A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats.

abstract：:Painful neuromas can cause severe loss of function and have great impact on the daily life of patients. Surgical management remains challenging; despite improving techniques, success rates are low. To accurately study the success of surgical neuroma treatment and factors predictive of outcome, a prospective follow-up ...

journal_title：Pain

authors： Stokvis A,van der Avoort DJC,van Neck JW,Hovius SER,Coert HJ

更新日期：2010-12-01 00:00:00

abstract：:P2X3 purinoceptor cellular distribution was studied in rat sensory neurons in naive animals and following peripheral nerve injury using immunohistochemical methods. Specific antiserum was raised in rabbits and characterized by Western blot, absorption assays and labeling of recombinant receptors. In naive animals, P2X...

journal_title：Pain

authors： Novakovic SD,Kassotakis LC,Oglesby IB,Smith JA,Eglen RM,Ford AP,Hunter JC

更新日期：1999-03-01 00:00:00

abstract：:Chemical cauterization of the central cornea with silver nitrate was assessed as a superficial injury model of tissue sensitization accompanying acute inflammation. Adult male Sprague-Dawley rats were anesthetized with halothane gas, and the centers of their right corneas treated with a silver nitrate applicator stick...

journal_title：Pain

authors： Wenk NH,Honda NC

更新日期：2003-10-01 00:00:00

abstract：:Chronic dry eye disease (DE) is associated with an unstable tear film and symptoms of ocular discomfort. The characteristics of symptoms suggest a key role for central neural processing; however, little is known about central neuroplasticity and DE. We used a model for tear deficient DE and assessed effects on eye bli...

journal_title：Pain

authors： Rahman M,Okamoto K,Thompson R,Katagiri A,Bereiter DA

更新日期：2015-05-01 00:00:00

abstract：:Sciatica is a common pain problem and current pharmacologic therapies have proven inadequate for many patients. The objective of this sham-controlled investigation was to compare a novel non-pharmacologic technique, percutaneous electrical nerve stimulation (PENS), to transcutaneous electrical nerve stimulation (TENS)...

journal_title：Pain

authors： Ghoname EA,White PF,Ahmed HE,Hamza MA,Craig WF,Noe CE

更新日期：1999-11-01 00:00:00

abstract：:Metastatic bone cancer causes severe pain that is primarily treated with opioids. A model of bone cancer pain in which the progression of cancer pain and bone destruction is tightly controlled was used to evaluate the effects of sustained morphine treatment. In cancer-treated mice, morphine enhanced, rather than dimin...

journal_title：Pain

authors： King T,Vardanyan A,Majuta L,Melemedjian O,Nagle R,Cress AE,Vanderah TW,Lai J,Porreca F

更新日期：2007-11-01 00:00:00

abstract：:Using the circumplex model of interpersonal behavior [Handbook of research methods in clinical psychology, 1982], this study tested the communal coping model of catastrophizing (CCM) in a large (N = 179) sample of patients with irritable bowel syndrome (IBS), a common, benign chronic pain disorder associated with sign...

journal_title：Pain

authors： Lackner JM,Gurtman MB

更新日期：2004-08-01 00:00:00

abstract：:We report on a patient suffering severe pain following a long-standing sacral chordoma in whom management of therapy and pain was extremely difficult. Because orally administered morphine was observed to be ineffective in the early stages of treatment, we tried to achieve pain relief by using epidural morphine. This w...

journal_title：Pain

authors： Aguilar JL,Espachs P,Roca G,Samper D,Cubells C,Vidal F

更新日期：1994-11-01 00:00:00

abstract：:According to fear-avoidance models, a catastrophic interpretation of a painful experience may give rise to pain-related fear and avoidance, leading to the development and maintenance of chronic pain problems in the long term. However, little is known about how exactly motivation and goal prioritization play a role in ...

journal_title：Pain

authors： Claes N,Crombez G,Vlaeyen JWS

更新日期：2015-08-01 00:00:00

abstract：:Morphine (M) and hydromorphone (HM) are commonly used opioid analgesics for cancer pain. Opioid rotation is often necessary in the event of toxicity and/or inadequate analgesia. Equianalgesic reference tables based on single dose comparisons are possibly inadequate for patients on chronic treatment and developing tole...

