Top-down attentional modulation of analgesia induced by heterotopic noxious counterstimulation.

abstract：:Expectations modulate the subjective experience of pain by increasing sensitivity to nociceptive inputs, an effect mediated by brain regions such as the insula. However, it is still unknown whether the neural structures underlying pain expectancy hold sensory-specific information or, alternatively, code for modality-i...

journal_title：Pain

authors： Sharvit G,Corradi-DellʼAcqua C,Vuilleumier P

更新日期：2018-08-01 00:00:00

abstract：:Morphine is widely used to treat severe pain in neonatal intensive care unit patients. Animal studies suggest adverse long-term side effects of neonatal morphine, but a follow-up study of 5-year-old children who participated in a morphine-placebo controlled trial as newborns found no such effects on the child's genera...

journal_title：Pain

authors： de Graaf J,van Lingen RA,Valkenburg AJ,Weisglas-Kuperus N,Jebbink LG,Wijnberg-Williams B,Anand KJS,Tibboel D,van Dijk M

更新日期：2013-03-01 00:00:00

abstract：:Migraine encompasses a broader spectrum of sensory symptoms than just headache. These "other" symptoms, eg, sensory phobias, cognitive and mood changes, allodynia, and many others indicate an altered sensitivity to sensory input which can be measured, in principle, by quantifying sensory threshold changes longitudinal...

journal_title：Pain

authors： Peng KP,May A

更新日期：2019-07-01 00:00:00

abstract：:In several pain models, tricyclic antidepressants (TCAs) have been shown to reduce nociception. In the present study, we evaluated the antinociceptive effect of metapramine (META) in 4 nociception tests: (1) the hot plate test; (2) the phenylbenzoquinone-induced writhing; (3) the tail flick test; and (4) the test of e...

journal_title：Pain

authors： Michael-Titus A,Costentin J

更新日期：1987-12-01 00:00:00

abstract：:In a double-blind placebo-controlled cross-over study the effects of epidural morphine (4 mg) on somatosensory functions were investigated in 10 healthy volunteers. Detection, pain detection and pain tolerance thresholds to thermal, mechanical and electrical stimuli as well as magnitude rating of short-lasting stimuli...

journal_title：Pain

authors： Brennum J,Arendt-Nielsen L,Horn A,Secher NH,Jensen TS

更新日期：1993-01-01 00:00:00

abstract：:We assessed nimodipine's ability to increase the analgesic effect of morphine in 32 patients suffering from cancer pain in a double-blind, placebo controlled cross-over study. Morphine administration began a few days before the start of the study. The analgesic effects of two combinations were compared: morphine (M) p...

journal_title：Pain

authors： Roca G,Aguilar JL,Gomar C,Mazo V,Costa J,Vidal F

更新日期：1996-12-01 00:00:00

abstract：:Individual differences in interoceptive sensitivity are associated with differences in reported intensity of emotional experience, vulnerability to anxiety and mood disorder and capacity for emotional self-regulation. Enhanced sensitivity to autonomic state is often accompanied by increased autonomic reactivity. Here ...

journal_title：Pain

authors： Pollatos O,Füstös J,Critchley HD

更新日期：2012-08-01 00:00:00

abstract：:G-protein coupled inwardly rectifying potassium (GIRK) channels are effectors determining degree of analgesia experienced upon opioid receptor activation by endogenous and exogenous opioids. The impact of GIRK-related genetic variation on human pain responses has received little research attention. We used a tag singl...

journal_title：Pain

authors： Bruehl S,Denton JS,Lonergan D,Koran ME,Chont M,Sobey C,Fernando S,Bush WS,Mishra P,Thornton-Wells TA

更新日期：2013-12-01 00:00:00

abstract：:In a study to determine how children describe the experience of pain, we queried a convenience sample of 100 children in hospitals and 114 children in church and private schools who were between 9 and 12 years old. The questions were designed to seek correlations by age among boys and girls, and between hospitalized a...

journal_title：Pain

authors： Savedra M,Gibbons P,Tesler M,Ward J,Wegner C

更新日期：1982-10-01 00:00:00

abstract：:Preclinical assessment of pain has increasingly explored operant methods that may allow behavioral assessment of ongoing pain. In animals with incisional injury, peripheral nerve block produces conditioned place preference (CPP) and activates the mesolimbic dopaminergic reward pathway. We hypothesized that activation ...

