Abstract:
:The thermal sensitivity of the eyelid and cornea was compared using an automated apparatus to produce stimulus pulses of known magnitude and duration over the range 33--45 degrees C. Subjects reported only temperature sensation when the skin of the upper eyelid was tested; however, corneal stimulation in the same subjects was always perceived as nociceptive. The possibility that other ocular tissues may be involved in the pain responses was shown to be unlikely by direct experimentation or by calculation of heat flow in those tissues. Cornea and eyelid thresholds were compared in relationship to the structural and physical properties of these tissues. It was found that the nerve endings of the corneal epithelium are less sensitive to temperature change when compared to the thermal receptors of the eyelid. It is concluded that the cornea is useful for the experimental study of pain.
journal_name
Painjournal_title
Painauthors
Beuerman RW,Tanelian DLdoi
10.1016/0304-3959(79)90102-7subject
Has Abstractpub_date
1979-08-01 00:00:00pages
1-14issue
1eissn
0304-3959issn
1872-6623pii
00006396-197908000-00001journal_volume
7pub_type
杂志文章相关文献
PAIN文献大全abstract::Tolerance to the antinociceptive (analgesic) effect of morphine, a mu-opioid agonist, was developed in male CD-1 mice as assessed by a shift to the right of the analgesic (tail-flick) dose-response curves and an increase in the ED50 values. Administration of dextromethorphan at 30 mg/kg s.c., but not saline, 30 min pr...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)90022-1
更新日期:1994-12-01 00:00:00
abstract::Physical and psychosocial disability in patients with chronic pain have been shown to be associated with patients' pain-related beliefs, tendency to catastrophize, and pain coping strategy use. However, little is known about whether beliefs, catastrophizing, and coping strategies are independently associated with pati...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(99)00259-6
更新日期:2000-03-01 00:00:00
abstract::Heat shock protein 90 (Hsp90) is a ubiquitous signal transduction regulator, and Hsp90 inhibitors are in clinical development as cancer therapeutics. However, there have been very few studies on the impact of Hsp90 inhibitors on pain or analgesia, a serious concern for cancer patients. We previously found that Hsp90 i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001886
更新日期:2020-08-01 00:00:00
abstract::Snakebites are a relevant public health problem in Central and South America. Snake bite envenomations cause intense pain, not relieved by anti-venom. The fangs of many species are short, causing subcutaneous injection. Fangs of larger species inflict subcutaneous or intramuscular envenomation. To understand pain indu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.06.001
更新日期:2004-09-01 00:00:00
abstract::Spiritual healing is a popular complementary and alternative therapy; in the UK almost 13000 members are registered in nine separate healing organisations. The present randomized clinical trial was designed to investigate the efficacy of healing in the treatment of chronic pain. One hundred and twenty patients sufferi...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0304-3959(00)00421-8
更新日期:2001-03-01 00:00:00
abstract::Injection of a dilute solution of formalin into a rat hindpaw produces a biphasic nociceptive response consisting of an early phase during the first 5 min after formalin injection and a later phase starting after 15 min and lasting for 40-50 min. The period between the two phases of nociceptive responding is generally...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(99)00033-0
更新日期:1999-07-01 00:00:00
abstract::This paper presents the results of a detailed study of the pain epidemiology and health related quality of life (HRQL) in 150 chronic non-malignant pain patients consecutively referred to a Danish multidisciplinary pain center. Mean pain severity was 71.6 (SD = 18.5) on the VAS scale. Forty-two percent reported poor q...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/S0304-3959(97)00126-7
更新日期:1997-12-01 00:00:00
abstract::There are few prospective studies assessing risk factors for onset of temporomandibular (TMD) pain disorders in any age group. The aim of this prospective cohort study was to identify risk factors for onset of clinically significant TMD pain (i.e., pain meeting research diagnostic criteria for myofascial pain and/or a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.10.012
更新日期:2007-06-01 00:00:00
abstract::The relationship was investigated between algogenic potential of gallbladder pathology and occurrence/extent of sensory and trophic changes in the referred area. Five groups of subjects were studied, with: symptomatic gallbladder calculosis (3-20 colics); asymptomatic calculosis; symptomatic gallbladder shape abnormal...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.12.024
更新日期:2005-03-01 00:00:00
abstract::The results of two experiments show that ratio scales of sensory and affective verbal pain descriptors are valid, reliable and objective. In the first experiment, 16 subjects rated 15 sensory and 15 affective verbal pain descriptors by numerical magnitude estimation and by cross-modality matching to handgrip force. Ra...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(78)90020-9
更新日期:1978-06-01 00:00:00
abstract::The TRPA1 and TRPV1 receptors are important pharmaceutical targets for antipruritic and analgesic therapy. Obtaining further knowledge on their roles and interrelationship in humans is therefore crucial. Preclinical results are contradictory concerning coexpression and functional interdependency of TRPV1 and TRPA1, bu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001298
更新日期:2018-10-01 00:00:00
abstract::Osteoarthritis (OA) is a major healthcare burden of increasing prevalence. It has been demonstrated that the relationship between pain and sleep produces changes in sleep patterns and pain perception. However, electrophysiological studies in animal models of pain are limited. The current study examined the effect of c...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.09.025
更新日期:2008-12-01 00:00:00
abstract::Tailored treatment based on individual risk factors is an area with promise to improve options for pain relief. Musculoskeletal pain has a biopsychosocial nature, and multiple factors should be considered when determining risk for chronic pain. This study investigated whether subgroups comprised genetic and psychologi...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.0000000000000012
更新日期:2015-01-01 00:00:00
abstract:ABSTRACT:Mobile health (mHealth) apps have the potential to enhance pain management through the use of daily diaries, medication and appointment reminders, education, and facilitating communication between patients and providers. Although many pain management apps exist, the extent to which these apps use evidence-base...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002090
