Abstract：
:The role of proinflammatory cytokines in neuropathic and inflammatory pain is well established. Recent studies suggest that cytokines such as tumor necrosis factor-alpha (TNF) may also be involved in the development of muscle pain. To investigate the pathophysiology of intramuscular TNF, exogenous TNF (0.1-10 microg), formalin (9%) or vehicle was injected into the gastrocnemius or biceps brachii muscles of rats. To quantify muscle hyperalgesia, changes in forelimb grip force or withdrawal thresholds to increasing pressure applied to the gastrocnemius muscle were measured. TNF evoked a time- and dose-dependent muscle hyperalgesia within several hours after injection that was totally reversed by systemic treatment with the non-opioid analgesic metamizol. Paw withdrawal thresholds or latencies to mechanical and thermal stimuli, respectively, were unchanged after intramuscular injection of TNF or formalin. In contrast to formalin, which induced significant muscle tissue damage, macrophage infiltration, swelling and partial motor impairment demonstrated in rotarod tests, TNF induced neither histopathological tissue damage nor motor dysfunction. To investigate the effect of TNF and formalin on other potentially algesic mediators, muscles were analyzed for calcitonin-gene related peptide (CGRP), prostaglandin E2 (PGE2) and nerve growth factor (NGF) 1 day after injection. TNF and formalin evoked intramuscular upregulation of CGRP and NGF, whereas PGE2 was increased exclusively after TNF injection. These findings allow us to speculate that endogenous TNF may play a role in the development of muscle hyperalgesia. Targeting proinflammatory cytokines might be beneficial for the treatment of musculoskeletal pain syndromes.
journal_name
Painjournal_title
Painauthors
Schäfers M,Sorkin LS,Sommer Cdoi
10.1016/S0304-3959(03)00115-5keywords:
subject
Has Abstractpub_date
2003-08-01 00:00:00pages
579-588issue
3eissn
0304-3959issn
1872-6623pii
00006396-200308000-00017journal_volume
104pub_type
杂志文章相关文献
PAIN文献大全abstract：:In this study, we examined the relationship between astrocyte activation in the cuneate nucleus (CN) and behavioral hypersensitivity after chronic constriction injury (CCI) of the median nerve. In addition, we also examined the effects of pre-emptive treatment with a number of drugs on astrocyte activation and hyperse...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2009.11.004
更新日期：2010-01-01 00:00:00
abstract：:Mechanisms of chronic pain, including neuropathic pain, are poorly understood. Upregulation of voltage-gated calcium channel (VGCC) alpha2delta1 subunit (Ca(v)alpha2delta1) in sensory neurons and dorsal spinal cord by peripheral nerve injury has been suggested to contribute to neuropathic pain. To investigate the mech...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2006.04.022
更新日期：2006-11-01 00:00:00
abstract：:Noxious C-fibre stimulation produces increased sensitivity within the injured area (primary hyperalgesia), and a surrounding zone of secondary hyperalgesia. As significant changes in nociceptive processing occur during development, we compared C-fibre induced primary and secondary hyperalgesia in rat pups aged 3, 10 a...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2006.09.015
更新日期：2007-03-01 00:00:00
abstract：:Previous work in this laboratory has indicated that the transplantation of adrenal medullary tissue into the subarachnoid space of the rat spinal cord can reduce pain sensitivity to acute noxious stimuli, particularly following stimulation by nicotine. This most likely results from the stimulated release of opioid pep...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(90)91093-X
更新日期：1990-07-01 00:00:00
abstract：:Pain is a complex human trait. It is likely that the interaction of multiple genes, each with a small individual effect, along with the effect of environmental factors, influences the clinical efficacy of opioids rather than a single gene alone. Polymorphisms in genes coding for the mu-opioid receptor (A118G) and cate...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2006.10.023
更新日期：2007-07-01 00:00:00
abstract：:The effect of PF-04457845, a potent and selective fatty acid amide hydrolase-1 (FAAH1) inhibitor, on pain due to osteoarthritis of the knee was investigated in a randomised placebo and active-controlled clinical trial. The trial involved 2 periods (separated by a 2-week washout) consisting of a 1-week wash-in phase fo...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2012.04.020
更新日期：2012-09-01 00:00:00
abstract：:This study evaluated two brief (3-5 min) interventions for controlling responses to acute pain. Eighty male subjects were randomly assigned to 1 of 2 intervention groups (Positive Emotion Induction (PEI) or Brief Relaxation (BR)) or to 1 of 2 control groups (No-instruction or Social Demand). The PEI focused on re-crea...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0304-3959(93)90096-8
更新日期：1993-07-01 00:00:00
abstract：:Peripheral nerve injury provokes heightened excitability of primary sensory afferents including nociceptors, and elicits ectopic activity in lesioned and neighboring intact nerve fibers. The major transmitter released by sensory afferents in the superficial dorsal horn of the spinal cord is glutamate. Glutamate is cri...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2012.08.011
更新日期：2012-12-01 00:00:00
abstract：:Chronic low back pain (CLBP) and obesity are interrelated, but the physiological mechanisms linking the 2 conditions remain to be determined. Functional brain imaging data from CLBP patients show functional and structural alterations in areas mediating the attribution of hedonic value to food. Accordingly, we hypothes...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2013.12.027
更新日期：2014-04-01 00:00:00
abstract：:Pain is a biologically relevant signal and response to bodily threat, associated with the urge to restore the integrity of the body. Immediate protective responses include increased arousal, selective attention, escape, and facial expressions, followed by recuperative avoidance and safety-seeking behaviors. To facilit...
