Pain epidemiology and health related quality of life in chronic non-malignant pain patients referred to a Danish multidisciplinary pain center.

abstract：:Injection of bee venom into one hindpaw of rat can elicit acute inflammation together with spontaneous pain, heat hyperalgesia and mechanical hyperalgesia/allodynia in the injected paw. 5-hydroxytryptamine (5-HT)1A receptor is the predominant receptor subtype in the spinal dorsal horn mediating the function of 5-HT in...

journal_title：Pain

authors： Wang W,Wu SX,Wang YY,Liu XY,Li YQ

更新日期：2003-11-01 00:00:00

abstract：:This study evaluated movement velocity, frequency, and amplitude, as well as the number of arrests in three different subject groups, by kinematic analysis of repetitive movements during a finger tapping (FT) task. The most affected hands of 80 patients with complex regional pain syndrome (CRPS) were compared with the...

journal_title：Pain

authors： Schilder JCM,Schouten AC,Perez RSGM,Huygen FJPM,Dahan A,Noldus LPJJ,van Hilten JJ,Marinus J

更新日期：2012-04-01 00:00:00

abstract：:We investigated the effects of acute and of chronic morphine treatment on T-lymphocyte function and natural killer (NK) cell activity in rats receiving chronic constriction injury (CCI) of the sciatic nerve. T-Lymphocyte function was evaluated based on concanavalin-A (ConA)- and phytohemagglutinin (PHA)-induced spleno...

journal_title：Pain

authors： Tsai YC,Won SJ,Lin MT

更新日期：2000-11-01 00:00:00

abstract：:The aim of the present study was to determine if acupuncture stimulation inhibits sympathetic nerve activity in humans. Multiunit efferent postganglionic sympathetic activity was recorded with a tungsten microelectrode inserted in a muscle fascicle of the peroneal nerve. Mean arterial pressure, heart rate and skin blo...

journal_title：Pain

authors： Knardahl S,Elam M,Olausson B,Wallin GB

更新日期：1998-03-01 00:00:00

abstract：:Chronic and acute pre-mastectomy pain as well as prevalence and characteristics of phantom phenomena following mastectomy were investigated by interview in a sample of 39 women who had undergone unilateral breast amputation. Twenty of 39 participants reported phantom sensations in the breast. Nine of the participants ...

journal_title：Pain

authors： Rothemund Y,Grüsser SM,Liebeskind U,Schlag PM,Flor H

更新日期：2004-01-01 00:00:00

abstract：:We know little about the safety or efficacy of pharmacological medicines for children and adolescents with chronic pain, despite their common use. Our aim was to conduct an overview review of systematic reviews of pharmacological interventions that purport to reduce pain in children with chronic noncancer pain (CNCP) ...

journal_title：Pain

authors： Eccleston C,Fisher E,Cooper TE,Grégoire MC,Heathcote LC,Krane E,Lord SM,Sethna NF,Anderson AK,Anderson B,Clinch J,Gray AL,Gold JI,Howard RF,Ljungman G,Moore RA,Schechter N,Wiffen PJ,Wilkinson NMR,Williams DG,Wood

更新日期：2019-08-01 00:00:00

abstract：:Unlike most classical analgesics, botulinum toxin type A (BoNT/A) does not alter acute nociceptive thresholds, and shows selectivity primarily for allodynic and hyperalgesic responses in certain pain conditions. We hypothesized that this phenomenon might be explained by characterizing the sensory neurons targeted by B...

journal_title：Pain

authors： Matak I,Rossetto O,Lacković Z

更新日期：2014-08-01 00:00:00

abstract：:Previous work in this laboratory has indicated that the transplantation of adrenal medullary tissue into the subarachnoid space of the rat spinal cord can reduce pain sensitivity to acute noxious stimuli, particularly following stimulation by nicotine. This most likely results from the stimulated release of opioid pep...

journal_title：Pain

authors： Sagen J,Wang H,Pappas GD

更新日期：1990-07-01 00:00:00

abstract：:The purpose of this study was to increase knowledge through research in the area of operant management of chronic back pain, using a strong experimental design. Reinforcement was made contingent on rate of walking, and feedback about progress was provided at certain intervals during each observation session. The chang...

journal_title：Pain

authors： Geiger G,Todd DD,Clark HB,Miller RP,Kori SH

更新日期：1992-05-01 00:00:00

abstract：:Previous evidence suggests that, in adult animals, nerve growth factor (NGF) can induce hyperalgesia, and may be an endogenous mediator in some persistent pain states. Here we have studied the effects of single intradermal injections of 50-500 ng of human recombinant NGF into the plantar skin of adult rat hindpaws. We...

