Cocaine and morphine interaction in acute and chronic cancer pain.

Abstract:

:An evaluation of the analgesic, mood and side effects of the combination of intramuscular morphine and oral cocaine was conducted in 17 patients with postoperative pain and 19 others with chronic malignant pain for the purpose of assessing the therapeutic merits of so-called 'euphoriant' elixirs in the management of pain in cancer patients. The study was designed as a randomized and double-blind single dose but complete cross-over comparison of the combination of 10 mg intramuscular morphine and 10 mg oral cocaine with morphine alone, cocaine alone, and placebo. While patients clearly discriminated between the analgesic effects of morphine and placebo, there were no differences in the analgesic responses to cocaine and placebo, or in responses to morphine and the combination of morphine and cocaine in either patient group. Side effects were predominantly morphine-like and occurred in 59% of patients after the combination, 43% after morphine, 34% after cocaine and 25% after placebo. Interaction effects between cocaine and morphine were observed in terms of positive changes toward selected aspects of mood (e.g., cheerful, friendly) in postoperative patients but toward negative aspects of mood (e.g., sad, serious) in patients with chronic pain.

journal_name

Pain

journal_title

Pain

authors

Kaiko RF,Kanner R,Foley KM,Wallenstein SL,Canel AM,Rogers AG,Houde RW

doi

10.1016/0304-3959(87)90004-2

subject

Has Abstract

pub_date

1987-10-01 00:00:00

pages

35-45

issue

1

eissn

0304-3959

issn

1872-6623

pii

00006396-198710000-00003

journal_volume

31

pub_type

临床试验,杂志文章,随机对照试验

相关文献

PAIN文献大全
  • The effect of trans-ACPD, a metabotropic excitatory amino acid receptor agonist, on the responses of primate spinothalamic tract neurons.

    abstract::The responses of primate spinothalamic tract (STT) neurons to innocuous and noxious mechanical stimuli applied to the skin can be enhanced for more than an hour following prolonged noxious stimulation. This increased responsiveness is thought to reflect sensitization of dorsal horn neurons and may help account for sec...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(94)90164-3

    authors: Paleček J,Palečková V,Dougherty PM,Willis WD

    更新日期:1994-03-01 00:00:00

  • Psychological interventions that target sleep reduce pain catastrophizing in knee osteoarthritis.

    abstract::Pain catastrophizing is a significant risk factor for patients with knee osteoarthritis (KOA) and thus is a target for many psychological interventions for pain. This study examined if interventions targeting sleep found to be effective in improving sleep in KOA also reduce pain catastrophizing measured as a trait thr...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001023

    authors: Lerman SF,Finan PH,Smith MT,Haythornthwaite JA

    更新日期:2017-11-01 00:00:00

  • Differential neurophysiological correlates of bottom-up and top-down modulations of pain.

    abstract::The perception of pain is highly variable. It depends on bottom-up-mediated factors like stimulus intensity and top-down-mediated factors like expectations. In the brain, pain is associated with a complex pattern of neuronal responses including evoked potentials and induced responses at alpha and gamma frequencies. Al...

    journal_title:Pain

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.j.pain.0000460309.94442.44

    authors: Tiemann L,May ES,Postorino M,Schulz E,Nickel MM,Bingel U,Ploner M

    更新日期:2015-02-01 00:00:00

  • Conditioned place preference and spontaneous dorsal horn neuron activity in chronic constriction injury model in rats.

    abstract::Patients with neuropathic pain commonly present with spontaneous pain, in addition to allodynia and hyperalgesia. Although evoked responses in neuropathic pain models are well characterized, determining the presence of spontaneous pain is more challenging. We determined whether the chronic constriction injury (CCI) mo...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000000365

    authors: Dalm BD,Reddy CG,Howard MA,Kang S,Brennan TJ

    更新日期:2015-12-01 00:00:00

  • Stress-related pain behavior in rats with peripheral nerve injuries.

    abstract::The effects of cold stress were studied on rats with unilaterally sectioned sciatic nerves. Behaviors suggestive of pain occurred in a number of these animals. These behaviors vanished when removing the rats from the stressful environment. Some severely painful syndromes in man might in part be due to mechanisms simil...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(80)90073-1

    authors: Wiesenfeld Z,Hallin RG

    更新日期:1980-06-01 00:00:00

  • Reactive oxygen species contribute to neuropathic pain by reducing spinal GABA release.

    abstract::Although both a loss of spinal inhibitory neurotransmission and the involvement of oxidative stress have been regarded as important mechanisms in the pathogenesis of pain, the relationship between these 2 mechanisms has not been studied. To determine whether reactive oxygen species (ROS) involvement in pain mechanisms...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2010.12.034

    authors: Yowtak J,Lee KY,Kim HY,Wang J,Kim HK,Chung K,Chung JM

    更新日期:2011-04-01 00:00:00

  • Secondary hyperalgesia to mechanical but not heat stimuli following a capsaicin injection in hairy skin.

