Cooperation of NMDA and tachykinin NK(1) and NK(2) receptors in the medullary transmission of vagal afferent input from the acid-threatened rat stomach.

abstract：:Exacerbation of pain by chronic stress and comorbidity of pain with stress-related psychiatric disorders, including anxiety and depression, represent significant clinical challenges. However, the underlying mechanisms still remain unclear. Here, we investigated whether chronic forced swim stress (CFSS)-induced exacerb...

journal_title：Pain

authors： Li MJ,Liu LY,Chen L,Cai J,Wan Y,Xing GG

更新日期：2017-04-01 00:00:00

abstract：:Pain is processed in multiple cortical and subcortical brain areas. Subcortical structures are substantially involved in different processes that are closely linked to pain processing, e.g. motor preparation, autonomic responses, affective components and learning. However, it is unclear to which extent nociceptive inf...

journal_title：Pain

authors： Bingel U,Quante M,Knab R,Bromm B,Weiller C,Büchel C

更新日期：2002-09-01 00:00:00

abstract：:Compared with other European countries, French laws and restrictions concerning the use of opioids are of medium severity only. Still, together with Germany, Belgium and Spain, France belongs to the group of countries with a low national consumption of morphine, calculated by the International Narcotics Control Board ...

journal_title：Pain

authors： Vainio A

更新日期：1995-08-01 00:00:00

abstract：:Effects of electrical stimulation of the cervical vagus nerve were determined in cervical or lumbar spinal neurons in 27 rats anesthetized with pentobarbital. Ipsilateral cervical vagus stimulation (ICVS) increased activity of 44 neurons in the C1 segment. At the same stimulation parameters, contralateral cervical vag...

journal_title：Pain

authors： Qing-Gong F,Chandler MJ,McNeill DL,Foreman RD

更新日期：1992-10-01 00:00:00

abstract：:This study focuses on changes in adrenergic sensitivity in untransected sensory axons that innervate an area of skin made neuropathic by transection of neighboring nerves. The segmental nerve injury model is favorable for this since all axons in the L5 and L6 nerves are transected whereas the L4 axons are intact. Earl...

journal_title：Pain

authors： Moon DE,Lee DH,Han HC,Xie J,Coggeshall RE,Chung JM

更新日期：1999-04-01 00:00:00

abstract：:Musculoskeletal disorders (MSDs) are highly prevalent, painful, and costly disorders. The MSD Cohort was created to characterize variation in pain, comorbidities, treatment, and outcomes among patients with MSD receiving Veterans Health Administration care across demographic groups, geographic regions, and facilities....

journal_title：Pain

authors： Goulet JL,Kerns RD,Bair M,Becker WC,Brennan P,Burgess DJ,Carroll CM,Dobscha S,Driscoll MA,Fenton BT,Fraenkel L,Haskell SG,Heapy AA,Higgins DM,Hoff RA,Hwang U,Justice AC,Piette JD,Sinnott P,Wandner L,Womack JA,Br

更新日期：2016-08-01 00:00:00

abstract：:We have examined the effects of cannabinoid agonists on hyperalgesia in a model of neuropathic pain in the rat and investigated the possible sites of action. The antihyperalgesic activity of the cannabinoids was compared with their ability to elicit behavioural effects characteristic of central cannabinoid activity. W...

journal_title：Pain

authors： Fox A,Kesingland A,Gentry C,McNair K,Patel S,Urban L,James I

更新日期：2001-05-01 00:00:00

abstract：:Recent meta-analyses have shown mindfulness-based interventions (MBIs) to be effective for chronic pain, but no pooled estimates of the effect of MBIs on acute pain are available. This meta-analysis was conducted to fill that gap. A literature search was conducted in 4 databases. Articles were eligible if they reporte...

journal_title：Pain

authors： Shires A,Sharpe L,Davies JN,Newton-John TRO

更新日期：2020-08-01 00:00:00

abstract：:Caffeine is frequently added to mild analgesic preparations but its effect when used alone on pain has never been studied in humans. Using a double-blind placebo-controlled multiple crossover design, 53 patients with non-migrainous headaches were given placebo, acetaminophen, 2 doses of caffeine and 2 combinations of ...

journal_title：Pain

authors： Ward N,Whitney C,Avery D,Dunner D

更新日期：1991-02-01 00:00:00

abstract：:The purpose of this study was to explore gender differences in pain experiences, pain control beliefs, pain coping strategies, and depressive tendency among Chinese elderly with knee osteoarthritis (OA). Participants (N=199) were drawn from a previous convenience sample of outpatients with OA in Taiwan. Results indica...

