Abstract:
:The present study investigated whether the level of cognitive impairment (CI) affects acute pain behavior and how it is manifested. Participants were 159 individuals (mean age 42+/-12), 121 with CI (divided into four groups according to the level of CI: mild, moderate, severe, profound) and 38 with normal cognition (controls). The behavior of the participants before and during acute pain (influenza vaccination) was coded by two raters with the Facial Action Coding System (FACS - scores facial reactions to pain) and the Non-Communicating Children's Pain Checklist (NCCPC-R - scores both facial and general body reactions). Individuals with severe-profound CI exhibited elevated FACS and NCCPC-R values at baseline compared with all other groups (p<0.01). Both FACS and NCCPC-R scores of individuals with mild-moderate CI and controls increased significantly during vaccination (p<0.001). In contrast, individuals with severe-profound CI exhibited high rates of "freezing reaction" (stillness) during vaccination, manifested mainly in the face and therefore resulting in elevation of only NCCPC-R scores but not of FACS's. The results suggest that the level of CI affects baseline as well as pain behavior and it is therefore necessary to choose an appropriate behavioral tool to measure pain in these individuals accordingly. For example, tools based on facial reactions alone might provide the false impression that individuals with severe-profound CI are insensitive to pain (due to freezing).
journal_name
Painjournal_title
Painauthors
Defrin R,Lotan M,Pick CGdoi
10.1016/j.pain.2006.04.031subject
Has Abstractpub_date
2006-10-01 00:00:00pages
312-320issue
3eissn
0304-3959issn
1872-6623pii
00006396-200610000-00011journal_volume
124pub_type
临床试验,杂志文章相关文献
PAIN文献大全abstract::Investigating dose-dependent effects of placebo analgesia (PA) in laboratory subjects undergoing pain testing, we evaluated 2 hypotheses: (1) greater expectancy for relief produces greater PA, and (2) cued expectancy for relief triggered by a predictive cue leads to more enhanced analgesia than does passive expectancy...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.10.024
更新日期:2012-01-01 00:00:00
abstract::Evidence has been accumulated suggesting that a dysfunction in pain inhibitory systems, i.e. in 'diffuse noxious inhibitory controls' (DNIC)-like mechanisms, might be-amongst other factors-responsible for the development of anatomically generalized chronic pain like fibromyalgia. The aim of the present study was to lo...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2005.08.019
更新日期:2005-11-01 00:00:00
abstract::Aquaporin 1 (AQP1) is the archetypal member of a family of water channel proteins that contribute to water homeostasis in kidney, lung, and other tissues. Although there is limited evidence that aquaporins are expressed in the nervous system, AQP4 is expressed in glia and AQP9 is present on some neuronal and glial mit...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.11.018
更新日期:2007-09-01 00:00:00
abstract::Recent evidence indicates that pain-related fear can be acquired through associative learning. In the clinic, however, spreading of fear and avoidance is observed beyond movements/activities that were associated with pain during the original pain episode. One mechanism accounting for this spreading of fear is stimulus...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.10.025
更新日期:2013-02-01 00:00:00
abstract::In the present study 366 patients suffering acute or chronic musculoskeletal pain of different origin were given vibratory stimulation for the pain. Many of the patients had previously had treatments of various kinds without satisfactory relief. The effect of vibratory stimulation was assessed during and after stimula...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90808-X
更新日期:1984-09-01 00:00:00
abstract::There is extensive evidence that spinal excitatory amino acids (EAAs) like glutamate (Glu) and aspartate (Asp) are important in the processing of nociceptive behaviors caused by incisions. To better understand EAA-induced dorsal horn sensitization caused by surgery, we examined the time course and extent of spinal ami...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(02)00241-5
更新日期:2002-11-01 00:00:00
abstract::The effects of cognitive and competing sensory processing tasks on pain perception and as a function of time are only partially understood. To study these effects, we compared the simultaneous effects of noxious heat stimulation (HS), auditory stimulation (AS) (sinusoidally modulated speech-like signal, SMSLS), and a ...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2005.10.029
更新日期:2006-01-01 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) using the blood oxygen level-dependent (BOLD) contrast was used to study sensory processing in the brain of isoflurane-anesthetized mice. The use of a cryogenic surface coil in a small animal 9.4T system provided the sensitivity required for detection and quantitative analy...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.08.025
更新日期:2010-12-01 00:00:00
abstract::Neurotrophin-3 (NT-3) is a target-derived neurotrophic factor that regulates sensory neuronal survival and growth. Here we report that NT-3 plays a critical permissive role in cutaneous sensory nerve sprouting that contributes to pain and sensitivity following skin wounding in young animals. Sensory terminal sprouting...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.07.012
更新日期:2012-10-01 00:00:00
abstract:UNLABELLED:The German Randomized Acupuncture Trial for chronic shoulder pain (GRASP) comprised 424 outpatients with chronic shoulder pain (CSP) > or =6 weeks and an average pain score of VAS > or =50 mm, who were randomly assigned to receive Chinese acupuncture (verum), sham acupuncture (sham) or conventional conservat...
