Abstract:
:Migraine encompasses a broader spectrum of sensory symptoms than just headache. These "other" symptoms, eg, sensory phobias, cognitive and mood changes, allodynia, and many others indicate an altered sensitivity to sensory input which can be measured, in principle, by quantifying sensory threshold changes longitudinally over time. Photophobia, for example, can be quantified by investigating the discomfort thresholds towards the luminance of light. The aim of this review is to look into how thresholds change in patients with migraine. We performed a PubMed search up to June 2018 targeting all peer-reviewed articles evaluating the changes in threshold, sensory phobia, or sensitivity in patients with migraine. Migraineurs, in general, exhibit lower sensory thresholds compared with healthy controls. These threshold changes seem to follow the different phases during a migraine cycle. In general, thresholds reach a nadir when the headache starts (the ictal phase), rise after the headache ends, and then gradually descend towards the next attack. The sensory modality of measurement-mechanical, thermal, or nociceptive-and the location of measurement-trigeminal vs somatic dermatome-also influence the sensory threshold. Functional imaging studies provide evidence that the hypothalamo-thalamo-brainstem network may be the driving force behind the periodic threshold changes. In summary, there is evidence in the literature that migraine could be understood as a periodic sensory dysregulation originating from the brain. Nevertheless, the interstudy discrepancy is still high due to different study designs and a lack of focus on distinct migraine phases. Further well-designed and harmonized studies with an emphasis on the cyclic changes still need to be conducted.
journal_name
Painjournal_title
Painauthors
Peng KP,May Adoi
10.1097/j.pain.0000000000001531subject
Has Abstractpub_date
2019-07-01 00:00:00pages
1494-1501issue
7eissn
0304-3959issn
1872-6623pii
00006396-201907000-00003journal_volume
160pub_type
杂志文章,评审相关文献
PAIN文献大全abstract::Treatment of adult rats with a single dose of nerve growth factor (NGF, 1 mg/kg, i.p.) results in a prolonged hypersensitivity to noxious thermal stimulation which becomes noticeable within 30 min of administration and lasts for several days. A significant mechanical hyperalgesia develops within 7 h following injectio...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(96)03060-6
更新日期:1996-08-01 00:00:00
abstract::These experiments quantitatively analyzed effects of electrical midbrain stimulation on a nociceptive hind limb flexion reflex in rats anesthetized with sodium pentobarbital. We recorded the force of isometric hind limb flexion withdrawal, and related flexor electromyographic (EMG) activity, elicited by noxious heat (...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(88)90092-9
更新日期:1988-05-01 00:00:00
abstract::Age and sex differences were investigated in children's self-report of venipuncture pain. Equal numbers of boys and girls aged 3-15 years (n = 110) made separate ratings of the intensity and unpleasantness of their needle pain, using a paired Visual Analogue Scale (VAS) technique. The parents of these children used th...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(98)00201-2
更新日期:1999-03-01 00:00:00
abstract::Many studies of pain and nociception use short-lasting acute stimuli which may have limited relevance to prolonged or chronic pain states. Using extracellular single-unit recording in the dorsal horn of the rat lumbar spinal cord the present study examines the response of neurones to a long-lasting nociceptive stimulu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(87)90023-6
更新日期:1987-09-01 00:00:00
abstract::The treatment of neuropathic pain by neuromodulation is an objective for more than 40 years in modern clinical practice. With respect to spinal cord and deep brain structures, the cerebral cortex is the most recently evaluated target of invasive neuromodulation therapy for pain. In the early 90s, the first successes o...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1097/j.pain.0000000000000401
更新日期:2016-02-01 00:00:00
abstract::Persistent Idiopathic Facial Pain (PIFP) is a poorly understood chronic pain syndrome of the face, formerly known as atypical facial pain. It is characterized by a constant painful sensation without neurological abnormalities and without clinically objectifiable cause. Similarities to neuropathic pain conditions have ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002126
更新日期:2020-10-26 00:00:00
abstract::Pain that interferes with daily life appears to be strongly age-related in cross-sectional studies, although the nature of this relationship over time has not been established. We have investigated the onset and persistence of pain and pain interference over a 3-year period to determine their association with age in o...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.09.027
更新日期:2007-05-01 00:00:00
abstract::Clinical trials on the treatment of pain syndromes have adopted Patient Global Impression of Change (PGIC) as a primary outcome. However, little is known about how change in clinical status influences these ratings. The present study examined relationships between changes in pain, depressed mood, physical functioning,...
