Sensitization of trigeminal brainstem pathways in a model for tear deficient dry eye.

abstract：:Cyclin-dependent kinase 5 (Cdk5) is a unique member of the CDK family. It is predominantly expressed in postmitotic neurons and has been implicated in neuronal plasticity. The present study showed that Cdk5 and p35 were expressed in primary sensory and dorsal horn neurons, while p25, an N-terminal truncated derivative...

journal_title：Pain

authors： Yang YR,He Y,Zhang Y,Li Y,Li Y,Han Y,Zhu H,Wang Y

更新日期：2007-01-01 00:00:00

abstract：:Bradykinin is an endogenous peptide that is thought to be a chemical mediator of the hyperalgesia following inflammation. In rat, bradykinin has been postulated to cause hyperalgesia to mechanical stimuli by releasing prostaglandin from sympathetic post-ganglionic terminals. The aim of this study was to determine whet...

journal_title：Pain

authors： Meyer RA,Davis KD,Raja SN,Campbell JN

更新日期：1992-12-01 00:00:00

abstract：:Few surveys have been performed to define the characteristics and impact of breakthrough pain in the cancer population. In this cross-sectional survey of inpatients with cancer, patients responded to a structured interview (the Breakthrough Pain Questionnaire) designed to characterize breakthrough pain, and also compl...

journal_title：Pain

authors： Portenoy RK,Payne D,Jacobsen P

更新日期：1999-05-01 00:00:00

abstract：:Mindfulness-based stress reduction (MBSR) is a structured 8-week group program teaching mindfulness meditation and mindful yoga exercises. MBSR aims to help participants develop nonjudgmental awareness of moment-to-moment experience. Fibromyalgia is a clinical syndrome with chronic pain, fatigue, and insomnia as major...

journal_title：Pain

authors： Schmidt S,Grossman P,Schwarzer B,Jena S,Naumann J,Walach H

更新日期：2011-02-01 00:00:00

abstract：:Beneficial effects have been observed in University of Washington Pain Clinic patients treated with tricyclic antidepressants, but such effects occur much earlier than predicted mood elevation. A laboratory investigation of pain perception was employed to test the hypothesis that doxepin, a tricyclic antidepressant, h...

journal_title：Pain

authors： Chapman RC,Butler SH

更新日期：1978-10-01 00:00:00

abstract：:Current opinion concerning the pathophysiology of tension-type headache (TTH) and its related pericranial muscle tenderness proposes a primary role of central sensitization at the level of dorsalhorn/trigeminal nucleus as well as the supraspinal level. Investigation of these phenomena can be conducted using laser-evok...

journal_title：Pain

authors： de Tommaso M,Libro G,Guido M,Sciruicchio V,Losito L,Puca F

更新日期：2003-07-01 00:00:00

abstract：:Manipulative therapy is frequently used in the management of musculoskeletal pain. A frequently reported clinical feature of this treatment is the immediacy with which it appears to initiate improvement in pain and function. A randomised, double blind, placebo controlled, repeated measures design was employed to study...

journal_title：Pain

authors： Vicenzino B,Collins D,Wright A

更新日期：1996-11-01 00:00:00

abstract：:Tailored treatment based on individual risk factors is an area with promise to improve options for pain relief. Musculoskeletal pain has a biopsychosocial nature, and multiple factors should be considered when determining risk for chronic pain. This study investigated whether subgroups comprised genetic and psychologi...

journal_title：Pain

authors： George SZ,Wallace MR,Wu SS,Moser MW,Wright TW,Farmer KW,Borsa PA,Parr JJ,Greenfield WH 3rd,Dai Y,Li H,Fillingim RB

更新日期：2015-01-01 00:00:00

abstract：:The ability of a painful stimulus to suppress pain in another, remote area (DNIC) has been intensely studied. However, the effect of the distance between the two painful stimuli and the attentional factors during the measurement of pain perception received minimal treatment. We evaluated the effect of these factors on...

journal_title：Pain

authors： Defrin R,Tsedek I,Lugasi I,Moriles I,Urca G

更新日期：2010-11-01 00:00:00

abstract：:The present report describes a nation-wide survey on the incidence, the indications and the efficacy of spinal cord stimulation (SCS), as assessed by the Belgian health authorities. The direct motive for this survey was the rapidly growing expenditures resulting from the increasing use of SCS. Between 1983 and 1992, n...

journal_title：Pain

authors： Kupers RC,Van den Oever R,Van Houdenhove B,Vanmechelcn W,Hepp B,Nuttin B,Gybels JM

