Abstract：
:The effects of electrical and chemical stimulation of the arcuate nucleus of the hypothalamus (ARH) on the tail flick latency (TFL) and paw pressure withdrawal threshold (PWT) were investigated in the lightly pentobarbital-anesthetized and acutely prepared rat. Electrical stimulation of the ARH for 20 sec at 8 Hz produced a more potent elevation of the TFL (98%) and PWT (68%) compared to when stimulation was applied to the same site at 2 Hz (41% and 25%, respectively), 32 Hz (64% and 42%) and 128 Hz (57% and 39%). An even more marked and longer attenuation of the nociceptive reflexes was observed when the ARH stimulation was extended to a period of 1 or 3 min. Microinjection of the excitant amino acid, L-glutamate (0.5 M, 0.1 mul), into the same areas of the ARH consistently elicited antinociception to an extent similar to that observed with electrical stimulation. The data indicate that 8 Hz seems to be an optimal frequency for stimulating ARH to produce an analgesic effect as tested by the two spinal nociceptive reflexes.
journal_name
Painjournal_title
Painauthors
Wang Q,Mao L,Han Jdoi
10.1016/0304-3959(90)91114-Xsubject
Has Abstractpub_date
1990-04-01 00:00:00pages
101-108issue
1eissn
0304-3959issn
1872-6623pii
00006396-199004000-00014journal_volume
41pub_type
杂志文章相关文献
PAIN文献大全abstract：:Oxytocin (OT), known for its neurohormonal effects around birth, has recently been suggested for being a critical determinant in neurodevelopmental disorders. This hypothalamic neuropeptide exerts a potent analgesic effect through an action on the nociceptive system. This endogenous control of pain has an important ad...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001375
更新日期：2018-12-01 00:00:00
abstract：:VGF (nonacronymic) is a granin-like protein that is packaged and proteolytically processed within the regulated secretory pathway. VGF and peptides derived from its processing have been implicated in neuroplasticity associated with learning, memory, depression, and chronic pain. In sensory neurons, VGF is rapidly incr...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2014.03.012
更新日期：2014-07-01 00:00:00
abstract：:Tri-cyclic antidepressants (TCAs) have been widely used in treating major depressive disorders. Recent studies further demonstrated that TCAs have potent sodium channel blocking effect, and amitriptyline, one of the TCAs, has a potent spinal anesthetic effect. The aim of the study was to evaluate the spinal anesthetic...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2004.08.003
更新日期：2004-11-01 00:00:00
abstract：:Despite decades of research, hundreds of studies, and a number of recent reviews, the effects of aging on the experience of pain remain poorly understood. Many prior investigators have reported increases in persistent pain conditions and diminished tolerance for certain types of laboratory-induced pain among the elder...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(02)00324-x
更新日期：2003-01-01 00:00:00
abstract：:The purpose of this study was to determine if some commonly used admission variables could predict treatment outcome on a multidisciplinary pain center. Specifically, it was designed as a prospective study of an index proposed by Maruta et al. The subjects were 104 patients. The 4 outcome measures used were staff judg...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(82)90082-3
更新日期：1982-09-01 00:00:00
abstract：:Non-cardiac chest pain (NCCP) is a common and distressing condition. Prior studies suggest that psychotropic medication or pain coping skills training (CST) may benefit NCCP patients. To our knowledge, no clinical trials have examined the separate and combined effects of CST and psychotropic medication in the manageme...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.pain.2010.08.040
更新日期：2011-04-01 00:00:00
abstract：:Noxious challenge of the rat gastric mucosa by hydrochloric acid (HCl) is signaled to the nucleus tractus solitarii (NTS) and area postrema (AP). This study examined the participation of glutamate and tachykinins in the medullary transmission process. Activation of neurons was visualized by in situ hybridization autor...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(00)00357-2
更新日期：2001-01-01 00:00:00
