Abstract:
:Musculoskeletal disorders (MSDs) are highly prevalent, painful, and costly disorders. The MSD Cohort was created to characterize variation in pain, comorbidities, treatment, and outcomes among patients with MSD receiving Veterans Health Administration care across demographic groups, geographic regions, and facilities. We searched electronic health records to identify patients treated in Veterans Health Administration who had ICD-9-CM codes for diagnoses including, but not limited to, joint, back, and neck disorders, and osteoarthritis. Cohort inclusion criteria were 2 or more outpatient visits occurring within 18 months of one another or one inpatient visit with an MSD diagnosis between 2000 and 2011. The first diagnosis is the index date. Pain intensity numeric rating scale (NRS) scores, comorbid medical and mental health diagnoses, pain-related treatments, and other characteristics were collected retrospectively and prospectively. The cohort included 5,237,763 patients; their mean age was 59, 6% were women, 15% identified as black, and 18% reported severe pain (NRS ≥ 7) on the index date. Nontraumatic joint disorder (27%), back disorder (25%), and osteoarthritis (21%) were the most common MSD diagnoses. Patients entering the cohort in recent years had more concurrent MSD diagnoses and higher NRS scores. The MSD Cohort is a rich resource for collaborative pain-relevant health service research.
journal_name
Painjournal_title
Painauthors
Goulet JL,Kerns RD,Bair M,Becker WC,Brennan P,Burgess DJ,Carroll CM,Dobscha S,Driscoll MA,Fenton BT,Fraenkel L,Haskell SG,Heapy AA,Higgins DM,Hoff RA,Hwang U,Justice AC,Piette JD,Sinnott P,Wandner L,Womack JA,Brdoi
10.1097/j.pain.0000000000000567subject
Has Abstractpub_date
2016-08-01 00:00:00pages
1696-1703issue
8eissn
0304-3959issn
1872-6623pii
00006396-201608000-00018journal_volume
157pub_type
杂志文章相关文献
PAIN文献大全abstract::A survey of the psychological characteristics of a large sample of chronic headache cases (n = 360), including classical and common migraine and tension headache sufferers, was carried out. Comparing groups defined in terms of the chronicity of their headache problems, it was found that those with a longer history of ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(85)90286-6
更新日期:1985-02-01 00:00:00
abstract::The anterior cingulate cortex (ACC) has a pivotal role in human pain processing by integrating sensory, executive, attentional, emotional, and motivational components of pain. Cognitive modulation of pain-related ACC activation has been shown by hypnosis, illusion and anticipation. The expectation of a potentially nox...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.12.036
更新日期:2005-04-01 00:00:00
abstract::This study aimed to characterize the prevalence of various pain qualities in older adults with chronic nonmalignant pain and determine the association of pain quality to other pain characteristics namely: severity, interference, distribution, and pain-associated conditions. In the population-based MOBILIZE Boston Stud...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000719
更新日期:2016-12-01 00:00:00
abstract::Experimental C-fiber pain caused by radiant heat was applied to the skin area supplied by the left sural nerve of 20 subjects. Percutaneous electrical stimulation (PNS) was performed on the left sural nerve, the left superficial peroneal nerve and the right superficial radial nerve. Stimulation frequencies were: 3, 50...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(79)90004-6
更新日期:1979-10-01 00:00:00
abstract::There is considerable evidence to implicate N-methyl-D-aspartate (NMDA) receptor activation in the mechanisms that underly thermal hyperalgesia in the spinal cord. As many of the effects of NMDA receptor activation appear to be ultimately mediated through production of nitric oxide (NO), recent reports have begun to d...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/0304-3959(93)90124-8
更新日期:1993-02-01 00:00:00
abstract::Tri-cyclic antidepressants (TCAs) have been widely used in treating major depressive disorders. Recent studies further demonstrated that TCAs have potent sodium channel blocking effect, and amitriptyline, one of the TCAs, has a potent spinal anesthetic effect. The aim of the study was to evaluate the spinal anesthetic...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.08.003
更新日期:2004-11-01 00:00:00
abstract::The neuropeptide bradykinin (BK) sensitizes nociceptor activation following its release in response to inflammatory injury. Thereafter, the bioactivity of bradykinin is controlled by the enzymatic activities of circulating peptidases. One such enzyme, the metalloendopeptidase EC3.4.24.15 (EP24.15), is co-expressed wit...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.02.044