journal_title:Pain
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.pain.2010.06.036
更新日期:2010-10-01 00:00:00
abstract::To investigate the pathways of noxious information in the spinal cord in humans, we recorded cortical potentials following the stimulation of A-delta fibers using a YAG laser applied to two cutaneous points on the back at the C7 and Th10 level, 4cm to the right of the vertebral spinous process. A multiple source analy...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.03.009
更新日期:2006-08-01 00:00:00
abstract::Plasticity of inhibitory transmission in the spinal dorsal horn (SDH) is believed to be a key mechanism responsible for pain hypersensitivity in neuropathic pain syndromes. We evaluated this plasticity by recording responses to mechanical stimuli in silent neurons (nonspontaneously active [NSA]) and neurons showing on...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000538
更新日期:2016-07-01 00:00:00
abstract::The current investigation studied the effectiveness of a secondary prevention program for nurses with back pain who were deemed at risk for developing a chronic problem. A 2 X 3 repeated measures design was employed with 2 groups and 3 assessment periods. The treatment group received an intervention designed to reduce...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(89)90024-9
更新日期:1989-02-01 00:00:00
abstract::Eight patients with established lower limb postamputation stump pain were given lumbar intrathecal fentanyl 25 micrograms and lidocaine 70 mg 2 weeks apart in an attempt to better understand the role of peripheral and central mechanisms in this condition. Baseline pain was recorded and then analgetic and side effects ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)90064-K
更新日期:1990-02-01 00:00:00
abstract::Tissue acidosis due to ischemia occurs under several pathological conditions and is believed to contribute to pain in these circumstances. TRPV1, TRPA1, and ASICs are known to be sensitive to acidic pH. Addressing their possible role in acidosis perception, the respective antagonists BCTC, A-967079, and amiloride were...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001848
更新日期:2020-07-01 00:00:00
abstract::This study compared individuals with fibromyalgia (FM) and individuals with chronic low back pain (CLBP) on repetition-induced summation of activity-related pain (RISP). Fear of movement, pain catastrophizing and depression were examined as potential mediators of group differences. The sample consisted of 50 women wit...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.02.030
更新日期:2011-06-01 00:00:00
abstract::According to fear-avoidance models, a catastrophic interpretation of a painful experience may give rise to pain-related fear and avoidance, leading to the development and maintenance of chronic pain problems in the long term. However, little is known about how exactly motivation and goal prioritization play a role in ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000116
更新日期:2015-08-01 00:00:00
abstract::Both physicians and nurses are responsible for adequate pain management. The aim of this study was to assess pain management behavior of physicians and nurses, and to evaluate the effects of a Pain Monitoring Program for nurses on the extent to which nurses administer analgesics. The Pain Monitoring Program consisted ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(00)00344-4
更新日期:2000-12-15 00:00:00
abstract::Limited information on the prevalence and risk factors for chronic pain is available for developing countries. Therefore, we investigated the prevalence of chronic pain and the association between this pain and various personal and sociodemographic factors by including questions in the South Africa Demographic and Hou...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001844
更新日期:2020-07-01 00:00:00
abstract::Extracellular nucleosides and nucleotides have widespread functions in responding to physiological stress. The "purinome" encompasses 4 G-protein-coupled receptors (GPCRs) for adenosine, 8 GPCRs activated by nucleotides, 7 adenosine 5'-triphosphate-gated P2X ion channels, as well as the associated enzymes and transpor...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001857
