The evaluation of acute pain in individuals with cognitive impairment: a differential effect of the level of impairment.

Abstract:

:The present study investigated whether the level of cognitive impairment (CI) affects acute pain behavior and how it is manifested. Participants were 159 individuals (mean age 42+/-12), 121 with CI (divided into four groups according to the level of CI: mild, moderate, severe, profound) and 38 with normal cognition (controls). The behavior of the participants before and during acute pain (influenza vaccination) was coded by two raters with the Facial Action Coding System (FACS - scores facial reactions to pain) and the Non-Communicating Children's Pain Checklist (NCCPC-R - scores both facial and general body reactions). Individuals with severe-profound CI exhibited elevated FACS and NCCPC-R values at baseline compared with all other groups (p<0.01). Both FACS and NCCPC-R scores of individuals with mild-moderate CI and controls increased significantly during vaccination (p<0.001). In contrast, individuals with severe-profound CI exhibited high rates of "freezing reaction" (stillness) during vaccination, manifested mainly in the face and therefore resulting in elevation of only NCCPC-R scores but not of FACS's. The results suggest that the level of CI affects baseline as well as pain behavior and it is therefore necessary to choose an appropriate behavioral tool to measure pain in these individuals accordingly. For example, tools based on facial reactions alone might provide the false impression that individuals with severe-profound CI are insensitive to pain (due to freezing).

journal_name

Pain

journal_title

Pain

authors

Defrin R,Lotan M,Pick CG

doi

10.1016/j.pain.2006.04.031

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

312-320

issue

3

eissn

0304-3959

issn

1872-6623

pii

00006396-200610000-00011

journal_volume

124

pub_type

临床试验,杂志文章

相关文献

PAIN文献大全
  • Investigating dose-dependent effects of placebo analgesia: a psychophysiological approach.

    abstract::Investigating dose-dependent effects of placebo analgesia (PA) in laboratory subjects undergoing pain testing, we evaluated 2 hypotheses: (1) greater expectancy for relief produces greater PA, and (2) cued expectancy for relief triggered by a predictive cue leads to more enhanced analgesia than does passive expectancy...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2011.10.024

    authors: Nakamura Y,Donaldson GW,Kuhn R,Bradshaw DH,Jacobson RC,Chapman RC

    更新日期:2012-01-01 00:00:00

  • Impairment of pain inhibition in chronic tension-type headache.

    abstract::Evidence has been accumulated suggesting that a dysfunction in pain inhibitory systems, i.e. in 'diffuse noxious inhibitory controls' (DNIC)-like mechanisms, might be-amongst other factors-responsible for the development of anatomically generalized chronic pain like fibromyalgia. The aim of the present study was to lo...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2005.08.019

    authors: Pielsticker A,Haag G,Zaudig M,Lautenbacher S

    更新日期:2005-11-01 00:00:00

  • Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons.

    abstract::Aquaporin 1 (AQP1) is the archetypal member of a family of water channel proteins that contribute to water homeostasis in kidney, lung, and other tissues. Although there is limited evidence that aquaporins are expressed in the nervous system, AQP4 is expressed in glia and AQP9 is present on some neuronal and glial mit...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2006.11.018

    authors: Shields SD,Mazario J,Skinner K,Basbaum AI

    更新日期:2007-09-01 00:00:00

  • The acquisition and generalization of cued and contextual pain-related fear: an experimental study using a voluntary movement paradigm.

    abstract::Recent evidence indicates that pain-related fear can be acquired through associative learning. In the clinic, however, spreading of fear and avoidance is observed beyond movements/activities that were associated with pain during the original pain episode. One mechanism accounting for this spreading of fear is stimulus...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2012.10.025

    authors: Meulders A,Vlaeyen JWS

    更新日期:2013-02-01 00:00:00

  • Pain alleviation by vibratory stimulation.

    abstract::In the present study 366 patients suffering acute or chronic musculoskeletal pain of different origin were given vibratory stimulation for the pain. Many of the patients had previously had treatments of various kinds without satisfactory relief. The effect of vibratory stimulation was assessed during and after stimula...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(84)90808-X

    authors: Lundeberg T,Nordemar R,Ottoson D

    更新日期:1984-09-01 00:00:00

  • Excitatory amino acid release in the spinal cord caused by plantar incision in the rat.