journal_title：Pain

authors： Tsai YF

更新日期：2007-07-01 00:00:00

abstract：:Postmastectomy pain (PMP), a distinctive postsurgical neuropathic pain syndrome, has been thought to be consequence of 4-6% of surgical procedures for cancer of the breast, but remains understudied and poorly documented. In this cross-sectional descriptive study, a convenience sample of 95 women who had undergone brea...

journal_title：Pain

authors： Stevens PE,Dibble SL,Miaskowski C

更新日期：1995-04-01 00:00:00

abstract：:Many studies of pain and nociception use short-lasting acute stimuli which may have limited relevance to prolonged or chronic pain states. Using extracellular single-unit recording in the dorsal horn of the rat lumbar spinal cord the present study examines the response of neurones to a long-lasting nociceptive stimulu...

journal_title：Pain

authors： Dickenson AH,Sullivan AF

更新日期：1987-09-01 00:00:00

abstract：:Many aspects of bilateral presentation or recurrence of reflex sympathetic dystrophy (RSD) are unknown. For this reason 1183 consecutive patients with RSD were analyzed. In 10 patients RSD started in symmetrical limbs. In 34 patients RSD recurred in the same limb after a period of no or few complaints and in 76 patien...

journal_title：Pain

authors： Veldman PHJM,Goris JAR

更新日期：1996-03-01 00:00:00

abstract：:This study investigated the antinociceptive effect of opioids given via intraperitoneal and intrathecal routes in a diabetes-induced neuropathic pain model in rats. Streptozotocin induced diabetes in 91% of juvenile male Wistar rats at the dose of 150 mg/kg (75 mg/kg intraperitoneal on 2 successive days). When compare...

journal_title：Pain

authors： Zurek JR,Nadeson R,Goodchild CS

更新日期：2001-02-01 00:00:00

abstract：:Pain that interferes with daily life appears to be strongly age-related in cross-sectional studies, although the nature of this relationship over time has not been established. We have investigated the onset and persistence of pain and pain interference over a 3-year period to determine their association with age in o...

journal_title：Pain

authors： Thomas E,Mottram S,Peat G,Wilkie R,Croft P

更新日期：2007-05-01 00:00:00

abstract：:Two cases of reflex sympathetic dystrophy in the upper extremity of patients with traumatic cervical spinal cord injuries are reported. Both patients had very incomplete lesions with early neurological recovery, suggesting an underlying central cord syndrome. Although reflex sympathetic dystrophy is often seen followi...

journal_title：Pain

authors： Wainapel SF

更新日期：1984-04-01 00:00:00

abstract：:Two different modes of cutaneous sensory reinnervation are thought to be engaged following nerve injury: regenerative growth of the injured nerve and 'collateral sprouting' of neighboring intact nerves. Although both processes are well known from experimental preparations, there is little unequivocal documentation of ...

journal_title：Pain

authors： Inbal R,Rousso M,Ashur H,Wall PD,Devor M

更新日期：1987-02-01 00:00:00

abstract：:Do contrasting neuropathic pain diagnoses share common pathophysiological mechanisms? Selective breeding was used to derive rat lines with a common genetic background but a striking difference in the degree of spontaneous pain behavior expressed in the neuroma model of neuropathic pain (HA rats (high autotomy) and LA ...

journal_title：Pain

authors： Ziv-Sefer S,Raber P,Barbash S,Devor M

更新日期：2009-11-01 00:00:00

abstract：:Twenty patients with chronic low back pain received 12 lumbar sympathetic injections, in a series of 6 with bupivacaine and a series of 6 with saline. Changes in subjective pain intensity, EMG from paravertebral muscles, joint ranges of mobility, and daily activity levels were measured at multiple intervals throughout...

journal_title：Pain

authors： Brena SF,Wolf SL,Chapman SL,Hammonds WD

更新日期：1980-02-01 00:00:00

abstract：:The facial expression of pain plays a crucial role in pain communication and pain diagnostics. Despite its importance, it has remained unknown which dimensions of pain (sensory and/or affective) are encoded in the face. To answer this question, we used a well-established cognitive strategy (suggestions) to differentia...

