Multiple pathways for noxious information in the human spinal cord.

abstract：:Numerous animal studies suggest that acute and chronic exposure to opioids can be associated with the development of hyperalgesia, i.e. an increased sensitivity to noxious stimuli. Hyperalgesia has been documented during withdrawal and on occasion while animals were still exposed to opioids. A pivotal role in the gene...

journal_title：Pain

authors： Angst MS,Koppert W,Pahl I,Clark DJ,Schmelz M

更新日期：2003-11-01 00:00:00

abstract：:Recent research has focused on identification of clinically meaningful subgroupings within the chronic pain population in contrast to prior emphasis on the homogeneity of these patients. The present study investigates site of pain as a potentially useful classification variable for identification of differences among ...

journal_title：Pain

authors： Toomey TC,Gover VF,Jones BN

更新日期：1984-08-01 00:00:00

abstract：:Activated mammalian target of rapamycin (P-mTOR) has been shown to maintain the sensitivity of subsets of small-diameter primary afferent A-nociceptors. Local or systemic inhibition of the mTOR complex 1 (mTORC1) pathway reduced punctate mechanical and cold sensitivity in neuropathic pain and therefore offered a new a...

journal_title：Pain

authors： Obara I,Medrano MC,Signoret-Genest J,Jiménez-Díaz L,Géranton SM,Hunt SP

更新日期：2015-08-01 00:00:00

abstract：:Anti-nerve growth factor (anti-NGF) therapy has shown significant promise in attenuating several types of skeletal pain. However, whether anti-NGF therapy changes the level of physical activity in individuals with or without skeletal pain is largely unknown. Here, automated day/night activity boxes monitored the effec...

journal_title：Pain

authors： Majuta LA,Mitchell SAT,Kuskowski MA,Mantyh PW

更新日期：2018-11-01 00:00:00

abstract：:The inability of opioids to control pain over time may be influenced by different factors such as drug tolerance, hyperalgesia due to repeated morphine administration or progression of the original disease. In addition, chronic pain may alter morphine tolerance development. This study examined whether chronic morphine...

journal_title：Pain

authors： Christensen D,Kayser V

更新日期：2000-12-01 00:00:00

abstract：:The proinflammatory cytokines tumor necrosis factor (TNF) α and interleukin (IL) 1β have been strongly implicated in the pathogenesis of neuropathic pain, but the intracellular signaling of these cytokines in glial cells is not fully understood. TNF receptor-associated factor 6 (TRAF6) plays a key role in signal trans...

journal_title：Pain

authors： Lu Y,Jiang BC,Cao DL,Zhang ZJ,Zhang X,Ji RR,Gao YJ

更新日期：2014-12-01 00:00:00

abstract：:Thirty-eight patients maintained on opioid analgesics for non-malignant pain were retrospectively evaluated to determine the indications, course, safety and efficacy of this therapy. Oxycodone was used by 12 patients, methadone by 7, and levorphanol by 5; others were treated with propoxyphene, meperidine, codeine, pen...

journal_title：Pain

authors： Portenoy RK,Foley KM

更新日期：1986-05-01 00:00:00

abstract：:The opiate antagonist naloxone has been reported to cause pain relief. Therefore, the effect was determined of naloxone, injected intravenously, on the activity in single neurones of the dorsomedial part of the ventral nucleus (VDM) in the thalamus of rats under urethane anaesthesia elicited by electrical stimulation ...

journal_title：Pain

authors： Jurna I

更新日期：1988-12-01 00:00:00

abstract：:Plastic changes in the anterior cingulate cortex (ACC) are critical in pain hypersensitivity caused by peripheral nerves injury. The Notch signaling pathway has been shown to regulate synaptic differentiation and transmission. Therefore, this study was to investigate the function of the Notch signaling pathway in the ...

journal_title：Pain

authors： Duan H,Shen F,Li L,Tu Z,Chen P,Chen P,Wang Z,Liang W,Wang Y

更新日期：2021-01-01 00:00:00

abstract：:Pain modulation by placebo mechanisms is one of the most robust and best-studied phenomena, yet almost all research investigating the mechanisms and implications of the placebo analgesia are based on adult research. After highlighting crucial aspects that need to be considered in studying pain modulation in children, ...

journal_title：Pain

authors： Simmons K,Ortiz R,Kossowsky J,Krummenacher P,Grillon C,Pine D,Colloca L

更新日期：2014-11-01 00:00:00

abstract：:We report a case control study comparing patients attending a pain clinic whose symptoms were not considered medically explained (cases) with those whose symptoms were considered medically explained (controls). Principal comparisons were psychiatric morbidity, medication use, and iatrogenic factors assessed by intervi...

