Abstract:
:The efficacy of amitriptyline was evaluated in 28 patients with chronic oral-facial pain. Most of the patients had evidence of musculoskeletal pain while some had a history suggesting pain of neurogenic origin. Two patients had mixed elements of neurogenic and musculoskeletal pain. Amitriptyline was more effective than placebo in reducing pain after 4 weeks of treatment. No effect was found after only 1 week of drug administration in either dose range. When the patients were divided into depressed and non-depressed groups based on their Hamilton depression scores, amitriptyline reduced pain in the depressed and in the non-depressed groups as compared to placebo. Amitriptyline reduced the depression scores in the depressed group but had no effect on the depression scores in the non-depressed group. Thus, pain reduction was not associated with a change in mood in the non-depressed group. Amitriptyline had no effect on patients' ratings of the intensity of experimental heat stimuli. We conclude that amitriptyline is effective in the treatment of chronic oral-facial pain and that its efficacy is independent of its effects on depression. It appears that tricyclic antidepressants act in a fashion different from opiate drugs that alter the sensory discriminative component of pain.
journal_name
Painjournal_title
Painauthors
Sharav Y,Singer E,Schmidt E,Dionne RA,Dubner Rdoi
10.1016/0304-3959(87)90036-4subject
Has Abstractpub_date
1987-11-01 00:00:00pages
199-209issue
2eissn
0304-3959issn
1872-6623pii
00006396-198711000-00005journal_volume
31pub_type
临床试验,杂志文章相关文献
PAIN文献大全abstract::Rats and humans manifest elevated response thresholds to aversive stimuli during gestation and parturition. This pregnancy-associated antinociception is mediated, in part, by a spinal cord dynorphin/kappa antinociceptive system. Simulating the maternal pregnancy blood concentration profile (in non-pregnant animals) of...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(95)00092-5
更新日期:1996-01-01 00:00:00
abstract::Percentage of pain intensity difference (PercentPID) is a recognized way of evaluating pain relief with an 11-point numerical rating scale (NRS) but is not without flaws. A new metric, the slope of relative pain intensity difference (SlopePID), which consists in dividing PercentPID by the time between 2 pain measureme...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000382
更新日期:2016-02-01 00:00:00
abstract::This study determined preoperative predictors of movement and resting pain following total knee replacement (TKR). We hypothesized that younger patients with higher preoperative pain intensity, pain sensitivity, trait anxiety, pain catastrophizing, and depression would be more likely to experience higher postoperative...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.06.021
更新日期:2012-11-01 00:00:00
abstract::This study analyzed the relationship between the density of intraepidermal nerve fibers (IENF) and the characteristics of either nociceptive laser-evoked potentials (LEPs) or contact heat-evoked potentials (CHEPs) in patients with painful sensory polyneuropathy with the aim to determine which parameters of LEPs and CH...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.11.012
更新日期:2011-02-01 00:00:00
abstract::It has been suggested that a number of peptides may be involved in the transmission of pain. In order to evaluate the possible role of peptides in the development of headache, we have, in the present study, examined the presence of nerve fibres containing neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), subs...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(86)90162-4
更新日期:1986-12-01 00:00:00
abstract::Indicators of persistent pain in preterm neonates are poorly defined. In the setting of a double blind, placebo-controlled trial investigating morphine use in ventilated preterm infants (NEOPAIN Trial) we aimed to identify factors that may be useful in assessing persistent pain. Twenty-two babies (morphine 12; placebo...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2006.03.019
更新日期:2006-09-01 00:00:00
abstract::Fibromyalgia is a painful syndrome of non-articular origin, predominantly involving muscles, and the commonest cause of chronic widespread musculoskeletal pain. The diversity of therapeutic programs for patients with fibromyalgia reflects both the lack of a known pathophysiology for this disorder and the low efficacy ...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(95)00199-9
更新日期:1996-05-01 00:00:00
abstract::Internet-delivered interventions are emerging as a strategy to address barriers to care for individuals with chronic pain. This is the first large multicenter randomized controlled trial of Internet-delivered cognitive-behavioral therapy (CBT) for pediatric chronic pain. Participants included were 273 adolescents (205...
