Abstract:
:Injection of a dilute solution of formalin into a rat hindpaw produces a biphasic nociceptive response consisting of an early phase during the first 5 min after formalin injection and a later phase starting after 15 min and lasting for 40-50 min. The period between the two phases of nociceptive responding is generally considered to be a phase of inactivity. We compared the nociceptive behaviors produced by a single hindpaw injection of 50 microl of formalin with those produced by two formalin injections given 20 min apart. A single formalin injection at concentrations of either 1 or 2.5%, produced the typical biphasic nociceptive responses. In rats given a second injection of either 1 or 2.5% formalin 20 min after the first, a triphasic response occurred, with a second diminution of nociceptive behavior observed between 10 and 15 min after the second injection. When a second injection of 2.5% formalin was given 5 min after the first, there was no difference from the scores in the group given only one injection. In electrophysiological experiments on single dorsal horn nociceptive neurons, a second injection of 2.5% formalin into the peripheral cutaneous receptive field, 40 min after the first and at the same site of injection as the first formalin injection, depressed neuronal activity for approximately 15-20 min. From the data it can be concluded that the interphase period in the formalin test is due to active inhibition. Furthermore, the inhibition which we are reporting here is independent of the concentration of formalin used, and thus of any so-called inflammatory component. The lack of additive nociceptive effects when the inter-injection interval was only 5 min, suggests that a maximum inhibition was provoked by 2.5% formalin; it can also be concluded that the active inhibition is of overriding importance physiologically, compared with the nociceptive activity. Data from parallel electrophysiological experiments on spinal dorsal horn neurons demonstrated a diminution in excitability after a second formalin injection into the cutaneous receptive field. As these data were obtained from pentobarbital-anesthetized, spinalized rats, the data suggest further that the two excitatory phases and the active inhibition are mediated by spinal mechanisms and that the inhibition is not under regulation of a GABAergic mechanism. The implication of the results is not only further evidence of physiological control mechanisms interacting to regulate pain, but they also indicate the overriding priority of intrinsic inhibitory mechanisms. This, in turn, suggests that the clinical management of pain may be enhanced by efforts to potentiate mechanisms of inhibition.
journal_name
Painjournal_title
Painauthors
Henry JL,Yashpal K,Pitcher GM,Coderre TJdoi
10.1016/S0304-3959(99)00033-0keywords:
subject
Has Abstractpub_date
1999-07-01 00:00:00pages
57-63issue
1eissn
0304-3959issn
1872-6623pii
00006396-199907010-00008journal_volume
82pub_type
杂志文章相关文献
PAIN文献大全abstract::Animal and human studies indicate that electrical stimulation of dorsal root ganglion (DRG) neurons may modulate neuropathic pain signals. ACCURATE, a pivotal, prospective, multicenter, randomized comparative effectiveness trial, was conducted in 152 subjects diagnosed with complex regional pain syndrome or causalgia ...
journal_title:Pain
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/j.pain.0000000000000814
更新日期:2017-04-01 00:00:00
abstract::A young female outpatient experienced painful tonic contractions in the right triceps surae muscles as a result of a partial damage of the right peroneal nerve. Electrophysiological recordings of the soleus muscle showed a tonic EMG activity and an hyperexcitability of the monosynaptic H reflex (Hmax/Mmax ratio: 90%)....
