Women, but not men, report increasingly more pain during repeated (un)predictable painful electrocutaneous stimulation: Evidence for mediation by fear of pain.

abstract：:Intramedullary or subarachnoid injections of alumina cream were made in the lumbar region of 38 adult cats. The animals were observed for 3 to 12 months and then subjected to acute neurophysiologic and histologic analysis. Neuronal hyperactivity in the dorsal horns was reliably produced by either subarachnoid or intra...

journal_title：Pain

authors： Loeser JD,Peirce KR

更新日期：1978-10-01 00:00:00

abstract：:Extracellular signal-regulated kinase (ERK), a mitogen-activated protein kinases (MAPK), transduces a broad range of extracellular stimuli into diverse intracellular responses. Recent studies have showed that ERK activation in the supraspinal level involved in the development of drug dependence, especially in psycholo...

journal_title：Pain

authors： Cao JL,He JH,Ding HL,Zeng YM

更新日期：2005-12-05 00:00:00

abstract：:Evidence of the relationship between childhood abuse and pain problems in adulthood has been based on cross-sectional studies using retrospective self-reports of childhood victimization. The objective of the current study was to determine whether childhood victimization increases risk for adult pain complaints, using ...

journal_title：Pain

authors： Raphael KG,Widom CS,Lange G

更新日期：2001-05-01 00:00:00

abstract：:Coping with the demands of pain diminishes self-regulatory capacity and causes self-regulatory fatigue, which then leads to deteriorated executive task performance. It has been suggested that optimism can counteract the depletion of self-regulatory capacity. This study employed a 2 (optimism/no optimism)×2 (pain/no pa...

journal_title：Pain

authors： Boselie JJLM,Vancleef LMG,Smeets T,Peters ML

更新日期：2014-02-01 00:00:00

abstract：:We assessed for the first time the long-term maintenance of repetitive transcranial magnetic stimulation (rTMS)-induced analgesia in patients with chronic widespread pain due to fibromyalgia. Forty consecutive patients were randomly assigned, in a double-blind fashion, to 2 groups: one receiving active rTMS (n=20) and...

journal_title：Pain

authors： Mhalla A,Baudic S,de Andrade DC,Gautron M,Perrot S,Teixeira MJ,Attal N,Bouhassira D

更新日期：2011-07-01 00:00:00

abstract：:In this study, construct validity of 2 pain behaviour observation measurement instruments for young children aged 1 to 56 months (mean age was 20 months) with burns is assessed by using Rasch analysis. The Rasch model, wherein data should meet the model expectations, assumes that an instrument measures one unidimensio...

journal_title：Pain

authors： de Jong AEE,Tuinebreijer WE,Bremer M,van Komen R,Middelkoop E,van Loey N

更新日期：2012-11-01 00:00:00

abstract：:The analgesic efficacy of the novel anxiolytic buspirone in tests of acute thermal, mechanical and formalin-induced chemical-inflammatory pain were examined. Buspirone produced dose- and time-dependent analgesia in all nociceptive tests, with greatest effects against chemical and mechanical pain. Buspirone was less po...

journal_title：Pain

authors： Giordano J,Rogers L

更新日期：1989-10-01 00:00:00

abstract：:Combined oral administration of morphine sulfate (MS) and the over-the-counter antitussive drug and N-methyl-D-aspartate receptor antagonist dextromethorphan (DM) prevented the development of tolerance to the antinociceptive effects of MS (15, 24, or 32 mg/kg) in rats. This combined oral treatment regimen also attenua...

journal_title：Pain

authors： Mao J,Price DD,Caruso FS,Mayer DJ

更新日期：1996-10-01 00:00:00

abstract：:Fibromyalgia (FM) is a prevalent and disabling chronic disease. Recent studies have found elevated levels of glutamate in several brain regions, leading to hypotheses about the usefulness of glutamate-blocking drugs such as memantine in the treatment of FM. The aim of this study was to evaluate the efficacy of memanti...

journal_title：Pain

authors： Olivan-Blázquez B,Herrera-Mercadal P,Puebla-Guedea M,Pérez-Yus MC,Andrés E,Fayed N,López-Del-Hoyo Y,Magallon R,Roca M,Garcia-Campayo J

更新日期：2014-12-01 00:00:00

abstract：:The aim of this study was to investigate how exercise influenced endogenous pain modulation in healthy controls, shoulder myalgia patients and fibromyalgia (FM) patients. Twenty-one healthy subjects, 20 shoulder myalgia patients and 20 FM patients, all females, participated. They performed standardized static contract...

