Abstract:
:Animal studies have suggested that the cerebellum, in addition to its motor functions, also has a role in pain processing and modulation, possibly because of its extensive connections with the prefrontal cortex and with brainstem regions involved in descending pain control. Consistently, human imaging studies have shown cerebellar activation in response to painful stimulation. However, it is presently not clear whether cerebellar lesions affect pain perception in humans. In the present study, we used experimental pain testing to compare acute pain perception and endogenous pain inhibition in 30 patients 1 to 11 years after cerebellar infarction and in 30 sex- and age-matched healthy control subjects. Compared to controls, patients exhibited a significantly increased pain perception in response to acute heat stimuli (44 °C-48 °C, average pain intensity rating for patients 3.4±2.8 and for controls 1.5±1.7 [on a numeric rating scale of 0-10], P<.01) and to repeated 256 mN pinprick stimuli (1.3±1.9 vs. 0.6±1.0 [0-10], P<.05). Heat hyperalgesia in patients was more pronounced on the body side ipsilateral to the infarction. In addition, patients showed reduced offset analgesia (change in pain intensity rating: 0.0%±15.8% vs. -16.9%±36.3%, P<.05) and reduced placebo analgesia (change in pain intensity rating: -1.0±1.1 vs. -1.8±1.3 [0-10], P<.05) compared to controls. In contrast, heat and pressure pain thresholds were not significantly different between groups. These results show that, after cerebellar infarction, patients perceive heat and repeated mechanical stimuli as more painful than do healthy control subjects and have deficient activation of endogenous pain inhibitory mechanisms (offset and placebo analgesia). This suggests that the cerebellum has a previously underestimated role in human pain perception and modulation.
journal_name
Painjournal_title
Painauthors
Ruscheweyh R,Kühnel M,Filippopulos F,Blum B,Eggert T,Straube Adoi
10.1016/j.pain.2014.04.006subject
Has Abstractpub_date
2014-07-01 00:00:00pages
1303-1312issue
7eissn
0304-3959issn
1872-6623pii
00006396-201407000-00020journal_volume
155pub_type
杂志文章相关文献
PAIN文献大全abstract::Previous work has suggested an attenuated sensitivity to painful stimulation in hypertensive men. We recently reported that, compared with persons with negative parental history, men, but not women, with a positive history for hypertension showed attenuated pain perception. This study specifically addressed factors th...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(00)00306-7
更新日期:2000-10-01 00:00:00
abstract::Acute microinjection of mu-, delta-, or kappa-opioid receptor (MOPr, DOPr, KOPr) agonists into the rostral ventromedial medulla (RVM) produces antinociception. Thermal antinociception produced by MOPr and DOPr agonists is potentiated during inflammation [Hurley RW, Hammond DL. The analgesic effects of supraspinal mu a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.07.010
更新日期:2008-06-01 00:00:00
abstract::In a double-blind, cross-over study, ibuprofen (600 mg), a peripherally-acting selective kappa-opioid receptor agonist (7.5 mg), or placebo were given orally in experiments on healthy volunteers 1 h before assessment of pain thresholds to radiant heat and of pain ratings to controlled mechanical impact stimuli. Mechan...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0304-3959(98)00062-1
更新日期:1998-06-01 00:00:00
abstract::Behavioral analgesic techniques such as distraction reduce pain in both clinical and experimental settings. Individuals differ in the magnitude of distraction-induced analgesia, and additional study is needed to identify the factors that influence the pain relieving effects of distraction. Catastrophizing, a set of ne...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.11.012
更新日期:2010-05-01 00:00:00
abstract::Chronic pain is frequently accompanied by a deterioration of emotional behavior and cognitive function. A small number of studies in humans concluded that pain-associated negative affect is more pronounced when pain is localized in the left side of the body. It has been suggested that such side bias results from corti...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.07.007
更新日期:2012-11-01 00:00:00
