Abstract:
:We have previously reported that the level of 5-HT in the masseter muscle is increased in patients with fibromyalgia as compared with healthy subjects and that high intramuscular level of 5-HT is associated with muscle pain. We have also reported that injection of the 5-HT(3) receptor antagonist granisetron (GRA) into the masseter muscle of healthy subjects reduced pain induced by 5-HT and abolished allodynia/hyperalgesia. The aim of this study was to investigate whether GRA can influence pain and allodynia/hyperalgesia of the masseter muscle in patients with fibromyalgia. Eighteen female patients who met the criteria of fibromyalgia according to the American College of Rheumatology participated in the study. They were examined regarding pain intensity and pressure pain threshold (PPT) over the masseter muscle. One milliliter of GRA (1 mg/ml) was injected into the masseter muscle on one side and 1 ml of isotonic saline on the other side in a randomized and double-blind manner. After the injections, the pain intensity and PPT were recorded during 30 min. The pain intensity increased after injection of saline and to a lower degree after injection of GRA. The PPT increased after injection of GRA, while no such change was observed after saline. The difference between GRA and saline was, however, not significant. Eight of the patients responded to the GRA injection by an increase of PPT during the experimental period that differed from saline. They also showed a tendency to a lower increase of pain intensity after injection of GRA when compared to saline. In conclusion, the results of this study do not prove that injection of the 5-HT(3)-antagonist GRA into the masseter muscle influences local pain and allodynia/hyperalgesia in patients with fibromyalgia.
journal_name
Painjournal_title
Painauthors
Ernberg M,Lundeberg T,Kopp Sdoi
10.1016/S0304-3959(02)00334-2keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
275-282issue
3eissn
0304-3959issn
1872-6623pii
00006396-200302000-00008journal_volume
101pub_type
临床试验,杂志文章相关文献
PAIN文献大全abstract::We aimed to investigate whether small-fibre pathology, a common skin biopsy finding in patients with fibromyalgia, implies clinically important abnormalities of somatosensory system function and verify whether it is associated with voltage-gated sodium channel variants. In 57 consecutively enrolled patients with fibro...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001920
更新日期:2020-10-01 00:00:00
abstract::Animal and human studies indicate that electrical stimulation of dorsal root ganglion (DRG) neurons may modulate neuropathic pain signals. ACCURATE, a pivotal, prospective, multicenter, randomized comparative effectiveness trial, was conducted in 152 subjects diagnosed with complex regional pain syndrome or causalgia ...
journal_title:Pain
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/j.pain.0000000000000814
更新日期:2017-04-01 00:00:00
abstract::The perception of pain is determined by a combination of genetic, neurobiological, cultural, and emotional factors. Recent studies have demonstrated an association between specific genotypes and pain perception. Particular focus has been given to the triallelic polymorphism in the promoter region of the serotonin tran...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2013.05.011
更新日期:2013-08-01 00:00:00
abstract::Fibromyalgia is a painful syndrome of non-articular origin, predominantly involving muscles, and the commonest cause of chronic widespread musculoskeletal pain. The diversity of therapeutic programs for patients with fibromyalgia reflects both the lack of a known pathophysiology for this disorder and the low efficacy ...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(95)00199-9
更新日期:1996-05-01 00:00:00
abstract::The treatment of neuropathic pain remains a clinical challenge because of its unclear mechanisms and broad clinical morbidity. Matrix metalloproteinase (MMP)-9 and MMP-2 have previously been described as key components in neuropathic pain because of their facilitation of inflammatory cytokine maturation and induction ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000575
更新日期:2016-08-01 00:00:00
abstract::The role of proinflammatory cytokines in neuropathic and inflammatory pain is well established. Recent studies suggest that cytokines such as tumor necrosis factor-alpha (TNF) may also be involved in the development of muscle pain. To investigate the pathophysiology of intramuscular TNF, exogenous TNF (0.1-10 microg),...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(03)00115-5
更新日期:2003-08-01 00:00:00
abstract::Temporomandibular disorders (TMD) represent a group of chronic painful conditions involving the muscles of mastication and the temporomandibular joint. Several studies have reported that TMD is associated with enhanced sensitivity to experimental pain. Twenty-three TMD subjects and 24 pain-free matched control subject...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(98)00028-1
