Stress-related pain behavior in rats with peripheral nerve injuries.

abstract：:In a study to determine how children describe the experience of pain, we queried a convenience sample of 100 children in hospitals and 114 children in church and private schools who were between 9 and 12 years old. The questions were designed to seek correlations by age among boys and girls, and between hospitalized a...

journal_title：Pain

authors： Savedra M,Gibbons P,Tesler M,Ward J,Wegner C

更新日期：1982-10-01 00:00:00

abstract：:Burning mouth syndrome is a common disorder that frequently affects women in the 5th-7th decade. It is characterized by persisting painful symptoms mainly involving the anterior two-thirds of the tongue. For several years it has been attributed to psychological causes. We investigated the innervation of the epithelium...

journal_title：Pain

authors： Lauria G,Majorana A,Borgna M,Lombardi R,Penza P,Padovani A,Sapelli P

更新日期：2005-06-01 00:00:00

abstract：:The effectiveness of a brief clinical and basic science seminar on pain for 1st year medical students was examined by comparing attitudes about pain prior to the seminar to attitudes 5 months after the seminar. The 6-h course combined written materials conveying facts about behavioral, social and biological aspects of...

journal_title：Pain

authors： Wilson JF,Brockopp GW,Kryst S,Steger H,Witt WO

更新日期：1992-09-01 00:00:00

abstract：:In a rat model of artificial ureteral calculosis, the aim of the study was to characterize the behavioural manifestations of direct visceral pain and to evaluate the relationship between number, duration and complexity of the visceral episodes and the extent of referred lumbar muscular hyperalgesia. As evidenced by no...

journal_title：Pain

authors： Giamberardino MA,Valente R,de Bigontina P,Vecchiet L

更新日期：1995-06-01 00:00:00

abstract：:Chronic pain in adults has been associated with early-life stress. To examine the pronociceptive effect of early-life stress, we evaluated cutaneous and muscle nociception and activity in muscle nociceptors in an animal model of neonatal stress, limited bedding, in the rat. In this neonatal limited bedding (NLB) model...

journal_title：Pain

authors： Green PG,Chen X,Alvarez P,Ferrari LF,Levine JD

更新日期：2011-11-01 00:00:00

abstract：:The treatment of neuropathic pain remains a clinical challenge because of its unclear mechanisms and broad clinical morbidity. Matrix metalloproteinase (MMP)-9 and MMP-2 have previously been described as key components in neuropathic pain because of their facilitation of inflammatory cytokine maturation and induction ...

journal_title：Pain

authors： Li J,Xu L,Deng X,Jiang C,Pan C,Chen L,Han Y,Dai W,Hu L,Zhang G,Cheng Z,Liu W

更新日期：2016-08-01 00:00:00

abstract：:In several pain models, tricyclic antidepressants (TCAs) have been shown to reduce nociception. In the present study, we evaluated the antinociceptive effect of metapramine (META) in 4 nociception tests: (1) the hot plate test; (2) the phenylbenzoquinone-induced writhing; (3) the tail flick test; and (4) the test of e...

journal_title：Pain

authors： Michael-Titus A,Costentin J

更新日期：1987-12-01 00:00:00

abstract：:Previous studies have shown that the peripheral nerve regeneration process is linked to pain in several neuropathic pain models. Other studies show that sympathetic blockade may relieve pain in some pain models and clinical conditions. This study examined reduction in peripheral nerve regeneration as one possible mech...

journal_title：Pain

authors： Xie W,Strong JA,Zhang JM

更新日期：2020-08-01 00:00:00

abstract：:A number of investigators have suggested that the generic classification temporomandibular disorders (TMD) may consist of several subsets of patients. Two primary factors are to be significant in discriminating subgroups, namely, presence or absence of TM joint abnormalities and psychological characteristics such as t...

journal_title：Pain

authors： Rudy TE,Turk DC,Zaki HS,Curtin HD

更新日期：1989-03-01 00:00:00

abstract：:Topically applied norepinephrine, dopamine, serotonin, GABA and glycine, and systemically administered clonidine, L-DOPA (plus carbidopa) and 5-hydroxytryptophan completely suppressed the cutaneous hyper-irritability produced in the trigeminal sensory distribution by picrotoxin overlying the caudal medulla. Cholinergi...

