Abstract:
:We performed a prospective study in 32 patients with Guillain-Barré syndrome (GBS) or its variants to correlate intraepidermal nerve fiber density (IENFD) at the distal leg and lumbar region with pain, autonomic dysfunction, and outcome. In the acute phase, IENFD was reduced in 60% and 61.9% of patients at the distal leg and lumbar region, respectively. In the acute phase, 43.7% of patients complained of neuropathic pain. Their IENFD at the distal leg was significantly lower than in patients without pain (P<.001) and correlated with pain intensity (r(s)=-0.51; P=.003). Intriguingly, also patients with the pure motor variant of GBS and pain had low IENFD. At 6-month follow-up, only 3 patients complained of persisting neuropathic pain, whereas 3 patients reported late-onset pain symptoms. IENFD in the acute phase did not predict presence or intensity of pain at 6-month follow-up. IENFD in the acute phase did not correlate with clinical dysautonomia or GBS severity at nadir. However, it correlated with poorer GBS disability score at 6 months (P=.04), GBS score at nadir (P=.03), and clinically probable dysautonomia (P=.004). At 6-month follow-up, median IENFD remained significantly low both at the distal leg (P=.024) and lumbar region (P=.005). Double and triple staining confocal microscope studies showed diffuse damage of myelinated dermal nerves along with axonal degeneration, and mononuclear cell infiltration. Unmyelinated and myelinated skin nerves are diffusely affected in GBS and its variants, including the pure motor form. IENFD declines early, remains low over time, correlates with pain severity in the acute phase, and may predict long-term disability.
journal_name
Painjournal_title
Painauthors
Ruts L,van Doorn PA,Lombardi R,Haasdijk ED,Penza P,Tulen JHM,Hempel RJ,van den Meiracker AH,Lauria Gdoi
10.1016/j.pain.2011.10.037subject
Has Abstractpub_date
2012-02-01 00:00:00pages
399-409issue
2eissn
0304-3959issn
1872-6623pii
00006396-201202000-00022journal_volume
153pub_type
杂志文章相关文献
PAIN文献大全abstract::We describe audible and ultrasonic vocalization elicited in rats by a short electrical pulse applied to the tail. Three types of vocal emissions were recorded: (1) 'peep', characterized by a repartition of energy over a wide range (0-50 kHz) of frequencies without any clear structure; (2) 'chatters', characterized by ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(95)00049-X
更新日期:1995-11-01 00:00:00
abstract::Ketanserin, a selective S2 serotonergic antagonist, was assessed against placebo in a double-blind cross-over study of 16 patients with chronic peripheral burning pain. Nine of these had signs of reflex sympathetic dystrophy (RSD). All patients underwent 4 intravenous regional treatments, 2 with ketanserin (10 mg for ...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(89)90232-7
更新日期:1989-08-01 00:00:00
abstract::The nationwide multicenter trials of the German Research Network on Neuropathic Pain (DFNS) aim to characterize the somatosensory phenotype of patients with neuropathic pain. For this purpose, we have implemented a standardized quantitative sensory testing (QST) protocol giving a complete profile for one region within...