abstract::Diffuse noxious inhibitory controls (DNICs) utilize descending inhibitory controls through poorly understood brain stem pathways. The human counterpart, conditioned pain modulation, is reduced in patients with neuropathy aligned with animal data showing a loss of descending inhibitory noradrenaline controls together w...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000240
更新日期:2015-09-01 00:00:00
abstract::Heat and electrical detection thresholds were assessed in 72 patients suffering from painful temporomandibular disorder. Employing widely accepted criteria, 44 patients were classified as suffering from temporomandibular joint (TMJ) arthralgia (i.e. pain originating from the TMJ) and 28 from myalgia (i.e. pain origina...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(03)00077-0
更新日期:2003-08-01 00:00:00
abstract::This study examined the adaptational classification stability of the multidimensional pain inventory (MPI) in two samples of female fibromyalgia syndrome patients. Retest resulted in one-third of patients being assigned to a different classification. Twenty patients had four repeated MPI assessments over a 10-month pe...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.01.014
更新日期:2004-05-01 00:00:00
abstract::The relationship was investigated between algogenic potential of gallbladder pathology and occurrence/extent of sensory and trophic changes in the referred area. Five groups of subjects were studied, with: symptomatic gallbladder calculosis (3-20 colics); asymptomatic calculosis; symptomatic gallbladder shape abnormal...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.12.024
更新日期:2005-03-01 00:00:00
abstract::Preventing and treating opioid dependence and withdrawal is a major clinical challenge, and the underlying mechanisms of opioid dependence and withdrawal remain elusive. We hypothesized that prolonged morphine exposure or chronic inflammation-induced μ-opioid receptor activity serves as a severe stress that elicits ne...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001738
更新日期:2020-03-01 00:00:00
abstract::Chronic pain was induced in rats by daily injections of complete Freund's adjuvant into hind paws. Daily changes of pain threshold and endorphin (ED) content and their receptors in 4 divided parts: cortex, diencephalon-mesencephalon containing striatum (D-M), pons-medulla (P-M) and spinal cord, were measured. Decrease...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(83)90131-8
更新日期:1983-09-01 00:00:00
abstract::Chronic pain after tissue trauma is frequent and may have a lasting impact on the functioning and quality of life of the affected person. Despite this, chronic postsurgical and posttraumatic pain is underrecognised and, consequently, undertreated. It is not represented in the current International Classification of Di...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1097/j.pain.0000000000001413
更新日期:2019-01-01 00:00:00
abstract:ABSTRACT:Spinal cord stimulation (SCS) is an approved treatment for truncal and limb neuropathic pain. However, pain relief is often suboptimal and SCS efficacy may reduce over time, requiring sometimes the addition of other pain therapies, stimulator revision, or even explantation. We designed and tested a new procedu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002160
更新日期:2020-11-30 00:00:00
abstract::Our objectives were to determine whether procedural pain and glucose exposure are associated with altered structural and functional brain development differently in preterm males and females, and neurodevelopment at 18-month corrected age. Fifty-one very preterm neonates (22 males; median [interquartile range] gestati...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001123
更新日期:2018-03-01 00:00:00
abstract::We know little about the safety or efficacy of pharmacological medicines for children and adolescents with chronic pain, despite their common use. Our aim was to conduct an overview review of systematic reviews of pharmacological interventions that purport to reduce pain in children with chronic noncancer pain (CNCP) ...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1097/j.pain.0000000000001609
更新日期:2019-08-01 00:00:00
abstract::The nationwide multicenter trials of the German Research Network on Neuropathic Pain (DFNS) aim to characterize the somatosensory phenotype of patients with neuropathic pain. For this purpose, we have implemented a standardized quantitative sensory testing (QST) protocol giving a complete profile for one region within...
