The expression of pain in infants and toddlers: developmental changes in facial action.

abstract：:The relationship between chronic pain and depression has become enmeshed in the literature. In an attempt to unravel the relationship between chronic pain and depression, the authors studied a uniform group of 80 chronic back pain patients with and without depression using the dexamethasone suppression test (DST). The...

journal_title：Pain

authors： France RD,Krishnan RRK

更新日期：1985-01-01 00:00:00

abstract：:In order to clarify the mechanism of reference of pain following cordotomy (ROPC), the authors investigated ROPC in 66 patients undergoing percutaneous cervical cordotomy (PCC) and examined the features of ROPC and the correlation between the occurrence of ROPC and the pre-operative pain states, as well as the results...

journal_title：Pain

authors： Nagaro T,Amakawa K,Kimura S,Arai T

更新日期：1993-05-01 00:00:00

abstract：:In a double-blind placebo-controlled cross-over study the effects of epidural morphine (4 mg) on somatosensory functions were investigated in 10 healthy volunteers. Detection, pain detection and pain tolerance thresholds to thermal, mechanical and electrical stimuli as well as magnitude rating of short-lasting stimuli...

journal_title：Pain

authors： Brennum J,Arendt-Nielsen L,Horn A,Secher NH,Jensen TS

更新日期：1993-01-01 00:00:00

abstract：:Pain catastrophizing is associated with enhanced temporal summation of pain (TS-Pain). However, because prior studies have found that pain catastrophizing is not associated with a measure of spinal nociception (nociceptive flexion reflex [NFR] threshold), this association may not result from changes in spinal nocicept...

journal_title：Pain

authors： Rhudy JL,Martin SL,Terry EL,France CR,Bartley EJ,DelVentura JL,Kerr KL

更新日期：2011-04-01 00:00:00

abstract：:Laser-evoked potentials (LEPs) are acknowledged as the most reliable laboratory tool for assessing thermal and pain pathways. Electrical stimulation with a newly developed planar concentric electrode, delivering stimuli limited to the superficial skin layers, has been suggested to provide selective activation of Aδ fi...

journal_title：Pain

authors： Perchet C,Frot M,Charmarty A,Flores C,Mazza S,Magnin M,Garcia-Larrea L

更新日期：2012-06-01 00:00:00

abstract：:We studied the prevalence of chronic pain and long term sensory changes after cosmetic augmentation mammoplasty and the effects of a single i.v. preoperative dose of methylprednisolone 125 mg (n=74), parecoxib 40 mg (n=71), or placebo (n=74). A questionnaire was mailed 6 weeks and 1 year after surgery. Response rate a...

journal_title：Pain

authors： Romundstad L,Breivik H,Roald H,Skolleborg K,Romundstad PR,Stubhaug A

更新日期：2006-09-01 00:00:00

abstract：:A controlled trial of diamorphine (diacetylmorphine, heroin) and morphine is reported in which the two drugs were administered regularly by mouth in individually determined effective analgesic doses. Elixirs contained cocaine hydrochloride 10 mg/dose; other drugs were prescribed when indicated clinically. 699 patients...

journal_title：Pain

authors： Twycross RG

更新日期：1977-04-01 00:00:00

abstract：:While a variety of cultural, psychological and physiological factors contribute to variability in both clinical and experimental contexts, the role of genetic factors in human pain sensitivity is increasingly recognized as an important element. This study was performed to evaluate genetic influences on variability in ...

journal_title：Pain

authors： Kim H,Neubert JK,San Miguel A,Xu K,Krishnaraju RK,Iadarola MJ,Goldman D,Dionne RA

更新日期：2004-06-01 00:00:00

abstract：:Human experimental pain models are widely used to study drug effects under controlled conditions, but they require further optimization to better reflect clinical pain conditions. To this end, we measured experimentally induced pain in 110 (46 men) healthy volunteers. The quantitative sensory testing (QST) battery (Ge...

journal_title：Pain

authors： Lötsch J,Dimova V,Hermens H,Zimmermann M,Geisslinger G,Oertel BG,Ultsch A

更新日期：2015-03-01 00:00:00

abstract：:Peripheral nerve injury provokes heightened excitability of primary sensory afferents including nociceptors, and elicits ectopic activity in lesioned and neighboring intact nerve fibers. The major transmitter released by sensory afferents in the superficial dorsal horn of the spinal cord is glutamate. Glutamate is cri...

