Abstract：
:Changes in perception of pure thermal stimuli delivered to the hand at threshold intensity were observed during ischemic nerve block in 27 healthy subjects in order to study the significance of unmyelinated cutaneous cold receptors for thermal sensibility. Paresthesias and an increasing feeling of numbness were followed by a sudden change in cold sensation which developed a clearly dysesthetic quality. When complete motor block was reached and no myelinated axon functions were left, cold stimuli were still clearly but abnormally perceived. Warm sensation was little affected during the whole course of nerve block. The results indicate that the information from unmyelinated low threshold cold receptors alone leads to a dysesthetic cold sensation which normally is suppressed by the activity of myelinated cold afferents. Obviously these receptors are not needed for the discrimination of minor cold stimuli but they seem to be essential for the perception of the first burning cold pain.
journal_name
Painjournal_title
Painauthors
Fruhstorfer Hdoi
10.1016/0304-3959(84)90112-Xsubject
Has Abstractpub_date
1984-12-01 00:00:00pages
355-361issue
4eissn
0304-3959issn
1872-6623pii
00006396-198412000-00004journal_volume
20pub_type
杂志文章相关文献
PAIN文献大全abstract：:Cultures differ as to typical linguistic reports and classifications of pain. In some languages upwards of a dozen specific pain terms are in common use, each indicating a particular pain experience. In other languages a single inclusive term is the norm, perhaps with optional qualifiers added to make desired distinct...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(80)90025-1
更新日期：1980-08-01 00:00:00
abstract：:Ten healthy subjects (four male) of mean age 31 years (range 25-40) took part in a randomized double-blind four-way crossover study to examine the cognitive and psychomotor effects of repeated oral doses of dextropropoxyphene and morphine. Four treatments were compared: dextropropoxyphene napsylate 100 mg, morphine su...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0304-3959(99)00274-2
更新日期：2000-03-01 00:00:00
abstract：:Unilateral intraplantar injection of Freund's complete adjuvant (FCA) into 1 hind paw of rats was used as a model of peripheral inflammation and persistent pain in order to examine time course effects of a continuous barrage of nociceptive input on the second-messenger transducing systems in the spinal cord. cAMP, cGM...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(94)90185-6
更新日期：1994-07-01 00:00:00
abstract：:There is evidence of greater opioid prescription to individuals in the United States with mental health conditions. Whether these associations generalize beyond the US prescription environment and to familial mental health and socioeconomic status (SES) has not been examined comprehensively. This study estimated assoc...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001643
更新日期：2019-11-01 00:00:00
abstract：:Although perceived control has been used as a means of reducing the reaction to pain, conceptually, much is still unclear. The purpose of this study was to clarify the effects of control as a mediating variable in the reaction to pain as a function of the predispositional variables of perceived self-efficacy and trait...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(85)90059-4
更新日期：1985-10-01 00:00:00
abstract：:Recent research has focused on identification of clinically meaningful subgroupings within the chronic pain population in contrast to prior emphasis on the homogeneity of these patients. The present study investigates site of pain as a potentially useful classification variable for identification of differences among ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(84)90085-X
更新日期：1984-08-01 00:00:00
abstract：:Two different modes of cutaneous sensory reinnervation are thought to be engaged following nerve injury: regenerative growth of the injured nerve and 'collateral sprouting' of neighboring intact nerves. Although both processes are well known from experimental preparations, there is little unequivocal documentation of ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(87)90112-6
更新日期：1987-02-01 00:00:00
abstract：:Opiate-adrenergic interactions were investigated by studying the effect of the selective alpha 2-adrenergic agonist, clonidine, on the analgesia produced by intravenous placebo and by the predominantly kappa-opiate agonist, pentazocine, in patients with dental postoperative pain. Clonidine did not affect the pain leve...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0304-3959(92)90054-F
更新日期：1992-02-01 00:00:00
