Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations.

abstract：:Beneficial effects have been observed in University of Washington Pain Clinic patients treated with tricyclic antidepressants, but such effects occur much earlier than predicted mood elevation. A laboratory investigation of pain perception was employed to test the hypothesis that doxepin, a tricyclic antidepressant, h...

journal_title：Pain

authors： Chapman RC,Butler SH

更新日期：1978-10-01 00:00:00

abstract：:Chronic pain after laparoscopic cholecystectomy is related to postoperative pain during the first postoperative week, but it is unknown which components of the early pain response is important. In this prospective study, 100 consecutive patients were examined preoperatively, 1 week postoperatively, and 3, 6, and 12 mo...

journal_title：Pain

authors： Blichfeldt-Eckhardt MR,Ording H,Andersen C,Licht PB,Toft P

更新日期：2014-11-01 00:00:00

abstract：:Although many patients with multiple sclerosis (MS) complain of trigeminal neuralgia (TN), its cause and mechanisms are still debatable. In a multicentre controlled study, we collected 130 patients with MS: 50 patients with TN, 30 patients with trigeminal sensory disturbances other than TN (ongoing pain, dysaesthesia,...

journal_title：Pain

authors： Cruccu G,Biasiotta A,Di Rezze S,Fiorelli M,Galeotti F,Innocenti P,Mameli S,Millefiorini E,Truini A

更新日期：2009-06-01 00:00:00

abstract：:Shoulder pain is common in primary care and has an unfavourable outcome in many patients. Information about predictors of outcome is scarce and inconsistent. The objective of this study was to develop clinical prediction rules for calculating the absolute risk of persistent shoulder symptoms for individual patients, 6...

journal_title：Pain

authors： Kuijpers T,van der Windt DAWM,Boeke JPA,Twisk JWR,Vergouwe Y,Bouter LM,van der Heijden GJMG

更新日期：2006-02-01 00:00:00

abstract：:Intraperitoneal administration of the serotonin 5-HT1A agonist, buspirone (1-5 mg/kg), produced dose- and time-related core hypothermia that was coincident with analgesia against a thermally noxious stimulus. Surface body temperature was not altered by buspirone. The 5-HT1A antagonist, NAN-190 (2 mg/kg, s.c.), blocked...

journal_title：Pain

authors： Giordano J,Rogers L

更新日期：1992-09-01 00:00:00

abstract：:Behavioral analgesic techniques such as distraction reduce pain in both clinical and experimental settings. Individuals differ in the magnitude of distraction-induced analgesia, and additional study is needed to identify the factors that influence the pain relieving effects of distraction. Catastrophizing, a set of ne...

journal_title：Pain

authors： Campbell CM,Witmer K,Simango M,Carteret A,Loggia ML,Campbell JN,Haythornthwaite JA,Edwards RR

更新日期：2010-05-01 00:00:00

abstract：:Migraine is a common and disabling neurologic disorder, with important psychiatric comorbidities. Its pathophysiology involves activation of neurons in the trigeminocervical complex (TCC). Kainate receptors carrying the glutamate receptor subunit 5 (GluK1) are present in key brain areas involved in migraine pathophysi...

journal_title：Pain

authors： Andreou AP,Holland PR,Lasalandra MP,Goadsby PJ

更新日期：2015-03-01 00:00:00

abstract：:Snakebites are a relevant public health problem in Central and South America. Snake bite envenomations cause intense pain, not relieved by anti-venom. The fangs of many species are short, causing subcutaneous injection. Fangs of larger species inflict subcutaneous or intramuscular envenomation. To understand pain indu...

journal_title：Pain

authors： Chacur M,Gutiérrez JM,Milligan ED,Wieseler-Frank J,Britto LR,Maier SF,Watkins LR,Cury Y

更新日期：2004-09-01 00:00:00

abstract：:Chronic pain due to surgery, radiotherapy, or chemotherapy is prevalent in long-term cancer survivors. Chronic pain due to successful cancer treatment should be treated as chronic nonmalignant pain, primarily with nonpharmacological strategies. Based on complete national data from the Cancer Registry of Norway and the...

journal_title：Pain

authors： Fredheim OM,Skurtveit S,Handal M,Hjellvik V

更新日期：2019-04-01 00:00:00

abstract：:Many studies of pain and nociception use short-lasting acute stimuli which may have limited relevance to prolonged or chronic pain states. Using extracellular single-unit recording in the dorsal horn of the rat lumbar spinal cord the present study examines the response of neurones to a long-lasting nociceptive stimulu...