journal_title：Pain
pub_type： 杂志文章,评审
doi：10.1097/j.pain.0000000000000107
更新日期：2015-04-01 00:00:00
abstract：:The effects of cognitive and competing sensory processing tasks on pain perception and as a function of time are only partially understood. To study these effects, we compared the simultaneous effects of noxious heat stimulation (HS), auditory stimulation (AS) (sinusoidally modulated speech-like signal, SMSLS), and a ...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2005.10.029
更新日期：2006-01-01 00:00:00
abstract：:A noxious cold stimulus can evoke multiple sensations each occurring with a different time course. We have performed psychophysical studies to identify the time course of five sensations evoked by a noxious cold stimulus applied to the hand. Subjects continuously rated either pain, ache, cold, heat or prickle sensatio...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(02)00043-x
更新日期：2002-07-01 00:00:00
abstract：:Although pediatric functional abdominal pain (FAP) has been linked to abdominal pain later in life, childhood predictors of long-term outcomes have not been identified. This study evaluated whether distinct FAP profiles based on patterns of pain and adaptation in childhood could be identified and whether these profile...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2012.03.026
更新日期：2012-09-01 00:00:00
abstract：:We report on 8 patients treated with subcutaneous methadone for cancer-related pain at 2 institutions. The success of other subcutaneous agents for pain control has been well demonstrated. It was felt that methadone would be useful due to its low cost. Unfortunately, 7 of the 8 patients experienced adverse reactions a...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(91)90179-2
更新日期：1991-05-01 00:00:00
abstract：:The proinflammatory cytokine interferon-gamma (IFN-gamma), which can be present in elevated levels in the central nervous system during pathological conditions, may be involved in the generation of persistent pain states by inducing neuronal hyperexcitability. The aim of the present study was to examine whether loss o...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2007.02.010
更新日期：2007-12-15 00:00:00
abstract：:The present study describes a new test of tonic pain to be used as an animal model of persistent pain. First, pain responses and edema produced by subcutaneous injection of increasing doses of honey bee venom into the hind paw of the rat were quantified. Second, the effect of morphine and aspirin on the pain responses...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(96)03075-8
更新日期：1996-08-01 00:00:00
abstract：:Extraterritorial spread of sensory symptoms is frequent in carpal tunnel syndrome (CTS). Animal models suggest that this phenomenon may depend on central sensitization. We sought to obtain psychophysical evidence of sensitization in CTS with extraterritorial symptoms spread. We recruited 100 unilateral CTS patients. A...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2009.10.025
更新日期：2010-02-01 00:00:00
abstract：:Return of sensory nerve function in rat molars following cut or crush injury to the inferior alveolar nerve (IAN) was measured by observing the jaw opening reflex (JOR) response of the digastric muscle to electrical stimulation of individual molars or the gingiva. The IAN was injured from a lateral approach to the man...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(83)90071-4
更新日期：1983-04-01 00:00:00
abstract：:In a study to determine how children describe the experience of pain, we queried a convenience sample of 100 children in hospitals and 114 children in church and private schools who were between 9 and 12 years old. The questions were designed to seek correlations by age among boys and girls, and between hospitalized a...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(82)90091-4
更新日期：1982-10-01 00:00:00
abstract：:Psychological trauma is associated with an increased risk for chronification of nonspecific chronic back pain (nsCLBP) independent of posttraumatic stress disorder (PTSD). However, the mechanisms underlying the role of psychological trauma in nsCLBP are less clear than in PTSD. Therefore, this study considered whether...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/01.j.pain.0000460350.30707.8d
