Abstract：
:Extracellular signal-regulated kinase (ERK), a mitogen-activated protein kinases (MAPK), transduces a broad range of extracellular stimuli into diverse intracellular responses. Recent studies have showed that ERK activation in the supraspinal level involved in the development of drug dependence, especially in psychological dependence. In this study, we reported that the spinal ERK signaling pathway was activated by chronic morphine injection. There was a further increase in ERK activation after naloxone-precipitated withdrawal. Furthermore, attenuation of the spinal ERK phosphorylation by intrathecal a MAPK kinase (MEK) inhibitor U0126 or knockdown of the spinal ERK by antisense oligonucleotides not only decreased the scores of morphine withdrawal, but also attenuated withdrawal-induced allodynia, which were accompanied by decreased ERK phosphorylation in the spinal cord. The spinal ERK inhibition or knockdown also reduced morphine withdrawal-induced phosphorylation of cAMP response element binding protein (CREB), which is one of the important downstream substrates of ERK pathway, and Fos expression. The involvement of the spinal ERK in morphine withdrawal was supported by our finding that intrathecal N-methyl-D-aspartate receptor antagonist MK-801 or protein kinase C inhibitor chelerythrine chloride suppressed withdrawal-induced ERK activation in the spinal cord and attenuated morphine withdrawal symptoms. These findings suggest activation of the spinal ERK signaling pathway contributes naloxone-precipitated withdrawal in morphine-dependent rats.
journal_name
Painjournal_title
Painauthors
Cao JL,He JH,Ding HL,Zeng YMdoi
10.1016/j.pain.2005.09.006keywords:
subject
Has Abstractpub_date
2005-12-05 00:00:00pages
336-349issue
3eissn
0304-3959issn
1872-6623pii
00006396-200512050-00007journal_volume
118pub_type
杂志文章相关文献
PAIN文献大全abstract：:The neuropeptide bradykinin (BK) sensitizes nociceptor activation following its release in response to inflammatory injury. Thereafter, the bioactivity of bradykinin is controlled by the enzymatic activities of circulating peptidases. One such enzyme, the metalloendopeptidase EC3.4.24.15 (EP24.15), is co-expressed wit...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2011.02.044
更新日期：2011-07-01 00:00:00
abstract：:Many chronic pain syndromes, including fibromyalgia (FM), show evidence of central nervous system hyperexcitability related to central sensitization. Windup (WU) of second pain reflects increased excitability of spinal cord neurons that is related to central sensitization. Psychophysical testing can help characterize ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2004.05.009
更新日期：2004-08-01 00:00:00
abstract：:Women with chronic pelvic pain experience serious distress and lifestyle disruption. Confronted with a difficult condition to diagnose and treat effectively, doctors express a negative perception of this group of 'heartsink' patients. This study aimed to characterise medical attitudes towards the treatment of women wi...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(98)00104-3
更新日期：1998-08-01 00:00:00
abstract：:In the present study 366 patients suffering acute or chronic musculoskeletal pain of different origin were given vibratory stimulation for the pain. Many of the patients had previously had treatments of various kinds without satisfactory relief. The effect of vibratory stimulation was assessed during and after stimula...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(84)90808-X
更新日期：1984-09-01 00:00:00
abstract：:Venlafaxine hydrochloride (Effexor) is a structurally novel antidepressant that inhibits reuptake of 5-hydroxytryptamine and noradrenaline, but unlike the older antidepressants, has few side-effects. The objective of this study was to determine whether venlafaxine relieves thermal hyperalgesia in rats with neuropathic...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(96)03223-X
更新日期：1996-11-01 00:00:00
abstract：:The induction of hyperalgesia upon capsaicin administration requires activation of specific sub-classes of nociceptive afferent C-fibres providing nociceptive input to the central nervous system. It has been demonstrated in animal models that the endocannabinoid anandamide has anti-hyperalgesic properties upon capsaic...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(02)00401-3
更新日期：2003-04-01 00:00:00
abstract：:Multimodal neuroimaging studies provide support for a role of alterations in sensory processing circuits and endogenous pain modulatory systems in provoked vestibulodynia (PVD). In this study, we tested the hypotheses that PVD compared with healthy controls (HCs) would demonstrate gray matter volume (GMV) alterations ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001532
更新日期：2019-07-01 00:00:00
abstract：:Although classical trigeminal neuralgia (CTN) is frequently caused by neurovascular contact (NVC) at the trigeminal root entry zone (REZ), both anatomical and MRI studies have shown that NVC of the trigeminal nerve frequently occurs in individuals without CTN. To assess the accuracy of MRI in distinguishing symptomati...