journal_title：Pain

authors： Dickenson AH,Sullivan AF

更新日期：1987-09-01 00:00:00

abstract：:In this study, we examined the relationship between astrocyte activation in the cuneate nucleus (CN) and behavioral hypersensitivity after chronic constriction injury (CCI) of the median nerve. In addition, we also examined the effects of pre-emptive treatment with a number of drugs on astrocyte activation and hyperse...

journal_title：Pain

authors： Chen JJ,Lue JH,Lin LH,Huang CT,Chiang RP,Chen CL,Tsai YJ

更新日期：2010-01-01 00:00:00

abstract：:Nociceptive impulse activity was recorded extracellularly from single A delta and C primary afferents of the guinea pig's medial articular nerve after induction of an experimental osteoarthritis in the knee joint by partial medial menisectomy and transection of the anterior cruciate ligament (PMM+TACL). Also, the anal...

journal_title：Pain

authors： Gomis A,Miralles A,Schmidt RF,Belmonte C

更新日期：2007-07-01 00:00:00

abstract：:Age-related changes in the facial expression of pain during the first 18 months of life have important implications for our understanding of pain and pain assessment. We examined facial reactions video recorded during routine immunization injections in 75 infants stratified into 2-, 4-, 6-, 12-, and 18-month age group...

journal_title：Pain

authors： Lilley CM,Craig KD,Grunau RE

更新日期：1997-08-01 00:00:00

abstract：:Measurement of depression and other mood states in pain patients has been criticised in recent years on the grounds that most questionnaires were not developed in pain populations and suffer from criterion contamination by somatic items. In addition, there is no accepted measurement for positive emotions which are mor...

journal_title：Pain

authors： Pincus T,Williams AC,Vogel S,Field A

更新日期：2004-05-01 00:00:00

abstract：:Tanezumab is a humanized monoclonal antinerve growth factor antibody in development for treatment of chronic pain. In a phase III, placebo- and active-controlled study, we investigated the efficacy and safety of tanezumab for osteoarthritis (OA) hip or knee pain. Patients (N=610) received up to 2 doses of intravenous ...

journal_title：Pain

authors： Spierings ELH,Fidelholtz J,Wolfram G,Smith MD,Brown MT,West CR

更新日期：2013-09-01 00:00:00

abstract：:Migraine headache is an episodic phenomenon, and patients with episodic migraine have ictal (headache), peri-ictal (premonitory, aura, and postdrome), and interictal (asymptomatic) phases. We aimed to find the functional characteristics of the migraine brain regardless of headache phase using dynamic functional connec...

journal_title：Pain

authors： Lee MJ,Park BY,Cho S,Park H,Kim ST,Chung CS

更新日期：2019-12-01 00:00:00

abstract：:Glutamate is a major excitatory neurotransmitter in primary afferent terminals and is critical for normal spinal excitatory synaptic transmission. However, little is known about the regulation of synaptically released glutamate in the spinal cord under physiologic conditions. The sodium-dependent, high-affinity glutam...

journal_title：Pain

authors： Liaw WJ,Stephens RL Jr,Binns BC,Chu Y,Sepkuty JP,Johns RA,Rothstein JD,Tao YX

更新日期：2005-05-01 00:00:00

abstract：:The ability to sense visceral pain during appendicitis is diminished with age leading to delay in seeking health care and poorer clinical outcomes. To understand the mechanistic basis of this phenomenon, we examined visceral nociception in aged mouse and human tissue. Inflamed and noninflamed appendixes were collected...

journal_title：Pain

authors： Cibert-Goton V,Kung VWS,McGuire C,Hockley JRF,Tranter MM,Dogra H,Belai A,Blackshaw LA,Sanger GJ,Knowles CH,Araujo EJA,Winchester WJ,Bulmer DC

更新日期：2020-04-01 00:00:00

abstract：:Endogenous pain inhibition is less efficient in chronic pain patients. Diffuse noxious inhibitory control (DNIC), a form of endogenous pain inhibition, is compromised in women and older people, making them more vulnerable to chronic pain. However, the underlying mechanisms remain unclear. Here, we used a capsaicin-ind...

journal_title：Pain

authors： Da Silva JT,Tricou C,Zhang Y,Seminowicz DA,Ro JY

更新日期：2020-06-01 00:00:00

abstract：:Percutaneous radiofrequency lumbar facet denervation has been in use as a treatment for intractable, mechanical low back pain for over 2 decades. A number of case series have been reported with high rates of success in selected patients; however, there has been limited objective outcome assessment, long-term follow-up...

