Desipramine potentiates spinal antinociception by 5-hydroxytryptamine, morphine and adenosine.

abstract：:Measurement of depression and other mood states in pain patients has been criticised in recent years on the grounds that most questionnaires were not developed in pain populations and suffer from criterion contamination by somatic items. In addition, there is no accepted measurement for positive emotions which are mor...

journal_title：Pain

authors： Pincus T,Williams AC,Vogel S,Field A

更新日期：2004-05-01 00:00:00

abstract：:Pain-related diseases are the top leading causes of life disability. Identifying brain regions involved in persistent neuronal changes will provide new insights for developing efficient chronic pain treatment. Here, we showed that anterior nucleus of paraventricular thalamus (PVA) plays an essential role in the develo...

journal_title：Pain

authors： Chang YT,Chen WH,Shih HC,Min MY,Shyu BC,Chen CC

更新日期：2019-05-01 00:00:00

abstract：:The responses of primate spinothalamic tract (STT) neurons to innocuous and noxious mechanical stimuli applied to the skin can be enhanced for more than an hour following prolonged noxious stimulation. This increased responsiveness is thought to reflect sensitization of dorsal horn neurons and may help account for sec...

journal_title：Pain

authors： Paleček J,Palečková V,Dougherty PM,Willis WD

更新日期：1994-03-01 00:00:00

abstract：:Ten patients who suffered from severe cancer-related pain participated in a randomised, double-blind and cross-over study to compare the effectiveness and acceptability of epidural and subcutaneous administration of morphine. The patients titrated themselves pain-free in 48 h using a patient controlled analgesia syste...

journal_title：Pain

authors： Kalso E,Heiskanen T,Rantio M,Rosenberg PH,Vainio A

更新日期：1996-10-01 00:00:00

abstract：:Preliminary reports have shown that hyperbaric oxygen (HBO) interrupts cluster headache (CH) attacks. In the present study, 6 of 7 patients with episodic cluster headache who were treated with hyperbaric oxygen experienced an interruption of the attack. In 3 of 6 responders the florid period of the cluster headache wa...

journal_title：Pain

authors： Di Sabato F,Fusco BM,Pelaia P,Giacovazzo M

更新日期：1993-02-01 00:00:00

abstract：:Supraspinal opioid analgesia is mediated in part by connections between the periaqueductal gray (PAG) and rostral ventromedial medulla (RVM). Morphine analgesia elicited from the PAG is respectively decreased by selective serotonergic and opioid receptor antagonists administered into the RVM, and increased by RVM neur...

journal_title：Pain

authors： Spinella M,Cooper ML,Bodnar RJ

更新日期：1996-03-01 00:00:00

abstract：:Dynorphin A is an endogenous opioid peptide, which has previously been shown to produce a long-lasting allodynia and hyperalgesia in mice, behavioral states consistent with signs of clinically observed neuropathic pain. This dynorphin-induced allodynia was used as a pharmacological, central model of neuropathic pain. ...

journal_title：Pain

authors： Laughlin TM,Bethea JR,Yezierski RP,Wilcox GL

更新日期：2000-02-01 00:00:00

abstract：:In previous studies, pain behaviors produced in the spinal nerve ligation rat model of neuropathic pain were partly reduced by surgical lumbar sympathectomy. However, systemic injection of phentolamine, an alpha-adrenoceptor blocker, was not effective in reducing pain behaviors, at least in the Sprague-Dawley strain o...

journal_title：Pain

authors： Park SK,Chung K,Chung JM

更新日期：2000-08-01 00:00:00

abstract：:Musculoskeletal disorders (MSDs) are highly prevalent, painful, and costly disorders. The MSD Cohort was created to characterize variation in pain, comorbidities, treatment, and outcomes among patients with MSD receiving Veterans Health Administration care across demographic groups, geographic regions, and facilities....

journal_title：Pain

authors： Goulet JL,Kerns RD,Bair M,Becker WC,Brennan P,Burgess DJ,Carroll CM,Dobscha S,Driscoll MA,Fenton BT,Fraenkel L,Haskell SG,Heapy AA,Higgins DM,Hoff RA,Hwang U,Justice AC,Piette JD,Sinnott P,Wandner L,Womack JA,Br

更新日期：2016-08-01 00:00:00

abstract：:Evidence has shown that electrical stimulation at the dorsal columns attenuated the "wind-up" phenomenon in dorsal horn neurons in nerve-injured rats. This study was aimed to test the effect of spinal cord stimulation (SCS) on temporal summation (TS), the clinical correlate of the wind-up phenomenon in patients with r...

