Abstract:
:Evidence has been accumulated suggesting that a dysfunction in pain inhibitory systems, i.e. in 'diffuse noxious inhibitory controls' (DNIC)-like mechanisms, might be-amongst other factors-responsible for the development of anatomically generalized chronic pain like fibromyalgia. The aim of the present study was to look for similar impairments in chronic tension-type headache (CTTH) as a regionally specific pain syndrome. Twenty-nine CTTH patients and 25 age- and sex-matched healthy control subjects participated in the study. After baseline assessment of electrical detection and pain thresholds, tonic heat stimuli were concurrently applied by a thermode to the thigh to induce DNIC-like pain inhibition. Tonic heat stimuli were applied either slightly above ('pain' condition) or slightly below ('heat' condition) pain threshold. For determination of electrical detection and pain thresholds, electrocutaneous stimuli were administered either to the forearm (extra-cranial site) or to the temple (cranial site), using a multiple staircase procedure. The increase in the electrical detection and pain thresholds induced by concurrent tonic heat stimulation was significantly smaller in the CTTH patients than in the control subjects. This group difference was present during the 'pain' as well as the 'heat' condition. Furthermore, the electrical detection and pain thresholds were affected in this group-specific manner both at the forearm and at the temple. These findings suggest that patients with CTTH suffer from deficient DNIC-like pain inhibitory mechanisms in a similar manner, as do patients with anatomically generalized chronic pain like fibromyalgia.
journal_name
Painjournal_title
Painauthors
Pielsticker A,Haag G,Zaudig M,Lautenbacher Sdoi
10.1016/j.pain.2005.08.019keywords:
subject
Has Abstractpub_date
2005-11-01 00:00:00pages
215-23issue
1-2eissn
0304-3959issn
1872-6623pii
S0304-3959(05)00418-5journal_volume
118pub_type
杂志文章相关文献
PAIN文献大全abstract::Changes in pain produced by psychological factors (e.g., placebo analgesia) are thought to result from the activity of specific cortical regions. However, subcortical nuclei, including the periaqueductal gray and the rostroventral medulla, also show selective activation when subjects expect pain relief. These brainste...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.11.011
更新日期:2007-07-01 00:00:00
abstract::Individual differences in interoceptive sensitivity are associated with differences in reported intensity of emotional experience, vulnerability to anxiety and mood disorder and capacity for emotional self-regulation. Enhanced sensitivity to autonomic state is often accompanied by increased autonomic reactivity. Here ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.04.030
更新日期:2012-08-01 00:00:00
abstract::We compared patient-controlled analgesia (PCA) and continuous infusion (CI) morphine delivery in a randomized controlled trial in adolescents during oropharyngeal mucositis pain after bone marrow transplantation. Results from 20 patients who completed 7 or more days on study (10 PCA, 10 CI) were evaluated. The group m...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(91)90109-B
更新日期:1991-09-01 00:00:00
abstract::The presence of a trigger point is essential to the myofascial pain syndrome. This study centres on identifying clearer criteria for the presence of trigger points in the quadratus lumborum and gluteus medius muscle by investigating the occurrence and inter-rater reliability of trigger point symptoms. Using the sympto...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(94)90125-2
更新日期:1994-09-01 00:00:00
abstract::The analgesic efficacy of single doses of oral morphine sulphate solution (10 mg) and ibuprofen 600 mg was compared in 12 volunteers using a double-blind, double-dummy, placebo-controlled design on the cold pressor experimental pain model. Measurement of pain intensity was made before medication and then at 30, 60, 90...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(88)90156-X
更新日期:1988-08-01 00:00:00
abstract::Complex regional pain syndrome (CRPS) is a painful condition affecting one or more extremities of the body, marked by a wide variety of symptoms and signs that are often difficult to manage because the pathophysiology is incompletely understood. Thus, diverse treatments might be ineffective. A recent report revealed t...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.06.012
更新日期:2011-12-01 00:00:00
abstract::To inform case definition for neck/shoulder pain in epidemiological research, we compared levels of disability, patterns of association, and prognosis for pain that was limited to the neck or shoulders (LNSP) and more generalised musculoskeletal pain that involved the neck or shoulder(s) (GPNS). Baseline data on muscu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000477