journal_title：Pain
pub_type： 杂志文章,meta分析
doi：10.1016/j.pain.2014.04.020
更新日期：2014-08-01 00:00:00
abstract：:Pain that interferes with daily life appears to be strongly age-related in cross-sectional studies, although the nature of this relationship over time has not been established. We have investigated the onset and persistence of pain and pain interference over a 3-year period to determine their association with age in o...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2006.09.027
更新日期：2007-05-01 00:00:00
abstract：:A growing body of literature suggests that the experience of clinical pain differs across ethnocultural groups. Additionally, some evidence indicates greater sensitivity to experimentally induced pain among African Americans; however, most studies have included only one pain modality. This study examined ethnic differ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2004.08.013
更新日期：2005-01-01 00:00:00
abstract：:A controlled clinical trial on the efficacy of a nortriptyline-fluphenazine combination was carried out in patients with painful diabetic polyneuropathy. A visual analog scale was used to evaluate the relief of pain or paresthesia. Significant relief of both pain and paresthesia was obtained with this combination. The...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/0304-3959(85)90010-7
更新日期：1985-12-01 00:00:00
abstract：:Unlike most classical analgesics, botulinum toxin type A (BoNT/A) does not alter acute nociceptive thresholds, and shows selectivity primarily for allodynic and hyperalgesic responses in certain pain conditions. We hypothesized that this phenomenon might be explained by characterizing the sensory neurons targeted by B...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2014.04.027
更新日期：2014-08-01 00:00:00
abstract：:Forty patients with chronic pain below the waist level not amenable to conventional medical and/or surgical treatment were randomly assigned to one or two different methods of acupuncture, after studying the underlying pain mechanisms using a Multidisciplinary Pain Clinic approach and the differential spinal block (DS...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0304-3959(76)90006-3
更新日期：1976-09-01 00:00:00
abstract：:Diffuse noxious inhibitory controls (DNICs) utilize descending inhibitory controls through poorly understood brain stem pathways. The human counterpart, conditioned pain modulation, is reduced in patients with neuropathy aligned with animal data showing a loss of descending inhibitory noradrenaline controls together w...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000240
更新日期：2015-09-01 00:00:00
abstract：:The aim of the present study was to investigate changes in the plasma calcitonin gene-related peptide (CGRP) concentration and platelet serotonin (5-hydroxytriptamine, 5-HT) content during the immediate headache and the delayed genuine migraine attack provoked by nitroglycerin. Fifteen female migraineurs (without aura...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2003.09.008
更新日期：2003-12-01 00:00:00
abstract：:Previous work has suggested an attenuated sensitivity to painful stimulation in hypertensive men. We recently reported that, compared with persons with negative parental history, men, but not women, with a positive history for hypertension showed attenuated pain perception. This study specifically addressed factors th...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(00)00306-7
更新日期：2000-10-01 00:00:00
abstract：:Serotonin is critically involved in neuropathic pain. However, its role is far from being understood owing to the number of cellular targets and receptor subtypes involved. In a rat model of neuropathic pain evoked by chronic constriction injury (CCI) of the sciatic nerve, we studied the role of 5-HT(2B) receptor in d...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2012.03.024
更新日期：2012-06-01 00:00:00
abstract：:In a rat model of artificial ureteral calculosis, the aim of the study was to characterize the behavioural manifestations of direct visceral pain and to evaluate the relationship between number, duration and complexity of the visceral episodes and the extent of referred lumbar muscular hyperalgesia. As evidenced by no...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(94)00208-V
更新日期：1995-06-01 00:00:00
abstract：:The role of 5-hydroxytryptamine (5-HT)(4), 5-HT(6), and 5-HT(7) receptors in formalin-induced secondary allodynia and hyperalgesia in rats was assessed. Formalin produced acute nociceptive behaviors (flinching and licking/lifting) followed by long-term secondary mechanical allodynia and hyperalgesia. Pretreatment (-10...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2010.12.020
更新日期：2011-03-01 00:00:00
abstract：:For genetic research to contribute more fully to furthering our knowledge of neuropathic pain, we require an agreed, valid, and feasible approach to phenotyping, to allow collaboration and replication in samples of sufficient size. Results from genetic studies on neuropathic pain have been inconsistent and have met wi...