abstract：:The present study examined the relationship between depression and a constellation of pain-related variables that describe the experience of chronic pain patients. Thirty-seven depressed and 32 non-depressed heterogeneous chronic pain patients were identified through structured interviews, use of standardized criteria...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(91)90073-7
更新日期：1991-08-01 00:00:00
abstract：:Recent studies into the common complaint of chronic neck pain have focused on its anatomical origin, identifying especially the cervical zygapophysial joints. However the pathophysiology of chronic neck pain remains poorly understood. In this psychophysical study, responses to electrocutaneous stimulation in subjects ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(98)00013-x
更新日期：1998-04-01 00:00:00
abstract：:Non-cardiac chest pain (NCCP) is a common and distressing condition. Prior studies suggest that psychotropic medication or pain coping skills training (CST) may benefit NCCP patients. To our knowledge, no clinical trials have examined the separate and combined effects of CST and psychotropic medication in the manageme...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.pain.2010.08.040
更新日期：2011-04-01 00:00:00
abstract：:The present study utilized recently developed diagnostic tests that permit recognition of functional deficits in spine mobility, trunk strength, endurance, coordination, and dynamic lifting capacity. Changes in these tests were compared to changes in psychological functioning (e.g., self-report of pain) as well as to ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(86)90007-2
更新日期：1986-04-01 00:00:00
abstract：:The ability of a painful stimulus to suppress pain in another, remote area (DNIC) has been intensely studied. However, the effect of the distance between the two painful stimuli and the attentional factors during the measurement of pain perception received minimal treatment. We evaluated the effect of these factors on...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2010.08.009
更新日期：2010-11-01 00:00:00
abstract：:The discTRODE probe applies radiofrequency (RF) current, heating the annulus to treat chronic discogenic low back pain. Randomized controlled studies have not been published. We assessed the long-term effect and safety aspects of percutaneous intradiscal radiofrequency thermocoagulation (PIRFT) with the discTRODE prob...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2009.05.001
更新日期：2009-10-01 00:00:00
abstract：:Despite many studies, the mechanisms underlying the pathogenesis of pain in cluster headache (CH) still remain obscure. An involvement of substance P (SP) containing neurons of the Gasserian ganglion and/or of the spinal trigeminal nucleus has recently been suggested, e.g., by impairment of inhibitory descending pathw...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(91)90219-N
更新日期：1991-12-01 00:00:00
abstract：:Inflammation induces an up-regulation of neuropeptide tyrosine (NPY) and its receptors in the dorsal horn, suggesting an important role in nociceptive transmission. Our initial studies revealed that NPY dose-dependently increased hotplate response latency, and to a lesser degree, thermal paw withdrawal latency (PWL); ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(01)00481-X
更新日期：2002-04-01 00:00:00
abstract：:The objective of the study was to examine the 1-year cumulative incidence of episodic neck pain and to explore its associations with individual risk factors, including a history of previous neck injury. A baseline cross-sectional survey of an adult general population sample made up of all 7669 adults aged 18-75 years,...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(01)00334-7
更新日期：2001-09-01 00:00:00
abstract：:Although many patients with multiple sclerosis (MS) complain of trigeminal neuralgia (TN), its cause and mechanisms are still debatable. In a multicentre controlled study, we collected 130 patients with MS: 50 patients with TN, 30 patients with trigeminal sensory disturbances other than TN (ongoing pain, dysaesthesia,...
journal_title：Pain
pub_type： 杂志文章,多中心研究
doi：10.1016/j.pain.2008.12.026
更新日期：2009-06-01 00:00:00
abstract：:Serotonin is critically involved in neuropathic pain. However, its role is far from being understood owing to the number of cellular targets and receptor subtypes involved. In a rat model of neuropathic pain evoked by chronic constriction injury (CCI) of the sciatic nerve, we studied the role of 5-HT(2B) receptor in d...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2012.03.024
更新日期：2012-06-01 00:00:00
abstract：:Pain is a biologically relevant signal and response to bodily threat, associated with the urge to restore the integrity of the body. Immediate protective responses include increased arousal, selective attention, escape, and facial expressions, followed by recuperative avoidance and safety-seeking behaviors. To facilit...
