Abstract:
:Indicators of persistent pain in preterm neonates are poorly defined. In the setting of a double blind, placebo-controlled trial investigating morphine use in ventilated preterm infants (NEOPAIN Trial) we aimed to identify factors that may be useful in assessing persistent pain. Twenty-two babies (morphine 12; placebo 10) were assessed for comfort, pain or distress and clinical staff described the factors they had considered. This assessment was performed during the first period of duty with the baby. Based on this, they stated which study drug they believed the infant was receiving. Eighty-nine assessments were made in total (1-14 per baby). The drug was correctly identified on 71% of occasions. Staff considered one or more of the following factors: infant activity; response to routine care; known pain-related behaviours; posture/quality of movements; respiratory effort; synchrony with ventilator; blood pressure and heart rate. Four factors most frequently identified babies receiving placebo: facial expressions of pain, high activity levels, poor response to handling and poor synchrony with ventilation. Absence of pain-related behaviour was less discriminating. Observation of a good response to handling, good synchrony with ventilation, a "settled" baby, normal blood pressure and heart rate were poor discriminators. Hypotension and poor respiratory drive were noted exclusively in babies receiving morphine infusions. Facial expressions of pain, high activity levels, poor response to routine care, and poor ventilator synchrony were associated with placebo versus morphine therapy, and may be considered useful markers for persistent pain in preterm infants.
journal_name
Painjournal_title
Painauthors
Boyle EM,Freer Y,Wong CM,McIntosh N,Anand KJdoi
10.1016/j.pain.2006.03.019subject
Has Abstractpub_date
2006-09-01 00:00:00pages
87-91issue
1-2eissn
0304-3959issn
1872-6623pii
S0304-3959(06)00185-0journal_volume
124pub_type
杂志文章,随机对照试验相关文献
PAIN文献大全abstract::Adrenal medullary transplants in the spinal subarachnoid space, by providing a continual source of opioid peptides and catecholamines, offer a potentially important adjunct in the management of chronic pain. While previous studies have shown that this approach is effective against high-intensity phasic stimuli, adrena...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(93)90135-C
更新日期:1993-02-01 00:00:00
abstract::The effects of pretreatment with desipramine, a selective noradrenaline (NA) uptake blocker, on spinal antinociception by 5-hydroxytryptamine (5-HT), morphine and an adenosine analog (NECA) in the rat hot-plate test were examined to determine if endogenous NA is involved in the spinal action of these agents. Desiprami...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90118-U
更新日期:1992-07-01 00:00:00
abstract::A wide range of environmental stimuli have been shown to induce antinociception. Investigation of the brain regions contributing to environmentally induced antinociception (EIA) has focused primarily on the effect of disrupting neural transmission at various CNS sites. In contrast, the present study analyzed changes i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(93)90108-2
更新日期:1993-01-01 00:00:00
abstract::When a peripheral nerve is severed, damaged sensory fibers emit a barrage of impulses that lasts for many seconds, or even several minutes ('injury discharge'). We have shown in rats that local anesthetic blockade of this discharge suppresses autotomy (a behavioral model of neuropathic pain). Correspondingly, mimickin...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90166-U
更新日期:1991-04-01 00:00:00
abstract::Numerous behavioral pain measures have been validated for young children, but none is appropriate to assess pain in emergency departments (EDs), where caregivers need a simple, easily completed scale. Our objective was to elaborate and validate a tool, relevant in any painful situation, with agitation or prostration, ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.02.024
更新日期:2012-08-01 00:00:00
abstract::Intradental nerve activity (INA) induced by cold stimulation of human teeth is regularly accompanied by pain perception. In this study a mathematical model was developed in order to quantify the relationship between INA and pain. In 5 patients (45 experiments) INA was recorded using electrodes implanted in lower incis...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90052-6
更新日期:1984-04-01 00:00:00
abstract::Primary afferent sensory neurons are incredibly long cells, often traversing distances of over 1 m in humans. Cutaneous sensory stimuli are transduced in the periphery by specialised end organs or free nerve endings, which code the stimulus into electrical action potentials that propagate towards the central nervous s...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001145