journal_title：Pain

authors： Andreev NY,Dimitrieva N,Koltzenburg M,McMahon SB

更新日期：1995-10-01 00:00:00

abstract：:Recent evidence indicates that pain-related fear can be acquired through associative learning. In the clinic, however, spreading of fear and avoidance is observed beyond movements/activities that were associated with pain during the original pain episode. One mechanism accounting for this spreading of fear is stimulus...

journal_title：Pain

authors： Meulders A,Vlaeyen JWS

更新日期：2013-02-01 00:00:00

abstract：:With increasing concerns about the potential harm of long-term opioid therapy, there is a need for the development and implementation of alternative treatment strategies for patients with chronic pain who have been using opioids for a prolonged period of time. Based on the findings from a recent qualitative investigat...

journal_title：Pain

authors： Andrews NE,Strong J,Meredith PJ,Fleming JA

更新日期：2016-02-01 00:00:00

abstract：:An 82-year-old woman experienced generalized pruritus not due to skin or systemic disease. Scratching the skin with a needle induced a crisis of intense pruritus, insensitive to any drug. The pruritus had the characteristics of a central sensation. ...

journal_title：Pain

authors： Procacci P,Maresca M

更新日期：1991-06-01 00:00:00

abstract：:Changes in chloride reversal potential in rat spinal cord neurons have previously been associated with persistent pain in nerve injury and inflammation models. These changes correlate with a decrease in the expression of the potassium chloride transporter, KCC2, and with increases in neuronal excitability. Here, we te...

journal_title：Pain

authors： Castro A,Li Y,Raver C,Chandra R,Masri R,Lobo MK,Keller A

更新日期：2017-07-01 00:00:00

abstract：:Although it is well known that cannabinoids produce antinociception in acute pain models, there is less information on the ability of cannabinoids to alleviate hyperalgesia. In the present study, we determined whether cannabinoids attenuated the development of hyperalgesia produced by intraplantar injection of capsaic...

journal_title：Pain

authors： Li J,Daughters RS,Bullis C,Bengiamin R,Stucky MW,Brennan J,Simone DA

更新日期：1999-05-01 00:00:00

abstract：:Although pains arising from the craniofacial complex can be severe and debilitating, relatively little is known about the peripheral and central mechanisms that generate and maintain orofacial pain. To better understand the neurons in the trigeminal complex and spinal cord that are activated following nociceptive stim...

journal_title：Pain

authors： Sabino MA,Honore P,Rogers SD,Mach DB,Luger NM,Mantyh PW

更新日期：2002-01-01 00:00:00

abstract：:This study records the consistency of transcutaneous electrical nerve stimulation (TENS) pulse frequency and pulse pattern used by 13 chronic patients over a 1 year period. The results show that patients prefer specific pulse frequencies and pulse patterns unique to the individual and that they turn to such frequencie...

journal_title：Pain

authors： Johnson MI,Ashton CH,Thompson JW

更新日期：1991-03-01 00:00:00

abstract：:Many cancerous solid tumors metastasize to the bone and induce pain (cancer-induced bone pain [CIBP]). Cancer-induced bone pain is often severe because of enhanced inflammation, rapid bone degradation, and disease progression. Opioids are prescribed to manage this pain, but they may enhance bone loss and increase tumo...

journal_title：Pain

authors： Forte BL,Slosky LM,Zhang H,Arnold MR,Staatz WD,Hay M,Largent-Milnes TM,Vanderah TW

更新日期：2016-12-01 00:00:00

abstract：:Two hundred and sixty-three ambulatory patients older than 21 years of age who were attending clinics at an oncology hospital in San Juan, Puerto Rico, were studied. They completed a questionnaire (BQ-PR) that measures 8 concerns about reporting pain and using analgesics, such as fears of addiction and tolerance and t...

journal_title：Pain

authors： Ward SE,Hernandez L

更新日期：1994-08-01 00:00:00

abstract：:Inflammation induces an up-regulation of neuropeptide tyrosine (NPY) and its receptors in the dorsal horn, suggesting an important role in nociceptive transmission. Our initial studies revealed that NPY dose-dependently increased hotplate response latency, and to a lesser degree, thermal paw withdrawal latency (PWL); ...