journal_title：Pain

authors： North RB,Han M,Zahurak M,Kidd DH

更新日期：1994-04-01 00:00:00

abstract：:Movement is changed in pain, but the mechanisms remain unclear. Key questions are unresolved such as whether activation can be inhomogeneously distributed within a muscle in a manner that is specific to the location of noxious input. This study addressed this question using high-density electromyography (EMG) to study...

journal_title：Pain

authors： Gallina A,Salomoni SE,Hall LM,Tucker K,Garland SJ,Hodges PW

更新日期：2018-11-01 00:00:00

abstract：:Anti-nociceptive tolerance to opioids is a well-described phenomenon, which severely limits the clinical efficacy of opioids for the treatment of chronic pain syndromes. The mechanisms that drive anti-nociceptive tolerance, however, are less well understood. We have previously shown that glia have a central role in th...

journal_title：Pain

authors： Horvath RJ,Romero-Sandoval AE,De Leo JA

更新日期：2010-09-01 00:00:00

abstract：:Aquaporin 1 (AQP1) is the archetypal member of a family of water channel proteins that contribute to water homeostasis in kidney, lung, and other tissues. Although there is limited evidence that aquaporins are expressed in the nervous system, AQP4 is expressed in glia and AQP9 is present on some neuronal and glial mit...

journal_title：Pain

authors： Shields SD,Mazario J,Skinner K,Basbaum AI

更新日期：2007-09-01 00:00:00

abstract：:Distinct developmental trajectories for neck disability and posttraumatic stress disorder (PTSD) symptoms after whiplash injury have recently been identified. This study aimed to identify baseline predictors of membership to these trajectories and to explore their dual development. In a prospective study, 155 individu...

journal_title：Pain

authors： Sterling M,Hendrikz J,Kenardy J

更新日期：2011-06-01 00:00:00

abstract：:In order to clarify the mechanism of reference of pain following cordotomy (ROPC), the authors investigated ROPC in 66 patients undergoing percutaneous cervical cordotomy (PCC) and examined the features of ROPC and the correlation between the occurrence of ROPC and the pre-operative pain states, as well as the results...

journal_title：Pain

authors： Nagaro T,Amakawa K,Kimura S,Arai T

更新日期：1993-05-01 00:00:00

abstract：:Advances in pain measurement using ecological momentary assessments offer novel opportunities for understanding the temporal dynamics of pain. This study examined whether regime-switching models, which capture processes characterized by recurrent shifts between different states, provide clinically relevant information...

journal_title：Pain

authors： Schneider S,Junghaenel DU,Ono M,Stone AA

更新日期：2018-07-01 00:00:00

abstract：:Interactions between the input from cutaneous and nociceptive muscle afferents in polysynaptic reflex pathways were investigated in man. Interaction was tested by evoking reflexes before, during, and after a period of muscle pain induced by intramuscular injection of hypertonic saline. Muscle pain was induced either i...

journal_title：Pain

authors： Andersen OK,Graven-Nielsen T,Matre D,Arendt-Nielsen L,Schomburg ED

更新日期：2000-01-01 00:00:00

abstract：:A variety of molecules released by inflammatory reactions in the dorsal root and dorsal root ganglion (DRG) may play important roles in the pathology of neuronal abnormalities in lumbar disc herniation. In order to elucidate the pathophysiological mechanisms of painful radiculopathy, secondary to lumbar disc herniatio...

journal_title：Pain

authors： Obata K,Tsujino H,Yamanaka H,Yi D,Fukuoka T,Hashimoto N,Yonenobu K,Yoshikawa H,Noguchi K

更新日期：2002-09-01 00:00:00

abstract：:A randomized, double-blind, placebo-controlled study of low-level laser therapy (LLLT) in 90 subjects with chronic neck pain was conducted with the aim of determining the efficacy of 300 mW, 830 nm laser in the management of chronic neck pain. Subjects were randomized to receive a course of 14 treatments over 7 weeks ...

journal_title：Pain

authors： Chow RT,Heller GZ,Barnsley L

更新日期：2006-09-01 00:00:00

abstract：:Mental stress induces endothelial dysfunction, that is a reduction of the post-occlusion brachial artery flow-mediated vasodilation (FMD). This does not occur in subjects highly susceptible to hypnosis (Highs) in either the waking or hypnotic state. The aim of the present experiment was to assess whether endothelial d...

journal_title：Pain

authors： Jambrik Z,Santarcangelo EL,Rudisch T,Varga A,Forster T,Carli G

更新日期：2005-08-01 00:00:00