journal_title:Pain
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.pain.2010.02.043
更新日期:2010-05-01 00:00:00
abstract::A chronic compression of the dorsal root ganglion (CCD) produces ipsilateral cutaneous hyperalgesia and allodynia in rats. Intracellular electrophysiological recordings from formerly compressed neurons in the intact dorsal root ganglion (DRG) reveal lower than normal current thresholds (CTs) and abnormal spontaneous a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.10.001
更新日期:2005-01-01 00:00:00
abstract::Recent research has focused on identification of clinically meaningful subgroupings within the chronic pain population in contrast to prior emphasis on the homogeneity of these patients. The present study investigates site of pain as a potentially useful classification variable for identification of differences among ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90085-X
更新日期:1984-08-01 00:00:00
abstract::Bone is one of the leading sites of metastasis for frequently diagnosed malignancies, including those arising in the breast, prostate and lung. Although these cancers develop unnoticed and are painless in their primary sites, bone metastases result in debilitating pain. Deeper investigation of this pain may reveal eti...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000681
更新日期:2016-11-01 00:00:00
abstract::The local anesthetic lidocaine was injected into the dentate gyrus (DG) of alert, unrestrained rats 10 min prior to investigation within the formalin test. Regional anesthesia of the DG resulted in a reduction of pain scores when administered contralateral to the site of subcutaneous formalin injection. The analgesic ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90195-H
更新日期:1992-04-01 00:00:00
abstract::A secondary zone of cutaneous hyperalgesia in humans is characterized by increased pain to mechanical stimuli. In contrast, the perception of heat stimuli delivered to a secondary zone of hyperalgesia in humans often shows a paradoxical decrease in magnitude. A number of studies have shown that the responses of spinal...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(98)00079-7
更新日期:1998-08-01 00:00:00
abstract::Although pediatric functional abdominal pain (FAP) has been linked to abdominal pain later in life, childhood predictors of long-term outcomes have not been identified. This study evaluated whether distinct FAP profiles based on patterns of pain and adaptation in childhood could be identified and whether these profile...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.03.026
更新日期:2012-09-01 00:00:00
abstract::We investigated the efficacy of local intraplantar (i.pl.) injection of peptide and non-peptide mu-, delta- and kappa-opioid receptor agonists in rat models of inflammatory and neuropathic pain. Locally applied agonists dose-dependently reduced formalin-induced flinching of the inflamed paw and induced antiallodynic a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.12.006
更新日期:2009-02-01 00:00:00
abstract::The spinal gray matter region around the central canal, lamina X, is critically involved in somatosensory processing and visceral nociception. Although several classes of primary afferent fibers terminate or decussate in this area, little is known about organization and functional significance of the afferent supply o...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001586
更新日期:2019-09-01 00:00:00
abstract::To clarify the relationships between physical, and psychosocial components of chronic pain, a path analytic model was tested conceptualizing self efficacy as a mediator of disability. In turn, disability was hypothesized to mediate depression. This model could help explain the circumstances under which disability deve...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(98)00220-6
更新日期:1999-04-01 00:00:00
abstract::Human unmyelinated (C) tactile afferents signal the pleasantness of gentle skin stroking on hairy (nonglabrous) skin. After neuronal injury, that same type of touch can elicit unpleasant sensations: tactile allodynia. The prevailing pathophysiological explanation is a spinal cord sensitization, triggered by nerve inju...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.10.024
更新日期:2013-02-01 00:00:00
abstract::Measurement of depression and other mood states in pain patients has been criticised in recent years on the grounds that most questionnaires were not developed in pain populations and suffer from criterion contamination by somatic items. In addition, there is no accepted measurement for positive emotions which are mor...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.02.004