journal_title：Pain

authors： Kunz M,Lautenbacher S,LeBlanc N,Rainville P

更新日期：2012-02-01 00:00:00

abstract：:Although known primarily for its role in neuronal development, brain-derived neurotrophic factor (BDNF) has also recently been implicated in processes mediated by the adult nervous system, such as spinal nociception. Peripheral inflammation increases expression of BDNF preferentially in dorsal root ganglion cells that...

journal_title：Pain

authors： Groth R,Aanonsen L

更新日期：2002-11-01 00:00:00

abstract：:Venoms peptides have produced exceptional sources for drug development to treat pain. In this study we examined the antinociceptive and side effects of Tx3-3, a peptide toxin isolated from Phoneutria nigriventer venom, which inhibits high-voltage-dependent calcium channels (VDCC), preferentially P/Q and R-type VDCC. W...

journal_title：Pain

authors： Dalmolin GD,Silva CR,Rigo FK,Gomes GM,do Nascimento Cordeiro M,Richardson M,Silva MAR,Prado MAM,Gomez MV,Ferreira J

更新日期：2011-10-01 00:00:00

abstract：:In the skin surrounding a site of injury, hyperalgesia develops to mechanical stimuli. Two types of secondary hyperalgesia (to light touch and punctate stimuli) have recently been differentiated, based on different durations and sizes of the area involved. We studied secondary hyperalgesia in a subject who had a loss ...

journal_title：Pain

authors： Treede RD,Cole JD

更新日期：1993-05-01 00:00:00

abstract：:The literature on cognitive and cognitive-behavioral methods for pain control is selectively reviewed, with particular focus on controlled studies. Such methods include the provision of preparatory information, cognitive coping skills or strategies, the provision of preparatory information plus some form of coping ski...

journal_title：Pain

authors： Tan SY

更新日期：1982-03-01 00:00:00

abstract：:A fundamental question for placebo research is whether such responses are a predisposition, quantifiable by brain characteristics. We examine this issue in chronic back pain (CBP) patients who participated in a double-blind brain imaging (functional magnetic resonance imaging) clinical trial. We recently reported that...

journal_title：Pain

authors： Hashmi JA,Baria AT,Baliki MN,Huang L,Schnitzer TJ,Apkarian VA

更新日期：2012-12-01 00:00:00

abstract：:Fibromyalgia is a painful syndrome of non-articular origin, predominantly involving muscles, and the commonest cause of chronic widespread musculoskeletal pain. The diversity of therapeutic programs for patients with fibromyalgia reflects both the lack of a known pathophysiology for this disorder and the low efficacy ...

journal_title：Pain

authors： Quijada-Carrera J,Valenzuela-Castaño A,Povedano-Gómez J,Fernández-Rodriguez A,Hernánz-Mediano W,Gutierrez-Rubio A,de la Iglesia-Salgado JL,García-López A

更新日期：1996-05-01 00:00:00

abstract：:Salmon calcitonin (s-CT) has been shown to be a valuable analgesic in phantom limb pain (PLP) in several case reports. To evaluate these findings a double-blind crossover comparison of s-CT treatment versus placebo was initiated. Twenty-one out of 161 patients who had undergone major amputations and developed severe P...

journal_title：Pain

authors： Jaeger H,Maier C

更新日期：1992-01-01 00:00:00

abstract：:Cyclin-dependent kinase 5 (Cdk5) is a unique member of the CDK family. It is predominantly expressed in postmitotic neurons and has been implicated in neuronal plasticity. The present study showed that Cdk5 and p35 were expressed in primary sensory and dorsal horn neurons, while p25, an N-terminal truncated derivative...

journal_title：Pain

authors： Yang YR,He Y,Zhang Y,Li Y,Li Y,Han Y,Zhu H,Wang Y

更新日期：2007-01-01 00:00:00

abstract：:This report describes a placebo-controlled study of transcutaneous electrical nerve stimulation (TENS) applied to the contralateral lower leg and outer ears of an amputee with non-painful phantom sensations. The subject received TENS or placebo stimulation on separate sessions in which baseline periods of no stimulati...

journal_title：Pain

authors： Katz J,France C,Melzack R

更新日期：1989-03-01 00:00:00

abstract：:The nociceptive flexion reflex (NFR) has been used as a psychophysiological tool to study spinal nociceptive processes in numerous clinical and experimental studies. Despite widespread use of the NFR, few attempts have been made to empirically test and compare different scoring criteria to detect the presence/absence ...

journal_title：Pain

authors： France CR,Rhudy JL,McGlone S

更新日期：2009-09-01 00:00:00