journal_title：Pain

authors： Inquimbert P,Bartels K,Babaniyi OB,Barrett LB,Tegeder I,Scholz J

更新日期：2012-12-01 00:00:00

abstract：:Back pain is a leading cause of disability. Previous research suggests that modifiable risk factors influence recovery from back pain, and practice guidelines recommend integrating such factors within primary care management. Toward this goal, a brief, multidimensional questionnaire, the STarT Back Tool, was designed ...

journal_title：Pain

authors： Wideman TH,Hill JC,Main CJ,Lewis M,Sullivan MJL,Hay EM

更新日期：2012-11-01 00:00:00

abstract：:Nociceptive long-term potentiation, a use dependent increase in synaptic efficacy in the dorsal horn of the spinal cord is thought to contribute to the development of persistent pain states. So far, no study has analyzed the effects of high-frequency stimulation (HFS) of afferents from deep tissues (muscle and fascia)...

journal_title：Pain

authors： Schilder A,Magerl W,Hoheisel U,Klein T,Treede RD

更新日期：2016-10-01 00:00:00

abstract：:Pain-related diseases are the top leading causes of life disability. Identifying brain regions involved in persistent neuronal changes will provide new insights for developing efficient chronic pain treatment. Here, we showed that anterior nucleus of paraventricular thalamus (PVA) plays an essential role in the develo...

journal_title：Pain

authors： Chang YT,Chen WH,Shih HC,Min MY,Shyu BC,Chen CC

更新日期：2019-05-01 00:00:00

abstract：:Heterotopic noxious counterstimulation (HNCS) by the application of a sustained noxious stimulus has been shown to inhibit nociceptive processes and decrease pain induced by a competing noxious stimulus. However, it is still not clear how attentional processes contribute to these effects. The main objective of this st...

journal_title：Pain

authors： Ladouceur A,Tessier J,Provencher B,Rainville P,Piché M

更新日期：2012-08-01 00:00:00

abstract：:Fibromyalgia (FM) is a common and often debilitating chronic pain condition. Research shows that symptoms of depression and anxiety are present in up to three quarters of individuals with FM. Of concern, most adults with FM cannot access traditional face-to-face cognitive behavioural pain management programs, which ar...

journal_title：Pain

authors： Friesen LN,Hadjistavropoulos HD,Schneider LH,Alberts NM,Titov N,Dear BF

更新日期：2017-04-01 00:00:00

abstract：:Spinal synaptic plasticity is believed to drive central sensitization that underlies the persistent nature of neuropathic pain. Our recent data showed that synaptic plasticity in the dorsal horn is cell type specific: intense afferent stimulation produced long-term potentiation (LTP) in excitatory spinothalamic tract ...

journal_title：Pain

authors： Bittar A,Jun J,La JH,Wang J,Leem JW,Chung JM

更新日期：2017-11-01 00:00:00

abstract：:An electrophysiological study was carried out in anesthetized rats to characterize the properties of single neurons in trigeminal (V) subnucleus caudalis. Each neuron was functionally classified in terms of its cutaneous mechanoreceptive field properties as low-threshold mechanoreceptive (LTM), wide dynamic range (WDR...

journal_title：Pain

authors： Hu JW

更新日期：1990-06-01 00:00:00

abstract：:Chronic pain is associated with large societal costs, but few studies have investigated the total costs of chronic pain with respect to elderly subjects. The elderly usually require informal care, care performed by municipalities, and care for chronic diseases, all factors that can result in extensive financial burden...

journal_title：Pain

authors： Bernfort L,Gerdle B,Rahmqvist M,Husberg M,Levin LÅ

更新日期：2015-03-01 00:00:00

abstract：:Online educational interventions are increasingly developed for health professionals and students, although graduate and undergraduate medical curricula often contain limited information about how to assess and manage pain. This study reviews the literature on the effectiveness of pain-related online educational resou...

journal_title：Pain

authors： Liossi C,Failo A,Schoth DE,Williams G,Howard RF

更新日期：2018-04-01 00:00:00

abstract：:This study investigated the effects of a single administration of 6-(4-methoxyphenyl)-5-methyl-3-pyridinyl-4-isoxazolo[4,5-c]pyridin-4(5H)-one (MMPIP), a negative allosteric modulator (NAM) of metabotropic glutamate receptor 7 (mGluR7), on pain and on affective and cognitive behavior in neuropathic mice. The activity ...

journal_title：Pain

authors： Palazzo E,Romano R,Luongo L,Boccella S,De Gregorio D,Giordano ME,Rossi F,Marabese I,Scafuro MA,de Novellis V,Maione S