journal_title：Pain

authors： Kouyanou K,Pither CE,Rabe-Hesketh S,Wessely S

更新日期：1998-06-01 00:00:00

abstract：:A growing body of literature suggests that the experience of clinical pain differs across ethnocultural groups. Additionally, some evidence indicates greater sensitivity to experimentally induced pain among African Americans; however, most studies have included only one pain modality. This study examined ethnic differ...

journal_title：Pain

authors： Campbell CM,Edwards RR,Fillingim RB

更新日期：2005-01-01 00:00:00

abstract：:The physiological properties of joint capsule mechanoreceptors in the ankle joint of the chicken were studied in the 3-h period immediately after intra-articular injection of microcrystal sodium urate. The electrical activity was recorded from single C- and A-delta sensory fibres dissected from the parafibular nerve. ...

journal_title：Pain

authors： Gentle MJ

更新日期：1997-04-01 00:00:00

abstract：:The present study observed the expression of the 5-hydroxytryptamine (5-HT) (1A) receptor mRNA in the lumbar spinal dorsal horn neurons following carrageenan inflammation using in situ hybridization (ISH). We also studied the co-localization of 5-HT(1A) receptor mRNA and gamma-amino butyric acid (GABA) or enkephalin (...

journal_title：Pain

authors： Zhang YQ,Gao X,Ji GC,Huang YL,Wu GC,Zhao ZQ

更新日期：2002-08-01 00:00:00

abstract：:Fifty-seven patients (74%) who had completed a multidisciplinary pain program returned mailed questionnaires assessing both outcome and compliance measures. Significant treatment gains were observed at follow-up. Compliance with prescribed therapeutic regimens was low, averaging around 42% for individual regimens. Com...

journal_title：Pain

authors： Lutz RW,Silbret M,Olshan N

更新日期：1983-11-01 00:00:00

abstract：:Altered pain sensitivity is believed to play an important role for chronification of headache. It has however mainly been evaluated in highly selected patients from headache clinics and never in longitudinal studies. The present study is a 12-year follow-up of a population-based study of primary headache disorders and...

journal_title：Pain

authors： Buchgreitz L,Lyngberg AC,Bendtsen L,Jensen R

更新日期：2008-07-31 00:00:00

abstract：:In the last decade, there has been burgeoning interest in the effectiveness of third-generation psychological therapies for managing fibromyalgia (FM) symptoms. The present study examined the effectiveness of acceptance and commitment therapy (ACT) on functional status as well as the role of pain acceptance as a media...

journal_title：Pain

authors： Luciano JV,Guallar JA,Aguado J,López-Del-Hoyo Y,Olivan B,Magallón R,Alda M,Serrano-Blanco A,Gili M,Garcia-Campayo J

更新日期：2014-04-01 00:00:00

abstract：:High-quality information on the potential benefit and harm of a drug is required for patients and clinicians to make informed treatment decisions and to enable cost-effectiveness modeling to be undertaken. This systematic review describes the collection and reporting of adverse event data as presented in published cli...

journal_title：Pain

authors： Cornelius VR,Sauzet O,Williams JE,Ayis S,Farquhar-Smith P,Ross JR,Branford RA,Peacock JL

更新日期：2013-02-01 00:00:00

abstract：:We have constructed and validated the Elderly Pain Caring Assessment 2 (EPCA-2) an 8 items behavioural scale to rate the intensity of pain in non-verbally communicating older (age 65 years) patients (NVC-OP). It was postulated that the assessed pain had two dimensions (signs outside and during caregiving). The first v...

journal_title：Pain

authors： Morello R,Jean A,Alix M,Sellin-Peres D,Fermanian J

更新日期：2007-12-15 00:00:00

abstract：:Extracellular adenosine triphosphate (ATP), acting at P2X ionotropic receptors, is implicated in numerous sensory processes. Exogenous ATP has been shown to be algogenic in both animals and humans. Research focus has been directed towards the P2X(3) receptor, as it is preferentially expressed on nociceptive C-fibers a...

journal_title：Pain

authors： Honore P,Kage K,Mikusa J,Watt AT,Johnston JF,Wyatt JR,Faltynek CR,Jarvis MF,Lynch K