更新日期:2016-05-01 00:00:00
abstract::In a study to determine how children describe the experience of pain, we queried a convenience sample of 100 children in hospitals and 114 children in church and private schools who were between 9 and 12 years old. The questions were designed to seek correlations by age among boys and girls, and between hospitalized a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(82)90091-4
更新日期:1982-10-01 00:00:00
abstract::In male rats, carrageenan (CAR)-induced inflammation or exposure to a selective protein kinase C epsilon (PKC epsilon ) agonist (psi epsilon RACK) produces prolongation of the hyperalgesia induced by a subsequent exposure to an inflammatory mediator, a phenomenon referred to as hyperalgesic priming. Since many chronic...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(03)00175-1
更新日期:2003-09-01 00:00:00
abstract::Many cancerous solid tumors metastasize to the bone and induce pain (cancer-induced bone pain [CIBP]). Cancer-induced bone pain is often severe because of enhanced inflammation, rapid bone degradation, and disease progression. Opioids are prescribed to manage this pain, but they may enhance bone loss and increase tumo...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000690
更新日期:2016-12-01 00:00:00
abstract::In a double-blind placebo-controlled cross-over study the effects of epidural morphine (4 mg) on somatosensory functions were investigated in 10 healthy volunteers. Detection, pain detection and pain tolerance thresholds to thermal, mechanical and electrical stimuli as well as magnitude rating of short-lasting stimuli...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(93)90117-8
更新日期:1993-01-01 00:00:00
abstract::Although conduction failure has been observed in nociceptive C-fibers, little is known regarding its significance or therapeutic potential. In a previous study, we demonstrated that C-fiber conduction failure, which is regarded as an intrinsic self-inhibition mechanism, was reduced in circumstances of painful diabetic...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000632
更新日期:2016-10-01 00:00:00
abstract::Genetics studies on the placebo hypoalgesic effect highlight a promising link between single nucleotide polymorphisms (SNPs) in the dopamine, opioid, and endocannabinoid genes and placebo hypoalgesia. However, epistasis and replication studies are missing. In this study, we expanded on previous findings related to the...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001578
更新日期:2019-08-01 00:00:00
abstract::We investigated whether intraoperative 'subanesthetic doses' of ketamine have a postoperative anti-hyperalgesic and an analgesic effect and which is the preferential route of administration, either systemic (intravenous, i.v.) or epidural. One hundred patients scheduled for rectal adenocarcinoma surgery under combined...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0304-3959(01)00278-0
更新日期:2001-06-01 00:00:00
abstract::Locus of control (LOC) beliefs, long thought important in adjustment to persistent pain, were studied among 160 subjects (67 males and 93 females) referred to a comprehensive pain rehabilitation program. The subscale structure of the Multidimensional Health Locus of Control (MHLC) was factorially replicated in our sam...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)91141-5
更新日期:1990-09-01 00:00:00
abstract::Chronic pain after joint replacement is common, affecting approximately 10% of patients after total hip replacement (THR) and 20% of patients after total knee replacement (TKR). Heightened generalized sensitivity to nociceptive input could be a risk factor for the development of this pain. The primary aim of this stud...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.0000000000000002
更新日期:2015-01-01 00:00:00
abstract::Intramedullary or subarachnoid injections of alumina cream were made in the lumbar region of 38 adult cats. The animals were observed for 3 to 12 months and then subjected to acute neurophysiologic and histologic analysis. Neuronal hyperactivity in the dorsal horns was reliably produced by either subarachnoid or intra...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(78)90011-8
更新日期:1978-10-01 00:00:00
abstract::Aiming at developing a new, noninvasive approach to spinal cord neuromodulation, we evaluated whether transcutaneous direct current (DC) stimulation induces long-lasting changes in the central pain pathways in human beings. A double-blind crossover design was used to investigate the effects of anodal direct current (2...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2010.10.041
更新日期:2011-02-01 00:00:00
