Abstract：
:Painful neuromas can cause severe loss of function and have great impact on the daily life of patients. Surgical management remains challenging; despite improving techniques, success rates are low. To accurately study the success of surgical neuroma treatment and factors predictive of outcome, a prospective follow-up study was performed. Between 2006 and 2009, pre- and post-operative questionnaires regarding pain (VAS, McGill), function (DASH), quality of life (SF-36), symptoms of psychopathology (SCL-90), epidemiologic determinants and other outcome factors were sent to patients surgically treated for upper extremity neuroma pain. Pain scores after diagnostic nerve blocks were documented at the outpatient clinic before surgery. Thirty-four patients were included, with an average follow up time of 22 months. The mean VAS score decreased from 6.8 to 4.9 after surgery (p<0.01), 19 (56%) of patients were satisfied with surgical results. Upper extremity function improved significantly (p=0.001). Neuroma patients had significantly lower quality of life compared to a normal population. Employment status, duration of pain and CRPS symptoms were found to be prognostic factors. VAS scores after diagnostic nerve block were predictive of post-operative VAS scores (p=0.001). Furthermore, smoking was significantly related to worse outcome (relative risk: 2.10). The results could lead to improved patient selection and treatment strategies. If a diagnostic nerve block is ineffective in relieving pain, patients will most likely not benefit from surgical treatment. Patients should be encouraged to focus on activity and employment instead of their symptoms. Smoking should be discouraged in patients who will undergo surgical neuroma treatment.
journal_name
Painjournal_title
Painauthors
Stokvis A,van der Avoort DJC,van Neck JW,Hovius SER,Coert HJdoi
10.1016/j.pain.2010.09.032subject
Has Abstractpub_date
2010-12-01 00:00:00pages
862-869issue
3eissn
0304-3959issn
1872-6623pii
00006396-201012000-00041journal_volume
151pub_type
杂志文章相关文献
PAIN文献大全abstract：:Pain that interferes with daily life appears to be strongly age-related in cross-sectional studies, although the nature of this relationship over time has not been established. We have investigated the onset and persistence of pain and pain interference over a 3-year period to determine their association with age in o...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2006.09.027
更新日期：2007-05-01 00:00:00
abstract：:Inflammation enhances release of neuropeptides from sensory nerve terminals in the spinal cord, and this may contribute to the development of hyperalgesia. In a similar manner, proinflammatory prostaglandins also augment peptide release from sensory neurons. To ascertain whether the inflammation-induced increase in pe...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(98)00113-4
更新日期：1998-10-01 00:00:00
abstract：:The efficacy of amitriptyline was evaluated in 28 patients with chronic oral-facial pain. Most of the patients had evidence of musculoskeletal pain while some had a history suggesting pain of neurogenic origin. Two patients had mixed elements of neurogenic and musculoskeletal pain. Amitriptyline was more effective tha...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/0304-3959(87)90036-4
更新日期：1987-11-01 00:00:00
abstract：:Total hindpaw denervation in rodents elicits an abnormal behavior of licking, scratching and self-injury of the anesthetic limb ("autotomy"). Since the same denervation produces phantom limb pain and anesthesia dolorosa in humans, autotomy has been used as a model of human neuropathic pain. Autotomy is an inherited tr...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(01)00295-0
更新日期：2001-08-01 00:00:00
abstract：:Pregnant women may take nonsteroidal antiinflammatory drugs (NSAIDs), selective cyclooxygenase (COX)-2 inhibitors, or biological agents to relieve symptoms or manage disease flares in late pregnancy. We aimed to quantify the risk of prematurity associated with late pregnancy exposure to nonselective NSAIDs, selective ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001163
更新日期：2018-05-01 00:00:00
abstract：:Acute microinjection of mu-, delta-, or kappa-opioid receptor (MOPr, DOPr, KOPr) agonists into the rostral ventromedial medulla (RVM) produces antinociception. Thermal antinociception produced by MOPr and DOPr agonists is potentiated during inflammation [Hurley RW, Hammond DL. The analgesic effects of supraspinal mu a...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2007.07.010
更新日期：2008-06-01 00:00:00
abstract：:Chronic compression of rat dorsal root ganglion (CCD) produced tactile allodynia accompanied with hyperexcitability of the myelinated Aβ dorsal root ganglion (DRG) neurons. The Aβ DRG neuron hyperexcitability exhibits as bursting discharges in response to peripherally evoked action potentials (evoked bursting [EB]). T...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2011.11.030