更新日期:2018-07-01 00:00:00
abstract::Pharmacological actions on the nociceptive flexion flexes of the hindlimb were investigated in 14 normal subjects. These reflexes were used as an index of pain and were recorded in the biceps femoris muscle, elicited by electrical stimulation of the ipsilateral sural nerve (RIII,su) and of the skin in the distal recep...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(77)90074-4
更新日期:1977-04-01 00:00:00
abstract::Blockade of the noradrenergic input to the nucleus raphe magnus (NRM) by the injection of alpha-adrenergic antagonists produces hypoalgesia. Previous studies show that this hypoalgesia is blocked by the intrathecal injection of either phentolamine or methysergide. The present study demonstrates that depletion of spina...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(83)90113-6
更新日期:1983-07-01 00:00:00
abstract::The aim of this study was to investigate the relationship between psychosocial work characteristics and neck and upper limb symptoms and to examine to what extent this relationship could be explained by other risk factors. Data were used from a prospective cohort study in a working population, with a follow-up period ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.12.008
更新日期:2005-03-01 00:00:00
abstract::Approximately 70-80% of women meeting criteria for borderline personality disorder (BPD) report attenuated pain perception or analgesia during non-suicidal, intentional self-mutilation. The aim of this study was to use laser-evoked potentials (LEPs) and psychophysical methods to differentiate the factors that may unde...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.04.035
更新日期:2004-07-01 00:00:00
abstract::Our previous studies in the Sprague-Dawley rat showed that the intrinsic antinociceptive effects of oxycodone are naloxone reversible in a manner analogous to morphine but that in contrast to morphine, oxycodone's antinociceptive effects have a rapid onset of maximum effect (approximately 5-7 min compared to 30-45 min...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(97)00093-6
更新日期:1997-11-01 00:00:00
abstract::Transcutaneous nerve stimulation (TENS) treatment was given for 30 min to 37 patients divided into 3 groups of 10 patients and 1 group of 7 patients. Two groups received low-frequency (2 Hz) and the other 2 groups high-frequency (100 Hz) stimulation. A diagnostic lumbar cerebrospinal fluid (CSF) sample was obtained im...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90218-M
更新日期:1991-12-01 00:00:00
abstract::The antinociception induced by the intraperitoneal coadministration of combinations of paracetamol with the nonsteroidal anti-inflammatory drugs (NSAIDs) diclofenac, ibuprofen, ketoprofen, meloxicam, metamizol, naproxen, nimesulide, parecoxib and piroxicam was studied by isobolographic analysis in the acetic acid abdo...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2005.11.012
更新日期:2006-03-01 00:00:00
abstract::Sensitization of purinergic P2X3 receptors (P2X3Rs) is a major mechanism contributing to injury-induced exaggerated pain responses. We showed in a previous study that cyclic adenosine monophosphate (cAMP)-dependent guanine nucleotide exchange factor 1 (Epac1) in rat sensory dorsal root ganglia (DRGs) is upregulated af...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000547
更新日期:2016-07-01 00:00:00
abstract::The current investigation studied the effectiveness of a secondary prevention program for nurses with back pain who were deemed at risk for developing a chronic problem. A 2 X 3 repeated measures design was employed with 2 groups and 3 assessment periods. The treatment group received an intervention designed to reduce...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(89)90024-9
更新日期:1989-02-01 00:00:00
abstract::(1) Quantitative measurements of somatosensory thresholds and skin temperature were made before (24 cases), 3-5 days after (12 cases), and 6 months after (11 cases) successful radiofrequency thermocoagulation of the proximal root and gasserian ganglion in 24 cases of idiopathic trigeminal neuralgia (TGN), 18 of whom h...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)91121-X
更新日期:1990-03-01 00:00:00
abstract::Aerobic exercise has been shown to activate endogenous opioid and adrenergic systems and attenuate experimental pain in normal control subjects (NC). In contrast, fibromyalgia (FM) subjects' experimental pain ratings increase after aerobic exercise, suggestive of abnormal pain modulation. In order to determine whether...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2005.08.007
更新日期:2005-11-01 00:00:00
