Primary sensory neurons exhibit altered gene expression in a rat model of neuropathic pain.

abstract：:The relation between personality characteristics and the psychological functioning of headache patients has long been a topic of interest. Early investigations focused on clinical and anecdotal reports while recent research has moved toward a more objective evaluation of headache groups by using the MMPI. However, the...

journal_title：Pain

authors： Williams DE,Thompson KJ,Haber JD,Raczynski JM

更新日期：1986-02-01 00:00:00

abstract：:Cultures differ as to typical linguistic reports and classifications of pain. In some languages upwards of a dozen specific pain terms are in common use, each indicating a particular pain experience. In other languages a single inclusive term is the norm, perhaps with optional qualifiers added to make desired distinct...

journal_title：Pain

authors： Diller A

更新日期：1980-08-01 00:00:00

abstract：:Noxious challenge of the rat gastric mucosa by hydrochloric acid (HCl) is signaled to the nucleus tractus solitarii (NTS) and area postrema (AP). This study examined the participation of glutamate and tachykinins in the medullary transmission process. Activation of neurons was visualized by in situ hybridization autor...

journal_title：Pain

authors： Jocic M,Schuligoi R,Schöninkle E,Pabst MA,Holzer P

更新日期：2001-01-01 00:00:00

abstract：:The treatment of neuropathic pain by neuromodulation is an objective for more than 40 years in modern clinical practice. With respect to spinal cord and deep brain structures, the cerebral cortex is the most recently evaluated target of invasive neuromodulation therapy for pain. In the early 90s, the first successes o...

journal_title：Pain

authors： Lefaucheur JP

更新日期：2016-02-01 00:00:00

abstract：:Pain behaviors are shaped by social demands and learning processes, and chronic pain has been previously suggested to affect their meaning. In this study, we combined functional magnetic resonance imaging with in-scanner video recording during thermal pain stimulations and use multilevel mediation analyses to study th...

journal_title：Pain

authors： Vachon-Presseau E,Roy M,Woo CW,Kunz M,Martel MO,Sullivan MJ,Jackson PL,Wager TD,Rainville P

更新日期：2016-08-01 00:00:00

abstract：:Drawing on advances in chronic pain metrics, a simplified Graded Chronic Pain Scale-Revised was developed to differentiate mild, bothersome, and high-impact chronic pain. Graded Chronic Pain Scale-Revised was validated among adult enrollees of 2 health plans (N = 2021). In this population, the prevalence of chronic pa...

journal_title：Pain

authors： Von Korff M,DeBar LL,Krebs EE,Kerns RD,Deyo RA,Keefe FJ

更新日期：2020-03-01 00:00:00

abstract：:Rats and humans manifest elevated response thresholds to aversive stimuli during gestation and parturition. This pregnancy-associated antinociception is mediated, in part, by a spinal cord dynorphin/kappa antinociceptive system. Simulating the maternal pregnancy blood concentration profile (in non-pregnant animals) of...

journal_title：Pain

authors： Dawson-Basoa ME,Gintzler AR

更新日期：1996-01-01 00:00:00

abstract：:Injection of bee venom into one hindpaw of rat can elicit acute inflammation together with spontaneous pain, heat hyperalgesia and mechanical hyperalgesia/allodynia in the injected paw. 5-hydroxytryptamine (5-HT)1A receptor is the predominant receptor subtype in the spinal dorsal horn mediating the function of 5-HT in...

journal_title：Pain

authors： Wang W,Wu SX,Wang YY,Liu XY,Li YQ

更新日期：2003-11-01 00:00:00

abstract：:The present study utilized recently developed diagnostic tests that permit recognition of functional deficits in spine mobility, trunk strength, endurance, coordination, and dynamic lifting capacity. Changes in these tests were compared to changes in psychological functioning (e.g., self-report of pain) as well as to ...

journal_title：Pain

authors： Mayer TG,Gatchel RJ,Kishino N,Keeley J,Mayer H,Capra P,Mooney V

更新日期：1986-04-01 00:00:00

abstract：:Cross-sectional research in clinical samples, as well as experimental studies in healthy adults, suggests that the experiences of pain and sleep are bi-directionally connected. However, whether sleep and pain experiences are prospectively linked to one another on a day-to-day basis in the general population has not pr...