更新日期：2012-03-01 00:00:00
abstract：:We propose a blade as a noninjurious nociceptive stimulus modeling sharp mechanical pain and yielding acute pain and hyperalgesia responses with closer proximity to incision-induced pain/hyperalgesia than punctate or blunt pressure mechanical pain models. Twenty-six healthy men and women were investigated to compare a...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000352
更新日期：2016-01-01 00:00:00
abstract：:Tetrodotoxin-resistant (TTX-R) Na(+) channels play a key role in the generation of action potentials in nociceptive dorsal root ganglion (DRG) neurons and are an important target for the proinflammatory mediator prostaglandin E(2), which augments these currents. Prostaglandin D(2) (PGD(2)) is released in the tissue to...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2011.01.033
更新日期：2011-05-01 00:00:00
abstract：:Chronic widespread pain (CWP) is associated with poor health-related quality of life (HRQoL). It is unclear whether pain itself is the cause of poor HRQoL or other factors play a role. We hypothesised that new onset of CWP was associated with poor physical and mental HRQoL but that psychosocial risk markers for CWP on...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2008.10.022
更新日期：2009-01-01 00:00:00
abstract：:Measuring health complaints by administrating a single report is common. Our aim was to assess variation in pain and other subjective complaints over an extended period, whether a single-sample produces representative data, and determine associations between complaints. Health-complaint reports were collected from pos...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2004.03.016
更新日期：2004-07-01 00:00:00
abstract：:Clinical evidence suggests that cutaneous and visceral pain differ in sensory, affective, and motivational realms, yet there has been little comparative characterization of these types of pain. This study uses psychophysical measures to compare directly visceral and cutaneous pain and sensitivity. Healthy subjects (10...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(02)00023-4
更新日期：2002-06-01 00:00:00
abstract：:The present study describes a new test of tonic pain to be used as an animal model of persistent pain. First, pain responses and edema produced by subcutaneous injection of increasing doses of honey bee venom into the hind paw of the rat were quantified. Second, the effect of morphine and aspirin on the pain responses...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(96)03075-8
更新日期：1996-08-01 00:00:00
abstract：:The human palm has a lower heat detection threshold and a higher heat pain threshold than hairy skin. Neurophysiological studies of monkeys suggest that glabrous skin has fewer low threshold heat nociceptors (AMH type 2) than hairy skin. Accordingly, we used a temperature-controlled contact heat evoked potential (CHEP...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2005.02.017
更新日期：2005-06-01 00:00:00
abstract：:Injection of bee venom into one hindpaw of rat can elicit acute inflammation together with spontaneous pain, heat hyperalgesia and mechanical hyperalgesia/allodynia in the injected paw. 5-hydroxytryptamine (5-HT)1A receptor is the predominant receptor subtype in the spinal dorsal horn mediating the function of 5-HT in...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(03)00315-4
更新日期：2003-11-01 00:00:00
abstract：:When a peripheral nerve is severed, damaged sensory fibers emit a barrage of impulses that lasts for many seconds, or even several minutes ('injury discharge'). We have shown in rats that local anesthetic blockade of this discharge suppresses autotomy (a behavioral model of neuropathic pain). Correspondingly, mimickin...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(91)90166-U
更新日期：1991-04-01 00:00:00
abstract：:An empirical determination of the nature and minimum number of dimension necessary to describe responses to the McGill Pain Questionnaire, and a comparison of groups, experiencing clinical or experimentally induced pain, on the dimensions were carried out. Eighty-five patients referred to a low back pain diagnostic cl...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(77)90131-2
更新日期：1977-12-01 00:00:00
abstract：:Nonopioid agents, such as nonsteroidal anti-inflammatory drugs (NSAIDs), are the most commonly used class of analgesics. Increasing evidence suggests that cyclooxygenase (COX) inhibition at both peripheral and central sites can contribute to the antihyperalgesic effects of NSAIDs, with the predominant clinical effect ...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1097/j.pain.0000000000000176
更新日期：2015-07-01 00:00:00
