Local toxicity with subcutaneous methadone. Experience of two centers.

abstract：:The efficacy of intravenous acetaminophen (1000mg) in the treatment of acute migraine attacks as an alternative to parenteral application of lysine acetylsalicylate or triptans was investigated, using a multi-center, randomized, double-blind, placebo controlled study design. Migraine diagnosis was made according to th...

journal_title：Pain

authors： Leinisch E,Evers S,Kaempfe N,Kraemer C,Sostak P,Jürgens T,Straube A,May A

更新日期：2005-10-01 00:00:00

abstract：:The aim of this study was to investigate the effect of injection of serotonin (5-HT) into the masseter muscle on pain and allodynia/hyperalgesia. Twelve female patients with fibromyalgia (FM) and 12 age-matched female healthy individuals (HI) participated in the study. The current pain intensity (CPI) and the pressure...

journal_title：Pain

authors： Ernberg M,Lundeberg T,Kopp S

更新日期：2000-03-01 00:00:00

abstract：:Patients with chronic low back pain (LBP) frequently demonstrate high scores for fear-avoidance beliefs and distress. We need better knowledge about fear-avoidance beliefs and distress in early stages of LBP. The objectives of this study were to compare the level of fear-avoidance beliefs and distress in patients with...

journal_title：Pain

authors： Grotle M,Vøllestad NK,Veierød MB,Brox JI

更新日期：2004-12-01 00:00:00

abstract：:Recent evidence indicates that pain-related fear can be acquired through associative learning. In the clinic, however, spreading of fear and avoidance is observed beyond movements/activities that were associated with pain during the original pain episode. One mechanism accounting for this spreading of fear is stimulus...

journal_title：Pain

authors： Meulders A,Vlaeyen JWS

更新日期：2013-02-01 00:00:00

abstract：:Although known primarily for its role in neuronal development, brain-derived neurotrophic factor (BDNF) has also recently been implicated in processes mediated by the adult nervous system, such as spinal nociception. Peripheral inflammation increases expression of BDNF preferentially in dorsal root ganglion cells that...

journal_title：Pain

authors： Groth R,Aanonsen L

更新日期：2002-11-01 00:00:00

abstract：:The influence of contextual factors on the pain evoked by a noxious stimulus is not well defined. In this study, a -20 degrees C rod was placed on one hand for 500 ms while we manipulated the evaluative context (or 'meaning') of, warning about, and visual attention to, the stimulus. For meaning, a red (hot, more tissu...

journal_title：Pain

authors： Moseley GL,Arntz A

更新日期：2007-12-15 00:00:00

abstract：:An indentical questionnaire are administered separately to 100 chronic pain patients and a close family member of each. The majority of patients and relatives agreed on the answers to these questions about the pain problem. Highest congruency between patient and relative was associated with cases in which there were m...

journal_title：Pain

authors： Swanson DW,Maruta T

更新日期：1980-04-01 00:00:00

abstract：:The aims of this study were two-fold: first, to simplify the method for creating a recently described neuropathic pain model in the rat, and second, to evaluate the effects of a number of drugs with analgesic or antihyperalgesic properties, in this model. Continuous intravenous vincristine infusion (1-100 microg kg(-1...

journal_title：Pain

authors： Nozaki-Taguchi N,Chaplan SR,Higuera ES,Ajakwe RC,Yaksh TL

更新日期：2001-07-01 00:00:00

abstract：:Patients with neuropathic pain commonly present with spontaneous pain, in addition to allodynia and hyperalgesia. Although evoked responses in neuropathic pain models are well characterized, determining the presence of spontaneous pain is more challenging. We determined whether the chronic constriction injury (CCI) mo...

journal_title：Pain

authors： Dalm BD,Reddy CG,Howard MA,Kang S,Brennan TJ

更新日期：2015-12-01 00:00:00

abstract：:Although several studies have shown that spouses of chronic pain patients may experience clinically significant depressive symptoms few studies have comprehensively examined the role of both patient and spouse-related factors in the development and maintenance of this emotional distress. Twenty-nine married male chron...

journal_title：Pain

authors： Schwartz L,Slater MA,Birchler GR,Atkinson HJ

更新日期：1991-01-01 00:00:00

abstract：:Online educational interventions are increasingly developed for health professionals and students, although graduate and undergraduate medical curricula often contain limited information about how to assess and manage pain. This study reviews the literature on the effectiveness of pain-related online educational resou...