journal_title：Pain

authors： Xie JY,Qu C,Patwardhan A,Ossipov MH,Navratilova E,Becerra L,Borsook D,Porreca F

更新日期：2014-08-01 00:00:00

abstract：:Thirty-eight patients maintained on opioid analgesics for non-malignant pain were retrospectively evaluated to determine the indications, course, safety and efficacy of this therapy. Oxycodone was used by 12 patients, methadone by 7, and levorphanol by 5; others were treated with propoxyphene, meperidine, codeine, pen...

journal_title：Pain

authors： Portenoy RK,Foley KM

更新日期：1986-05-01 00:00:00

abstract：:In the spinal nerve ligation (SNL) model of neuropathic pain, synaptic plasticity shifts the excitation/inhibition balance toward excitation in the spinal dorsal horn. We investigated the deregulation of the synaptogenic neuroligin (NL) molecules, whose NL1 and NL2 isoforms are primarily encountered at excitatory and ...

journal_title：Pain

authors： Dolique T,Favereaux A,Roca-Lapirot O,Roques V,Léger C,Landry M,Nagy F

更新日期：2013-11-01 00:00:00

abstract：:Idiopathic chronic pain conditions with a mismatch between anatomical abnormalities and symptoms can be categorized as somatoform pain disorder according to the DSM-IV criteria. A dysfunction of pain processing circuits has been suggested as one underlying pathophysiological factor. There is accumulating evidence for ...

journal_title：Pain

authors： Gündel H,Valet M,Sorg C,Huber D,Zimmer C,Sprenger T,Tölle TR

更新日期：2008-07-15 00:00:00

abstract：:Disabling neuropathic pain (NeuP) is a common sequel of diabetic peripheral neuropathy (DPN). We aimed to characterise the sensory phenotype of patients with and without NeuP, assess screening tools for NeuP, and relate DPN severity to NeuP. The Pain in Neuropathy Study (PiNS) is an observational cross-sectional multi...

journal_title：Pain

authors： Themistocleous AC,Ramirez JD,Shillo PR,Lees JG,Selvarajah D,Orengo C,Tesfaye S,Rice ASC,Bennett DLH

更新日期：2016-05-01 00:00:00

abstract：:Injection of a dilute solution of formalin into a rat hindpaw produces a biphasic nociceptive response consisting of an early phase during the first 5 min after formalin injection and a later phase starting after 15 min and lasting for 40-50 min. The period between the two phases of nociceptive responding is generally...

journal_title：Pain

authors： Henry JL,Yashpal K,Pitcher GM,Coderre TJ

更新日期：1999-07-01 00:00:00

abstract：:Studies have shown that moderate alcohol consumption is strongly associated with reduced reporting of chronic widespread pain (CWP). The study designs used, however, are prone to confounding and are not able to establish the direction of causality. The current study overcomes these problems using the Mendelian randomi...

journal_title：Pain

authors： Beasley M,Freidin MB,Basu N,Williams FMK,Macfarlane GJ

更新日期：2019-02-01 00:00:00

abstract：:The use of long-term opioid therapy for chronic pain remains common, yet data on long-term outcomes, especially after dose escalation, are sparse. This study examined potential benefits and harms associated with prescription opioid dose escalation. Participants from 2 institutions were enrolled in a 2-year prospective...

journal_title：Pain

authors： Morasco BJ,Smith N,Dobscha SK,Deyo RA,Hyde S,Yarborough BJH

更新日期：2020-06-01 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide found primarily in the C and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the central nervous system. Calcitonin gene-related peptide was found to play important roles in cardiovascular, digestive, and sensory functi...

journal_title：Pain

authors： Iyengar S,Ossipov MH,Johnson KW

更新日期：2017-04-01 00:00:00

abstract：:Spasticity is a major clinical manifestation of spinal cord injury and upper motor neuron syndrome. ...

journal_title：Pain

authors： Ridgeway B,Wallace M,Gerayli A

更新日期：2000-03-01 00:00:00

abstract：:This double-blind, within-subjects experiment examined the effects of ingesting two doses of caffeine on perceptions of leg muscle pain and blood pressure during moderate intensity cycling exercise. Low caffeine consuming college-aged males (N=12) ingested one of two doses of caffeine (5 or 10 mg.kg(-1) body weight) o...