abstract：:Cross-sectional research in clinical samples, as well as experimental studies in healthy adults, suggests that the experiences of pain and sleep are bi-directionally connected. However, whether sleep and pain experiences are prospectively linked to one another on a day-to-day basis in the general population has not pr...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2008.01.025
更新日期：2008-07-01 00:00:00
abstract：:The perception of pain is determined by a combination of genetic, neurobiological, cultural, and emotional factors. Recent studies have demonstrated an association between specific genotypes and pain perception. Particular focus has been given to the triallelic polymorphism in the promoter region of the serotonin tran...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2013.05.011
更新日期：2013-08-01 00:00:00
abstract：:Intrathecal (i.t.) administration of spermine (0.1-10000 fmol), an endogenous polyamine, produced the behavioural response mainly consisting of biting and/or licking of the hindpaw along with a slight hindlimb scratching directed toward the flank in mice, which peaked at 5-15 min and almost disappeared at 30 min after...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(99)00312-7
更新日期：2000-05-01 00:00:00
abstract：:This report describes a placebo-controlled study of transcutaneous electrical nerve stimulation (TENS) applied to the contralateral lower leg and outer ears of an amputee with non-painful phantom sensations. The subject received TENS or placebo stimulation on separate sessions in which baseline periods of no stimulati...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/0304-3959(89)90098-5
更新日期：1989-03-01 00:00:00
abstract：:Toll-like receptor 7 (TLR7) is associated with the pathophysiology of systemic lupus erythematosus and Sjögren syndrome, well-known diseases accompanying interstitial cystitis (IC). We studied TLR7 expression in the bladder of patients with Hunner-type IC (HIC) and its functional roles in bladder inflammation and noci...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000947
更新日期：2017-08-01 00:00:00
abstract：:The clinical effectiveness of locally administered opioids is still under discussion; in particular, the potency of morphine in settings other than intra-articular arthroscopy has been questioned. We developed another pain model, postpartum resection of the fallopian tubes for sterilisation, in which each patient serv...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/S0304-3959(98)00157-2
更新日期：1999-01-01 00:00:00
abstract：:The aim of this study was to investigate the effect of injection of serotonin (5-HT) into the masseter muscle on pain and allodynia/hyperalgesia. Twelve female patients with fibromyalgia (FM) and 12 age-matched female healthy individuals (HI) participated in the study. The current pain intensity (CPI) and the pressure...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0304-3959(99)00233-x
更新日期：2000-03-01 00:00:00
abstract：:Though it is clear that genomic variability plays an integral role in accounting for pain sensitivity, controversy exists over which genes are involved. While recent data suggest a "protective" (i.e., less pain) haplotype in the GTP cyclohydrolase (GCH1) gene, other research has failed to confirm this association. Pos...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2008.10.023
更新日期：2009-01-01 00:00:00
abstract：:We assessed nimodipine's ability to increase the analgesic effect of morphine in 32 patients suffering from cancer pain in a double-blind, placebo controlled cross-over study. Morphine administration began a few days before the start of the study. The analgesic effects of two combinations were compared: morphine (M) p...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0304-3959(96)03186-7
更新日期：1996-12-01 00:00:00
abstract：:Neuropathic pain behaviour is not observed in neonatal rats and tactile allodynia does not develop in the spared nerve injury (SNI) model until rats are 4 weeks of age at the time of surgery. Since activated spinal microglia are known to play a key role in neuropathic pain, we have investigated whether the microglial ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2006.09.018
更新日期：2007-04-01 00:00:00
abstract：:A young female outpatient experienced painful tonic contractions in the right triceps surae muscles as a result of a partial damage of the right peroneal nerve. Electrophysiological recordings of the soleus muscle showed a tonic EMG activity and an hyperexcitability of the monosynaptic H reflex (Hmax/Mmax ratio: 90%)....