journal_title:Pain
pub_type: 杂志文章,多中心研究
doi:10.1016/j.pain.2006.01.041
更新日期:2006-08-01 00:00:00
abstract::Fourteen patients whose post-herpetic neuralgia could not be alleviated by conventional methods were treated with cryocautery using a stick of solid carbon dioxide (dry ice) applied directly to the hyperesthetic skin areas of the cutaneous scars. Follow-up evaluation revealed that 5 of 14 subjects maintained excellent...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(80)90049-4
更新日期:1980-12-01 00:00:00
abstract::Data from daily diaries were used to analyze pain coping processes in rheumatoid arthritis patients. For 30 consecutive days, 53 individuals described the pain coping strategies they used that day and rated the efficacy of their coping, joint pain, and positive and negative mood. Relations among variables were examine...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(96)03246-0
更新日期:1997-01-01 00:00:00
abstract::The present study investigated the role of micro, delta, and kappa receptors within the RVM in mediating expression of conditional hypoalgesia (CHA). Five groups of rats with RVM cannulae were given daily sessions of paired or unpaired presentations of an auditory CS (white noise) and foot shock across three consecuti...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(99)00125-6
更新日期:1999-12-01 00:00:00
abstract::Combined oral administration of morphine sulfate (MS) and the over-the-counter antitussive drug and N-methyl-D-aspartate receptor antagonist dextromethorphan (DM) prevented the development of tolerance to the antinociceptive effects of MS (15, 24, or 32 mg/kg) in rats. This combined oral treatment regimen also attenua...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(96)03120-x
更新日期:1996-10-01 00:00:00
abstract::Indicators of persistent pain in preterm neonates are poorly defined. In the setting of a double blind, placebo-controlled trial investigating morphine use in ventilated preterm infants (NEOPAIN Trial) we aimed to identify factors that may be useful in assessing persistent pain. Twenty-two babies (morphine 12; placebo...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2006.03.019
更新日期:2006-09-01 00:00:00
abstract::Adults with mood disorders frequently use prescription opioids. The factors associated with this increased use remain unclear. We used the Medical Expenditure Panel Surveys from 2005 to 2011 to measure the association of mood disorders with new opioid use and the transition to longer-term opioid use for a variety of p...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000650
更新日期:2016-11-01 00:00:00
abstract::Altered pain sensitivity is believed to play an important role for chronification of headache. It has however mainly been evaluated in highly selected patients from headache clinics and never in longitudinal studies. The present study is a 12-year follow-up of a population-based study of primary headache disorders and...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.10.023
更新日期:2008-07-31 00:00:00
abstract::Musculoskeletal disorders (MSDs) are highly prevalent, painful, and costly disorders. The MSD Cohort was created to characterize variation in pain, comorbidities, treatment, and outcomes among patients with MSD receiving Veterans Health Administration care across demographic groups, geographic regions, and facilities....
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000567
更新日期:2016-08-01 00:00:00
abstract::In primary care and physical therapy settings, we evaluated an intervention for chronic back pain patients which incorporated fear reducing and activating techniques. Primary care patients seen for back pain in primary care were screened to identify persons with significant activity limitations 8-10 weeks after their ...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.pain.2004.11.007
更新日期:2005-02-01 00:00:00
abstract::Intrathecal (i.t.) administration of spermine (0.1-10000 fmol), an endogenous polyamine, produced the behavioural response mainly consisting of biting and/or licking of the hindpaw along with a slight hindlimb scratching directed toward the flank in mice, which peaked at 5-15 min and almost disappeared at 30 min after...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(99)00312-7
更新日期:2000-05-01 00:00:00
abstract::microRNAs (miRNAs) are small noncoding RNAs that have been linked to a number of disease-related signal transduction pathways. Several studies indicate that they are also involved in nociception. It is not clear, however, which miRNAs are important and which genes are modulated by miRNA-associated mechanisms. This stu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.11.010
更新日期:2013-03-01 00:00:00
abstract::Mechanical allodynia is pain caused by normally innocuous mechanical stimuli and is a cardinal and intractable symptom of neuropathic pain. Roles of low-threshold mechanoreceptors (LTMRs), including Aβ fibers, in mechanical allodynia have previously been proposed, but the necessity and sufficiency of LTMRs in allodyni...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1097/j.pain.0000000000001506
更新日期:2019-05-01 00:00:00
abstract::Experimental data have suggested that in neuropathic pain, tricyclic antidepressants may work solely through a β2-agonist action. The aim of this study was to test if the β2-agonist terbutaline relieves painful polyneuropathy. The study was a randomized, double-blind, placebo-controlled and active-controlled, 3-way, c...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002140
更新日期:2020-11-06 00:00:00
abstract::The present study investigated whether the level of cognitive impairment (CI) affects acute pain behavior and how it is manifested. Participants were 159 individuals (mean age 42+/-12), 121 with CI (divided into four groups according to the level of CI: mild, moderate, severe, profound) and 38 with normal cognition (c...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/j.pain.2006.04.031
更新日期:2006-10-01 00:00:00
abstract::A systematic review and meta-analysis of population-based epidemiological studies was undertaken to determine the prevalence of foot and ankle pain in middle and old age. Searches were conducted in the following electronic databases from inception to October 2010: PubMed, EMBASE, AMED, CINAHL, Cochrane, PEDro, and Spo...