journal_title:Pain
pub_type: 杂志文章,多中心研究
doi:10.1016/j.pain.2006.01.041
更新日期:2006-08-01 00:00:00
abstract::Late-life depression and pain more often co-occur than can be explained by chance. Determinants of pain in late-life depression are unknown, even though knowledge on possible determinants of pain in depression is important for clinical practice. Therefore, the objectives of the present study were 1) to describe pain c...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.07.019
更新日期:2014-10-01 00:00:00
abstract::microRNAs (miRNAs) are small noncoding RNAs that have been linked to a number of disease-related signal transduction pathways. Several studies indicate that they are also involved in nociception. It is not clear, however, which miRNAs are important and which genes are modulated by miRNA-associated mechanisms. This stu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.11.010
更新日期:2013-03-01 00:00:00
abstract::The responses of 144 spinothalamic tract (STT) cells were recorded in 15 anesthetized macaque monkeys (Macaca fascicularis). Three to 4 weeks prior to the acute experiment, the sciatic nerve was surgically exposed on one or both sides so that capsaicin or vehicle could be applied. Responses of STT cells recorded in 3 ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(93)90227-G
更新日期:1993-06-01 00:00:00
abstract::Studies in healthy human subjects and patients with irritable bowel syndrome suggest sex differences in cerebral nociceptive processing. Here we examine sex differences in functional brain activation in the rat during colorectal distention (CRD), a preclinical model of acute visceral pain. [(14)C]-iodoantipyrine was i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.05.025
更新日期:2009-09-01 00:00:00
abstract::Sendide is a selective and extremely potent antagonist of neurokinin-1 (NK1) receptors in the mouse spinal cord. The antinociceptive activities of sendide, an antagonist of NK1 receptors, and its analogue, [D-Trp7]sendide have been examined after intrathecal (i.t.) administrations in the mouse paw formalin test. Intra...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)00107-P
更新日期:1995-02-01 00:00:00
abstract::This preliminary study examined the self-efficacy of family caregivers with regard to helping cancer patients manage pain at end of life. A sample of 63 family caregivers of hospice-eligible cancer patients with pain provided ratings of their self-efficacy in assisting the patient in pain management and rated their ow...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(02)00448-7
更新日期:2003-05-01 00:00:00
abstract::In the present study, Brandtstädter's (1992) distinction between assimilation and accommodation as two fundamental means of coping is applied to the field of chronic pain. Assimilative coping involves active attempts (e.g. instrumental activities, self-corrective actions, compensatory measures) to alter unsatisfactory...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(96)03108-9
更新日期:1996-09-01 00:00:00
abstract::Below-level central neuropathic pain (CNP) affects a large proportion of spinal cord injured individuals. To better define the dynamic changes of the spinal cord neural network contributing to the development of CNP after spinal cord injury (SCI), we characterized the morphological and behavioral correlates of CNP in ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000422
更新日期:2016-03-01 00:00:00
abstract::A 78-year-old male patient had chronic, unrelieved abdominal pain due to mesenteric ischaemia. Unsuccessful pharmacological approaches included oral morphine plus coadjuvants as well as a sympathetic celiac plexus block which gave pain relief that lasted for 72 h. In order to obtain long-lasting relief, a trial epidur...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(00)00266-9
更新日期:2000-07-01 00:00:00
abstract::Five hundred consecutive patients attending a psychiatric clinic were examined in order to ascertain the prevalence of chronic pain in various psychiatric illnesses and demographic categories. Chronic pain was found to be a frequent symptom in anxiety neurosis (60%), neurotic depression (45%) and hysteria (24.3%). Les...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(87)91039-6
更新日期:1987-05-01 00:00:00
abstract::Manipulative therapy is frequently used in the management of musculoskeletal pain. A frequently reported clinical feature of this treatment is the immediacy with which it appears to initiate improvement in pain and function. A randomised, double blind, placebo controlled, repeated measures design was employed to study...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0304-3959(96)03221-6
更新日期:1996-11-01 00:00:00
abstract::Although calcitonin gene-related peptide (CGRP) has been shown to be elevated in jugular venous blood of adult migraineurs during acute migraine attacks, it remains unknown whether CGRP is increased outside of attacks in jugular or cubital venous blood. The aim of the present study was to compare interictal plasma lev...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(00)00232-3
更新日期:2000-05-01 00:00:00
abstract::Forty patients with cancer pain receiving intermittent narcotics were admitted to a prospective study designed to assess the cognitive effects of narcotics. Twenty patients had undergone no change in narcotic dose or type greater than or equal to 7 days (stable dose, SD, group), and 20 patients had undergone an increa...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(89)90169-3
更新日期:1989-10-01 00:00:00
abstract::Intramedullary or subarachnoid injections of alumina cream were made in the lumbar region of 38 adult cats. The animals were observed for 3 to 12 months and then subjected to acute neurophysiologic and histologic analysis. Neuronal hyperactivity in the dorsal horns was reliably produced by either subarachnoid or intra...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(78)90011-8
更新日期:1978-10-01 00:00:00