更新日期:2011-07-01 00:00:00
abstract::In a double-blind, crossover study, the effects of 75 mg amitriptyline alone during 5 weeks on pain intensity were compared with the effects of a combination of 75 mg amitriptyline and 3 mg flupentixol during 5 weeks in 34 patients with somatoform pain disorder. Both treatments resulted in a statistically significant ...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(91)90007-K
更新日期:1991-10-01 00:00:00
abstract::Currently, opioids targeting mu-opioid receptors are the most potent drugs for acute and cancer pain. However, opioids produce adverse side effects such as constipation, respiratory depression, or addiction potential. We recently developed (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide (NFEPP), a co...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001968
更新日期:2020-12-01 00:00:00
abstract::Clinical pain syndromes, and experimental assays of nociception, are differentially affected by manipulations such as drug administration and exposure to environmental stress. This suggests that there are different 'types' of pain. We exploited genetic differences among inbred strains of mice in an attempt to define t...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(98)00196-1
更新日期:1999-03-01 00:00:00
abstract::Fibromyalgia (FM) is a prevalent and disabling chronic disease. Recent studies have found elevated levels of glutamate in several brain regions, leading to hypotheses about the usefulness of glutamate-blocking drugs such as memantine in the treatment of FM. The aim of this study was to evaluate the efficacy of memanti...
journal_title:Pain
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.pain.2014.09.004
更新日期:2014-12-01 00:00:00
abstract::Polyneuropathy can be linked to chronic pain but also to reduced pain sensitivity. We investigated peripheral C-nociceptors in painful and painless polyneuropathy patients to identify pain-specific changes. Eleven polyneuropathy patients with persistent spontaneous pain and 8 polyneuropathy patients without spontaneou...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.05.017
更新日期:2012-10-01 00:00:00
abstract::Late-life depression and pain more often co-occur than can be explained by chance. Determinants of pain in late-life depression are unknown, even though knowledge on possible determinants of pain in depression is important for clinical practice. Therefore, the objectives of the present study were 1) to describe pain c...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.07.019
更新日期:2014-10-01 00:00:00
abstract::The responses of primate spinothalamic tract (STT) neurons to innocuous and noxious mechanical stimuli applied to the skin can be enhanced for more than an hour following prolonged noxious stimulation. This increased responsiveness is thought to reflect sensitization of dorsal horn neurons and may help account for sec...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)90164-3
更新日期:1994-03-01 00:00:00
abstract::Omega-3 and n-6 fatty acids are biosynthetic precursors to lipid mediators with antinociceptive and pronociceptive properties. We conducted a randomized, single-blinded, parallel-group clinical trial to assess clinical and biochemical effects of targeted alteration in dietary n-3 and n-6 fatty acids for treatment of c...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2013.07.028
更新日期:2013-11-01 00:00:00
abstract::To investigate the pathways of noxious information in the spinal cord in humans, we recorded cortical potentials following the stimulation of A-delta fibers using a YAG laser applied to two cutaneous points on the back at the C7 and Th10 level, 4cm to the right of the vertebral spinous process. A multiple source analy...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.03.009
更新日期:2006-08-01 00:00:00
abstract::An 82-year-old woman experienced generalized pruritus not due to skin or systemic disease. Scratching the skin with a needle induced a crisis of intense pruritus, insensitive to any drug. The pruritus had the characteristics of a central sensation. ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90055-3
更新日期:1991-06-01 00:00:00
abstract::Inflammation induces an up-regulation of neuropeptide tyrosine (NPY) and its receptors in the dorsal horn, suggesting an important role in nociceptive transmission. Our initial studies revealed that NPY dose-dependently increased hotplate response latency, and to a lesser degree, thermal paw withdrawal latency (PWL); ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(01)00481-X
更新日期:2002-04-01 00:00:00
abstract::The nociceptive flexion reflex (NFR) has been used as a psychophysiological tool to study spinal nociceptive processes in numerous clinical and experimental studies. Despite widespread use of the NFR, few attempts have been made to empirically test and compare different scoring criteria to detect the presence/absence ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.06.022