journal_title:Pain
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.pain.2011.09.019
更新日期:2011-12-01 00:00:00
abstract::Intraperitoneal administration of the serotonin 5-HT1A agonist, buspirone (1-5 mg/kg), produced dose- and time-related core hypothermia that was coincident with analgesia against a thermally noxious stimulus. Surface body temperature was not altered by buspirone. The 5-HT1A antagonist, NAN-190 (2 mg/kg, s.c.), blocked...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90042-A
更新日期:1992-09-01 00:00:00
abstract::Primary afferent sensory neurons are incredibly long cells, often traversing distances of over 1 m in humans. Cutaneous sensory stimuli are transduced in the periphery by specialised end organs or free nerve endings, which code the stimulus into electrical action potentials that propagate towards the central nervous s...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001145
更新日期:2018-07-01 00:00:00
abstract::Excessive pain during medical procedures performed in unanesthetized patients is frequently reported, but can be reduced with virtual reality (VR) distraction. Increasing the person's illusion of going into the virtual world may increase how effectively VR distracts pain. Healthy volunteers aged 18-20 years participat...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/j.pain.2004.06.013
更新日期:2004-09-01 00:00:00
abstract::Activation of extracellular signal-regulated kinase (ERK), a mitogen activated-protein kinase (MAPK), in dorsal horn neurons contributes to inflammatory pain by transcription-dependent and -independent means. We have now investigated if ERK is activated in the spinal cord after a spinal nerve ligation (SNL) and if thi...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.12.022
更新日期:2005-03-01 00:00:00
abstract::Despite frequent targeting of health beliefs in pediatric chronic pain treatment interventions, there are currently no reliable and valid self-efficacy measures for children with chronic pain and their parents. The current study examined the psychometric properties of parent and child versions of a self-efficacy measu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.04.026
更新日期:2006-11-01 00:00:00
abstract::A noxious cold stimulus can evoke multiple sensations each occurring with a different time course. We have performed psychophysical studies to identify the time course of five sensations evoked by a noxious cold stimulus applied to the hand. Subjects continuously rated either pain, ache, cold, heat or prickle sensatio...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(02)00043-x
更新日期:2002-07-01 00:00:00
abstract::Opioid use for chronic pain is limited by severe central adverse effects. We examined whether activating mu-opioid receptors (MORs) in the peripheral nervous system attenuates spinal cord injury (SCI) pain-like behavior in mice. We produced a contusive SCI at the T10 vertebral level and examined motor and sensory dysf...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001671
更新日期:2019-12-01 00:00:00
abstract::Postherpetic neuralgia (PHN) is a debilitating chronic pain condition, yet there is a lack of knowledge regarding underlying brain activity. Here we identify brain regions involved in spontaneous pain of PHN (n=11) and determine its modulation with Lidoderm therapy (patches of 5% lidocaine applied to the PHN affected ...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/j.pain.2006.09.014
更新日期:2007-03-01 00:00:00
abstract::Pain behaviors are shaped by social demands and learning processes, and chronic pain has been previously suggested to affect their meaning. In this study, we combined functional magnetic resonance imaging with in-scanner video recording during thermal pain stimulations and use multilevel mediation analyses to study th...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000587
更新日期:2016-08-01 00:00:00
abstract::An experimental mononeuropathy was produced in rats by unilateral loose ligation of the sciatic nerve, with a contralateral sham surgery. Repeated bilateral sensory testing was performed over time to investigate any threshold differences between the loose ligature side and the contralateral control side. A prolonged r...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(93)90004-9
更新日期:1993-12-01 00:00:00
abstract::Inflammation enhances release of neuropeptides from sensory nerve terminals in the spinal cord, and this may contribute to the development of hyperalgesia. In a similar manner, proinflammatory prostaglandins also augment peptide release from sensory neurons. To ascertain whether the inflammation-induced increase in pe...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(98)00113-4
更新日期:1998-10-01 00:00:00
abstract::This study evaluated movement velocity, frequency, and amplitude, as well as the number of arrests in three different subject groups, by kinematic analysis of repetitive movements during a finger tapping (FT) task. The most affected hands of 80 patients with complex regional pain syndrome (CRPS) were compared with the...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.12.018
更新日期:2012-04-01 00:00:00