更新日期：1994-02-01 00:00:00

abstract：ABSTRACT:High mobility group box 1 protein (HMGB1) is increasingly regarded as an important player in the spinal regulation of chronic pain. Although it has been reported that HMGB1 induces spinal glial activation in a Toll-like receptor (TLR)4-dependent fashion, the aspect of sexual dimorphisms has not been thoroughly...

journal_title：Pain

authors： Agalave NM,Rudjito R,Farinotti AB,Khoonsari PE,Sandor K,Nomura Y,Szabo-Pardi TA,Urbina CM,Palada V,Price TJ,Erlandsson Harris H,Burton MD,Kultima K,Svensson CI

更新日期：2021-02-01 00:00:00

abstract：:Physicians are frequently called upon to evaluate patients with chronic pain to (1) establish the etiology, (2) determine the extent of impairment and disability, and (3) prescribe treatment. In many cases, there is little agreement as to what evaluation procedures should be used or how to weight and integrate these f...

journal_title：Pain

authors： Rudy TE,Turk DC,Brena SF

更新日期：1988-07-01 00:00:00

abstract：:Despite many studies, the mechanisms underlying the pathogenesis of pain in cluster headache (CH) still remain obscure. An involvement of substance P (SP) containing neurons of the Gasserian ganglion and/or of the spinal trigeminal nucleus has recently been suggested, e.g., by impairment of inhibitory descending pathw...

journal_title：Pain

authors： Sandrini G,Alfonsi E,Ruiz L,Pavesi G,Micieli G,Manzoni GC,Mancia D,Nappi G

更新日期：1991-12-01 00:00:00

abstract：:Pain is generally considered to have a sensory and an affective component. Clinical research has suggested that morphine more potently attenuates the affective component as compared to the sensory component. Because preclinical nociception models typically focus on the sensory component of nociception, and do not asse...

journal_title：Pain

authors： van der Kam EL,De Vry J,Schiene K,Tzschentke TM

更新日期：2008-06-01 00:00:00

abstract：:The processes of individual adaptation to chronic pain are complex and occur across multiple domains. We examined the social, cognitive, and affective context of daily pain adaptation in individuals with fibromyalgia and osteoarthritis. By using a sample of 260 women with fibromyalgia or osteoarthritis, we examined th...

journal_title：Pain

authors： Sturgeon JA,Zautra AJ,Arewasikporn A

更新日期：2014-02-01 00:00:00

abstract：:We report findings from clinical examination and cutaneous laser stimulation in a 57-year-old male, who suffered from a right-sided postcentral stroke. In this patient, we were able to demonstrate (i) a dissociation of discriminative and affective components of pain perception and, for the first time in humans, (ii) t...

journal_title：Pain

authors： Ploner M,Freund HJ,Schnitzler A

更新日期：1999-05-01 00:00:00

abstract：:In the skin surrounding a site of injury, hyperalgesia develops to mechanical stimuli. Two types of secondary hyperalgesia (to light touch and punctate stimuli) have recently been differentiated, based on different durations and sizes of the area involved. We studied secondary hyperalgesia in a subject who had a loss ...

journal_title：Pain

authors： Treede RD,Cole JD

更新日期：1993-05-01 00:00:00

abstract：:The aim of the present study was to test (1) whether muscle pain is influenced by temporal and spatial summation, and (2) whether sequential noxious muscle stimuli applied at hourly interstimulus-intervals could produce an increased sensation of pain due to central hyperexcitability. In the study eleven healthy men we...

journal_title：Pain

authors： Graven-Nielsen T,Arendt-Nielsen L,Svensson P,Jensen TS

更新日期：1997-01-01 00:00:00

abstract：:A cohort of 243 female sewing machine operators were studied by questionnaire and clinical examinations with the purpose to study the efficiency of a screening questionnaire-based method to identify prevalent and incident cases of neck-shoulder disorders. The cross-sectional correlation between self-reported neck-shou...

journal_title：Pain

authors： Kaergaard A,Andersen JH,Rasmussen K,Mikkelsen S

更新日期：2000-06-01 00:00:00

abstract：:Patients with acute whiplash trauma were followed to examine if post-trauma ratings of pre-collision pain and psychological distress were associated with reduced work capability and neck pain at 12 months follow-up. The study included 740 consecutive patients (474 females, 266 males) referred from emergency department...

journal_title：Pain

authors： Carstensen TBW,Frostholm L,Oernboel E,Kongsted A,Kasch H,Jensen TS,Fink P