journal_title：Pain
pub_type： 杂志文章,评审
doi：10.1097/j.pain.0000000000000107
更新日期：2015-04-01 00:00:00
abstract：:Previous work in this laboratory has indicated that the transplantation of adrenal medullary tissue into the subarachnoid space of the rat spinal cord can reduce pain sensitivity to acute noxious stimuli, particularly following stimulation by nicotine. This most likely results from the stimulated release of opioid pep...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(90)91093-X
更新日期：1990-07-01 00:00:00
abstract：:In primary care and physical therapy settings, we evaluated an intervention for chronic back pain patients which incorporated fear reducing and activating techniques. Primary care patients seen for back pain in primary care were screened to identify persons with significant activity limitations 8-10 weeks after their ...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.pain.2004.11.007
更新日期：2005-02-01 00:00:00
abstract：:The responses of preterm neonates to acute tissue-damaging stimuli have been described. However, factors which influence these responses have received little attention. In this study, we observed 124 premature infants before, during and after a routine heel lance and determined how two contextual variables (severity o...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/0304-3959(94)90053-1
更新日期：1994-10-01 00:00:00
abstract：:Migraine headache pathophysiology involves trigeminovascular system activation, calcitonin gene-related peptide (CGRP) release, and dysfunctional nociceptive transmission. Triptans are 5-HT1B/1D/(1F) receptor agonists that prejunctionally inhibit trigeminal CGRP release, but their vasoconstrictor properties limit thei...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001801
更新日期：2020-05-01 00:00:00
abstract：:Slow-release strong opioids (SRSO) are indicated in patients with severe chronic pain. Side effects, lack of efficacy and risk of dependency limit their use in clinical practice. The aim of this study was to explore prescription patterns of SRSO in Swedish real-world data on patients with a diagnosis related to chroni...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2012.07.011
更新日期：2012-12-01 00:00:00
abstract：:Both mu opioid agonists and N-methyl-D-aspartate (NMDA) receptor antagonists are implicated in the regulation of neuropathic pain in post-nerve injury preclinical pain models. This study characterizes the effects of intravenously infused alfentanil (a mu-receptor agonist) and ketamine (an NMDA-receptor antagonist) on ...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0304-3959(00)00433-4
更新日期：2001-03-01 00:00:00
abstract：:Tolerance to the antinociceptive (analgesic) effect of morphine, a mu-opioid agonist, was developed in male CD-1 mice as assessed by a shift to the right of the analgesic (tail-flick) dose-response curves and an increase in the ED50 values. Administration of dextromethorphan at 30 mg/kg s.c., but not saline, 30 min pr...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(94)90022-1
更新日期：1994-12-01 00:00:00
abstract：:In order to understand how nociceptive information is processed in the spinal dorsal horn we need to unravel the complex synaptic circuits involving interneurons, which constitute the vast majority of the neurons in laminae I-III. The main limitation has been the difficulty in defining functional populations among the...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2013.05.001
更新日期：2013-12-01 00:00:00
abstract：:The present study was undertaken to investigate the possible involvement of peripheral nociceptors in 3 diagnostic categories of elderly patients with chronic pain. The 3 diagnostic groups consisted of: chronic lower lumbar pain of degenerative musculoskeletal etiology (LLP), post-herpetic neuralgia (PHN) and pain of ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(90)91104-Q
更新日期：1990-04-01 00:00:00
abstract：:Women with chronic pelvic pain experience serious distress and lifestyle disruption. Confronted with a difficult condition to diagnose and treat effectively, doctors express a negative perception of this group of 'heartsink' patients. This study aimed to characterise medical attitudes towards the treatment of women wi...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(98)00104-3
更新日期：1998-08-01 00:00:00