journal_title：Pain

authors： Sakai Y,Nishijima Y,Mikuni N,Iwata N

更新日期：1981-08-01 00:00:00

abstract：:Chronic or episodic severe itch is recurrent in atopic dermatitis (AD). Nonhistaminergic itch pathways are suggested to dominate in AD itch, contributing to an "itch-scratch-itch cycle" that prolongs and worsens itch, pain, and skin lesions. We hypothesized that nonhistaminergic neuronal sensitization contributes to i...

journal_title：Pain

authors： Andersen HH,Elberling J,Sølvsten H,Yosipovitch G,Arendt-Nielsen L

更新日期：2017-09-01 00:00:00

abstract：:Preclinical assessment of pain has increasingly explored operant methods that may allow behavioral assessment of ongoing pain. In animals with incisional injury, peripheral nerve block produces conditioned place preference (CPP) and activates the mesolimbic dopaminergic reward pathway. We hypothesized that activation ...

journal_title：Pain

authors： Xie JY,Qu C,Patwardhan A,Ossipov MH,Navratilova E,Becerra L,Borsook D,Porreca F

更新日期：2014-08-01 00:00:00

abstract：:Neuropathic pain affects millions of people worldwide, causing substantial disability and greatly impairing quality of life. Commonly used analgesics or antihyperalgesic compounds are generally characterized by limited therapeutic outcomes. Thus, there is a compelling need for novel therapeutic strategies able to prev...

journal_title：Pain

authors： Di Cesare Mannelli L,Cinci L,Micheli L,Zanardelli M,Pacini A,McIntosh JM,Ghelardini C

更新日期：2014-10-01 00:00:00

abstract：:Chronic pain after laparoscopic cholecystectomy is related to postoperative pain during the first postoperative week, but it is unknown which components of the early pain response is important. In this prospective study, 100 consecutive patients were examined preoperatively, 1 week postoperatively, and 3, 6, and 12 mo...

journal_title：Pain

authors： Blichfeldt-Eckhardt MR,Ording H,Andersen C,Licht PB,Toft P

更新日期：2014-11-01 00:00:00

abstract：:The behavioural response of infant rats to intraplantar injection of formalin consists of specific directed behaviours (limb flexion, shaking and licking the injected paw) and non-specific behaviours that are also induced by non-nociceptive stimulation (squirming, hind limb kicks and whole body jerks), with specific i...

journal_title：Pain

authors： Abbott FV,Guy ER

更新日期：1995-09-01 00:00:00

abstract：:Although known primarily for its role in neuronal development, brain-derived neurotrophic factor (BDNF) has also recently been implicated in processes mediated by the adult nervous system, such as spinal nociception. Peripheral inflammation increases expression of BDNF preferentially in dorsal root ganglion cells that...

journal_title：Pain

authors： Groth R,Aanonsen L

更新日期：2002-11-01 00:00:00

abstract：:Two hundred and sixty-three ambulatory patients older than 21 years of age who were attending clinics at an oncology hospital in San Juan, Puerto Rico, were studied. They completed a questionnaire (BQ-PR) that measures 8 concerns about reporting pain and using analgesics, such as fears of addiction and tolerance and t...

journal_title：Pain

authors： Ward SE,Hernandez L

更新日期：1994-08-01 00:00:00

abstract：:We know very little about the change in pain in the first 2 months after surgery. To address this gap, we studied 530 women scheduled for elective cesarean delivery who completed daily pain diaries for 2 months after surgery through text messaging. Over 82% of subjects missed fewer than 10 diary entries and were inclu...

journal_title：Pain

authors： Booth JL,Sharpe EE,Houle TT,Harris L,Curry RS,Aschenbrenner CA,Eisenach JC

更新日期：2018-10-01 00:00:00

abstract：:Inflammation enhances release of neuropeptides from sensory nerve terminals in the spinal cord, and this may contribute to the development of hyperalgesia. In a similar manner, proinflammatory prostaglandins also augment peptide release from sensory neurons. To ascertain whether the inflammation-induced increase in pe...

journal_title：Pain

authors： Southall DM,Michael LR,Vasko RM

更新日期：1998-10-01 00:00:00

abstract：:Chronic pain patients reported pain intensity on each of 3 pain intensity scales, the visual analog, numerical and adjectival scales, and then ranked the scales in order of perceived best communication of pain intensity. All patients were able to complete an adjectival scale but 11% were unable to complete a visual an...