更新日期:2020-07-01 00:00:00
abstract::Cyclooxygenase-2 (COX-2) activity in the spinal cord plays a key role in sensitization to sensory stimuli during acute inflammation. In contrast, intrathecal administration of COX-2 specific inhibitors has minimal analgesic effects in an incisional model of postoperative pain. We investigated the role of COX isoforms ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(02)00465-7
更新日期:2003-07-01 00:00:00
abstract::Facial expressions of pain and emotions provide powerful social signals, which impart information about a person's state. Unfortunately, research on pain and emotion expression has been conducted largely in parallel with few bridges allowing for direct comparison of the expressive displays and their impact on observer...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.05.008
更新日期:2008-03-01 00:00:00
abstract::Intradermal injection of capsaicin induces primary hyperalgesia at the injection site and secondary hyperalgesia in the surrounding undamaged skin. The secondary hyperalgesia is thought to be due to central sensitization of the dorsal horn neurons while primary hyperalgesia is caused by sensitization of nociceptors in...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(01)00351-7
更新日期:2001-11-01 00:00:00
abstract::The effects of nitrous oxide (N2O) are thought to be mediated by several pharmacological pathways at different levels of the central nervous system. Here, we focus on excitatory glutamatergic transmission in the superficial dorsal horn of the spinal cord with respect to its importance for the nociceptive processing. T...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.03.026
更新日期:2008-01-01 00:00:00
abstract::Immune activation near healthy peripheral nerves may have a greater role in creating pathological pain than previously recognized. We have developed a new model of sciatic inflammatory neuritis to assess how such immune activation may influence somatosensory processing. The present series of experiments reveal that zy...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(01)00354-2
更新日期:2001-12-01 00:00:00
abstract::Self-hypnosis was taught to 5 highly hypnotisable patients referred to Auckland Hospital Pain Clinic. Evaluation included the Illness Self-Concept Repertory Grid (ISCRG) and follow-up was at 1 and 6 months post treatment. Consensus grids indicated the subjects initially identified with physical illness but this associ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(88)90223-0
更新日期:1988-11-01 00:00:00
abstract::Atypical odontalgia (AO) is an intraoral pain condition of currently unknown mechanisms. In 10 AO patients and 10 matched healthy controls, we examined the effect of intravenous infusion of an N-methyl-D-aspartate (NMDA) receptor antagonist S-ketamine and a mu-opioid agonist fentanyl on spontaneous AO pain and on an a...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.pain.2006.09.032
更新日期:2007-05-01 00:00:00
abstract::Fourteen patients whose post-herpetic neuralgia could not be alleviated by conventional methods were treated with cryocautery using a stick of solid carbon dioxide (dry ice) applied directly to the hyperesthetic skin areas of the cutaneous scars. Follow-up evaluation revealed that 5 of 14 subjects maintained excellent...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(80)90049-4
更新日期:1980-12-01 00:00:00
abstract::Theoretical models and evidence increasingly identify chronic pain as a family issue. To date, much of this work has focused on risk conferred by parental chronic pain status despite evidence suggesting parent mental illness and non-pain-related chronic illness may also contribute to poorer chronic pain outcomes in ch...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001820
更新日期:2020-06-01 00:00:00
abstract::Many chronic pain syndromes, including fibromyalgia (FM), show evidence of central nervous system hyperexcitability related to central sensitization. Windup (WU) of second pain reflects increased excitability of spinal cord neurons that is related to central sensitization. Psychophysical testing can help characterize ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.05.009
更新日期:2004-08-01 00:00:00