abstract::This study aimed to identify areas of disagreement in the management of neurogenic pain. A short questionnaire was mailed to 179 consultants with an interest in chronic pain (response rate 89%). The questionnaire listed 11 specific conditions involving nerve pain (e.g., post-herpetic neuralgia, causalgia) together wit...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(93)90035-N
更新日期:1993-09-01 00:00:00
abstract::The human palm has a lower heat detection threshold and a higher heat pain threshold than hairy skin. Neurophysiological studies of monkeys suggest that glabrous skin has fewer low threshold heat nociceptors (AMH type 2) than hairy skin. Accordingly, we used a temperature-controlled contact heat evoked potential (CHEP...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2005.02.017
更新日期:2005-06-01 00:00:00
abstract::Morphine is widely used to treat severe pain in neonatal intensive care unit patients. Animal studies suggest adverse long-term side effects of neonatal morphine, but a follow-up study of 5-year-old children who participated in a morphine-placebo controlled trial as newborns found no such effects on the child's genera...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2012.12.006
更新日期:2013-03-01 00:00:00
abstract::Changes in perception of pure thermal stimuli delivered to the hand at threshold intensity were observed during ischemic nerve block in 27 healthy subjects in order to study the significance of unmyelinated cutaneous cold receptors for thermal sensibility. Paresthesias and an increasing feeling of numbness were follow...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90112-X
更新日期:1984-12-01 00:00:00
abstract::Intense stress and fear have long been known to give rise to a suppression of pain termed "stress-induced analgesia", mediated by brainstem pain-modulating circuitry, including pain-inhibiting neurons of the rostral ventromedial medulla. However, stress does not invariably suppress pain, and indeed, may exacerbate it....
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.01.011
更新日期:2009-04-01 00:00:00
abstract::This study evaluated the pre-emptive analgesic effect of intravenous (i.v.) ketorolac (KET) for total hip replacement (THR). Sixty patients who underwent surgery for THR under general anesthesia were randomly allocated to 3 groups. Two i.v. injections were administered: one before induction and one after surgery. The ...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(94)00184-G
更新日期:1995-05-01 00:00:00
abstract::The present study investigated the role of micro, delta, and kappa receptors within the RVM in mediating expression of conditional hypoalgesia (CHA). Five groups of rats with RVM cannulae were given daily sessions of paired or unpaired presentations of an auditory CS (white noise) and foot shock across three consecuti...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(99)00125-6
更新日期:1999-12-01 00:00:00
abstract::Slow-release strong opioids (SRSO) are indicated in patients with severe chronic pain. Side effects, lack of efficacy and risk of dependency limit their use in clinical practice. The aim of this study was to explore prescription patterns of SRSO in Swedish real-world data on patients with a diagnosis related to chroni...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.07.011
更新日期:2012-12-01 00:00:00
abstract::The cybernetic model of analgesia is a simple servo-loop: altered sensory input--complaints--medication--temporary restoration of acceptable processing of the sensory input--return of altered sensations. Under ordinary clinical circumstances the functioning of this mechanism is masked by "noise" generated by the inter...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(79)90129-5
更新日期:1979-04-01 00:00:00
abstract::Current treatments for post-injury movement-evoked pain are inadequate. Non-opioids may complement opioids, which preferentially reduce spontaneous pain, but most have incomplete efficacy as single agents. This trial evaluates efficacy of a gabapentin-rofecoxib combination following hysterectomy. In addition to IV-PCA...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.pain.2004.10.008
更新日期:2005-01-01 00:00:00
abstract::Distinct developmental trajectories for neck disability and posttraumatic stress disorder (PTSD) symptoms after whiplash injury have recently been identified. This study aimed to identify baseline predictors of membership to these trajectories and to explore their dual development. In a prospective study, 155 individu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.01.056
更新日期:2011-06-01 00:00:00
abstract::Cross-sectional research in clinical samples, as well as experimental studies in healthy adults, suggests that the experiences of pain and sleep are bi-directionally connected. However, whether sleep and pain experiences are prospectively linked to one another on a day-to-day basis in the general population has not pr...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.01.025
更新日期:2008-07-01 00:00:00