abstract::Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide found primarily in the C and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the central nervous system. Calcitonin gene-related peptide was found to play important roles in cardiovascular, digestive, and sensory functi...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1097/j.pain.0000000000000831
更新日期:2017-04-01 00:00:00
abstract::An 82-year-old woman experienced generalized pruritus not due to skin or systemic disease. Scratching the skin with a needle induced a crisis of intense pruritus, insensitive to any drug. The pruritus had the characteristics of a central sensation. ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90055-3
更新日期:1991-06-01 00:00:00
abstract::Involvement of the NMDA receptor system in the transmission of nociceptive information, including the development of central sensitization and a wind-up phenomenon, has increased interest in NMDA-receptor antagonists as antinociceptive drugs. This case report describes the use of an NMDA receptor antagonist 3-(2-carbo...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90266-E
更新日期:1992-11-01 00:00:00
abstract::Pain that interferes with daily life appears to be strongly age-related in cross-sectional studies, although the nature of this relationship over time has not been established. We have investigated the onset and persistence of pain and pain interference over a 3-year period to determine their association with age in o...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.09.027
更新日期:2007-05-01 00:00:00
abstract::Electron microscopy was used to study normal human extracted teeth in order to define the junctions between sensory nerve endings and other cells in external pulp and inner dentin at the crown tip. Two sets of associated cells were found: (1) Connective tissue cells. The pulpal fibroblast newtork made occasional desmo...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(82)90012-4
更新日期:1982-07-01 00:00:00
abstract::Two classes of neurons with distinct responses to opioids have been identified in the rostral ventromedial medulla (RVM), a region with a well-documented role in nociceptive modulation. 'On-cells' are directly inhibited by opioids, and opioids can thus gain access to the modulatory circuitry of the RVM by an action on...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(97)00226-1
更新日期:1998-04-01 00:00:00
abstract::The analgesic efficacy of single doses of oral morphine sulphate solution (10 mg) and ibuprofen 600 mg was compared in 12 volunteers using a double-blind, double-dummy, placebo-controlled design on the cold pressor experimental pain model. Measurement of pain intensity was made before medication and then at 30, 60, 90...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(88)90156-X
更新日期:1988-08-01 00:00:00
abstract::High-quality information on the potential benefit and harm of a drug is required for patients and clinicians to make informed treatment decisions and to enable cost-effectiveness modeling to be undertaken. This systematic review describes the collection and reporting of adverse event data as presented in published cli...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/j.pain.2012.08.012
更新日期:2013-02-01 00:00:00
abstract::Noxious C-fibre stimulation produces increased sensitivity within the injured area (primary hyperalgesia), and a surrounding zone of secondary hyperalgesia. As significant changes in nociceptive processing occur during development, we compared C-fibre induced primary and secondary hyperalgesia in rat pups aged 3, 10 a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.09.015
更新日期:2007-03-01 00:00:00
abstract::Tissue acidosis due to ischemia occurs under several pathological conditions and is believed to contribute to pain in these circumstances. TRPV1, TRPA1, and ASICs are known to be sensitive to acidic pH. Addressing their possible role in acidosis perception, the respective antagonists BCTC, A-967079, and amiloride were...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001848
更新日期:2020-07-01 00:00:00
abstract::Individual differences in interoceptive sensitivity are associated with differences in reported intensity of emotional experience, vulnerability to anxiety and mood disorder and capacity for emotional self-regulation. Enhanced sensitivity to autonomic state is often accompanied by increased autonomic reactivity. Here ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.04.030
更新日期:2012-08-01 00:00:00
abstract::Chronic pain not only interferes with daily activities, it may also have a negative impact on the perceived integrity of one's self through self-discrepancies. Self-discrepancies are experienced distances between the actual self and self-guides that can exist from 2 perspectives (ie, own and other). Self-discrepancies...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.11.009
更新日期:2011-02-01 00:00:00