更新日期:2004-05-01 00:00:00
abstract::Pain is processed in multiple cortical and subcortical brain areas. Subcortical structures are substantially involved in different processes that are closely linked to pain processing, e.g. motor preparation, autonomic responses, affective components and learning. However, it is unclear to which extent nociceptive inf...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(02)00157-4
更新日期:2002-09-01 00:00:00
abstract::Pregnant women may take nonsteroidal antiinflammatory drugs (NSAIDs), selective cyclooxygenase (COX)-2 inhibitors, or biological agents to relieve symptoms or manage disease flares in late pregnancy. We aimed to quantify the risk of prematurity associated with late pregnancy exposure to nonselective NSAIDs, selective ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001163
更新日期:2018-05-01 00:00:00
abstract::Formalin injection into the hindpaw of rats produces many neurons with c-fos protein-like immunoreactivity (fos-neurons) in the medial 3/4 of the ipsilateral dorsal horn laminae I and II at the junction of 4th and 5th lumbar segments (the sciatic territory). The tibial nerve transection 2 or 3 days earlier resulted in...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(95)00014-J
更新日期:1995-10-01 00:00:00
abstract::Polyneuropathy can be linked to chronic pain but also to reduced pain sensitivity. We investigated peripheral C-nociceptors in painful and painless polyneuropathy patients to identify pain-specific changes. Eleven polyneuropathy patients with persistent spontaneous pain and 8 polyneuropathy patients without spontaneou...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.05.017
更新日期:2012-10-01 00:00:00
abstract::We report on 8 patients treated with subcutaneous methadone for cancer-related pain at 2 institutions. The success of other subcutaneous agents for pain control has been well demonstrated. It was felt that methadone would be useful due to its low cost. Unfortunately, 7 of the 8 patients experienced adverse reactions a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90179-2
更新日期:1991-05-01 00:00:00
abstract::Chronic pain after laparoscopic cholecystectomy is related to postoperative pain during the first postoperative week, but it is unknown which components of the early pain response is important. In this prospective study, 100 consecutive patients were examined preoperatively, 1 week postoperatively, and 3, 6, and 12 mo...
journal_title:Pain
pub_type: 杂志文章,多中心研究
doi:10.1016/j.pain.2014.09.019
更新日期:2014-11-01 00:00:00
abstract::Wind-up and secondary hyperalgesia both are related to central sensitization, but whereas the former is explained by homosynaptic facilitation, the latter is due to heterosynaptic facilitation. To investigate possible interactions between both types of facilitation, we tested for alterations of perceptual wind-up in t...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(97)00177-2
更新日期:1998-02-01 00:00:00
abstract::In a rat model of artificial ureteral calculosis, the aim of the study was to characterize the behavioural manifestations of direct visceral pain and to evaluate the relationship between number, duration and complexity of the visceral episodes and the extent of referred lumbar muscular hyperalgesia. As evidenced by no...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)00208-V
更新日期:1995-06-01 00:00:00
abstract::Increased blood pressure and sweet taste are often associated with decreased pain sensitivity. Animal research suggests that endogenous opioids are involved in both these relationships. Fifty-eight healthy young adults (36 male, 22 female) participated in two sessions receiving a placebo tablet or 50mg of naltrexone o...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.05.003
更新日期:2008-03-01 00:00:00
abstract::The present prospective longitudinal study on chronic postoperative pain was conducted to assess the predictive power of attentional and emotional variables specifically assumed to augment pain, such as pain hypervigilance, pain-related anxiety, pain catastrophizing and attentional biases to pain. Their relevance was ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.08.041
更新日期:2010-12-01 00:00:00
abstract::A 1-year follow-up of two preadolescent age cohorts with musculoskeletal pain at least once a week was conducted to analyze predictive factors for the persistence of musculoskeletal pain. Of the 564 children with pain at baseline, representing one third of the sample studied, 515 (91.3%) could be followed and 452 (80....
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(98)00083-9
更新日期:1998-07-01 00:00:00