更新日期：2015-04-01 00:00:00
abstract：:Despite frequent targeting of health beliefs in pediatric chronic pain treatment interventions, there are currently no reliable and valid self-efficacy measures for children with chronic pain and their parents. The current study examined the psychometric properties of parent and child versions of a self-efficacy measu...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2006.04.026
更新日期：2006-11-01 00:00:00
abstract：:Adrenal medullary transplants in the spinal subarachnoid space, by providing a continual source of opioid peptides and catecholamines, offer a potentially important adjunct in the management of chronic pain. While previous studies have shown that this approach is effective against high-intensity phasic stimuli, adrena...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(93)90135-C
更新日期：1993-02-01 00:00:00
abstract：:Tolerance to morphine-induced analgesia is an intractable phenomenon, often hindering its prolonged applications in the clinics. The enhanced pronociceptive actions of spinal pain-related molecules such as calcitonin gene-related peptide (CGRP) may underlie this phenomenon and could be a promising target for intervent...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2010.07.006
更新日期：2010-10-01 00:00:00
abstract：:We investigated the role of endogenous opioid systems in the analgesic effects induced by repetitive transcranial magnetic stimulation (rTMS). We compared the analgesic effects of motor cortex (M1) or dorsolateral prefrontal cortex (DLPFC) stimulation before and after naloxone or placebo treatment, in a randomized, do...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2010.10.032
更新日期：2011-02-01 00:00:00
abstract：:Atypical odontalgia (AO) is an intraoral pain condition of currently unknown mechanisms. In 10 AO patients and 10 matched healthy controls, we examined the effect of intravenous infusion of an N-methyl-D-aspartate (NMDA) receptor antagonist S-ketamine and a mu-opioid agonist fentanyl on spontaneous AO pain and on an a...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.pain.2006.09.032
更新日期：2007-05-01 00:00:00
abstract：:To inform case definition for neck/shoulder pain in epidemiological research, we compared levels of disability, patterns of association, and prognosis for pain that was limited to the neck or shoulders (LNSP) and more generalised musculoskeletal pain that involved the neck or shoulder(s) (GPNS). Baseline data on muscu...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000477
更新日期：2016-05-01 00:00:00
abstract：:There is evidence that serotonin may be implicated in the pathophysiology of myofascial pain (MFP). Because of this, we used oral sumatriptan (Imitrex, Glaxo), a peripherally acting agonist of 5-HT1D receptors, in a double-blind, randomized, placebo-controlled double crossover pilot study of 7 patients with episodic M...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0304-3959(95)00025-N
更新日期：1995-08-01 00:00:00
abstract：:The aim of this study was to investigate the postnatal development of mu-(MOR) and delta-opioid receptor (DOR) immunoreactivity in rat dorsal root ganglia. Lumbar dorsal root ganglia (DRG) from postnatal day (P) 0, 3, 7 and 21 rat pups were immunostained for MOR and DOR. Proportions of MOR +ve and DOR +ve cells were c...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(00)00397-3
更新日期：2001-02-01 00:00:00
abstract：:Transcutaneous nerve stimulation (TENS) treatment was given for 30 min to 37 patients divided into 3 groups of 10 patients and 1 group of 7 patients. Two groups received low-frequency (2 Hz) and the other 2 groups high-frequency (100 Hz) stimulation. A diagnostic lumbar cerebrospinal fluid (CSF) sample was obtained im...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(91)90218-M
更新日期：1991-12-01 00:00:00
abstract：:Moderate to severe chronic pain affects 1 in 5 adults and its impact increases with age. People with chronic pain that interferes with their lives have an increased risk of mortality. Identifying how interfering chronic pain can lead to mortality may highlight potential intervention strategies. This study uses a novel...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001193
更新日期：2018-06-01 00:00:00