journal_title：Pain

authors： Lannersten L,Kosek E

更新日期：2010-10-01 00:00:00

abstract：:Tanezumab is a humanized monoclonal antibody that specifically inhibits nerve growth factor as a treatment for chronic pain. This phase IIB study investigated the efficacy and safety of tanezumab for chronic low back pain vs placebo and naproxen. Patients (N=1347) received intravenous tanezumab (5, 10, or 20mg every 8...

journal_title：Pain

authors： Kivitz AJ,Gimbel JS,Bramson C,Nemeth MA,Keller DS,Brown MT,West CR,Verburg KM

更新日期：2013-07-01 00:00:00

abstract：:Dysfunction in the motor system is a feature of persistent whiplash associated disorders. Little is known about motor dysfunction in the early stages following injury and of its progress in those persons who recover and those who develop persistent symptoms. This study measured prospectively, motor system function (ce...

journal_title：Pain

authors： Sterling M,Jull G,Vicenzino B,Kenardy J,Darnell R

更新日期：2003-05-01 00:00:00

abstract：:The effect of the central grey matter (CG) on pain sensitivity has been investigated in rats. It has been demonstrated that baseline pain thresholds, tested by the hot plate method (HPM) after surgical operation, were significantly greater in CG-lesioned rats than in controls. Baseline tail flick latencies did not dif...

journal_title：Pain

authors： Bragin EO,Vasilenko GF,Durinjan RA

更新日期：1983-05-01 00:00:00

abstract：:Concerns over prescription opioids contributing to high levels of opioid use disorder and overdose have led policymakers and clinicians to seek means to reduce inappropriate and high-dose initial prescriptions. To inform such efforts, we sought to describe the clinical indications associated with opioid initiation and...

journal_title：Pain

authors： Pasricha SV,Tadrous M,Khuu W,Juurlink DN,Mamdani MM,Paterson JM,Gomes T

更新日期：2018-08-01 00:00:00

abstract：:Pain is processed in multiple cortical and subcortical brain areas. Subcortical structures are substantially involved in different processes that are closely linked to pain processing, e.g. motor preparation, autonomic responses, affective components and learning. However, it is unclear to which extent nociceptive inf...

journal_title：Pain

authors： Bingel U,Quante M,Knab R,Bromm B,Weiller C,Büchel C

更新日期：2002-09-01 00:00:00

abstract：:Peripheral nerve injury produces a persistent neuropathic pain state characterized by spontaneous pain, allodynia and hyperalgesia. In this study, we evaluated the possible involvement of A 2ARs in the development of neuropathic pain and the expression of microglia and astrocytes in the spinal cord after sciatic nerve...

journal_title：Pain

authors： Bura AS,Nadal X,Ledent C,Maldonado R,Valverde O

更新日期：2008-11-15 00:00:00

abstract：:Part I of our earlier pilot study demonstrated that patients preferred modulated stimulation forms - frequency modulation and burst - rather than conventional continuous mode. To assess whether long-term therapeutic effects validate the immediate test results, this trial was performed in 14 patients with 21 pain condi...

journal_title：Pain

authors： Tulgar M,McGlone F,Bowsher D,Miles JB

更新日期：1991-11-01 00:00:00

abstract：:In a double-blind, crossover study, the effects of 75 mg amitriptyline alone during 5 weeks on pain intensity were compared with the effects of a combination of 75 mg amitriptyline and 3 mg flupentixol during 5 weeks in 34 patients with somatoform pain disorder. Both treatments resulted in a statistically significant ...

journal_title：Pain

authors： Zitman FG,Linssen ACG,Edelbroek PM,Van Kempen GMJ

更新日期：1991-10-01 00:00:00

abstract：:Heterotopic noxious counterstimulation (HNCS) by the application of a sustained noxious stimulus has been shown to inhibit nociceptive processes and decrease pain induced by a competing noxious stimulus. However, it is still not clear how attentional processes contribute to these effects. The main objective of this st...

journal_title：Pain

authors： Ladouceur A,Tessier J,Provencher B,Rainville P,Piché M

更新日期：2012-08-01 00:00:00

abstract：:The antinociception effect of clomipramine and the combination of clomipramine and morphine was evaluated using the constant temperature hot plate test, the increasing temperature hot plate test and the formalin test in mice. Both a single dose of clomipramine (10 mg/kg) given intraperitoneally (i.p.) and chronic clom...

journal_title：Pain

authors： Rosland JH,Hunskaar S,Hole K

更新日期：1988-06-01 00:00:00

abstract：:The efficacy of amitriptyline was evaluated in 28 patients with chronic oral-facial pain. Most of the patients had evidence of musculoskeletal pain while some had a history suggesting pain of neurogenic origin. Two patients had mixed elements of neurogenic and musculoskeletal pain. Amitriptyline was more effective tha...