journal_title：Pain

authors： Lawlor P,Turner K,Hanson J,Bruera E

更新日期：1997-08-01 00:00:00

abstract：:Loss of high-voltage-activated (HVA) calcium current (ICa) and gain of low-voltage-activated (LVA) ICa after painful peripheral nerve injury cause elevated excitability in sensory neurons. Nerve injury is also accompanied by increased expression of the extracellular matrix glycoprotein thrombospondin-4 (TSP4), and int...

journal_title：Pain

authors： Pan B,Guo Y,Wu HE,Park J,Trinh VN,Luo ZD,Hogan QH

更新日期：2016-09-01 00:00:00

abstract：:Injection of a dilute solution of formalin into a rat hindpaw produces a biphasic nociceptive response consisting of an early phase during the first 5 min after formalin injection and a later phase starting after 15 min and lasting for 40-50 min. The period between the two phases of nociceptive responding is generally...

journal_title：Pain

authors： Henry JL,Yashpal K,Pitcher GM,Coderre TJ

更新日期：1999-07-01 00:00:00

abstract：:Wind-up and secondary hyperalgesia both are related to central sensitization, but whereas the former is explained by homosynaptic facilitation, the latter is due to heterosynaptic facilitation. To investigate possible interactions between both types of facilitation, we tested for alterations of perceptual wind-up in t...

journal_title：Pain

authors： Magerl W,Wilk SH,Treede RD

更新日期：1998-02-01 00:00:00

abstract：:Neuroimaging studies of patients with chronic pain have shown that neurotransmitter abnormalities, including increases in glutamate and decreases in GABA, could be responsible for the cortical hyperactivity and hyperalgesia/allodynia observed in some pain conditions. These finding are particularly evident in the insul...

journal_title：Pain

authors： Watson CJ

更新日期：2016-10-01 00:00:00

abstract：:Central pain following traumatic brain injury (TBI) has not been studied in depth. Our purpose was to conduct a systematic study of patients with TBI suffering from chronic central pain, and to describe the characteristics of the central pain. Groups were TBI patients with (TBIP) and without central pain (TBINP) and h...

journal_title：Pain

authors： Ofek H,Defrin R

更新日期：2007-10-01 00:00:00

abstract：:The ability of a painful stimulus to suppress pain in another, remote area (DNIC) has been intensely studied. However, the effect of the distance between the two painful stimuli and the attentional factors during the measurement of pain perception received minimal treatment. We evaluated the effect of these factors on...

journal_title：Pain

authors： Defrin R,Tsedek I,Lugasi I,Moriles I,Urca G

更新日期：2010-11-01 00:00:00

abstract：:This study examined the adaptational classification stability of the multidimensional pain inventory (MPI) in two samples of female fibromyalgia syndrome patients. Retest resulted in one-third of patients being assigned to a different classification. Twenty patients had four repeated MPI assessments over a 10-month pe...

journal_title：Pain

authors： Broderick JE,Junghaenel DU,Turk DC

更新日期：2004-05-01 00:00:00

abstract：:Tailored treatment based on individual risk factors is an area with promise to improve options for pain relief. Musculoskeletal pain has a biopsychosocial nature, and multiple factors should be considered when determining risk for chronic pain. This study investigated whether subgroups comprised genetic and psychologi...

journal_title：Pain

authors： George SZ,Wallace MR,Wu SS,Moser MW,Wright TW,Farmer KW,Borsa PA,Parr JJ,Greenfield WH 3rd,Dai Y,Li H,Fillingim RB

更新日期：2015-01-01 00:00:00

abstract：:The assessment and development of pain in children is reviewed in the first part of a two-part series. Assessment of pain in children has relied on self-report measures that have included visual analogue procedures using concrete stimuli for ratings. Behavioral assessment procedures are more sophisticated, but researc...

journal_title：Pain

authors： Lavigne JV,Schulein MJ,Hahn YS

更新日期：1986-11-01 00:00:00

abstract：:Hip disorder patients typically present with extensive pain referral and hyperalgesia. To better understand underlying mechanisms, an experimental hip pain model was established in which pain referrals and hyperalgesia could be studied under standardized conditions. In 16 healthy subjects, pain was induced by hyperton...