    abstract::A psychophysical investigation was carried out to examine whether heat hyperalgesia exists within the secondary mechanical hyperalgesia zone surrounding a capsaicin injection site on hairy skin. A non-contact laser stimulator was used to deliver temperature controlled stimuli to sites within and outside the zone of me...

    journal_title:Pain

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0304-3959(96)03199-5

    authors: Ali Z,Meyer RA,Campbell JN

    更新日期:1996-12-01 00:00:00

  • Relationship between hypothalamic-pituitary-adrenal activity and blockade of tolerance to morphine analgesia by pain: a strain comparison.

    abstract::We previously reported that morphine fails to produce analgesic tolerance when administered in the presence of formalin-induced pain. The hypothalamic-pituitary-adrenal (HPA) axis is known to respond to stressful stimuli, including pain. To examine whether the blockade of tolerance by pain is related to HPA activity, ...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(95)00069-0

    authors: Vaccarino AL,Couret LC Jr

    更新日期:1995-12-01 00:00:00

  • Autoimmunity against the β2 adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome.

    abstract::Complex regional pain syndrome (CRPS) is a painful condition affecting one or more extremities of the body, marked by a wide variety of symptoms and signs that are often difficult to manage because the pathophysiology is incompletely understood. Thus, diverse treatments might be ineffective. A recent report revealed t...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2011.06.012

    authors: Kohr D,Singh P,Tschernatsch M,Kaps M,Pouokam E,Diener M,Kummer W,Birklein F,Vincent A,Goebel A,Wallukat G,Blaes F

    更新日期:2011-12-01 00:00:00

  • Self efficacy as a mediator of the relationship between pain intensity, disability and depression in chronic pain patients.

    abstract::To clarify the relationships between physical, and psychosocial components of chronic pain, a path analytic model was tested conceptualizing self efficacy as a mediator of disability. In turn, disability was hypothesized to mediate depression. This model could help explain the circumstances under which disability deve...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/S0304-3959(98)00220-6

    authors: Arnstein P,Caudill M,Mandle CL,Norris A,Beasley R

    更新日期:1999-04-01 00:00:00

  • Treatment of terminal cancer pain in France: a questionnaire study.

    abstract::Compared with other European countries, French laws and restrictions concerning the use of opioids are of medium severity only. Still, together with Germany, Belgium and Spain, France belongs to the group of countries with a low national consumption of morphine, calculated by the International Narcotics Control Board ...

    journal_title:Pain

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0304-3959(94)00264-F

    authors: Vainio A

    更新日期:1995-08-01 00:00:00

  • Independent effects of ischaemia and noradrenaline on thermal hyperalgesia in capsaicin-treated skin.

    abstract::Noradrenaline increases thermal hyperalgesia in skin previously sensitized by capsaicin. The aim of the present study was to determine whether a vasoconstrictor ischaemic effect of noradrenaline increases thermal hyperalgesia. Heat pain thresholds were measured in the capsaicin-treated and untreated skin on the forear...

    journal_title:Pain

    pub_type: 临床试验,杂志文章

    doi:10.1016/0304-3959(96)03115-6

    authors: Drummond PD

    更新日期:1996-09-01 00:00:00

  • 5-hydroxytryptamine1A receptor is involved in the bee venom induced inflammatory pain.

    abstract::Injection of bee venom into one hindpaw of rat can elicit acute inflammation together with spontaneous pain, heat hyperalgesia and mechanical hyperalgesia/allodynia in the injected paw. 5-hydroxytryptamine (5-HT)1A receptor is the predominant receptor subtype in the spinal dorsal horn mediating the function of 5-HT in...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/s0304-3959(03)00315-4

    authors: Wang W,Wu SX,Wang YY,Liu XY,Li YQ

    更新日期:2003-11-01 00:00:00

  • Discrepancies between registered and published primary outcome specifications in analgesic trials: ACTTION systematic review and recommendations.

    abstract::The National Institutes of Health released the trial registry ClinicalTrials.gov in 2000 to increase public reporting and clinical trial transparency. This systematic review examined whether registered primary outcome specifications (POS; ie, definitions, timing, and analytic plans) in analgesic treatment trials corre...

    journal_title:Pain

    pub_type: 杂志文章,评审

    doi:10.1016/j.pain.2013.08.011

    authors: Smith SM,Wang AT,Pereira A,Chang DR,McKeown A,Greene K,Rowbotham MC,Burke LB,Coplan P,Gilron I,Hertz SH,Katz NP,Lin AH,McDermott MP,Papadopoulos EJ,Rappaport BA,Sweeney M,Turk DC,Dworkin RH