journal_title：Pain

authors： Eisenberg E,Burstein Y,Suzan E,Treister R,Aviram J

更新日期：2015-03-01 00:00:00

abstract：:Although systemic lidocaine has been shown to suppress postoperative pain in a clinical setting, the mechanisms of action of lidocaine have not been elucidated. The present study was therefore designed to determine the relative contribution of central and peripheral sites to the action of lidocaine on incision-induced...

journal_title：Pain

authors： Kawamata M,Sugino S,Narimatsu E,Yamauchi M,Kiya T,Furuse S,Namiki A

更新日期：2006-05-01 00:00:00

abstract：ABSTRACT:The burden of pain in newborn infants has been investigated in numerous studies, but little is known about the appropriateness of the use of pain scales according to the specific type of pain or infant condition. This systematic review aimed to evaluate the reporting of neonatal pain scales in randomized trial...

journal_title：Pain

authors： Olsson E,Ahl H,Bengtsson K,Vejayaram DN,Norman E,Bruschettini M,Eriksson M

更新日期：2021-02-01 00:00:00

abstract：:To address the lack of appropriate patient-defined quality indicators (QIs) for assessment of pain clinic care in the Netherlands, we developed the "Quality Indicators Pain Patients' Perspective" (QiPPP) questionnaire. Quality indicators are widely used to measure the quality of the structure, process, and outcome of ...

journal_title：Pain

authors： de Meij N,Köke A,Thomassen I,Kallewaard JW,van Kleef M,van der Weijden T

更新日期：2018-12-01 00:00:00

abstract：:Intrathecal (i.t.) administration of spermine (0.1-10000 fmol), an endogenous polyamine, produced the behavioural response mainly consisting of biting and/or licking of the hindpaw along with a slight hindlimb scratching directed toward the flank in mice, which peaked at 5-15 min and almost disappeared at 30 min after...

journal_title：Pain

authors： Tan-No K,Taira A,Wako K,Niijima F,Nakagawasai O,Tadano T,Sakurada C,Sakurada T,Kisara K

更新日期：2000-05-01 00:00:00

abstract：:The effects of intrathecal administration of substance P and N-methyl-D-aspartate (NMDA) were studied in the formalin test in mice. Both substances were administered 5 min before injection of formalin into the hind paw. Co-administration of substance P and NMDA intensified the response in both the 1st (0-10 min) and t...

journal_title：Pain

authors： Mjellem-Joly N,Lund A,Berge OG,Hole K

更新日期：1992-11-01 00:00:00

abstract：:Systemic opioid dosing until adequate analgesia in neuropathic pain may involve intolerable and untreatable side effects. Peripheral opioid receptor mechanisms may participate in the antinociceptive effect of systemic morphine. We evaluated the effect of peripherally injected morphine alone, and the ability of the fun...

journal_title：Pain

authors： Martinez V,Christensen D,Kayser V

更新日期：2002-10-01 00:00:00

abstract：:Mechanical allodynia is pain caused by normally innocuous mechanical stimuli and is a cardinal and intractable symptom of neuropathic pain. Roles of low-threshold mechanoreceptors (LTMRs), including Aβ fibers, in mechanical allodynia have previously been proposed, but the necessity and sufficiency of LTMRs in allodyni...

journal_title：Pain

authors： Tsuda M

更新日期：2019-05-01 00:00:00

abstract：:This study compared individuals with fibromyalgia (FM) and individuals with chronic low back pain (CLBP) on repetition-induced summation of activity-related pain (RISP). Fear of movement, pain catastrophizing and depression were examined as potential mediators of group differences. The sample consisted of 50 women wit...

journal_title：Pain

authors： Lambin DI,Thibault P,Simmonds M,Lariviere C,Sullivan MJL

更新日期：2011-06-01 00:00:00

abstract：:We studied the prevalence of chronic pain and long term sensory changes after cosmetic augmentation mammoplasty and the effects of a single i.v. preoperative dose of methylprednisolone 125 mg (n=74), parecoxib 40 mg (n=71), or placebo (n=74). A questionnaire was mailed 6 weeks and 1 year after surgery. Response rate a...

journal_title：Pain

authors： Romundstad L,Breivik H,Roald H,Skolleborg K,Romundstad PR,Stubhaug A

更新日期：2006-09-01 00:00:00

abstract：:Existing estimates of sociodemographic disparities in chronic pain in the United States are based on cross-sectional data, often treat pain as a binary construct, and rarely test for nonresponse or other types of bias. This study uses 7 biennial waves of national data from the Health and Retirement Study (1998-2010; n...

