Abstract:
:Sendide is a selective and extremely potent antagonist of neurokinin-1 (NK1) receptors in the mouse spinal cord. The antinociceptive activities of sendide, an antagonist of NK1 receptors, and its analogue, [D-Trp7]sendide have been examined after intrathecal (i.t.) administrations in the mouse paw formalin test. Intrathecal administration of sendide (in pmol) reduced both the early and late phases of the formalin-induced licking response. [D-Trp7]sendide also produced a significant antinociceptive response with less potent activity than sendide. Even highest doses (4000 pmol sendide and 8000 pmol [D-Trp7]sendide) examined, there was no motor paralysis of the hindlimbs. Intrathecal morphine inhibited both the early and late phases of the formalin-induced licking response in a dose-dependent manner. The results indicate that the antinociceptive effects of sendide and [D-Trp7]sendide may be mediated at NK1 receptors in the formalin-induced nociception.
journal_name
Painjournal_title
Painauthors
Sakurada T,Katsumata K,Yogo H,Tan-No K,Sakurada S,Ohba M,Kisara Kdoi
10.1016/0304-3959(94)00107-Psubject
Has Abstractpub_date
1995-02-01 00:00:00pages
175-180issue
2eissn
0304-3959issn
1872-6623pii
00006396-199502000-00009journal_volume
60pub_type
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