journal_title：Pain
pub_type： 杂志文章,评审
doi：10.1097/j.pain.0000000000000335
更新日期：2015-11-01 00:00:00
abstract：:The anterior cingulate cortex (ACC) has a pivotal role in human pain processing by integrating sensory, executive, attentional, emotional, and motivational components of pain. Cognitive modulation of pain-related ACC activation has been shown by hypnosis, illusion and anticipation. The expectation of a potentially nox...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2004.12.036
更新日期：2005-04-01 00:00:00
abstract：:Activated mammalian target of rapamycin (P-mTOR) has been shown to maintain the sensitivity of subsets of small-diameter primary afferent A-nociceptors. Local or systemic inhibition of the mTOR complex 1 (mTORC1) pathway reduced punctate mechanical and cold sensitivity in neuropathic pain and therefore offered a new a...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000197
更新日期：2015-08-01 00:00:00
abstract：:The present study examined the role of catastrophizing in predicting levels of pain and disability in a sample of individuals who had sustained soft-tissue injuries to the neck, shoulders or back following work or motor vehicle accidents. Participants were 86 (27 men, 59 women) consecutive referrals to the Atlantic Pa...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(98)00097-9
更新日期：1998-09-01 00:00:00
abstract：:Noxious C-fibre stimulation produces increased sensitivity within the injured area (primary hyperalgesia), and a surrounding zone of secondary hyperalgesia. As significant changes in nociceptive processing occur during development, we compared C-fibre induced primary and secondary hyperalgesia in rat pups aged 3, 10 a...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2006.09.015
更新日期：2007-03-01 00:00:00
abstract：:This study evaluated the pre-emptive analgesic effect of intravenous (i.v.) ketorolac (KET) for total hip replacement (THR). Sixty patients who underwent surgery for THR under general anesthesia were randomly allocated to 3 groups. Two i.v. injections were administered: one before induction and one after surgery. The ...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0304-3959(94)00184-G
更新日期：1995-05-01 00:00:00
abstract：:Inflammation induces an up-regulation of neuropeptide tyrosine (NPY) and its receptors in the dorsal horn, suggesting an important role in nociceptive transmission. Our initial studies revealed that NPY dose-dependently increased hotplate response latency, and to a lesser degree, thermal paw withdrawal latency (PWL); ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(01)00481-X
更新日期：2002-04-01 00:00:00
abstract：:Physical and psychosocial disability in patients with chronic pain have been shown to be associated with patients' pain-related beliefs, tendency to catastrophize, and pain coping strategy use. However, little is known about whether beliefs, catastrophizing, and coping strategies are independently associated with pati...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/s0304-3959(99)00259-6
更新日期：2000-03-01 00:00:00
abstract：:Migraine is a common and disabling neurologic disorder, with important psychiatric comorbidities. Its pathophysiology involves activation of neurons in the trigeminocervical complex (TCC). Kainate receptors carrying the glutamate receptor subunit 5 (GluK1) are present in key brain areas involved in migraine pathophysi...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/01.j.pain.0000460325.25762.c0
更新日期：2015-03-01 00:00:00
abstract：:The localization of sodium channels (NaChs) change following nerve lesions and this change may contribute to the development of increased pain states. Here we examine the change in distribution of NaChs within the rat infraorbital nerve (ION) two weeks after a combined inflammatory/partial axotomy lesion that results ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2006.05.028
更新日期：2006-09-01 00:00:00
abstract：:Anti-nociceptive tolerance to opioids is a well-described phenomenon, which severely limits the clinical efficacy of opioids for the treatment of chronic pain syndromes. The mechanisms that drive anti-nociceptive tolerance, however, are less well understood. We have previously shown that glia have a central role in th...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2010.02.042
更新日期：2010-09-01 00:00:00