更新日期:2009-09-01 00:00:00
abstract::Nerve growth factor (NGF) is known to produce hyperalgesia as well as to stimulate synthesis of neuropeptides in dorsal root ganglia (DRG). In the present study, we wanted to determine the effects of local NGF administration and assess to which extent mast cell-dependent factors are mediating NGF responses. Rats recei...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(95)00120-4
更新日期:1996-02-01 00:00:00
abstract::The present study observed the expression of the 5-hydroxytryptamine (5-HT) (1A) receptor mRNA in the lumbar spinal dorsal horn neurons following carrageenan inflammation using in situ hybridization (ISH). We also studied the co-localization of 5-HT(1A) receptor mRNA and gamma-amino butyric acid (GABA) or enkephalin (...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(02)00026-X
更新日期:2002-08-01 00:00:00
abstract::The analgesic efficacy of single doses of oral morphine sulphate solution (10 mg) and ibuprofen 600 mg was compared in 12 volunteers using a double-blind, double-dummy, placebo-controlled design on the cold pressor experimental pain model. Measurement of pain intensity was made before medication and then at 30, 60, 90...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(88)90156-X
更新日期:1988-08-01 00:00:00
abstract::Animal studies have suggested that the cerebellum, in addition to its motor functions, also has a role in pain processing and modulation, possibly because of its extensive connections with the prefrontal cortex and with brainstem regions involved in descending pain control. Consistently, human imaging studies have sho...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.04.006
更新日期:2014-07-01 00:00:00
abstract::Migraine headache is an episodic phenomenon, and patients with episodic migraine have ictal (headache), peri-ictal (premonitory, aura, and postdrome), and interictal (asymptomatic) phases. We aimed to find the functional characteristics of the migraine brain regardless of headache phase using dynamic functional connec...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001676
更新日期:2019-12-01 00:00:00
abstract::The role of proinflammatory cytokines in neuropathic and inflammatory pain is well established. Recent studies suggest that cytokines such as tumor necrosis factor-alpha (TNF) may also be involved in the development of muscle pain. To investigate the pathophysiology of intramuscular TNF, exogenous TNF (0.1-10 microg),...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(03)00115-5
更新日期:2003-08-01 00:00:00
abstract::Nitric oxide (NO) acts as a neurotransmitter or neuromodulator involving in the modulation of thermal and/or inflammatory hyperalgesia. The neuronal nitric oxide synthase (nNOS) is a key enzyme for NO production in normal neuronal tissues, but its functional role in chronic pain remains unclear. The present study comb...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2005.09.024
更新日期:2005-12-15 00:00:00
abstract::The relationship between chronic pain and depression has become enmeshed in the literature. In an attempt to unravel the relationship between chronic pain and depression, the authors studied a uniform group of 80 chronic back pain patients with and without depression using the dexamethasone suppression test (DST). The...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(85)90076-4
更新日期:1985-01-01 00:00:00
abstract::Reports of pain during mammography show that there is great variability in both the incidence of reported pain (0.2-62%) and the intensity of that pain. Much of that variability may be due to the measures used to rate mammography pain. This is the first study that has examined the incidence, quality and intensity of m...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(96)03057-6
更新日期:1996-08-01 00:00:00
abstract::The aim of the present study was to test (1) whether muscle pain is influenced by temporal and spatial summation, and (2) whether sequential noxious muscle stimuli applied at hourly interstimulus-intervals could produce an increased sensation of pain due to central hyperexcitability. In the study eleven healthy men we...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(96)03243-5
更新日期:1997-01-01 00:00:00
abstract::Back pain is a leading cause of disability. Previous research suggests that modifiable risk factors influence recovery from back pain, and practice guidelines recommend integrating such factors within primary care management. Toward this goal, a brief, multidimensional questionnaire, the STarT Back Tool, was designed ...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2012.06.010
更新日期:2012-11-01 00:00:00