Abstract：
:A noxious cold stimulus can evoke multiple sensations each occurring with a different time course. We have performed psychophysical studies to identify the time course of five sensations evoked by a noxious cold stimulus applied to the hand. Subjects continuously rated either pain, ache, cold, heat or prickle sensations throughout repeated presentations of a noxious cold stimulus (3 degrees C) from a neutral (32 degrees C) baseline. Separate runs were used to assess each of the five types of sensation. Cold was reported throughout the period of cooling. The time course of pain and ache sensations were similar. However, prickle and heat sensations had time courses that could be distinguished from each other, and from ache and pain. Identification of these temporal profiles could provide clues to their underlying mechanisms. The temporal dissociation of these sensations will also enable neuroimaging studies of the cortical mechanisms associated with these sensations. Thus our results constitute a first step toward identifying the distinct modes of neural activity associated with different types of pain sensation.
journal_name
Painjournal_title
Painauthors
Davis KD,Pope GEdoi
10.1016/s0304-3959(02)00043-xkeywords:
subject
Has Abstractpub_date
2002-07-01 00:00:00pages
179-85issue
1-2eissn
0304-3959issn
1872-6623pii
S030439590200043Xjournal_volume
98pub_type
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