journal_title：Pain

authors： Taiwo OB,Taylor BK

更新日期：2002-04-01 00:00:00

abstract：:Venoms peptides have produced exceptional sources for drug development to treat pain. In this study we examined the antinociceptive and side effects of Tx3-3, a peptide toxin isolated from Phoneutria nigriventer venom, which inhibits high-voltage-dependent calcium channels (VDCC), preferentially P/Q and R-type VDCC. W...

journal_title：Pain

authors： Dalmolin GD,Silva CR,Rigo FK,Gomes GM,do Nascimento Cordeiro M,Richardson M,Silva MAR,Prado MAM,Gomez MV,Ferreira J

更新日期：2011-10-01 00:00:00

abstract：:Total hindpaw denervation in rodents elicits an abnormal behavior of licking, scratching and self-injury of the anesthetic limb ("autotomy"). Since the same denervation produces phantom limb pain and anesthesia dolorosa in humans, autotomy has been used as a model of human neuropathic pain. Autotomy is an inherited tr...

journal_title：Pain

authors： Seltzer Z,Wu T,Max MB,Diehl SR

更新日期：2001-08-01 00:00:00

abstract：:Pharmacological actions on the nociceptive flexion flexes of the hindlimb were investigated in 14 normal subjects. These reflexes were used as an index of pain and were recorded in the biceps femoris muscle, elicited by electrical stimulation of the ipsilateral sural nerve (RIII,su) and of the skin in the distal recep...

journal_title：Pain

authors： Willer JC,Bathien N

更新日期：1977-04-01 00:00:00

abstract：:Acute inflammation of the sigmoid wall was induced by perendoscopic injection of formalin (50 microliters, 5%) under brief anesthesia in rats. The procedure was followed by behavioral patterns that significantly differed from those in animals injected with isotonic saline instead of formalin. Analysis of the formalin-...

journal_title：Pain

authors： Miampamba M,Chéry-Croze S,Gorry F,Berger F,Chayvialle JA

更新日期：1994-06-01 00:00:00

abstract：:The present study investigated whether the level of cognitive impairment (CI) affects acute pain behavior and how it is manifested. Participants were 159 individuals (mean age 42+/-12), 121 with CI (divided into four groups according to the level of CI: mild, moderate, severe, profound) and 38 with normal cognition (c...

journal_title：Pain

authors： Defrin R,Lotan M,Pick CG

更新日期：2006-10-01 00:00:00

abstract：:In a double-blind, cross-over study, ibuprofen (600 mg), a peripherally-acting selective kappa-opioid receptor agonist (7.5 mg), or placebo were given orally in experiments on healthy volunteers 1 h before assessment of pain thresholds to radiant heat and of pain ratings to controlled mechanical impact stimuli. Mechan...

journal_title：Pain

authors： Bickel A,Dorfs S,Schmelz M,Forster C,Uhl W,Handwerker OH

更新日期：1998-06-01 00:00:00

abstract：:Bipolar intrapulpal stimulation was applied to human teeth using the same procedure as in animal experiments. The effects of variation of stimulus parameters on the quality of sensation were studied. A prepain sensation exists which cannot be explained by diffusion of the stimulus to periodontal tissues. When the inte...

journal_title：Pain

authors： Azerad J,Woda A

更新日期：1977-12-01 00:00:00

abstract：:Clinical evidence suggests that cutaneous and visceral pain differ in sensory, affective, and motivational realms, yet there has been little comparative characterization of these types of pain. This study uses psychophysical measures to compare directly visceral and cutaneous pain and sensitivity. Healthy subjects (10...

journal_title：Pain

authors： Strigo IA,Bushnell CM,Boivin M,Duncan GH

更新日期：2002-06-01 00:00:00

abstract：:The N-methyl-D-aspartic acid (NMDA) receptor antagonist D, L-2-amino-5-phosphonopentanoic acid (AP5) caused a stronger inhibition of wind-up in single wide dynamic range (WDR) neurons after carrageenan inflammation compared with control neurons without inflammation in the receptive field. This indicates that even a sh...

journal_title：Pain

authors： Svendsen F,Rygh LJ,Hole K,Tjølsen A

更新日期：1999-12-01 00:00:00

abstract：:This study reports a 9-18 month follow-up of a randomised controlled trial of pain management programmes for chronic, non-malignant pain. Twenty-two inpatients, 18 outpatients and 12 control subjects completed the follow-up assessments. Significant treatment effects were demonstrated by the inpatient group on pain rat...

journal_title：Pain

authors： Peters J,G Large R,Elkind G

更新日期：1992-07-01 00:00:00