更新日期：2015-06-01 00:00:00

abstract：:To clarify the relationships between physical, and psychosocial components of chronic pain, a path analytic model was tested conceptualizing self efficacy as a mediator of disability. In turn, disability was hypothesized to mediate depression. This model could help explain the circumstances under which disability deve...

journal_title：Pain

authors： Arnstein P,Caudill M,Mandle CL,Norris A,Beasley R

更新日期：1999-04-01 00:00:00

abstract：:Clinical evidence suggests that cutaneous and visceral pain differ in sensory, affective, and motivational realms, yet there has been little comparative characterization of these types of pain. This study uses psychophysical measures to compare directly visceral and cutaneous pain and sensitivity. Healthy subjects (10...

journal_title：Pain

authors： Strigo IA,Bushnell CM,Boivin M,Duncan GH

更新日期：2002-06-01 00:00:00

abstract：:Aquaporin 1 (AQP1) is the archetypal member of a family of water channel proteins that contribute to water homeostasis in kidney, lung, and other tissues. Although there is limited evidence that aquaporins are expressed in the nervous system, AQP4 is expressed in glia and AQP9 is present on some neuronal and glial mit...

journal_title：Pain

authors： Shields SD,Mazario J,Skinner K,Basbaum AI

更新日期：2007-09-01 00:00:00

abstract：:Many chronic pain syndromes, including fibromyalgia (FM), show evidence of central nervous system hyperexcitability related to central sensitization. Windup (WU) of second pain reflects increased excitability of spinal cord neurons that is related to central sensitization. Psychophysical testing can help characterize ...

journal_title：Pain

authors： Staud R,Price DD,Robinson ME,Mauderli AP,Vierck CJ

更新日期：2004-08-01 00:00:00

abstract：:In 1864, W. Mitchell and colleagues first described the clinical syndrome which came to be known as 'causalgia'. Since that time, the concept of sympathetically related pain has evolved. There is general agreement that profound emotional and behavioural changes can follow these types of pain. Opinions have varied wide...

journal_title：Pain

authors： Lynch ME

更新日期：1992-06-01 00:00:00

abstract：:Brief electrical pulses were applied to the pulp of individual pre-molar teeth of 14 healthy, adult volunteers via wire electrodes implanted and sealed in dentine. The sensation threshold was estimated in each individual by the Two-Alternative Forced-Choice Staircase (2AFCS) method. Seven, 5 or 4 stimulus intensities ...

journal_title：Pain

authors： Fernandes de Lima VM,Chatrian GE,Lettich E,Canfield RC,Miller CR,Soso MJ

更新日期：1982-11-01 00:00:00

abstract：:Recently, Bennett and Xie reported that when the sciatic nerve of the rat is ligated loosely, the rat develops a pain syndrome with many features similar to those observed in neuropathic pain states in man. Anatomical and physiological studies to date indicate that the major pathology is a loss of large diameter myeli...

journal_title：Pain

authors： Basbaum AI,Gautron M,Jazat F,Mayes M,Guilbaud G

更新日期：1991-12-01 00:00:00

abstract：:This study aimed to investigate the efficacy of an attention training technique (ATT) on pain ratings, threshold and tolerance during the cold pressor task. One hundred and three undergraduate students were randomly assigned to receive either threat-alleviating or threat-inducing information about the task. Participan...

journal_title：Pain

authors： Sharpe L,Perry NK,Rogers P,Dear BF,Nicholas MK,Refshauge K

更新日期：2010-09-01 00:00:00

abstract：:Heat shock protein 90 (Hsp90) is a ubiquitous signal transduction regulator, and Hsp90 inhibitors are in clinical development as cancer therapeutics. However, there have been very few studies on the impact of Hsp90 inhibitors on pain or analgesia, a serious concern for cancer patients. We previously found that Hsp90 i...

journal_title：Pain

authors： Stine C,Coleman DL,Flohrschutz AT,Thompson AL,Mishra S,Blagg BS,Largent-Milnes TM,Lei W,Streicher JM

更新日期：2020-08-01 00:00:00

abstract：:This study reports a 9-18 month follow-up of a randomised controlled trial of pain management programmes for chronic, non-malignant pain. Twenty-two inpatients, 18 outpatients and 12 control subjects completed the follow-up assessments. Significant treatment effects were demonstrated by the inpatient group on pain rat...

journal_title：Pain

authors： Peters J,G Large R,Elkind G

更新日期：1992-07-01 00:00:00