journal_title：Pain

authors： Izumi M,Petersen KK,Arendt-Nielsen L,Graven-Nielsen T

更新日期：2014-04-01 00:00:00

abstract：:Substance P (SP) is released from primary afferent fibers in response to nociceptive stimuli. Capsaicin, which produces an initial hyperalgesic response followed by persistent antinociception, also elicits release of SP from primary afferent fibers. Capsaicin pretreatment decreases the content and release of SP from p...

journal_title：Pain

authors： Goettl VM,Larson DL,Portoghese PS,Larson AA

更新日期：1997-07-01 00:00:00

abstract：:The antinociceptive effects of the serotonin (5-HT)1A/7 receptor agonist 8-hydroxy-dipropylaminotetralin (8-OH-DPAT) administered into the medial thalamus were evaluated. Pain behaviors organized at spinal (spinal motor reflexes, SMRs), medullary (vocalizations during shock, VDSs), and forebrain (vocalization after di...

journal_title：Pain

authors： Harte SE,Kender RG,Borszcz GS

更新日期：2005-02-01 00:00:00

abstract：:Managing acute procedural pain effectively in preterm infants in the neonatal intensive care unit remains a significant problem. The objectives of this study were to evaluate the efficacy of breastfeeding for reducing pain and to determine if breastfeeding skills were altered after this treatment. Fifty-seven infants ...

journal_title：Pain

authors： Holsti L,Oberlander TF,Brant R

更新日期：2011-11-01 00:00:00

abstract：:In children, many psychometric properties of the visual analogue scale (VAS) are known, including the minimum clinically significant difference (10mm on a 100-mm VAS). However, its imprecision or reliability is not well known. Thus, in order to determine the reliability of this scale, a prospective cohort study was pe...

journal_title：Pain

authors： Bailey B,Gravel J,Daoust R

更新日期：2012-04-01 00:00:00

abstract：:Abnormal endogenous pain modulation was suggested as a potential mechanism for chronic pain, ie, increased pain facilitation and/or impaired pain inhibition underlying symptoms manifestation. Endogenous pain modulation function can be tested using psychophysical methods such as temporal summation of pain (TSP) and con...

journal_title：Pain

authors： Moana-Filho EJ,Herrero Babiloni A,Theis-Mahon NR

更新日期：2018-08-01 00:00:00

abstract：:The significance of preamputation pain for the development of postamputation stump and phantom pain has been discussed over the years and is still a matter of dispute. It has been argued that preamputation pain increases the risk of phantom pain and that phantom pain is a revivification of pain experienced before the ...

journal_title：Pain

authors： Nikolajsen L,Ilkjaer S,Krøner K,Christensen JH,Jensen TS

更新日期：1997-09-01 00:00:00

abstract：:Do contrasting neuropathic pain diagnoses share common pathophysiological mechanisms? Selective breeding was used to derive rat lines with a common genetic background but a striking difference in the degree of spontaneous pain behavior expressed in the neuroma model of neuropathic pain (HA rats (high autotomy) and LA ...

journal_title：Pain

authors： Ziv-Sefer S,Raber P,Barbash S,Devor M

更新日期：2009-11-01 00:00:00

abstract：:A 78-year-old male patient had chronic, unrelieved abdominal pain due to mesenteric ischaemia. Unsuccessful pharmacological approaches included oral morphine plus coadjuvants as well as a sympathetic celiac plexus block which gave pain relief that lasted for 72 h. In order to obtain long-lasting relief, a trial epidur...

journal_title：Pain

authors： Ceballos A,Cabezudo L,Bovaira M,Fenollosa P,Moro B

更新日期：2000-07-01 00:00:00

abstract：:Bipolar intrapulpal stimulation was applied to human teeth using the same procedure as in animal experiments. The effects of variation of stimulus parameters on the quality of sensation were studied. A prepain sensation exists which cannot be explained by diffusion of the stimulus to periodontal tissues. When the inte...

journal_title：Pain

authors： Azerad J,Woda A

更新日期：1977-12-01 00:00:00

abstract：:Opiate-adrenergic interactions were investigated by studying the effect of the selective alpha 2-adrenergic agonist, clonidine, on the analgesia produced by intravenous placebo and by the predominantly kappa-opiate agonist, pentazocine, in patients with dental postoperative pain. Clonidine did not affect the pain leve...

journal_title：Pain

authors： Gordon NC,Heller PH,Levine JD

更新日期：1992-02-01 00:00:00