更新日期:1998-05-01 00:00:00
abstract::A study of the extent of sympathetic blockade after stellate ganglion block was assessed using liquid crystal thermography. Two volumes (10 and 20 ml) of bupivacaine 0.5% plain were used. Irrespective of the volume used cranial sympathetic block always occurred and thoracic sympathetic block never occurred. While uppe...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(89)90023-7
更新日期:1989-02-01 00:00:00
abstract::P2X3 purinoceptor cellular distribution was studied in rat sensory neurons in naive animals and following peripheral nerve injury using immunohistochemical methods. Specific antiserum was raised in rabbits and characterized by Western blot, absorption assays and labeling of recombinant receptors. In naive animals, P2X...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(98)00225-5
更新日期:1999-03-01 00:00:00
abstract::We evaluated the construct validity (including responsiveness), reliability, and feasibility of the Pain Squad multidimensional smartphone-based pain assessment application (app) in children and adolescents with cancer, using 2 descriptive studies with repeated measures. Participants (8-18 years) undergoing cancer tre...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000385
更新日期:2015-12-01 00:00:00
abstract::The purpose of this study was to investigate the mechanisms of referred pain observed in female patients with pain from the reproductive organs. We developed a model of inflammatory uterine pain in the rat. Inflammation of the uterus in rats pretreated with Evans Blue Dye resulted in dye extravasation in the skin over...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(97)00112-7
更新日期:1997-12-01 00:00:00
abstract::Long-term potentiation (LTP) in wide dynamic range (WDR) neurons in the dorsal horn has been suggested to contribute to central sensitization and the development of chronic pain. Indirect experimental evidence indicates an involvement of substance P (SP), in this respect. The aim of the present study was to monitor th...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(01)00414-6
更新日期:2002-03-01 00:00:00
abstract::Recent evidence indicates that pain-related fear can be acquired through associative learning. In the clinic, however, spreading of fear and avoidance is observed beyond movements/activities that were associated with pain during the original pain episode. One mechanism accounting for this spreading of fear is stimulus...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.10.025
更新日期:2013-02-01 00:00:00
abstract::Our aim was to assess the discriminative capacity of the McGill Pain Questionnaire (MPQ) in patients with temporomandibular joint (TMJ) disorders or with myogenous facial pain (MP). The MPQ was administered to 57 TMJ and 28 MP patients who were also asked to assess the level of pain using the Visual Analog Scale (VAS)...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(00)00461-9
更新日期:2001-04-01 00:00:00
abstract::There are few prospective studies assessing risk factors for onset of temporomandibular (TMD) pain disorders in any age group. The aim of this prospective cohort study was to identify risk factors for onset of clinically significant TMD pain (i.e., pain meeting research diagnostic criteria for myofascial pain and/or a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.10.012
更新日期:2007-06-01 00:00:00
abstract::In a group of 30 subjects suffering from sympathetic reflex dystrophies of the limbs, the sympathetic ganglia of the affected side were blocked with a local anesthetic. Using an original method, we measured the cutaneous pain threshold before the block and at prefixed intervals after the block during a period of 2 day...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(75)90100-1
更新日期:1975-06-01 00:00:00
abstract::Intrusive pain is likely to have a serious impact on older people with limited ability to respond to additional stressors. Frailty is conceptualised as a functional and biological pattern of decline accumulating across multiple physiological systems, resulting in a decreased capacity to respond to additional stressors...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.08.011
更新日期:2008-11-15 00:00:00
abstract::The facial expression of pain plays a crucial role in pain communication and pain diagnostics. Despite its importance, it has remained unknown which dimensions of pain (sensory and/or affective) are encoded in the face. To answer this question, we used a well-established cognitive strategy (suggestions) to differentia...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.10.027
更新日期:2012-02-01 00:00:00