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(88)90037-1
更新日期:1988-03-01 00:00:00
abstract::The aim of this study was to test the capacity of the Fear Avoidance Model to explain the relationship between pain and disability in patients with whiplash-associated disorders. Using the method of Baron and Kenny, we assessed the mediating effect of fear of movement on the cross-sectional and longitudinal relationsh...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.09.023
更新日期:2012-01-01 00:00:00
abstract::Chronic visceral pain affects millions of individuals worldwide and remains poorly understood, with current therapeutic options constrained by gastrointestinal adverse effects. Visceral pain is strongly associated with inflammation and distension of the gut. Here we report that the voltage-gated sodium channel subtype...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.06.015
更新日期:2014-10-01 00:00:00
abstract::Numerous behavioral pain measures have been validated for young children, but none is appropriate to assess pain in emergency departments (EDs), where caregivers need a simple, easily completed scale. Our objective was to elaborate and validate a tool, relevant in any painful situation, with agitation or prostration, ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.02.024
更新日期:2012-08-01 00:00:00
abstract::Neuropathic pain affects millions of people worldwide, causing substantial disability and greatly impairing quality of life. Commonly used analgesics or antihyperalgesic compounds are generally characterized by limited therapeutic outcomes. Thus, there is a compelling need for novel therapeutic strategies able to prev...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.06.023
更新日期:2014-10-01 00:00:00
abstract::The blood vessels and the pial surface of the brain, spinal cord and its roots are innervated by primary afferent neurones. Here, we have electrophysiologically characterized the functional properties of a subpopulation of these afferent fibres that supply the ventral roots of the cat sacral spinal cord. We have taken...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90167-V
更新日期:1991-04-01 00:00:00
abstract::The present study examined the role of spinal cholinergic modulation of spinal mechanical and thermal transmission. Intrathecal administration of the cholinergic muscarinic receptor antagonists atropine or scopolamine in awake rats produced a dose-dependent decrease in the nociceptive mechanical withdrawal threshold o...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90078-C
更新日期:1991-08-01 00:00:00
abstract::Inflammation enhances release of neuropeptides from sensory nerve terminals in the spinal cord, and this may contribute to the development of hyperalgesia. In a similar manner, proinflammatory prostaglandins also augment peptide release from sensory neurons. To ascertain whether the inflammation-induced increase in pe...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(98)00113-4
更新日期:1998-10-01 00:00:00
abstract::The GABA(B) receptor-mediated presynaptic inhibition of glycinergic transmission was studied from young rat substantia gelatinosa (SG) neurons using a conventional whole-cell patch clamp technique. Action potential-dependent glycinergic inhibitory postsynaptic currents (IPSCs) were recorded from SG neurons in the pres...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.01.005
更新日期:2008-08-31 00:00:00
abstract::Painful neuromas can cause severe loss of function and have great impact on the daily life of patients. Surgical management remains challenging; despite improving techniques, success rates are low. To accurately study the success of surgical neuroma treatment and factors predictive of outcome, a prospective follow-up ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.09.032
更新日期:2010-12-01 00:00:00
abstract::This study determined preoperative predictors of movement and resting pain following total knee replacement (TKR). We hypothesized that younger patients with higher preoperative pain intensity, pain sensitivity, trait anxiety, pain catastrophizing, and depression would be more likely to experience higher postoperative...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.06.021
更新日期:2012-11-01 00:00:00
abstract::Late-life depression and pain more often co-occur than can be explained by chance. Determinants of pain in late-life depression are unknown, even though knowledge on possible determinants of pain in depression is important for clinical practice. Therefore, the objectives of the present study were 1) to describe pain c...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.07.019
更新日期:2014-10-01 00:00:00
abstract::Although cognitive-behavioral therapies (CBT) have been demonstrated to be effective for a variety of chronic pain problems, patients vary in their response and little is known about patient characteristics that predict or moderate treatment effects. Furthermore, although cognitive-behavioral theory posits that change...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2006.09.005
更新日期:2007-02-01 00:00:00
abstract::Clinical trial participants often require additional instruction to prevent idiosyncratic interpretations regarding completion of patient-reported outcomes. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership developed a tr...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1097/j.pain.0000000000000502
更新日期:2016-05-01 00:00:00
abstract::Studies in healthy human subjects and patients with irritable bowel syndrome suggest sex differences in cerebral nociceptive processing. Here we examine sex differences in functional brain activation in the rat during colorectal distention (CRD), a preclinical model of acute visceral pain. [(14)C]-iodoantipyrine was i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.05.025
更新日期:2009-09-01 00:00:00