    abstract::There is extensive evidence that spinal excitatory amino acids (EAAs) like glutamate (Glu) and aspartate (Asp) are important in the processing of nociceptive behaviors caused by incisions. To better understand EAA-induced dorsal horn sensitization caused by surgery, we examined the time course and extent of spinal ami...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/s0304-3959(02)00241-5

    authors: Zahn PK,Sluka KA,Brennan TJ

    更新日期:2002-11-01 00:00:00

  • The effects of noxious heat, auditory stimulation, a cognitive task, and time on task on pain perception and performance accuracy in healthy volunteers: a new experimental model.

    abstract::The effects of cognitive and competing sensory processing tasks on pain perception and as a function of time are only partially understood. To study these effects, we compared the simultaneous effects of noxious heat stimulation (HS), auditory stimulation (AS) (sinusoidally modulated speech-like signal, SMSLS), and a ...

    journal_title:Pain

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.pain.2005.10.029

    authors: Pud D,Sapir S

    更新日期:2006-01-01 00:00:00

  • Assessment of brain responses to innocuous and noxious electrical forepaw stimulation in mice using BOLD fMRI.

    abstract::Functional magnetic resonance imaging (fMRI) using the blood oxygen level-dependent (BOLD) contrast was used to study sensory processing in the brain of isoflurane-anesthetized mice. The use of a cryogenic surface coil in a small animal 9.4T system provided the sensitivity required for detection and quantitative analy...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2010.08.025

    authors: Bosshard SC,Baltes C,Wyss MT,Mueggler T,Weber B,Rudin M

    更新日期:2010-12-01 00:00:00

  • A role for NT-3 in the hyperinnervation of neonatally wounded skin.

    abstract::Neurotrophin-3 (NT-3) is a target-derived neurotrophic factor that regulates sensory neuronal survival and growth. Here we report that NT-3 plays a critical permissive role in cutaneous sensory nerve sprouting that contributes to pain and sensitivity following skin wounding in young animals. Sensory terminal sprouting...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2012.07.012

    authors: Beggs S,Alvares D,Moss A,Currie G,Middleton J,Salter MW,Fitzgerald M

    更新日期:2012-10-01 00:00:00

  • German Randomized Acupuncture Trial for chronic shoulder pain (GRASP) - a pragmatic, controlled, patient-blinded, multi-centre trial in an outpatient care environment.

    abstract:UNLABELLED:The German Randomized Acupuncture Trial for chronic shoulder pain (GRASP) comprised 424 outpatients with chronic shoulder pain (CSP) > or =6 weeks and an average pain score of VAS > or =50 mm, who were randomly assigned to receive Chinese acupuncture (verum), sham acupuncture (sham) or conventional conservat...

    journal_title:Pain

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.pain.2010.06.036

    authors: Molsberger AF,Schneider T,Gotthardt H,Drabik A

    更新日期:2010-10-01 00:00:00

  • Multiple pathways for noxious information in the human spinal cord.

    abstract::To investigate the pathways of noxious information in the spinal cord in humans, we recorded cortical potentials following the stimulation of A-delta fibers using a YAG laser applied to two cutaneous points on the back at the C7 and Th10 level, 4cm to the right of the vertebral spinous process. A multiple source analy...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2006.03.009

    authors: Tsuji T,Inui K,Kojima S,Kakigi R

    更新日期:2006-08-01 00:00:00

  • Loss of inhibitory tone on spinal cord dorsal horn spontaneously and nonspontaneously active neurons in a mouse model of neuropathic pain.

    abstract::Plasticity of inhibitory transmission in the spinal dorsal horn (SDH) is believed to be a key mechanism responsible for pain hypersensitivity in neuropathic pain syndromes. We evaluated this plasticity by recording responses to mechanical stimuli in silent neurons (nonspontaneously active [NSA]) and neurons showing on...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000000538

    authors: Medrano MC,Dhanasobhon D,Yalcin I,Schlichter R,Cordero-Erausquin M

    更新日期:2016-07-01 00:00:00

  • The secondary prevention of low back pain: a controlled study with follow-up.

    abstract::The current investigation studied the effectiveness of a secondary prevention program for nurses with back pain who were deemed at risk for developing a chronic problem. A 2 X 3 repeated measures design was employed with 2 groups and 3 assessment periods. The treatment group received an intervention designed to reduce...

    journal_title:Pain

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0304-3959(89)90024-9

    authors: Linton SJ,Bradley LA,Jensen I,Spangfort E,Sundell L

    更新日期:1989-02-01 00:00:00

  • A comparison of the effects of intrathecal fentanyl and lidocaine on established postamputation stump pain.