journal_title：Pain

authors： Edwards RR,Almeida DM,Klick B,Haythornthwaite JA,Smith MT

更新日期：2008-07-01 00:00:00

abstract：:Visceral inflammation is thought to play an important role in the sensitization of low and high threshold mechanosensory and polymodal afferents and to recruit silent nociceptors. Yet, little is known about the potential role of the mediators involved in nociceptor sensitization to mechanical stimulation as compared t...

journal_title：Pain

authors： Roza C,Reeh PW

更新日期：2001-09-01 00:00:00

abstract：:Chronic pain not only interferes with daily activities, it may also have a negative impact on the perceived integrity of one's self through self-discrepancies. Self-discrepancies are experienced distances between the actual self and self-guides that can exist from 2 perspectives (ie, own and other). Self-discrepancies...

journal_title：Pain

authors： Kindermans HPJ,Huijnen IPJ,Goossens MEJB,Roelofs J,Verbunt JA,Vlaeyen JWS

更新日期：2011-02-01 00:00:00

abstract：:A number of investigators have suggested that the generic classification temporomandibular disorders (TMD) may consist of several subsets of patients. Two primary factors are to be significant in discriminating subgroups, namely, presence or absence of TM joint abnormalities and psychological characteristics such as t...

journal_title：Pain

authors： Rudy TE,Turk DC,Zaki HS,Curtin HD

更新日期：1989-03-01 00:00:00

abstract：:Functional magnetic resonance imaging (fMRI) using the blood oxygen level-dependent (BOLD) contrast was used to study sensory processing in the brain of isoflurane-anesthetized mice. The use of a cryogenic surface coil in a small animal 9.4T system provided the sensitivity required for detection and quantitative analy...

journal_title：Pain

authors： Bosshard SC,Baltes C,Wyss MT,Mueggler T,Weber B,Rudin M

更新日期：2010-12-01 00:00:00

abstract：:Evidence of the relationship between childhood abuse and pain problems in adulthood has been based on cross-sectional studies using retrospective self-reports of childhood victimization. The objective of the current study was to determine whether childhood victimization increases risk for adult pain complaints, using ...

journal_title：Pain

authors： Raphael KG,Widom CS,Lange G

更新日期：2001-05-01 00:00:00

abstract：:Morphine (M) and hydromorphone (HM) are commonly used opioid analgesics for cancer pain. Opioid rotation is often necessary in the event of toxicity and/or inadequate analgesia. Equianalgesic reference tables based on single dose comparisons are possibly inadequate for patients on chronic treatment and developing tole...

journal_title：Pain

authors： Lawlor P,Turner K,Hanson J,Bruera E

更新日期：1997-08-01 00:00:00

abstract：:Extracellular signal-regulated kinase (ERK), a mitogen-activated protein kinases (MAPK), transduces a broad range of extracellular stimuli into diverse intracellular responses. Recent studies have showed that ERK activation in the supraspinal level involved in the development of drug dependence, especially in psycholo...

journal_title：Pain

authors： Cao JL,He JH,Ding HL,Zeng YM

更新日期：2005-12-05 00:00:00

abstract：:Facial expressions of pain and emotions provide powerful social signals, which impart information about a person's state. Unfortunately, research on pain and emotion expression has been conducted largely in parallel with few bridges allowing for direct comparison of the expressive displays and their impact on observer...

journal_title：Pain

authors： Simon D,Craig KD,Gosselin F,Belin P,Rainville P

更新日期：2008-03-01 00:00:00

abstract：:The aim of this study was to investigate how exercise influenced endogenous pain modulation in healthy controls, shoulder myalgia patients and fibromyalgia (FM) patients. Twenty-one healthy subjects, 20 shoulder myalgia patients and 20 FM patients, all females, participated. They performed standardized static contract...

journal_title：Pain

authors： Lannersten L,Kosek E

更新日期：2010-10-01 00:00:00

abstract：:Intradermal injection of capsaicin induces primary hyperalgesia at the injection site and secondary hyperalgesia in the surrounding undamaged skin. The secondary hyperalgesia is thought to be due to central sensitization of the dorsal horn neurons while primary hyperalgesia is caused by sensitization of nociceptors in...

journal_title：Pain

authors： Kim HT,Park SK,Lee SE,Chung JM,Lee DH

更新日期：2001-11-01 00:00:00

abstract：:The proinflammatory cytokines tumor necrosis factor (TNF) α and interleukin (IL) 1β have been strongly implicated in the pathogenesis of neuropathic pain, but the intracellular signaling of these cytokines in glial cells is not fully understood. TNF receptor-associated factor 6 (TRAF6) plays a key role in signal trans...