journal_title:Pain
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/j.pain.0000000000000348
更新日期:2016-01-01 00:00:00
abstract::Capsaicin elicits burning pain via the activation of the vanilloid receptor (TRPV1). Intriguingly, several reports showed that capsaicin also inhibits Na+ currents but the mechanisms remain unclear. To explore this non-TRPV1 action we applied capsaicin to HEK293 cells stably expressing inactivation-deficient rat skele...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.08.002
更新日期:2007-01-01 00:00:00
abstract::The neurochemical effects of adenosine signaling in small-fiber neuropathy leading to neuropathic pain are yet to be explored in a direct manner. This study examined this system at the level of ligand (through the ectonucleotidase activity of prostatic acid phosphatase [PAP]) and adenosine A1 receptors (A1Rs) in resin...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001246
更新日期:2018-08-01 00:00:00
abstract::The aim of the present study has been to assess the responsiveness of various types of chronic pain to opioids given i.v. and tested against placebo in a double-blind, randomized fashion. Pain classified as primary nociceptive was effectively alleviated (P greater than 0.001) while neuropathic deafferentation pain was...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(88)90198-4
更新日期:1988-04-01 00:00:00
abstract::Regular physical activity in healthy individuals prevents development of chronic musculoskeletal pain; however, the mechanisms underlying this exercise-induced analgesia are not well understood. Interleukin-10 (IL-10), an antiinflammatory cytokine that can reduce nociceptor sensitization, increases during regular phys...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000312
更新日期:2016-01-01 00:00:00
abstract::This was a multicenter, double-blind (DB), placebo-controlled, randomized discontinuation trial to evaluate the efficacy of pregabalin monotherapy for durability of effect on fibromyalgia (FM) pain. The trial included a 6-week open-label (OL) pregabalin-treatment period followed by 26-week DB treatment with placebo or...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2008.02.027
更新日期:2008-06-01 00:00:00
abstract::The objective of this study was to examine pain as a predictor of frailty over 18 years of follow-up among older Mexican Americans who were nonfrail at baseline. Data were from a prospective cohort study of 1545 community-dwelling Mexican Americans aged ≥67 years from the Hispanic Established Populations for the Epide...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001711
更新日期:2020-01-01 00:00:00
abstract::Chronic pain is currently considered a public health problem with high costs to the individual and society. To improve prevention and treatment of chronic pain, epidemiologic studies are mandatory for assessing chronic pain. The aims of this study were to estimate the prevalence of chronic pain in the adult Danish pop...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.07.023
更新日期:2012-12-01 00:00:00
abstract::In 1864, W. Mitchell and colleagues first described the clinical syndrome which came to be known as 'causalgia'. Since that time, the concept of sympathetically related pain has evolved. There is general agreement that profound emotional and behavioural changes can follow these types of pain. Opinions have varied wide...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/0304-3959(92)90241-3
更新日期:1992-06-01 00:00:00
abstract::Back pain is a leading cause of disability. Previous research suggests that modifiable risk factors influence recovery from back pain, and practice guidelines recommend integrating such factors within primary care management. Toward this goal, a brief, multidimensional questionnaire, the STarT Back Tool, was designed ...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2012.06.010
更新日期:2012-11-01 00:00:00
abstract::Pain catastrophizing is associated with enhanced temporal summation of pain (TS-Pain). However, because prior studies have found that pain catastrophizing is not associated with a measure of spinal nociception (nociceptive flexion reflex [NFR] threshold), this association may not result from changes in spinal nocicept...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.12.041
更新日期:2011-04-01 00:00:00
abstract::Inflammation induces an up-regulation of neuropeptide tyrosine (NPY) and its receptors in the dorsal horn, suggesting an important role in nociceptive transmission. Our initial studies revealed that NPY dose-dependently increased hotplate response latency, and to a lesser degree, thermal paw withdrawal latency (PWL); ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(01)00481-X
