Pain and allodynia/hyperalgesia induced by intramuscular injection of serotonin in patients with fibromyalgia and healthy individuals.

abstract：:Neuropathic pain may be produced, at least in part, by the increased activity of primary afferent neurons. Studies have suggested that an accumulation of voltage-gated sodium channels at the site of peripheral nerve injury is a primary precursory event for subsequent afferent hyperexcitability. In this study, a human ...

journal_title：Pain

authors： Rabert DK,Koch BD,Ilnicka M,Obernolte RA,Naylor SL,Herman RC,Eglen RM,Hunter JC,Sangameswaran L

更新日期：1998-11-01 00:00:00

abstract：:This double-blind, within-subjects experiment examined the effects of ingesting two doses of caffeine on perceptions of leg muscle pain and blood pressure during moderate intensity cycling exercise. Low caffeine consuming college-aged males (N=12) ingested one of two doses of caffeine (5 or 10 mg.kg(-1) body weight) o...

journal_title：Pain

authors： O'Connor PJ,Motl RW,Broglio SP,Ely MR

更新日期：2004-06-01 00:00:00

abstract：:Chronic compression of rat dorsal root ganglion (CCD) produced tactile allodynia accompanied with hyperexcitability of the myelinated Aβ dorsal root ganglion (DRG) neurons. The Aβ DRG neuron hyperexcitability exhibits as bursting discharges in response to peripherally evoked action potentials (evoked bursting [EB]). T...

journal_title：Pain

authors： Song Y,Li HM,Xie RG,Yue ZF,Song XJ,Hu SJ,Xing JL

更新日期：2012-03-01 00:00:00

abstract：:Psychological trauma is associated with an increased risk for chronification of nonspecific chronic back pain (nsCLBP) independent of posttraumatic stress disorder (PTSD). However, the mechanisms underlying the role of psychological trauma in nsCLBP are less clear than in PTSD. Therefore, this study considered whether...

journal_title：Pain

authors： Tesarz J,Gerhardt A,Leisner S,Janke S,Treede RD,Eich W

更新日期：2015-04-01 00:00:00

abstract：:Activation of supraspinal gamma-aminobutyric acid-A (GABAA) receptors is known to result in antagonism of opioid analgesia. Since benzodiazepines enhance the action of GABA at GABAA receptors, we hypothesized that administration of these agents for preoperative sedation might antagonize the analgesic effects of opioid...

journal_title：Pain

authors： Gear RW,Miaskowski C,Heller PH,Paul SM,Gordon NC,Levine JD

更新日期：1997-05-01 00:00:00

abstract：:The purpose of this study was to explore gender differences in pain experiences, pain control beliefs, pain coping strategies, and depressive tendency among Chinese elderly with knee osteoarthritis (OA). Participants (N=199) were drawn from a previous convenience sample of outpatients with OA in Taiwan. Results indica...

journal_title：Pain

authors： Tsai YF

更新日期：2007-07-01 00:00:00

abstract：:Salmon calcitonin (s-CT) has been shown to be a valuable analgesic in phantom limb pain (PLP) in several case reports. To evaluate these findings a double-blind crossover comparison of s-CT treatment versus placebo was initiated. Twenty-one out of 161 patients who had undergone major amputations and developed severe P...

journal_title：Pain

authors： Jaeger H,Maier C

更新日期：1992-01-01 00:00:00

abstract：:Hindlimb pain models developed in rats have been transposed to mice, but assumed sciatic nerve neuroanatomic similarities have not been examined. We compared sciatic nerve structural organization in mouse strains (C57BL/6J, DBA/2J, and B6129PF2/J) and rat strains (Wistar, Brown Norway, and Sprague-Dawley). Dissection ...

journal_title：Pain

authors： Rigaud M,Gemes G,Barabas ME,Chernoff DI,Abram SE,Stucky CL,Hogan QH

更新日期：2008-05-01 00:00:00

abstract：:Questions concerning stump, phantom and other pain problems as well as demographic data were mailed to 5000 Americans whose amputations were connected with military service. Fifty-five percent responded and of these, 78% reported phantom pain. No predisposing factors, other than presence of stump pain, correlated with...

journal_title：Pain

authors： Sherman RA,Sherman CJ,Parker L

更新日期：1984-01-01 00:00:00

abstract：:Microvascular decompression (MVD) of cranial nerves has become an established treatment for trigeminal and (vago)glossopharyngeal neuralgia and for hemifacial spasm. The authors present the case of a 64-year-old man who had a 3.5-year history of severe, drug-resistant hemibody pain with sensory and autonomic disturban...