journal_title：Pain

authors： O'Connor PJ,Motl RW,Broglio SP,Ely MR

更新日期：2004-06-01 00:00:00

abstract：:A chronic compression of the dorsal root ganglion (CCD) produces ipsilateral cutaneous hyperalgesia and allodynia in rats. Intracellular electrophysiological recordings from formerly compressed neurons in the intact dorsal root ganglion (DRG) reveal lower than normal current thresholds (CTs) and abnormal spontaneous a...

journal_title：Pain

authors： Ma C,LaMotte RH

更新日期：2005-01-01 00:00:00

abstract：:The aim of the present study has been to assess the responsiveness of various types of chronic pain to opioids given i.v. and tested against placebo in a double-blind, randomized fashion. Pain classified as primary nociceptive was effectively alleviated (P greater than 0.001) while neuropathic deafferentation pain was...

journal_title：Pain

authors： Arnér S,Meyerson BA

更新日期：1988-04-01 00:00:00

abstract：:The role of proinflammatory cytokines in neuropathic and inflammatory pain is well established. Recent studies suggest that cytokines such as tumor necrosis factor-alpha (TNF) may also be involved in the development of muscle pain. To investigate the pathophysiology of intramuscular TNF, exogenous TNF (0.1-10 microg),...

journal_title：Pain

authors： Schäfers M,Sorkin LS,Sommer C

更新日期：2003-08-01 00:00:00

abstract：:Data from the World Health Organization's study of psychological problems in general health care were used to examine the course of persistent pain syndromes among primary care patients. Across 15 sites in 14 countries, 3197 randomly selected primary care patients completed baseline and 12-month follow-up assessments ...

journal_title：Pain

authors： Gureje O,Simon GE,Von Korff M

更新日期：2001-05-01 00:00:00

abstract：:To address the lack of appropriate patient-defined quality indicators (QIs) for assessment of pain clinic care in the Netherlands, we developed the "Quality Indicators Pain Patients' Perspective" (QiPPP) questionnaire. Quality indicators are widely used to measure the quality of the structure, process, and outcome of ...

journal_title：Pain

authors： de Meij N,Köke A,Thomassen I,Kallewaard JW,van Kleef M,van der Weijden T

更新日期：2018-12-01 00:00:00

abstract：:The aim of the present study was to test (1) whether muscle pain is influenced by temporal and spatial summation, and (2) whether sequential noxious muscle stimuli applied at hourly interstimulus-intervals could produce an increased sensation of pain due to central hyperexcitability. In the study eleven healthy men we...

journal_title：Pain

authors： Graven-Nielsen T,Arendt-Nielsen L,Svensson P,Jensen TS

更新日期：1997-01-01 00:00:00

abstract：:The effects of high temperature (53-61 degrees C) on membrane currents (I(heat)) or depolarization (V(heat)) induced by noxious heat were studied in cultured dorsal root ganglia neurons from neonatal rats using the whole cell patch clamp technique. I(heat) or V(heat) produced by 3 s ramps of increasing temperature bet...

journal_title：Pain

authors： Lyfenko A,Vlachová V,Vyklický L,Dittert I,Kress M,Reeh PW

更新日期：2002-02-01 00:00:00

abstract：:Noxious challenge of the rat gastric mucosa by hydrochloric acid (HCl) is signaled to the nucleus tractus solitarii (NTS) and area postrema (AP). This study examined the participation of glutamate and tachykinins in the medullary transmission process. Activation of neurons was visualized by in situ hybridization autor...

journal_title：Pain

authors： Jocic M,Schuligoi R,Schöninkle E,Pabst MA,Holzer P

更新日期：2001-01-01 00:00:00

abstract：:Pain catastrophizing is a significant risk factor for patients with knee osteoarthritis (KOA) and thus is a target for many psychological interventions for pain. This study examined if interventions targeting sleep found to be effective in improving sleep in KOA also reduce pain catastrophizing measured as a trait thr...

journal_title：Pain

authors： Lerman SF,Finan PH,Smith MT,Haythornthwaite JA

更新日期：2017-11-01 00:00:00

abstract：:The tendency to select threatening over benign interpretations of ambiguous bodily sensations and cues characterises young people with chronic pain. However, previous studies disagree over whether these biases extend to nonbodily harm situations such as social evaluation. Understanding the content of these biases is c...

journal_title：Pain

authors： Lau JYF,Badaoui M,Meehan AJ,Heathcote LC,Barker ED,Rimes KA

更新日期：2020-02-01 00:00:00