更新日期:2002-04-01 00:00:00
abstract::The aim of the present study was to determine if acupuncture stimulation inhibits sympathetic nerve activity in humans. Multiunit efferent postganglionic sympathetic activity was recorded with a tungsten microelectrode inserted in a muscle fascicle of the peroneal nerve. Mean arterial pressure, heart rate and skin blo...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/S0304-3959(97)00197-8
更新日期:1998-03-01 00:00:00
abstract::The ability of a painful stimulus to suppress pain in another, remote area (DNIC) has been intensely studied. However, the effect of the distance between the two painful stimuli and the attentional factors during the measurement of pain perception received minimal treatment. We evaluated the effect of these factors on...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.08.009
更新日期:2010-11-01 00:00:00
abstract::Ziconotide is a nonopioid intrathecal analgesic drug used to manage moderate to severe chronic pain. The aim of this work is to assess the safety and efficacy of intrathecal (IT) combination of ziconotide and morphine in malignant pain refractory to high doses of oral opioids. Patients with malignant pain refractory t...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.10.002
更新日期:2012-01-01 00:00:00
abstract::A chronic compression of the dorsal root ganglion (CCD) produces ipsilateral cutaneous hyperalgesia and allodynia in rats. Intracellular electrophysiological recordings from formerly compressed neurons in the intact dorsal root ganglion (DRG) reveal lower than normal current thresholds (CTs) and abnormal spontaneous a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.10.001
更新日期:2005-01-01 00:00:00
abstract::Chronic pain after tissue trauma is frequent and may have a lasting impact on the functioning and quality of life of the affected person. Despite this, chronic postsurgical and posttraumatic pain is underrecognised and, consequently, undertreated. It is not represented in the current International Classification of Di...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1097/j.pain.0000000000001413
更新日期:2019-01-01 00:00:00
abstract::Endometriosis, an estrogen-dependent chronic inflammatory disease, is the most common cause of chronic pelvic pain. Here, we investigated the effects of linaclotide, a Food and Drug Administration-approved treatment for IBS-C, in a rat model of endometriosis. Eight weeks after endometrium transplantation into the inte...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001657
更新日期:2019-11-01 00:00:00
abstract::Chronic pain often interferes with daily functioning, and may become a threat to an individual's sense of self. Despite the development of a recent theoretical account focussing upon the relationship between the presence of chronic pain and a person's self, research investigating this idea is limited. In the present s...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2013.07.055
更新日期:2013-12-01 00:00:00
abstract::Forty patients with cancer pain receiving intermittent narcotics were admitted to a prospective study designed to assess the cognitive effects of narcotics. Twenty patients had undergone no change in narcotic dose or type greater than or equal to 7 days (stable dose, SD, group), and 20 patients had undergone an increa...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(89)90169-3
更新日期:1989-10-01 00:00:00
abstract::Although perceived control has been used as a means of reducing the reaction to pain, conceptually, much is still unclear. The purpose of this study was to clarify the effects of control as a mediating variable in the reaction to pain as a function of the predispositional variables of perceived self-efficacy and trait...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(85)90059-4
更新日期:1985-10-01 00:00:00
abstract::P2X3 purinoceptor cellular distribution was studied in rat sensory neurons in naive animals and following peripheral nerve injury using immunohistochemical methods. Specific antiserum was raised in rabbits and characterized by Western blot, absorption assays and labeling of recombinant receptors. In naive animals, P2X...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(98)00225-5
更新日期:1999-03-01 00:00:00
abstract::The behavioural response of infant rats to intraplantar injection of formalin consists of specific directed behaviours (limb flexion, shaking and licking the injected paw) and non-specific behaviours that are also induced by non-nociceptive stimulation (squirming, hind limb kicks and whole body jerks), with specific i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)00277-L
更新日期:1995-09-01 00:00:00