Crombez G

更新日期：2018-06-01 00:00:00

abstract：:Chronic pain is gender-related, since there is a clear predominance of one sex with respect to the other in most pain syndromes. Gonadal hormones are known to affect the occurrence and incidence of pain. Transsexuals receive cross-sex hormones to develop and maintain somatic characteristics of the opposite sex: male t...

journal_title：Pain

authors： Aloisi AM,Bachiocco V,Costantino A,Stefani R,Ceccarelli I,Bertaccini A,Meriggiola MC

更新日期：2007-11-01 00:00:00

abstract：:No research to date has descriptively catalogued what parents of healthy infants are naturalistically doing to manage their infant's pain over immunization appointments during the first year of life. This knowledge, in conjunction with an understanding of the relationships different parental techniques have with infan...

journal_title：Pain

authors： Lisi D,Campbell L,Pillai Riddell R,Garfield H,Greenberg S

更新日期：2013-08-01 00:00:00

abstract：:Endogenous TRPV1 agonists such as oxidized linoleic acid metabolites (OLAMs) and the enzymes releasing them [eg, cytochrome P450 (CYP)] are up-regulated after inflammation in the rat. However, it is not known whether such agonists are elevated in human inflammatory pain conditions. Because TRPV1 is expressed in human ...

journal_title：Pain

authors： Ruparel S,Hargreaves KM,Eskander M,Rowan S,de Almeida JFA,Roman L,Henry MA

更新日期：2013-11-01 00:00:00

abstract：:Below-level central neuropathic pain (CNP) affects a large proportion of spinal cord injured individuals. To better define the dynamic changes of the spinal cord neural network contributing to the development of CNP after spinal cord injury (SCI), we characterized the morphological and behavioral correlates of CNP in ...

journal_title：Pain

authors： Nees TA,Tappe-Theodor A,Sliwinski C,Motsch M,Rupp R,Kuner R,Weidner N,Blesch A

更新日期：2016-03-01 00:00:00

abstract：:Loss of high-voltage-activated (HVA) calcium current (ICa) and gain of low-voltage-activated (LVA) ICa after painful peripheral nerve injury cause elevated excitability in sensory neurons. Nerve injury is also accompanied by increased expression of the extracellular matrix glycoprotein thrombospondin-4 (TSP4), and int...

journal_title：Pain

authors： Pan B,Guo Y,Wu HE,Park J,Trinh VN,Luo ZD,Hogan QH

更新日期：2016-09-01 00:00:00

abstract：:Clinical observations and recent studies suggest that arthritis patients vary considerably in their involvement in self-management efforts. In the literature on health promotion, there is growing recognition that patients may be at different stages of change with respect to the adoption of self-management strategies. ...

journal_title：Pain

authors： Keefe FJ,Lefebvre JC,Kerns RD,Rosenberg R,Beaupre P,Prochaska J,Prochaska JO,Caldwell DS

更新日期：2000-09-01 00:00:00

abstract：:The behavioral response to acute tissue injury is usually characterized by different phases, but the brain mechanisms underlying changes in pain-related behavior over time are still poorly understood. We aimed to analyze time-dependent changes in metabolic activity levels of 49 forebrain structures in the formalin pai...

journal_title：Pain

authors： Porro CA,Cavazzuti M,Lui F,Giuliani D,Pellegrini M,Baraldi P

更新日期：2003-07-01 00:00:00

abstract：:Chronic pain in adults has been associated with early-life stress. To examine the pronociceptive effect of early-life stress, we evaluated cutaneous and muscle nociception and activity in muscle nociceptors in an animal model of neonatal stress, limited bedding, in the rat. In this neonatal limited bedding (NLB) model...

journal_title：Pain

authors： Green PG,Chen X,Alvarez P,Ferrari LF,Levine JD

更新日期：2011-11-01 00:00:00

abstract：:Individuals diagnosed with fibromyalgia syndrome (FMS) report chronic pain that is frequently worsened by physical activity and improved by rest. Palpation of muscle and tendinous structures suggests that nociceptors in deep tissues are abnormally sensitive in FMS, but methods of controlled mechanical stimulation of m...

journal_title：Pain

authors： Staud R,Cannon RC,Mauderli AP,Robinson ME,Price DD,Vierck CJ Jr

更新日期：2003-03-01 00:00:00

abstract：:Chronic pain after joint replacement is common, affecting approximately 10% of patients after total hip replacement (THR) and 20% of patients after total knee replacement (TKR). Heightened generalized sensitivity to nociceptive input could be a risk factor for the development of this pain. The primary aim of this stud...

journal_title：Pain

authors： Wylde V,Sayers A,Lenguerrand E,Gooberman-Hill R,Pyke M,Beswick AD,Dieppe P,Blom AW

更新日期：2015-01-01 00:00:00

abstract：:Two models of the relationship between paraspinal EMG and low back pain have been proposed. Specific predictions arising from these are listed and the literature relating to them reviewed. Recent research on patterns of EMG rather than absolute levels is also discussed. It is concluded that there is no consistent evid...

journal_title：Pain

authors： Nouwen A,Bush C

更新日期：1984-10-01 00:00:00

abstract：:The present study examined antinociception produced by systemic administration of caffeine in the rat hot-plate (HP) and formalin tests and addressed several aspects of the mechanism of action of caffeine. Locomotor activity was monitored throughout. Caffeine produced a dose-related antinociception the HP (50-100 mg/k...

journal_title：Pain

authors： Sawynok J,Reid AR,Doak GJ

更新日期：1995-05-01 00:00:00

abstract：:Although many patients with multiple sclerosis (MS) complain of trigeminal neuralgia (TN), its cause and mechanisms are still debatable. In a multicentre controlled study, we collected 130 patients with MS: 50 patients with TN, 30 patients with trigeminal sensory disturbances other than TN (ongoing pain, dysaesthesia,...

journal_title：Pain

authors： Cruccu G,Biasiotta A,Di Rezze S,Fiorelli M,Galeotti F,Innocenti P,Mameli S,Millefiorini E,Truini A

更新日期：2009-06-01 00:00:00

abstract：:Although it is well known that cannabinoids produce antinociception in acute pain models, there is less information on the ability of cannabinoids to alleviate hyperalgesia. In the present study, we determined whether cannabinoids attenuated the development of hyperalgesia produced by intraplantar injection of capsaic...

journal_title：Pain

authors： Li J,Daughters RS,Bullis C,Bengiamin R,Stucky MW,Brennan J,Simone DA

更新日期：1999-05-01 00:00:00