更新日期:2020-09-22 00:00:00
abstract::Abnormal endogenous pain modulation was suggested as a potential mechanism for chronic pain, ie, increased pain facilitation and/or impaired pain inhibition underlying symptoms manifestation. Endogenous pain modulation function can be tested using psychophysical methods such as temporal summation of pain (TSP) and con...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1097/j.pain.0000000000001263
更新日期:2018-08-01 00:00:00
abstract::Persons with chronic musculoskeletal pain may be hypervigilant for pain-related cues which, paradoxically, may be maintaining their pain. Several randomized controlled trials have assessed whether a modified dot-probe protocol (ie, attention bias modification [ABM]) reduces chronic pain- and pain-related symptoms in p...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001746
更新日期:2020-03-01 00:00:00
abstract::Few surveys have been performed to define the characteristics and impact of breakthrough pain in the cancer population. In this cross-sectional survey of inpatients with cancer, patients responded to a structured interview (the Breakthrough Pain Questionnaire) designed to characterize breakthrough pain, and also compl...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(99)00006-8
更新日期:1999-05-01 00:00:00
abstract::The chronic pain syndrome inherited erythromelalgia (IEM) is attributed to mutations in the voltage-gated sodium channel (NaV) 1.7. Still, recent studies targeting NaV1.7 in clinical trials have provided conflicting results. Here, we differentiated induced pluripotent stem cells from IEM patients with the NaV1.7/I848T...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001511
更新日期:2019-06-01 00:00:00
abstract::Hydromorphone is an alternative to morphine for intrathecal drug delivery system to treat refractory cancer pain; however, there is not enough clinical evidence to prove it. In our study, 233 patients from 12 different pain management centers across China were enrolled, 121 and 112 in the intrathecal hydromorphone (IT...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001957
更新日期:2020-11-01 00:00:00
abstract::Clinical evidence suggests that cutaneous and visceral pain differ in sensory, affective, and motivational realms, yet there has been little comparative characterization of these types of pain. This study uses psychophysical measures to compare directly visceral and cutaneous pain and sensitivity. Healthy subjects (10...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(02)00023-4
更新日期:2002-06-01 00:00:00
abstract::Epidural and intrathecal techniques are well established techniques in cancer pain. However, several questions remain unresolved. The several problems of long-term spinal opioid treatment in advance cancer patients were reviewed. Indications for the use of spinal opioids include patients treated by systemic opioids wi...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/S0304-3959(98)00118-3
更新日期:1999-01-01 00:00:00
abstract::The effect of different formalin concentrations on the nociceptive response in the formalin test was examined in mice. Subcutaneous formalin injection induces 2 distinct periods of high licking activity: an early phase lasting the first 5 min, and a late phase lasting 20-30 min after the injection. Formalin concentrat...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)91167-H
更新日期:1990-08-01 00:00:00
abstract::The purpose of this study was to increase knowledge through research in the area of operant management of chronic back pain, using a strong experimental design. Reinforcement was made contingent on rate of walking, and feedback about progress was provided at certain intervals during each observation session. The chang...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90141-W
更新日期:1992-05-01 00:00:00
abstract::Activation of extracellular signal-regulated kinase (ERK), a mitogen activated-protein kinase (MAPK), in dorsal horn neurons contributes to inflammatory pain by transcription-dependent and -independent means. We have now investigated if ERK is activated in the spinal cord after a spinal nerve ligation (SNL) and if thi...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.12.022
更新日期:2005-03-01 00:00:00
abstract::Heat and electrical detection thresholds were assessed in 72 patients suffering from painful temporomandibular disorder. Employing widely accepted criteria, 44 patients were classified as suffering from temporomandibular joint (TMJ) arthralgia (i.e. pain originating from the TMJ) and 28 from myalgia (i.e. pain origina...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(03)00077-0
更新日期:2003-08-01 00:00:00
abstract::Recent research has focused on identification of clinically meaningful subgroupings within the chronic pain population in contrast to prior emphasis on the homogeneity of these patients. The present study investigates site of pain as a potentially useful classification variable for identification of differences among ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90085-X
更新日期:1984-08-01 00:00:00
abstract::Anti-nociceptive tolerance to opioids is a well-described phenomenon, which severely limits the clinical efficacy of opioids for the treatment of chronic pain syndromes. The mechanisms that drive anti-nociceptive tolerance, however, are less well understood. We have previously shown that glia have a central role in th...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.02.042
更新日期:2010-09-01 00:00:00
abstract::An indentical questionnaire are administered separately to 100 chronic pain patients and a close family member of each. The majority of patients and relatives agreed on the answers to these questions about the pain problem. Highest congruency between patient and relative was associated with cases in which there were m...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(88)90003-6
更新日期:1980-04-01 00:00:00
abstract::Experimental data have suggested that in neuropathic pain, tricyclic antidepressants may work solely through a β2-agonist action. The aim of this study was to test if the β2-agonist terbutaline relieves painful polyneuropathy. The study was a randomized, double-blind, placebo-controlled and active-controlled, 3-way, c...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002140
更新日期:2020-11-06 00:00:00
abstract::The efficacy of psychological treatments emphasising a self-management approach to chronic pain has been demonstrated by substantial empirical research. Nevertheless, high drop-out and relapse rates and low or unsuccessful engagement in self-management pain rehabilitation programs have prompted the suggestion that peo...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(01)00493-6
更新日期:2002-05-01 00:00:00