journal_title：Pain

authors： Kremer E,Atkinson HJ,Ignelzi RJ

更新日期：1981-04-01 00:00:00

abstract：:Numerous medications prolong the rate-corrected QT (QTc) interval and induce arrhythmias by blocking ionic current through cardiac potassium channels composed of subunits expressed by the human ether-a-go-go-related gene (HERG). Recent reports suggest that high doses of methadone cause torsades de pointes. To date, no...

journal_title：Pain

authors： Kornick CA,Kilborn MJ,Santiago-Palma J,Schulman G,Thaler HT,Keefe DL,Katchman AN,Pezzullo JC,Ebert SN,Woosley RL,Payne R,Manfredi PL

更新日期：2003-10-01 00:00:00

abstract：:Changes in pain produced by psychological factors (e.g., placebo analgesia) are thought to result from the activity of specific cortical regions. However, subcortical nuclei, including the periaqueductal gray and the rostroventral medulla, also show selective activation when subjects expect pain relief. These brainste...

journal_title：Pain

authors： Goffaux P,Redmond WJ,Rainville P,Marchand S

更新日期：2007-07-01 00:00:00

abstract：:The efficacy of amitriptyline was evaluated in 28 patients with chronic oral-facial pain. Most of the patients had evidence of musculoskeletal pain while some had a history suggesting pain of neurogenic origin. Two patients had mixed elements of neurogenic and musculoskeletal pain. Amitriptyline was more effective tha...

journal_title：Pain

authors： Sharav Y,Singer E,Schmidt E,Dionne RA,Dubner R

更新日期：1987-11-01 00:00:00

abstract：:The synaptic vesicle protein synapsin II plays an important role in the regulation of neurotransmitter release and synaptic plasticity. Here, we investigated its involvement in the synaptic transmission of nociceptive signals in the spinal cord and the development of pain hypersensitivity. We show that synapsin II is ...

journal_title：Pain

authors： Schmidtko A,Del Turco D,Coste O,Ehnert C,Niederberger E,Ruth P,Deller T,Geisslinger G,Tegeder I

更新日期：2005-05-01 00:00:00

abstract：:After a pilot study had indicated that the topical application of guanethidine might be of value in the treatment of tooth dentine hypersensitivity, a double-blind study was undertaken to investigate whether guanethidine was more effective than a distilled water control in alleviating dentinal pain. In 39 adult subjec...

journal_title：Pain

authors： Dunne SM,Hannington-Kiff JG

更新日期：1993-08-01 00:00:00

abstract：:Injection of a dilute solution of formalin into a rat hindpaw produces a biphasic nociceptive response consisting of an early phase during the first 5 min after formalin injection and a later phase starting after 15 min and lasting for 40-50 min. The period between the two phases of nociceptive responding is generally...

journal_title：Pain

authors： Henry JL,Yashpal K,Pitcher GM,Coderre TJ

更新日期：1999-07-01 00:00:00

abstract：:In preparation for a series of electrophysiological experiments in a model of neuropathic pain, the present spinal reflex study was done to determine the optimal time after sciatic nerve constriction in the rat for tactile allodynia and to determine also the appropriate 'control' for the nerve constriction model. Ther...

journal_title：Pain

authors： Pitcher GM,Ritchie J,Henry JL

更新日期：1999-10-01 00:00:00

abstract：:The thermal sensitivity of the eyelid and cornea was compared using an automated apparatus to produce stimulus pulses of known magnitude and duration over the range 33--45 degrees C. Subjects reported only temperature sensation when the skin of the upper eyelid was tested; however, corneal stimulation in the same subj...

journal_title：Pain

authors： Beuerman RW,Tanelian DL

更新日期：1979-08-01 00:00:00

abstract：:We have previously reported that the level of 5-HT in the masseter muscle is increased in patients with fibromyalgia as compared with healthy subjects and that high intramuscular level of 5-HT is associated with muscle pain. We have also reported that injection of the 5-HT(3) receptor antagonist granisetron (GRA) into...

journal_title：Pain

authors： Ernberg M,Lundeberg T,Kopp S

更新日期：2003-02-01 00:00:00

abstract：:Pain is a complex human trait. It is likely that the interaction of multiple genes, each with a small individual effect, along with the effect of environmental factors, influences the clinical efficacy of opioids rather than a single gene alone. Polymorphisms in genes coding for the mu-opioid receptor (A118G) and cate...

journal_title：Pain

authors： Reyes-Gibby CC,Shete S,Rakvåg T,Bhat SV,Skorpen F,Bruera E,Kaasa S,Klepstad P

更新日期：2007-07-01 00:00:00