abstract::The enzyme 3alpha-hydroxysteroid oxido-reductase (3alpha-HSOR) catalyzes the synthesis and bioavailability of 3alpha,5alpha-neurosteroids as allopregnanolone (3alpha,5alpha-THP) which activates GABA(A) receptors and blocks T-type calcium channels involved in pain mechanisms. Here, we used a multidisciplinary approach ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.06.004
更新日期:2010-09-01 00:00:00
abstract::The effect of the central grey matter (CG) on pain sensitivity has been investigated in rats. It has been demonstrated that baseline pain thresholds, tested by the hot plate method (HPM) after surgical operation, were significantly greater in CG-lesioned rats than in controls. Baseline tail flick latencies did not dif...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(83)90083-0
更新日期:1983-05-01 00:00:00
abstract::Pain symptoms of many disorders are reported to vary with menstrual stage. This study investigated how pain thresholds to electrical stimulation of the skin, subcutis and muscle tissue varied with menstrual stage in normal women and compared these variations with those in women with dysmenorrhea and in healthy men at ...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(97)03362-9
更新日期:1997-06-01 00:00:00
abstract::Intrathecal administration of serotonin type 2 (5-HT(2)) receptor agonists, alpha-methyl-5-hydroxytryptamine maleate (alpha-m-5-HT) or (+/-)-1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane hydrochloride (DOI), produces antiallodynic effects in a rat model of neuropathic pain. In the present study, we examined the antial...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2003.12.019
更新日期:2004-03-01 00:00:00
abstract::This open prospective study evaluated the combination of initial dose titration with patient-controlled analgesia (PCA) and long-term treatment with transdermal fentanyl in 50 cancer patients requiring opioids for severe pain. The delivery rate of the first transdermal therapeutic system (TTS) was calculated from the ...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(96)03254-x
更新日期:1997-01-01 00:00:00
abstract::Substance P (SP) plays a central role in the transduction of second messenger signals from primary afferent nociceptive terminals to second-order neurons in the spinal cord. We have tested a recombinant engineered diphtheria toxin/SP fusion protein (DAB389SP) in acute and chronic pain models in the rat. DAB389SP binds...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(98)00170-5
更新日期:1999-02-01 00:00:00
abstract::Clinical observations and recent studies suggest that arthritis patients vary considerably in their involvement in self-management efforts. In the literature on health promotion, there is growing recognition that patients may be at different stages of change with respect to the adoption of self-management strategies. ...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0304-3959(00)00294-3
更新日期:2000-09-01 00:00:00
abstract::The effects of electrical and chemical stimulation of the arcuate nucleus of the hypothalamus (ARH) on the tail flick latency (TFL) and paw pressure withdrawal threshold (PWT) were investigated in the lightly pentobarbital-anesthetized and acutely prepared rat. Electrical stimulation of the ARH for 20 sec at 8 Hz prod...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)91114-X
更新日期:1990-04-01 00:00:00
abstract::Drawing on advances in chronic pain metrics, a simplified Graded Chronic Pain Scale-Revised was developed to differentiate mild, bothersome, and high-impact chronic pain. Graded Chronic Pain Scale-Revised was validated among adult enrollees of 2 health plans (N = 2021). In this population, the prevalence of chronic pa...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001758
更新日期:2020-03-01 00:00:00
abstract::Using the chronic constriction injury (CCI) model of neuropathic pain, we profiled gene expression in the rat spinal cord, and identified SIP30 as a gene whose expression was elevated after CCI. SIP30 was previously shown to interact with SNAP25, but whose function was otherwise unknown. We now show that in the spinal...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.07.011
更新日期:2009-11-01 00:00:00
abstract::Although known primarily for its role in neuronal development, brain-derived neurotrophic factor (BDNF) has also recently been implicated in processes mediated by the adult nervous system, such as spinal nociception. Peripheral inflammation increases expression of BDNF preferentially in dorsal root ganglion cells that...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(02)00264-6
更新日期:2002-11-01 00:00:00
abstract::Clinical trial participants often require additional instruction to prevent idiosyncratic interpretations regarding completion of patient-reported outcomes. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership developed a tr...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1097/j.pain.0000000000000502
更新日期:2016-05-01 00:00:00