journal_title：Pain

authors： Liossi C,Failo A,Schoth DE,Williams G,Howard RF

更新日期：2018-04-01 00:00:00

abstract：:The pathophysiology of burning mouth syndrome (BMS) is largely unknown. Thus, the aim was to study oral mucosal blood flow in BMS-patients using laser Doppler flowmetry (LDF). Thirteen BMS patients (11 female, two male; mean age+/-SD 64.3+/-7.9 years, mean disease duration 18.9+/-6.2 months) and 13 healthy non-smoking...

journal_title：Pain

authors： Heckmann SM,Heckmann JG,HiIz MJ,Popp M,Marthol H,Neundörfer B,Hummel T

更新日期：2001-02-15 00:00:00

abstract：:Using a number of complementary anatomical and molecular techniques, we studied the effects of chronic constriction injury (CCI), a model of partial nerve injury that elicits behavioral hyperalgesia, on primary sensory neurons in the rat. Dorsal root ganglia taken from animals with CCI were analyzed for alterations in...

journal_title：Pain

authors： Nahin RL,Ren K,De León M,Ruda M

更新日期：1994-07-01 00:00:00

abstract：:The relationship between subjective measurements of pain (pain report and threshold of sensation) and evoked potentials following painful electrical stimulation of tooth pulp was evaluated after intake of different weak analgesics. These time-response curves for the dolorimetric parameters were correlated to the in vi...

journal_title：Pain

authors： Rohdewald P,Derendorf H,Drehsen G,Elger CE,Knoll O

更新日期：1982-04-01 00:00:00

abstract：:In a consecutive series of 227 psychiatric hospital admissions, data were recorded in respect of the complaint of pain. Eighty-six (38%) had pain. Fourty-four (19%) mentioned it spontaneously and 49 (22%) had no relevant physical cause. Women were affected more often than men (P less than 0.01) and tended to complain ...

journal_title：Pain

authors： Delaplaine R,Ifabumuyi OI,Merskey H,Zarfas J

更新日期：1978-04-01 00:00:00

abstract：:The aim of the study was to investigate to what extent cortical hyper-reactivity to visual stimuli is present in upper limb amputees. Five amputees with phantom limb pain (PLP), five amputees without PLP (Non-PLP) and 10 healthy controls (HC) were investigated using a visual oddball paradigm. Two hundred visual stimul...

journal_title：Pain

authors： Karl A,Diers M,Flor H

更新日期：2004-07-01 00:00:00

abstract：:The clinical effectiveness of locally administered opioids is still under discussion; in particular, the potency of morphine in settings other than intra-articular arthroscopy has been questioned. We developed another pain model, postpartum resection of the fallopian tubes for sterilisation, in which each patient serv...

journal_title：Pain

authors： Rorarius M,Suominen P,Baer G,Pajunen P,Tuimala R,Laippala P

更新日期：1999-01-01 00:00:00

abstract：:In children, many psychometric properties of the visual analogue scale (VAS) are known, including the minimum clinically significant difference (10mm on a 100-mm VAS). However, its imprecision or reliability is not well known. Thus, in order to determine the reliability of this scale, a prospective cohort study was pe...

journal_title：Pain

authors： Bailey B,Gravel J,Daoust R

更新日期：2012-04-01 00:00:00

abstract：:Reduced sensitivity to naturally occurring and laboratory pain stimuli has been observed in individuals with hypertension, high-normal blood pressure, and a family history of hypertension. The present study sought to extend these findings by examining the relationship between familial history of hypertension and pain ...

journal_title：Pain

authors： France CR,Taddio A,Shah VS,Pagé GM,Katz J

更新日期：2009-04-01 00:00:00

abstract：:Compared with other European countries, French laws and restrictions concerning the use of opioids are of medium severity only. Still, together with Germany, Belgium and Spain, France belongs to the group of countries with a low national consumption of morphine, calculated by the International Narcotics Control Board ...

journal_title：Pain

authors： Vainio A

更新日期：1995-08-01 00:00:00

abstract：:There is considerable evidence to implicate N-methyl-D-aspartate (NMDA) receptor activation in the mechanisms that underly thermal hyperalgesia in the spinal cord. As many of the effects of NMDA receptor activation appear to be ultimately mediated through production of nitric oxide (NO), recent reports have begun to d...