journal_title：Pain

authors： Simpson BA,Amato-Watkins A,Hourihan MD

更新日期：2014-08-01 00:00:00

abstract：:The present study sought to discover whether information clarifying how the analgesic/sedative drug nitrous oxide (N2O) works would result in increased analgesic responses to painful stimuli when various concentrations of N2O were administered. Subjects were provided with high and low levels of information regarding t...

journal_title：Pain

authors： Dworkin SF,Chen ACN,Schubert MM,Clark DW

更新日期：1984-08-01 00:00:00

abstract：:This study characterized the pain reported in a selected group of obstetrical patients in labor and compared the pain experienced at 2 stages of dilation, dilation of 2-5 cm and of 6-10 cm. Pain was defined as the perception of an unpleasant sensory and emotional experience with multidimensional factors that evoke beh...

journal_title：Pain

authors： Brown ST,Campbell D,Kurtz A

更新日期：1989-09-01 00:00:00

abstract：:Postmastectomy pain (PMP), a distinctive postsurgical neuropathic pain syndrome, has been thought to be consequence of 4-6% of surgical procedures for cancer of the breast, but remains understudied and poorly documented. In this cross-sectional descriptive study, a convenience sample of 95 women who had undergone brea...

journal_title：Pain

authors： Stevens PE,Dibble SL,Miaskowski C

更新日期：1995-04-01 00:00:00

abstract：:Drawing on advances in chronic pain metrics, a simplified Graded Chronic Pain Scale-Revised was developed to differentiate mild, bothersome, and high-impact chronic pain. Graded Chronic Pain Scale-Revised was validated among adult enrollees of 2 health plans (N = 2021). In this population, the prevalence of chronic pa...

journal_title：Pain

authors： Von Korff M,DeBar LL,Krebs EE,Kerns RD,Deyo RA,Keefe FJ

更新日期：2020-03-01 00:00:00

abstract：:The localization of sodium channels (NaChs) change following nerve lesions and this change may contribute to the development of increased pain states. Here we examine the change in distribution of NaChs within the rat infraorbital nerve (ION) two weeks after a combined inflammatory/partial axotomy lesion that results ...

journal_title：Pain

authors： Henry MA,Freking AR,Johnson LR,Levinson SR

更新日期：2006-09-01 00:00:00

abstract：:The tricyclic antidepressant drugs (TCAs) are commonly used in the treatment of chronic, especially neuropathic, pain. We evaluated their possible effect on a new model of neuropathic pain-related behaviour induced by ligatures tied loosely around the common sciatic nerve. The effects of 3 TCAs with different monoamin...

journal_title：Pain

authors： Ardid D,Guilbaud G

更新日期：1992-05-01 00:00:00

abstract：:Two hundred and sixty-three ambulatory patients older than 21 years of age who were attending clinics at an oncology hospital in San Juan, Puerto Rico, were studied. They completed a questionnaire (BQ-PR) that measures 8 concerns about reporting pain and using analgesics, such as fears of addiction and tolerance and t...

journal_title：Pain

authors： Ward SE,Hernandez L

更新日期：1994-08-01 00:00:00

abstract：:Advances in pain measurement using ecological momentary assessments offer novel opportunities for understanding the temporal dynamics of pain. This study examined whether regime-switching models, which capture processes characterized by recurrent shifts between different states, provide clinically relevant information...

journal_title：Pain

authors： Schneider S,Junghaenel DU,Ono M,Stone AA

更新日期：2018-07-01 00:00:00

abstract：:In several pain models, tricyclic antidepressants (TCAs) have been shown to reduce nociception. In the present study, we evaluated the antinociceptive effect of metapramine (META) in 4 nociception tests: (1) the hot plate test; (2) the phenylbenzoquinone-induced writhing; (3) the tail flick test; and (4) the test of e...

journal_title：Pain

authors： Michael-Titus A,Costentin J

更新日期：1987-12-01 00:00:00

abstract：:Individuals diagnosed with fibromyalgia syndrome (FMS) report chronic pain that is frequently worsened by physical activity and improved by rest. Palpation of muscle and tendinous structures suggests that nociceptors in deep tissues are abnormally sensitive in FMS, but methods of controlled mechanical stimulation of m...