journal_title：Pain

authors： Lu Y,Jiang BC,Cao DL,Zhang ZJ,Zhang X,Ji RR,Gao YJ

更新日期：2014-12-01 00:00:00

abstract：:Hydromorphone is an alternative to morphine for intrathecal drug delivery system to treat refractory cancer pain; however, there is not enough clinical evidence to prove it. In our study, 233 patients from 12 different pain management centers across China were enrolled, 121 and 112 in the intrathecal hydromorphone (IT...

journal_title：Pain

authors： Ma K,Jin Y,Wang L,Feng ZY,Song T,Yang XQ,Chen FQ,Duan BL,Huang YQ,Xie GL,Bao HG,Wang K,Xu JT,Lu Y,Liu YQ

更新日期：2020-11-01 00:00:00

abstract：:The role of proinflammatory cytokines in neuropathic and inflammatory pain is well established. Recent studies suggest that cytokines such as tumor necrosis factor-alpha (TNF) may also be involved in the development of muscle pain. To investigate the pathophysiology of intramuscular TNF, exogenous TNF (0.1-10 microg),...

journal_title：Pain

authors： Schäfers M,Sorkin LS,Sommer C

更新日期：2003-08-01 00:00:00

abstract：:(1) Capsaicin solution was applied for 15 min around a 1 cm length of sciatic nerve in the mid upper leg of adult rats. (2) Electron microscopic examinations of the nerve in the treated region after 14 days shows no signs of degeneration of either myelinated or unmyelinated fibres attributable to the capsaicin. (3) Fl...

journal_title：Pain

authors： Ainsworth A,Hall P,Wall PD,Allt G,MacKenzie ML,Gibson S,Polak JM

更新日期：1981-12-01 00:00:00

abstract：:Postherpetic neuralgia (PHN) is a debilitating chronic pain condition, yet there is a lack of knowledge regarding underlying brain activity. Here we identify brain regions involved in spontaneous pain of PHN (n=11) and determine its modulation with Lidoderm therapy (patches of 5% lidocaine applied to the PHN affected ...

journal_title：Pain

authors： Geha PY,Baliki MN,Chialvo DR,Harden RN,Paice JA,Apkarian AV

更新日期：2007-03-01 00:00:00

abstract：:A controlled clinical trial on the efficacy of a nortriptyline-fluphenazine combination was carried out in patients with painful diabetic polyneuropathy. A visual analog scale was used to evaluate the relief of pain or paresthesia. Significant relief of both pain and paresthesia was obtained with this combination. The...

journal_title：Pain

authors： Gomez-Perez FJ,Rull JA,Dies H,Rodriguez-Rivera GJ,Gonzalez-Barranco J,Lozano-Castañeda O

更新日期：1985-12-01 00:00:00

abstract：:Changes in pain produced by psychological factors (e.g., placebo analgesia) are thought to result from the activity of specific cortical regions. However, subcortical nuclei, including the periaqueductal gray and the rostroventral medulla, also show selective activation when subjects expect pain relief. These brainste...

journal_title：Pain

authors： Goffaux P,Redmond WJ,Rainville P,Marchand S

更新日期：2007-07-01 00:00:00

abstract：:Recent research has focused on identification of clinically meaningful subgroupings within the chronic pain population in contrast to prior emphasis on the homogeneity of these patients. The present study investigates site of pain as a potentially useful classification variable for identification of differences among ...

journal_title：Pain

authors： Toomey TC,Gover VF,Jones BN

更新日期：1984-08-01 00:00:00

abstract：:The investigation of neurotransmitter systems in placebo and nocebo effects has improved our understanding of these phenomena. Yet, most studies involve healthy participants. Because the pain modulatory system may differ in healthy participants and patients with chronic pain, it is important to investigate the evidenc...

journal_title：Pain

authors： Skyt I,Lunde SJ,Baastrup C,Svensson P,Jensen TS,Vase L

更新日期：2020-01-01 00:00:00

abstract：:The perception of pain is highly variable. It depends on bottom-up-mediated factors like stimulus intensity and top-down-mediated factors like expectations. In the brain, pain is associated with a complex pattern of neuronal responses including evoked potentials and induced responses at alpha and gamma frequencies. Al...

journal_title：Pain

authors： Tiemann L,May ES,Postorino M,Schulz E,Nickel MM,Bingel U,Ploner M

更新日期：2015-02-01 00:00:00