journal_title：Pain

authors： Meller ST,Gebhart GF

更新日期：1993-02-01 00:00:00

abstract：:Injection of a dilute solution of formalin into a rat hindpaw produces a biphasic nociceptive response consisting of an early phase during the first 5 min after formalin injection and a later phase starting after 15 min and lasting for 40-50 min. The period between the two phases of nociceptive responding is generally...

journal_title：Pain

authors： Henry JL,Yashpal K,Pitcher GM,Coderre TJ

更新日期：1999-07-01 00:00:00

abstract：:We previously reported that morphine fails to produce analgesic tolerance when administered in the presence of formalin-induced pain. The hypothalamic-pituitary-adrenal (HPA) axis is known to respond to stressful stimuli, including pain. To examine whether the blockade of tolerance by pain is related to HPA activity, ...

journal_title：Pain

authors： Vaccarino AL,Couret LC Jr

更新日期：1995-12-01 00:00:00

abstract：:Rats and humans manifest elevated response thresholds to aversive stimuli during gestation and parturition. This pregnancy-associated antinociception is mediated, in part, by a spinal cord dynorphin/kappa antinociceptive system. Simulating the maternal pregnancy blood concentration profile (in non-pregnant animals) of...

journal_title：Pain

authors： Dawson-Basoa ME,Gintzler AR

更新日期：1996-01-01 00:00:00

abstract：:This study was designed to investigate the relative efficacy of cognitive-behavioral group treatment, including relaxation training, in comparison with a control condition in a sample of 20 outpatients with chronic low back pain. Subjects in both conditions also received the same physiotherapy back-education and exerc...

journal_title：Pain

authors： Nicholas MK,Wilson PH,Goyen J

更新日期：1992-03-01 00:00:00

abstract：:Both mu opioid agonists and N-methyl-D-aspartate (NMDA) receptor antagonists are implicated in the regulation of neuropathic pain in post-nerve injury preclinical pain models. This study characterizes the effects of intravenously infused alfentanil (a mu-receptor agonist) and ketamine (an NMDA-receptor antagonist) on ...

journal_title：Pain

authors： Leung A,Wallace MS,Ridgeway B,Yaksh T

更新日期：2001-03-01 00:00:00

abstract：:A variety of molecules released by inflammatory reactions in the dorsal root and dorsal root ganglion (DRG) may play important roles in the pathology of neuronal abnormalities in lumbar disc herniation. In order to elucidate the pathophysiological mechanisms of painful radiculopathy, secondary to lumbar disc herniatio...

journal_title：Pain

authors： Obata K,Tsujino H,Yamanaka H,Yi D,Fukuoka T,Hashimoto N,Yonenobu K,Yoshikawa H,Noguchi K

更新日期：2002-09-01 00:00:00

abstract：:The analgesic efficacy of the novel anxiolytic buspirone in tests of acute thermal, mechanical and formalin-induced chemical-inflammatory pain were examined. Buspirone produced dose- and time-dependent analgesia in all nociceptive tests, with greatest effects against chemical and mechanical pain. Buspirone was less po...

journal_title：Pain

authors： Giordano J,Rogers L

更新日期：1989-10-01 00:00:00

abstract：:Animal and human studies indicate that electrical stimulation of dorsal root ganglion (DRG) neurons may modulate neuropathic pain signals. ACCURATE, a pivotal, prospective, multicenter, randomized comparative effectiveness trial, was conducted in 152 subjects diagnosed with complex regional pain syndrome or causalgia ...

journal_title：Pain

authors： Deer TR,Levy RM,Kramer J,Poree L,Amirdelfan K,Grigsby E,Staats P,Burton AW,Burgher AH,Obray J,Scowcroft J,Golovac S,Kapural L,Paicius R,Kim C,Pope J,Yearwood T,Samuel S,McRoberts WP,Cassim H,Netherton M,Miller N

更新日期：2017-04-01 00:00:00

abstract：:Morphine (M) and hydromorphone (HM) are commonly used opioid analgesics for cancer pain. Opioid rotation is often necessary in the event of toxicity and/or inadequate analgesia. Equianalgesic reference tables based on single dose comparisons are possibly inadequate for patients on chronic treatment and developing tole...

journal_title：Pain

authors： Lawlor P,Turner K,Hanson J,Bruera E

更新日期：1997-08-01 00:00:00