    abstract::Eight patients with established lower limb postamputation stump pain were given lumbar intrathecal fentanyl 25 micrograms and lidocaine 70 mg 2 weeks apart in an attempt to better understand the role of peripheral and central mechanisms in this condition. Baseline pain was recorded and then analgetic and side effects ...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(90)90064-K

    authors: Jacobson L,Chabal C,Brody MC,Mariano AJ,Chaney EF

    更新日期:1990-02-01 00:00:00

  • TRPV1 antagonist BCTC inhibits pH 6.0-induced pain in human skin.

    abstract::Tissue acidosis due to ischemia occurs under several pathological conditions and is believed to contribute to pain in these circumstances. TRPV1, TRPA1, and ASICs are known to be sensitive to acidic pH. Addressing their possible role in acidosis perception, the respective antagonists BCTC, A-967079, and amiloride were...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001848

    authors: Heber S,Ciotu CI,Hartner G,Gold-Binder M,Ninidze N,Gleiss A,Kress HG,Fischer MJM

    更新日期:2020-07-01 00:00:00

  • Repetition-induced activity-related summation of pain in patients with fibromyalgia.

    abstract::This study compared individuals with fibromyalgia (FM) and individuals with chronic low back pain (CLBP) on repetition-induced summation of activity-related pain (RISP). Fear of movement, pain catastrophizing and depression were examined as potential mediators of group differences. The sample consisted of 50 women wit...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2011.02.030

    authors: Lambin DI,Thibault P,Simmonds M,Lariviere C,Sullivan MJL

    更新日期:2011-06-01 00:00:00

  • Pain-avoidance versus reward-seeking: an experimental investigation.

    abstract::According to fear-avoidance models, a catastrophic interpretation of a painful experience may give rise to pain-related fear and avoidance, leading to the development and maintenance of chronic pain problems in the long term. However, little is known about how exactly motivation and goal prioritization play a role in ...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000000116

    authors: Claes N,Crombez G,Vlaeyen JWS

    更新日期:2015-08-01 00:00:00

  • A Pain Monitoring Program for nurses: effect on the administration of analgesics.

    abstract::Both physicians and nurses are responsible for adequate pain management. The aim of this study was to assess pain management behavior of physicians and nurses, and to evaluate the effects of a Pain Monitoring Program for nurses on the extent to which nurses administer analgesics. The Pain Monitoring Program consisted ...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/S0304-3959(00)00344-4

    authors: de Rond MEJ,de Wit R,van Dam FSAM,Muller MJ

    更新日期:2000-12-15 00:00:00

  • Almost 1 in 5 South African adults have chronic pain: a prevalence study conducted in a large nationally representative sample.

    abstract::Limited information on the prevalence and risk factors for chronic pain is available for developing countries. Therefore, we investigated the prevalence of chronic pain and the association between this pain and various personal and sociodemographic factors by including questions in the South Africa Demographic and Hou...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001844

    authors: Kamerman PR,Bradshaw D,Laubscher R,Pillay-van Wyk V,Gray GE,Mitchell D,Chetty S

    更新日期:2020-07-01 00:00:00

  • Treatment of chronic neuropathic pain: purine receptor modulation.

    abstract::Extracellular nucleosides and nucleotides have widespread functions in responding to physiological stress. The "purinome" encompasses 4 G-protein-coupled receptors (GPCRs) for adenosine, 8 GPCRs activated by nucleotides, 7 adenosine 5'-triphosphate-gated P2X ion channels, as well as the associated enzymes and transpor...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001857

    authors: Jacobson KA,Giancotti LA,Lauro F,Mufti F,Salvemini D

    更新日期:2020-07-01 00:00:00

  • Cyclooxygenase-1 in the spinal cord plays an important role in postoperative pain.

    abstract::Cyclooxygenase-2 (COX-2) activity in the spinal cord plays a key role in sensitization to sensory stimuli during acute inflammation. In contrast, intrathecal administration of COX-2 specific inhibitors has minimal analgesic effects in an incisional model of postoperative pain. We investigated the role of COX isoforms ...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/s0304-3959(02)00465-7

    authors: Zhu X,Conklin D,Eisenach JC

    更新日期:2003-07-01 00:00:00

  • Recognition and discrimination of prototypical dynamic expressions of pain and emotions.

    abstract::Facial expressions of pain and emotions provide powerful social signals, which impart information about a person's state. Unfortunately, research on pain and emotion expression has been conducted largely in parallel with few bridges allowing for direct comparison of the expressive displays and their impact on observer...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2007.05.008

    authors: Simon D,Craig KD,Gosselin F,Belin P,Rainville P

    更新日期:2008-03-01 00:00:00

  • Non-noxious A fiber afferent input enhances capsaicin-induced mechanical hyperalgesia in the rat.