    更新日期:2013-12-01 00:00:00

  • Peripheral nerve injury and sensitization underlie pain associated with oral cancer perineural invasion.

    abstract::Cancer invading into nerves, termed perineural invasion (PNI), is associated with pain. Here, we show that oral cancer patients with PNI report greater spontaneous pain and mechanical allodynia compared with patients without PNI, suggesting that unique mechanisms drive PNI-induced pain. We studied the impact of PNI on...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001986

    authors: Salvo E,Campana WM,Scheff NN,Nguyen TH,Jeong SH,Wall I,Wu AK,Zhang S,Kim H,Bhattacharya A,Janal MN,Liu C,Albertson DG,Schmidt BL,Dolan JC,Schmidt RE,Boada MD,Ye Y

    更新日期:2020-11-01 00:00:00

  • Mapping a gene for neuropathic pain-related behavior following peripheral neurectomy in the mouse.

    abstract::Total hindpaw denervation in rodents elicits an abnormal behavior of licking, scratching and self-injury of the anesthetic limb ("autotomy"). Since the same denervation produces phantom limb pain and anesthesia dolorosa in humans, autotomy has been used as a model of human neuropathic pain. Autotomy is an inherited tr...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/S0304-3959(01)00295-0

    authors: Seltzer Z,Wu T,Max MB,Diehl SR

    更新日期:2001-08-01 00:00:00

  • Disproportionate longer-term opioid use among U.S. adults with mood disorders.

    abstract::Adults with mood disorders frequently use prescription opioids. The factors associated with this increased use remain unclear. We used the Medical Expenditure Panel Surveys from 2005 to 2011 to measure the association of mood disorders with new opioid use and the transition to longer-term opioid use for a variety of p...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000000650

    authors: Halbert BT,Davis RB,Wee CC

    更新日期:2016-11-01 00:00:00

  • "Being" in pain: the role of self-discrepancies in the emotional experience and activity patterns of patients with chronic low back pain.

    abstract::Chronic pain not only interferes with daily activities, it may also have a negative impact on the perceived integrity of one's self through self-discrepancies. Self-discrepancies are experienced distances between the actual self and self-guides that can exist from 2 perspectives (ie, own and other). Self-discrepancies...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2010.11.009

    authors: Kindermans HPJ,Huijnen IPJ,Goossens MEJB,Roelofs J,Verbunt JA,Vlaeyen JWS

    更新日期:2011-02-01 00:00:00

  • Anterior nucleus of paraventricular thalamus mediates chronic mechanical hyperalgesia.

    abstract::Pain-related diseases are the top leading causes of life disability. Identifying brain regions involved in persistent neuronal changes will provide new insights for developing efficient chronic pain treatment. Here, we showed that anterior nucleus of paraventricular thalamus (PVA) plays an essential role in the develo...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001497

    authors: Chang YT,Chen WH,Shih HC,Min MY,Shyu BC,Chen CC

    更新日期:2019-05-01 00:00:00

  • Why cooling is beneficial: non-linear temperature-dependency of stimulated iCGRP release from isolated rat skin.

    abstract::The capsaicin receptor in nociceptive neurons is a target for the sensitizing actions of algogenic inflammatory mediators. Capsaicin and potential endogenous ligands are thought not to gate this heat-activated ion channel but to sensitize it so profoundly that even room temperature can open it. We investigated the tem...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2004.03.033

    authors: Kichko TI,Reeh PW

    更新日期:2004-07-01 00:00:00

  • Examiner expectancy effects in the measurement of pressure pain thresholds.

    abstract::The ascending Method of Limits, used for the determination of pressure pain thresholds (PPT), is not a psychophysically robust method. The present study sought to determine if the examiner's expectancy, based on whether the measurement site was clinically 'painful' or 'non-painful', would bias the obtained PPT values....

    journal_title:Pain

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0304-3959(97)00174-7

    authors: Ohrbach R,Crow H,Kamer A

    更新日期:1998-02-01 00:00:00

  • The use of topical 4% lidocaine in spheno-palatine ganglion blocks for the treatment of chronic muscle pain syndromes: a randomized, controlled trial.

    abstract::To assess the efficacy of 4% topical lidocaine in spheno-palatine blocks, a randomized controlled trial was carried out on patients with chronic muscle pain syndromes. Sixty-one patients (42 with fibromyalgia (FM) and 19 with myofascial pain syndrome (MPS)) completed the trial. Outcome measures included pain intensity...

    journal_title:Pain

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0304-3959(94)00232-4

    authors: Scudds RA,Janzen V,Delaney G,Heck C,McCain GA,Russell AL,Teasell RW,Varkey G,Woodbury GM