abstract：:Neuropathic pain affects millions of people worldwide, causing substantial disability and greatly impairing quality of life. Commonly used analgesics or antihyperalgesic compounds are generally characterized by limited therapeutic outcomes. Thus, there is a compelling need for novel therapeutic strategies able to prev...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2014.06.023
更新日期：2014-10-01 00:00:00
abstract：:We have previously reported a novel method for producing chronic nociceptive behavior in rats following compression of the trigeminal ganglion. In the present study, we have further studied the role of demyelination in the development of prolonged nociceptive behavior in the trigeminal territory. For this purpose, lys...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2009.07.012
更新日期：2009-11-01 00:00:00
abstract：:Reduced sensitivity to naturally occurring and laboratory pain stimuli has been observed in individuals with hypertension, high-normal blood pressure, and a family history of hypertension. The present study sought to extend these findings by examining the relationship between familial history of hypertension and pain ...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2008.12.010
更新日期：2009-04-01 00:00:00
abstract：:In a double-blind placebo-controlled cross-over study the effects of epidural morphine (4 mg) on somatosensory functions were investigated in 10 healthy volunteers. Detection, pain detection and pain tolerance thresholds to thermal, mechanical and electrical stimuli as well as magnitude rating of short-lasting stimuli...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0304-3959(93)90117-8
更新日期：1993-01-01 00:00:00
abstract：:Extracellular signal-regulated kinase (ERK), a mitogen-activated protein kinases (MAPK), transduces a broad range of extracellular stimuli into diverse intracellular responses. Recent studies have showed that ERK activation in the supraspinal level involved in the development of drug dependence, especially in psycholo...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2005.09.006
更新日期：2005-12-05 00:00:00
abstract：:Non-invasive, movement-based models were used to investigate muscle pain. In rats, the masseter muscle was rapidly stretched or electrically stimulated during forced lengthening to produce eccentric muscle contractions (EC). Both EC and stretching disrupted scattered myofibers and produced intramuscular plasma extrava...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2010.02.022
更新日期：2010-05-01 00:00:00
abstract：:The primary purpose of this study was to examine the extent to which specific patient attitudes and beliefs about medical care and self-care for back pain predict future healthcare use. An automated database allowed examination of the predictive relationships in two primary care patient samples. In general, beliefs th...
journal_title：Pain
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0304-3959(99)00121-9
更新日期：1999-11-01 00:00:00
abstract：:Chronic pain is associated with large societal costs, but few studies have investigated the total costs of chronic pain with respect to elderly subjects. The elderly usually require informal care, care performed by municipalities, and care for chronic diseases, all factors that can result in extensive financial burden...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/01.j.pain.0000460336.31600.01
更新日期：2015-03-01 00:00:00
abstract：:Catechol-O-methyltransferase (COMT) regulates extracellular catecholamines. A widely studied COMT single nucleotide polymorphism (rs4680) changes the translated amino acid from valine to methionine (Val158Met); the polymorphism has been shown to influence opioid use. The aims of this study were to investigate the infl...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001400
更新日期：2019-01-01 00:00:00
abstract：:Neuropathic pain (NP) in cancer patients lacks standards for diagnosis. This study is aimed at reaching consensus on the application of the International Association for the Study of Pain (IASP) special interest group for neuropathic pain (NeuPSIG) criteria to the diagnosis of NP in cancer patients and on the relevanc...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2014.09.038
更新日期：2014-12-01 00:00:00
abstract：:Neuropathic pain behaviour is not observed in neonatal rats and tactile allodynia does not develop in the spared nerve injury (SNI) model until rats are 4 weeks of age at the time of surgery. Since activated spinal microglia are known to play a key role in neuropathic pain, we have investigated whether the microglial ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2006.09.018
更新日期：2007-04-01 00:00:00
abstract：:The responses of preterm neonates to acute tissue-damaging stimuli have been described. However, factors which influence these responses have received little attention. In this study, we observed 124 premature infants before, during and after a routine heel lance and determined how two contextual variables (severity o...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/0304-3959(94)90053-1
更新日期：1994-10-01 00:00:00