    abstract::Intradermal injection of capsaicin induces primary hyperalgesia at the injection site and secondary hyperalgesia in the surrounding undamaged skin. The secondary hyperalgesia is thought to be due to central sensitization of the dorsal horn neurons while primary hyperalgesia is caused by sensitization of nociceptors in...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/S0304-3959(01)00351-7

    authors: Kim HT,Park SK,Lee SE,Chung JM,Lee DH

    更新日期:2001-11-01 00:00:00

  • Nitrous oxide inhibits glutamatergic transmission in spinal dorsal horn neurons.

    abstract::The effects of nitrous oxide (N2O) are thought to be mediated by several pharmacological pathways at different levels of the central nervous system. Here, we focus on excitatory glutamatergic transmission in the superficial dorsal horn of the spinal cord with respect to its importance for the nociceptive processing. T...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2007.03.026

    authors: Georgiev SK,Kohno T,Ikoma M,Yamakura T,Baba H

    更新日期:2008-01-01 00:00:00

  • A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats.

    abstract::Immune activation near healthy peripheral nerves may have a greater role in creating pathological pain than previously recognized. We have developed a new model of sciatic inflammatory neuritis to assess how such immune activation may influence somatosensory processing. The present series of experiments reveal that zy...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/S0304-3959(01)00354-2

    authors: Chacur M,Milligan ED,Gazda LS,Armstrong C,Wang H,Tracey KJ,Maier SF,Watkins LR

    更新日期:2001-12-01 00:00:00

  • Personalized evaluation of self-hypnosis as a treatment of chronic pain: a repertory grid analysis.

    abstract::Self-hypnosis was taught to 5 highly hypnotisable patients referred to Auckland Hospital Pain Clinic. Evaluation included the Illness Self-Concept Repertory Grid (ISCRG) and follow-up was at 1 and 6 months post treatment. Consensus grids indicated the subjects initially identified with physical illness but this associ...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(88)90223-0

    authors: Large RG,James FR

    更新日期:1988-11-01 00:00:00

  • Differential effect of intravenous S-ketamine and fentanyl on atypical odontalgia and capsaicin-evoked pain.

    abstract::Atypical odontalgia (AO) is an intraoral pain condition of currently unknown mechanisms. In 10 AO patients and 10 matched healthy controls, we examined the effect of intravenous infusion of an N-methyl-D-aspartate (NMDA) receptor antagonist S-ketamine and a mu-opioid agonist fentanyl on spontaneous AO pain and on an a...

    journal_title:Pain

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.pain.2006.09.032

    authors: Baad-Hansen L,Juhl GI,Jensen TS,Brandsborg B,Svensson P

    更新日期:2007-05-01 00:00:00

  • Cryocautery of sensitized skin areas for the relief of pain due to post-herpetic neuralgia.

    abstract::Fourteen patients whose post-herpetic neuralgia could not be alleviated by conventional methods were treated with cryocautery using a stick of solid carbon dioxide (dry ice) applied directly to the hyperesthetic skin areas of the cutaneous scars. Follow-up evaluation revealed that 5 of 14 subjects maintained excellent...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(80)90049-4

    authors: Suzuki H,Ogawa S,Nakagawa H,Kanayama T,Taj K,Saitoh H,Ohshima Y

    更新日期:1980-12-01 00:00:00

  • Parent physical and mental health contributions to interpersonal fear avoidance processes in pediatric chronic pain.

    abstract::Theoretical models and evidence increasingly identify chronic pain as a family issue. To date, much of this work has focused on risk conferred by parental chronic pain status despite evidence suggesting parent mental illness and non-pain-related chronic illness may also contribute to poorer chronic pain outcomes in ch...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001820

    authors: Birnie KA,Heathcote LC,Bhandari RP,Feinstein A,Yoon IA,Simons LE

    更新日期:2020-06-01 00:00:00

  • Maintenance of windup of second pain requires less frequent stimulation in fibromyalgia patients compared to normal controls.

    abstract::Many chronic pain syndromes, including fibromyalgia (FM), show evidence of central nervous system hyperexcitability related to central sensitization. Windup (WU) of second pain reflects increased excitability of spinal cord neurons that is related to central sensitization. Psychophysical testing can help characterize ...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2004.05.009

    authors: Staud R,Price DD,Robinson ME,Mauderli AP,Vierck CJ

    更新日期:2004-08-01 00:00:00