journal_title：Pain

authors： Staud R,Cannon RC,Mauderli AP,Robinson ME,Price DD,Vierck CJ Jr

更新日期：2003-03-01 00:00:00

abstract：:A portable constant current electrical stimulator with bipolar felt disk electrodes was developed for quantitative assessment of cutaneous sensibility. The new method was used in the measurement of thresholds for perception and pain in healthy volunteers. The mean values of the threshold for perception in different ar...

journal_title：Pain

authors： Laitinen LV,Eriksson TA

更新日期：1985-06-01 00:00:00

abstract：:Cognitions and beliefs appear important in predicting adjustment to chronic pain. The current study examines how cognitions and beliefs are related to psychosocial functioning. One hundred and sixty-three chronic pain out-patients were assessed. Regression analyses were performed using scores on the Pain Beliefs and P...

journal_title：Pain

authors： Stroud MW,Thorn BE,Jensen MP,Boothby JL

更新日期：2000-02-01 00:00:00

abstract：:Intraoral somatosensory sensitivity in patients with atypical odontalgia (AO) has not been investigated systematically according to the most recent guidelines. The aims of this study were to examine intraoral somatosensory disturbances in AO patients using healthy subjects as reference, and to evaluate the percent agr...

journal_title：Pain

authors： Baad-Hansen L,Pigg M,Ivanovic SE,Faris H,List T,Drangsholt M,Svensson P

更新日期：2013-08-01 00:00:00

abstract：:The TRPA1 and TRPV1 receptors are important pharmaceutical targets for antipruritic and analgesic therapy. Obtaining further knowledge on their roles and interrelationship in humans is therefore crucial. Preclinical results are contradictory concerning coexpression and functional interdependency of TRPV1 and TRPA1, bu...

journal_title：Pain

authors： Nielsen TA,Eriksen MA,Gazerani P,Andersen HH

更新日期：2018-10-01 00:00:00

abstract：:Ketanserin, a selective S2 serotonergic antagonist, was assessed against placebo in a double-blind cross-over study of 16 patients with chronic peripheral burning pain. Nine of these had signs of reflex sympathetic dystrophy (RSD). All patients underwent 4 intravenous regional treatments, 2 with ketanserin (10 mg for ...

journal_title：Pain

authors： Hanna MH,Peat SJ

更新日期：1989-08-01 00:00:00

abstract：:An evaluation of the analgesic, mood and side effects of the combination of intramuscular morphine and oral cocaine was conducted in 17 patients with postoperative pain and 19 others with chronic malignant pain for the purpose of assessing the therapeutic merits of so-called 'euphoriant' elixirs in the management of p...

journal_title：Pain

authors： Kaiko RF,Kanner R,Foley KM,Wallenstein SL,Canel AM,Rogers AG,Houde RW

更新日期：1987-10-01 00:00:00

abstract：:The termination of an unpleasant or painful somatic condition can produce a rewarding sense of relief, even if the stimulus that causes the termination is itself unpleasant or painful under normal circumstances. We aimed to identify central neural mechanisms of pain relief from capsaicin-elicited heat-hyperalgesia by ...

journal_title：Pain

authors： Mohr C,Leyendecker S,Mangels I,Machner B,Sander T,Helmchen C

更新日期：2008-10-15 00:00:00

abstract：:Numerous animal studies suggest that acute and chronic exposure to opioids can be associated with the development of hyperalgesia, i.e. an increased sensitivity to noxious stimuli. Hyperalgesia has been documented during withdrawal and on occasion while animals were still exposed to opioids. A pivotal role in the gene...

journal_title：Pain

authors： Angst MS,Koppert W,Pahl I,Clark DJ,Schmelz M

更新日期：2003-11-01 00:00:00

abstract：:In previous studies, pain behaviors produced in the spinal nerve ligation rat model of neuropathic pain were partly reduced by surgical lumbar sympathectomy. However, systemic injection of phentolamine, an alpha-adrenoceptor blocker, was not effective in reducing pain behaviors, at least in the Sprague-Dawley strain o...

journal_title：Pain

authors： Park SK,Chung K,Chung JM

更新日期：2000-08-01 00:00:00

abstract：:Percentage of pain intensity difference (PercentPID) is a recognized way of evaluating pain relief with an 11-point numerical rating scale (NRS) but is not without flaws. A new metric, the slope of relative pain intensity difference (SlopePID), which consists in dividing PercentPID by the time between 2 pain measureme...

journal_title：Pain

authors： Chauny JM,Paquet J,Lavigne G,Marquis M,Daoust R

更新日期：2016-02-01 00:00:00