更新日期：2008-10-15 00:00:00

abstract：:Intrathecal (i.t.) administration of spermine (0.1-10000 fmol), an endogenous polyamine, produced the behavioural response mainly consisting of biting and/or licking of the hindpaw along with a slight hindlimb scratching directed toward the flank in mice, which peaked at 5-15 min and almost disappeared at 30 min after...

journal_title：Pain

authors： Tan-No K,Taira A,Wako K,Niijima F,Nakagawasai O,Tadano T,Sakurada C,Sakurada T,Kisara K

更新日期：2000-05-01 00:00:00

abstract：:Pain is a biologically relevant signal and response to bodily threat, associated with the urge to restore the integrity of the body. Immediate protective responses include increased arousal, selective attention, escape, and facial expressions, followed by recuperative avoidance and safety-seeking behaviors. To facilit...

journal_title：Pain

authors： Vlaeyen JWS

更新日期：2015-04-01 00:00:00

abstract：:Fourteen patients whose post-herpetic neuralgia could not be alleviated by conventional methods were treated with cryocautery using a stick of solid carbon dioxide (dry ice) applied directly to the hyperesthetic skin areas of the cutaneous scars. Follow-up evaluation revealed that 5 of 14 subjects maintained excellent...

journal_title：Pain

authors： Suzuki H,Ogawa S,Nakagawa H,Kanayama T,Taj K,Saitoh H,Ohshima Y

更新日期：1980-12-01 00:00:00

abstract：:A noncontrolled, randomized, multicenter study (NCT00924664) evaluated long-term safety and effectiveness of tanezumab in patients with chronic low back pain following a randomized placebo- and active-controlled parent study that evaluated analgesic efficacy. Patients were randomized to tanezumab 10mg (n=321) or 20mg ...

journal_title：Pain

authors： Gimbel JS,Kivitz AJ,Bramson C,Nemeth MA,Keller DS,Brown MT,West CR,Verburg KM

更新日期：2014-09-01 00:00:00

abstract：:Endometriosis, an estrogen-dependent chronic inflammatory disease, is the most common cause of chronic pelvic pain. Here, we investigated the effects of linaclotide, a Food and Drug Administration-approved treatment for IBS-C, in a rat model of endometriosis. Eight weeks after endometrium transplantation into the inte...

journal_title：Pain

authors： Ge P,Ren J,Harrington AM,Grundy L,Castro J,Brierley SM,Hannig G

更新日期：2019-11-01 00:00:00

abstract：:Injured afferent neurons produce spontaneous activity that is generated away from the normal impulse generation site. Since this activity, referred to as ectopic discharges, may play a significant role in neuropathic pain, it is important to systematically analyze the activity in various pain states. The present study...

journal_title：Pain

authors： Han HC,Lee DH,Chung JM

更新日期：2000-02-01 00:00:00

abstract：:The objective of this study was to examine which factors during pregnancy and postpartum predict pelvic girdle pain (PGP) at 12 weeks postpartum among working women. A total of 548 Dutch pregnant employees were recruited in 15 companies, mainly health care, child care, and supermarkets. The definition of PGP was any p...

journal_title：Pain

authors： Stomp-van den Berg SGM,Hendriksen IJM,Bruinvels DJ,Twisk JWR,van Mechelen W,van Poppel MNM

更新日期：2012-12-01 00:00:00

abstract：:There is evidence of greater opioid prescription to individuals in the United States with mental health conditions. Whether these associations generalize beyond the US prescription environment and to familial mental health and socioeconomic status (SES) has not been examined comprehensively. This study estimated assoc...

journal_title：Pain

authors： Quinn PD,Rickert ME,Franck J,Sariaslan A,Boersma K,Lichtenstein P,Larsson H,D'Onofrio BM

更新日期：2019-11-01 00:00:00

abstract：:The tendency to select threatening over benign interpretations of ambiguous bodily sensations and cues characterises young people with chronic pain. However, previous studies disagree over whether these biases extend to nonbodily harm situations such as social evaluation. Understanding the content of these biases is c...

journal_title：Pain

authors： Lau JYF,Badaoui M,Meehan AJ,Heathcote LC,Barker ED,Rimes KA

更新日期：2020-02-01 00:00:00

abstract：:We know very little about the change in pain in the first 2 months after surgery. To address this gap, we studied 530 women scheduled for elective cesarean delivery who completed daily pain diaries for 2 months after surgery through text messaging. Over 82% of subjects missed fewer than 10 diary entries and were inclu...

journal_title：Pain

authors： Booth JL,Sharpe EE,Houle TT,Harris L,Curry RS,Aschenbrenner CA,Eisenach JC

更新日期：2018-10-01 00:00:00