journal_title：Pain

authors： Grol-Prokopczyk H

更新日期：2017-02-01 00:00:00

abstract：:Back pain is a leading cause of disability. Previous research suggests that modifiable risk factors influence recovery from back pain, and practice guidelines recommend integrating such factors within primary care management. Toward this goal, a brief, multidimensional questionnaire, the STarT Back Tool, was designed ...

journal_title：Pain

authors： Wideman TH,Hill JC,Main CJ,Lewis M,Sullivan MJL,Hay EM

更新日期：2012-11-01 00:00:00

abstract：:The effects of cold stress were studied on rats with unilaterally sectioned sciatic nerves. Behaviors suggestive of pain occurred in a number of these animals. These behaviors vanished when removing the rats from the stressful environment. Some severely painful syndromes in man might in part be due to mechanisms simil...

journal_title：Pain

authors： Wiesenfeld Z,Hallin RG

更新日期：1980-06-01 00:00:00

abstract：:The effect of the central grey matter (CG) on pain sensitivity has been investigated in rats. It has been demonstrated that baseline pain thresholds, tested by the hot plate method (HPM) after surgical operation, were significantly greater in CG-lesioned rats than in controls. Baseline tail flick latencies did not dif...

journal_title：Pain

authors： Bragin EO,Vasilenko GF,Durinjan RA

更新日期：1983-05-01 00:00:00

abstract：:Primary afferent sensory neurons are incredibly long cells, often traversing distances of over 1 m in humans. Cutaneous sensory stimuli are transduced in the periphery by specialised end organs or free nerve endings, which code the stimulus into electrical action potentials that propagate towards the central nervous s...

journal_title：Pain

authors： Clark AJ,Menendez G,AlQatari M,Patel N,Arstad E,Schiavo G,Koltzenburg M

更新日期：2018-07-01 00:00:00

abstract：:It has been suggested that a number of peptides may be involved in the transmission of pain. In order to evaluate the possible role of peptides in the development of headache, we have, in the present study, examined the presence of nerve fibres containing neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), subs...

journal_title：Pain

authors： Uddman R,Edvinsson L,Jansen I,Stiernholm P,Jensen K,Olesen J,Sundler F

更新日期：1986-12-01 00:00:00

abstract：:The aim of the present study was to investigate changes in the plasma calcitonin gene-related peptide (CGRP) concentration and platelet serotonin (5-hydroxytriptamine, 5-HT) content during the immediate headache and the delayed genuine migraine attack provoked by nitroglycerin. Fifteen female migraineurs (without aura...

journal_title：Pain

authors： Juhasz G,Zsombok T,Modos EA,Olajos S,Jakab B,Nemeth J,Szolcsanyi J,Vitrai J,Bagdy G

更新日期：2003-12-01 00:00:00

abstract：:Morphine is increasingly used in patients with chronic non-cancer pain, but a major concern associated with chronic use relates to possible cognitive side-effects. The aim of this long-term prospective study was to evaluate the cognitive impact of oral sustained release morphine in patients with non-cancer pain. A bat...

journal_title：Pain

authors： Tassain V,Attal N,Fletcher D,Brasseur L,Dégieux P,Chauvin M,Bouhassira D

更新日期：2003-07-01 00:00:00

abstract：:Polyneuropathy can be linked to chronic pain but also to reduced pain sensitivity. We investigated peripheral C-nociceptors in painful and painless polyneuropathy patients to identify pain-specific changes. Eleven polyneuropathy patients with persistent spontaneous pain and 8 polyneuropathy patients without spontaneou...

journal_title：Pain

authors： Kleggetveit IP,Namer B,Schmidt R,Helås T,Rückel M,Ørstavik K,Schmelz M,Jørum E

更新日期：2012-10-01 00:00:00

abstract：:Adults with mood disorders frequently use prescription opioids. The factors associated with this increased use remain unclear. We used the Medical Expenditure Panel Surveys from 2005 to 2011 to measure the association of mood disorders with new opioid use and the transition to longer-term opioid use for a variety of p...

journal_title：Pain

authors： Halbert BT,Davis RB,Wee CC

更新日期：2016-11-01 00:00:00

abstract：:The present report describes a nation-wide survey on the incidence, the indications and the efficacy of spinal cord stimulation (SCS), as assessed by the Belgian health authorities. The direct motive for this survey was the rapidly growing expenditures resulting from the increasing use of SCS. Between 1983 and 1992, n...

journal_title：Pain

authors： Kupers RC,Van den Oever R,Van Houdenhove B,Vanmechelcn W,Hepp B,Nuttin B,Gybels JM

更新日期：1994-02-01 00:00:00