    更新日期:1995-07-01 00:00:00

  • Disruption and restoration of dorsal horn sensory map after peripheral nerve crush and regeneration.

    abstract::Formalin injection into the hindpaw of rats produces many neurons with c-fos protein-like immunoreactivity (fos-neurons) in the medial 3/4 of the ipsilateral dorsal horn laminae I and II at the junction of 4th and 5th lumbar segments (the sciatic territory). The tibial nerve transection 2 or 3 days earlier resulted in...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(95)00014-J

    authors: Sugimoto T,Yoshida A,Nishijima K,Ichikawa H

    更新日期:1995-10-01 00:00:00

  • Experimental evaluation of the analgesic effect of ibuprofen on primary and secondary hyperalgesia.

    abstract::The analgesic effect of systemic ibuprofen was investigated with two human experimental pain models: (i) static mechanical stimulation of the inter digital web between the 2nd and 3rd finger and (ii) primary and secondary hyperalgesia induced by a 7-min burn injury on the calf. In each double-blind, randomized, two-wa...

    journal_title:Pain

    pub_type: 临床试验,杂志文章,随机对照试验,评审

    doi:10.1016/s0304-3959(96)03316-7

    authors: Petersen KL,Brennum J,Dahl JB

    更新日期:1997-04-01 00:00:00

  • Prevalence of chronic pain with or without neuropathic characteristics in France using the capture-recapture method: a population-based study.

    abstract::Capture-recapture methods are increasingly used to determine the prevalence of numerous chronic conditions but have never been used in the context of chronic pain (CP). This study sought to provide up-to-date estimates of the prevalence of people experiencing CP ± neuropathic characteristics in France using the captur...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001347

    authors: Chenaf C,Delorme J,Delage N,Ardid D,Eschalier A,Authier N

    更新日期:2018-11-01 00:00:00

  • A role for NT-3 in the hyperinnervation of neonatally wounded skin.

    abstract::Neurotrophin-3 (NT-3) is a target-derived neurotrophic factor that regulates sensory neuronal survival and growth. Here we report that NT-3 plays a critical permissive role in cutaneous sensory nerve sprouting that contributes to pain and sensitivity following skin wounding in young animals. Sensory terminal sprouting...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2012.07.012

    authors: Beggs S,Alvares D,Moss A,Currie G,Middleton J,Salter MW,Fitzgerald M

    更新日期:2012-10-01 00:00:00

  • Personalized evaluation of self-hypnosis as a treatment of chronic pain: a repertory grid analysis.

    abstract::Self-hypnosis was taught to 5 highly hypnotisable patients referred to Auckland Hospital Pain Clinic. Evaluation included the Illness Self-Concept Repertory Grid (ISCRG) and follow-up was at 1 and 6 months post treatment. Consensus grids indicated the subjects initially identified with physical illness but this associ...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(88)90223-0

    authors: Large RG,James FR

    更新日期:1988-11-01 00:00:00

  • Intraspinal alumina injection: the relationship between epileptiform focus, root scarring and chronic pain.

    abstract::Intramedullary or subarachnoid injections of alumina cream were made in the lumbar region of 38 adult cats. The animals were observed for 3 to 12 months and then subjected to acute neurophysiologic and histologic analysis. Neuronal hyperactivity in the dorsal horns was reliably produced by either subarachnoid or intra...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(78)90011-8

    authors: Loeser JD,Peirce KR

    更新日期:1978-10-01 00:00:00

  • Interaction between protein kinase D1 and transient receptor potential V1 in primary sensory neurons is involved in heat hypersensitivity.

    abstract::In previous studies we demonstrated that protein kinase D1 (PKD1/PKCmu) could directly phosphorylate the transient receptor potential V1 (TRPV1) at its N-terminal region and enhance the function of TRPV1 in CHO cells stably transfected with TRPV1. In the current study we assessed the involvement of PKD1 in pain modula...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/j.pain.2007.10.025

    authors: Zhu H,Yang Y,Zhang H,Han Y,Li Y,Zhang Y,Yin D,He Q,Zhao Z,Blumberg PM,Han J,Wang Y

    更新日期:2008-07-31 00:00:00

  • Prevalence of chronic pain in psychiatric patients.

    abstract::Five hundred consecutive patients attending a psychiatric clinic were examined in order to ascertain the prevalence of chronic pain in various psychiatric illnesses and demographic categories. Chronic pain was found to be a frequent symptom in anxiety neurosis (60%), neurotic depression (45%) and hysteria (24.3%). Les...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1016/0304-3959(87)91039-6

    authors: Chaturvedi SK

    更新日期:1987-05-01 00:00:00