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(88)90037-1
更新日期：1988-03-01 00:00:00
abstract：:Back pain is a leading cause of disability. Previous research suggests that modifiable risk factors influence recovery from back pain, and practice guidelines recommend integrating such factors within primary care management. Toward this goal, a brief, multidimensional questionnaire, the STarT Back Tool, was designed ...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2012.06.010
更新日期：2012-11-01 00:00:00
abstract：:Immune activation near healthy peripheral nerves may have a greater role in creating pathological pain than previously recognized. We have developed a new model of sciatic inflammatory neuritis to assess how such immune activation may influence somatosensory processing. The present series of experiments reveal that zy...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(01)00354-2
更新日期：2001-12-01 00:00:00
abstract：:We developed a mouse model of cancer pain to investigate its underlying mechanisms. SCC-7, squamous cell carcinoma (SCC) derived from C3H mice, was inoculated subcutaneously into either the plantar region or thigh in male C3H/Hej mice. Heat and mechanical sensitivity as well as spontaneous behavior were measured at th...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2005.05.010
更新日期：2005-09-01 00:00:00
abstract：:Low Back Pain Rating scale is an index scale which includes measurements of pain intensity, disability, and physical impairment. The scale was designed to monitor the outcome of clinical trials of low back pain treatment. It has been validated in 58 patients following first-time discectomy. The scale rating can be rap...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/0304-3959(94)90007-8
更新日期：1994-06-01 00:00:00
abstract：:Inflammatory thermal hyperalgesia is principally mediated through transient receptor potential vanilloid 1 (TRPV1) channels, as demonstrated by prior studies using models of cutaneous inflammation. Muscle pain is significantly different from cutaneous pain, and the involvement of TRPV1 in hyperalgesia induced by muscl...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2012.04.034
更新日期：2012-08-01 00:00:00
abstract：:It has been confirmed that the voltage-gated persistent sodium currents mediate the generation of subthreshold membrane potential oscillations (SMPOs) and contribute to shaping repetitive firing. Our previous study indicated that gabapentin (GBP) administration induced a dose-dependent inhibition of SMPO in chronicall...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2009.01.020
更新日期：2009-05-01 00:00:00
abstract：:The primary purpose of this study was to examine the extent to which specific patient attitudes and beliefs about medical care and self-care for back pain predict future healthcare use. An automated database allowed examination of the predictive relationships in two primary care patient samples. In general, beliefs th...
journal_title：Pain
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0304-3959(99)00121-9
更新日期：1999-11-01 00:00:00
abstract：:Sendide is a selective and extremely potent antagonist of neurokinin-1 (NK1) receptors in the mouse spinal cord. The antinociceptive activities of sendide, an antagonist of NK1 receptors, and its analogue, [D-Trp7]sendide have been examined after intrathecal (i.t.) administrations in the mouse paw formalin test. Intra...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(94)00107-P
更新日期：1995-02-01 00:00:00
abstract：:OnabotulinumtoxinA (onabotA) has shown efficacy in chronic migraine (CM). Its mechanism of action, however, remains obscure. We have analysed whether treatment with onabotA is able to induce changes in interictal plasma calcitonin gene-related peptide (CGRP) concentrations, which have been shown to be increased in pat...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000119
更新日期：2015-05-01 00:00:00
abstract：:This study aimed to identify areas of disagreement in the management of neurogenic pain. A short questionnaire was mailed to 179 consultants with an interest in chronic pain (response rate 89%). The questionnaire listed 11 specific conditions involving nerve pain (e.g., post-herpetic neuralgia, causalgia) together wit...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(93)90035-N
更新日期：1993-09-01 00:00:00
abstract：:This study characterized the pain reported in a selected group of obstetrical patients in labor and compared the pain experienced at 2 stages of dilation, dilation of 2-5 cm and of 6-10 cm. Pain was defined as the perception of an unpleasant sensory and emotional experience with multidimensional factors that evoke beh...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(89)90215-7
更新日期：1989-09-01 00:00:00
abstract：:Quantitative sensory testing (QST) in accordance with the DFNS (German Research Network on Neuropathic Pain) protocol assesses the function of afferent nerve fibers on the basis of 13 parameters. Within the consortia IMI (Innovative Medicines Initiative) Europain and Neuropain, QST results from pain research units exp...
journal_title：Pain
pub_type： 杂志文章,多中心研究
doi：10.1097/j.pain.0000000000000433
更新日期：2016-03-01 00:00:00