更新日期：2002-09-01 00:00:00

abstract：:Although pediatric functional abdominal pain (FAP) has been linked to abdominal pain later in life, childhood predictors of long-term outcomes have not been identified. This study evaluated whether distinct FAP profiles based on patterns of pain and adaptation in childhood could be identified and whether these profile...

journal_title：Pain

authors： Walker LS,Sherman AL,Bruehl S,Garber J,Smith CA

更新日期：2012-09-01 00:00:00

abstract：:This study investigated the antinociceptive effect of opioids given via intraperitoneal and intrathecal routes in a diabetes-induced neuropathic pain model in rats. Streptozotocin induced diabetes in 91% of juvenile male Wistar rats at the dose of 150 mg/kg (75 mg/kg intraperitoneal on 2 successive days). When compare...

journal_title：Pain

authors： Zurek JR,Nadeson R,Goodchild CS

更新日期：2001-02-01 00:00:00

abstract：:We performed a prospective study in 32 patients with Guillain-Barré syndrome (GBS) or its variants to correlate intraepidermal nerve fiber density (IENFD) at the distal leg and lumbar region with pain, autonomic dysfunction, and outcome. In the acute phase, IENFD was reduced in 60% and 61.9% of patients at the distal ...

journal_title：Pain

authors： Ruts L,van Doorn PA,Lombardi R,Haasdijk ED,Penza P,Tulen JHM,Hempel RJ,van den Meiracker AH,Lauria G

更新日期：2012-02-01 00:00:00

abstract：:Catechol-O-methyltransferase (COMT) regulates extracellular catecholamines. A widely studied COMT single nucleotide polymorphism (rs4680) changes the translated amino acid from valine to methionine (Val158Met); the polymorphism has been shown to influence opioid use. The aims of this study were to investigate the infl...

journal_title：Pain

authors： Hooten WM,Biernacka JM,O'Brien TG,Cunningham JM,Black JL

更新日期：2019-01-01 00:00:00

abstract：:The initial stages in the development of an Arabic pain inventory are described. 279 Kuwaiti adults were asked to nominate as many words as they could think of to describe pain. A dictionary translation of the McGill Pain Questionnaire (MPQ) was prepared, and subjects judged which of these represent acceptable pain de...

journal_title：Pain

authors： Harrison A

更新日期：1988-02-01 00:00:00

abstract：:Chronic pain is associated with large societal costs, but few studies have investigated the total costs of chronic pain with respect to elderly subjects. The elderly usually require informal care, care performed by municipalities, and care for chronic diseases, all factors that can result in extensive financial burden...

journal_title：Pain

authors： Bernfort L,Gerdle B,Rahmqvist M,Husberg M,Levin LÅ

更新日期：2015-03-01 00:00:00

abstract：:Injection of high-dose of morphine into the spinal lumbar intrathecal (i.t.) space of rats elicits a nociceptive behavioural syndrome characterized by periodic bouts of spontaneous agitation and severe vocalization. The induced behavioural response such as vocalization and agitation was observed dose-dependently by i....

journal_title：Pain

authors： Watanabe C,Sakurada T,Okuda K,Sakurada C,Ando R,Sakurada S

更新日期：2003-12-01 00:00:00

abstract：:Migraine headache is an episodic phenomenon, and patients with episodic migraine have ictal (headache), peri-ictal (premonitory, aura, and postdrome), and interictal (asymptomatic) phases. We aimed to find the functional characteristics of the migraine brain regardless of headache phase using dynamic functional connec...

journal_title：Pain

authors： Lee MJ,Park BY,Cho S,Park H,Kim ST,Chung CS

更新日期：2019-12-01 00:00:00

abstract：:A noncontrolled, randomized, multicenter study (NCT00924664) evaluated long-term safety and effectiveness of tanezumab in patients with chronic low back pain following a randomized placebo- and active-controlled parent study that evaluated analgesic efficacy. Patients were randomized to tanezumab 10mg (n=321) or 20mg ...

journal_title：Pain

authors： Gimbel JS,Kivitz AJ,Bramson C,Nemeth MA,Keller DS,Brown MT,West CR,Verburg KM

更新日期：2014-09-01 00:00:00

abstract：:The results of a considerable number of recent prospective studies have demonstrated that greater acute pain severity in herpes zoster patients is associated with a significantly greater risk of developing postherpetic neuralgia (PHN). Only a few studies have examined the relationships between acute pain severity and ...

journal_title：Pain

authors： Dworkin RH,Nagasako EM,Johnson RW,Griffin DRJ

更新日期：2001-10-01 00:00:00