journal_title：Pain

authors： Sharav Y,Singer E,Schmidt E,Dionne RA,Dubner R

更新日期：1987-11-01 00:00:00

abstract：:The ability to sense visceral pain during appendicitis is diminished with age leading to delay in seeking health care and poorer clinical outcomes. To understand the mechanistic basis of this phenomenon, we examined visceral nociception in aged mouse and human tissue. Inflamed and noninflamed appendixes were collected...

journal_title：Pain

authors： Cibert-Goton V,Kung VWS,McGuire C,Hockley JRF,Tranter MM,Dogra H,Belai A,Blackshaw LA,Sanger GJ,Knowles CH,Araujo EJA,Winchester WJ,Bulmer DC

更新日期：2020-04-01 00:00:00

abstract：:This study aimed to identify areas of disagreement in the management of neurogenic pain. A short questionnaire was mailed to 179 consultants with an interest in chronic pain (response rate 89%). The questionnaire listed 11 specific conditions involving nerve pain (e.g., post-herpetic neuralgia, causalgia) together wit...

journal_title：Pain

authors： Davies HTO,Crombie IK,Macrae WA

更新日期：1993-09-01 00:00:00

abstract：:One year follow-up data are analyzed for the effects of using transcutaneous neurostimulators on patients with chronic benign pain. Those who have successful surgery for pain relief have lower pain and analgesic intake levels than those who supplement their surgery with neurostimulation. Those who do not receive surge...

journal_title：Pain

authors： Sternbach RA,Ignelzi RJ,Deems LM,Timmermans G

更新日期：1976-03-01 00:00:00

abstract：:The existence of prostaglandin (PG) receptors in the spinal cord has been demonstrated, but their role in sensory processing is not yet well defined. PGE1 is widely used clinically as a vasodilator. The present study was designed to investigate the effects of intrathecally administered PGE1 on the transmission of diff...

journal_title：Pain

authors： Saito Y,Kaneko M,Kirihara Y,Kosaka Y,Collins JG

更新日期：1995-12-01 00:00:00

abstract：:Eight patients with established lower limb postamputation stump pain were given lumbar intrathecal fentanyl 25 micrograms and lidocaine 70 mg 2 weeks apart in an attempt to better understand the role of peripheral and central mechanisms in this condition. Baseline pain was recorded and then analgetic and side effects ...

journal_title：Pain

authors： Jacobson L,Chabal C,Brody MC,Mariano AJ,Chaney EF

更新日期：1990-02-01 00:00:00

abstract：:Clinical observations and recent studies suggest that arthritis patients vary considerably in their involvement in self-management efforts. In the literature on health promotion, there is growing recognition that patients may be at different stages of change with respect to the adoption of self-management strategies. ...

journal_title：Pain

authors： Keefe FJ,Lefebvre JC,Kerns RD,Rosenberg R,Beaupre P,Prochaska J,Prochaska JO,Caldwell DS

更新日期：2000-09-01 00:00:00

abstract：:The superficial dorsal horn, which is the main target for nociceptive and pruritoceptive primary afferents, contains a high density of excitatory interneurons. Our understanding of their roles in somatosensory processing has been restricted by the difficulty of distinguishing functional populations among these cells. ...

journal_title：Pain

authors： Gutierrez-Mecinas M,Bell AM,Marin A,Taylor R,Boyle KA,Furuta T,Watanabe M,Polgár E,Todd AJ

更新日期：2017-03-01 00:00:00

abstract：:A variety of molecules released by inflammatory reactions in the dorsal root and dorsal root ganglion (DRG) may play important roles in the pathology of neuronal abnormalities in lumbar disc herniation. In order to elucidate the pathophysiological mechanisms of painful radiculopathy, secondary to lumbar disc herniatio...

journal_title：Pain

authors： Obata K,Tsujino H,Yamanaka H,Yi D,Fukuoka T,Hashimoto N,Yonenobu K,Yoshikawa H,Noguchi K

更新日期：2002-09-01 00:00:00

abstract：:The ability of a painful stimulus to suppress pain in another, remote area (DNIC) has been intensely studied. However, the effect of the distance between the two painful stimuli and the attentional factors during the measurement of pain perception received minimal treatment. We evaluated the effect of these factors on...

journal_title：Pain

authors： Defrin R,Tsedek I,Lugasi I,Moriles I,Urca G

更新日期：2010-11-01 00:00:00