abstract::A wide range of environmental stimuli have been shown to induce antinociception. Investigation of the brain regions contributing to environmentally induced antinociception (EIA) has focused primarily on the effect of disrupting neural transmission at various CNS sites. In contrast, the present study analyzed changes i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(93)90108-2
更新日期:1993-01-01 00:00:00
abstract::Electronic diary assessment methods offer the potential to accurately characterize pain and other daily experiences. However, the frequent assessment of experiences over time often results in missing data. It is important to identify systematic reasons for missing data because such a pattern may bias study results and...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.02.014
更新日期:2004-06-01 00:00:00
abstract::Our previous studies in the Sprague-Dawley rat showed that the intrinsic antinociceptive effects of oxycodone are naloxone reversible in a manner analogous to morphine but that in contrast to morphine, oxycodone's antinociceptive effects have a rapid onset of maximum effect (approximately 5-7 min compared to 30-45 min...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(97)00093-6
更新日期:1997-11-01 00:00:00
abstract::Extracellular signal-regulated kinase (ERK), a mitogen-activated protein kinases (MAPK), transduces a broad range of extracellular stimuli into diverse intracellular responses. Recent studies have showed that ERK activation in the supraspinal level involved in the development of drug dependence, especially in psycholo...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2005.09.006
更新日期:2005-12-05 00:00:00
abstract::A chronic compression of the dorsal root ganglion (CCD) produces ipsilateral cutaneous hyperalgesia and allodynia in rats. Intracellular electrophysiological recordings from formerly compressed neurons in the intact dorsal root ganglion (DRG) reveal lower than normal current thresholds (CTs) and abnormal spontaneous a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.10.001
更新日期:2005-01-01 00:00:00
abstract::Noxious challenge of the rat gastric mucosa by hydrochloric acid (HCl) is signaled to the nucleus tractus solitarii (NTS) and area postrema (AP). This study examined the participation of glutamate and tachykinins in the medullary transmission process. Activation of neurons was visualized by in situ hybridization autor...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(00)00357-2
更新日期:2001-01-01 00:00:00
abstract::Using the chronic constriction injury (CCI) model of neuropathic pain, we profiled gene expression in the rat spinal cord, and identified SIP30 as a gene whose expression was elevated after CCI. SIP30 was previously shown to interact with SNAP25, but whose function was otherwise unknown. We now show that in the spinal...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.07.011
更新日期:2009-11-01 00:00:00
abstract::A 1-year follow-up of two preadolescent age cohorts with musculoskeletal pain at least once a week was conducted to analyze predictive factors for the persistence of musculoskeletal pain. Of the 564 children with pain at baseline, representing one third of the sample studied, 515 (91.3%) could be followed and 452 (80....
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(98)00083-9
更新日期:1998-07-01 00:00:00
abstract::The blockade of spinal glycine receptors with intrathecal (i.t.) strychnine produces segmentally-localized allodynia in the rat; a reversible and highly reproducible effect that is attained without peripheral or central nerve injury. We investigated the effect of i.v. mexiletine, an orally active congener of lidocaine...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(97)00021-3
更新日期:1997-09-01 00:00:00
abstract::Total hip replacement (THR) and total knee replacement (TKR) are usually effective at relieving pain; however, 7% to 23% of patients experience chronic postsurgical pain. These trials aimed to investigate the effect of local anaesthetic wound infiltration on pain severity at 12 months after primary THR or TKR for oste...
journal_title:Pain
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/j.pain.0000000000000114
更新日期:2015-06-01 00:00:00
abstract::A 78-year-old male patient had chronic, unrelieved abdominal pain due to mesenteric ischaemia. Unsuccessful pharmacological approaches included oral morphine plus coadjuvants as well as a sympathetic celiac plexus block which gave pain relief that lasted for 72 h. In order to obtain long-lasting relief, a trial epidur...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(00)00266-9
更新日期:2000-07-01 00:00:00
abstract::The failure to translate research evidence into day-to-day clinical practices is identified as a significant reason for suboptimal quality care across the health system, including procedural pain management in children. Clinical practice guidelines (CPGs) have been developed to assist in this process by synthesizing a...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1097/j.pain.0000000000000090
更新日期:2015-04-01 00:00:00
abstract::The use of long-term opioid therapy for chronic pain remains common, yet data on long-term outcomes, especially after dose escalation, are sparse. This study examined potential benefits and harms associated with prescription opioid dose escalation. Participants from 2 institutions were enrolled in a 2-year prospective...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001817
更新日期:2020-06-01 00:00:00
abstract::Although it is well known that cannabinoids produce antinociception in acute pain models, there is less information on the ability of cannabinoids to alleviate hyperalgesia. In the present study, we determined whether cannabinoids attenuated the development of hyperalgesia produced by intraplantar injection of capsaic...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(98)00263-2
更新日期:1999-05-01 00:00:00