The cognitive and psychomotor effects of morphine in healthy subjects: a randomized controlled trial of repeated (four) oral doses of dextropropoxyphene, morphine, lorazepam and placebo.

abstract：:Evidence has shown that electrical stimulation at the dorsal columns attenuated the "wind-up" phenomenon in dorsal horn neurons in nerve-injured rats. This study was aimed to test the effect of spinal cord stimulation (SCS) on temporal summation (TS), the clinical correlate of the wind-up phenomenon in patients with r...

journal_title：Pain

authors： Eisenberg E,Burstein Y,Suzan E,Treister R,Aviram J

更新日期：2015-03-01 00:00:00

abstract：:Medical case management has improved in the past few decades, changing the dynamic interaction between depression and prevalent medical diseases. It is relevant to describe the comorbidity between depression and medical diseases to further improve the effectiveness of case management. We analyzed the data of adults ag...

journal_title：Pain

authors： Johnson K,Politis MD,Hansen AR,McKenzie LE,Duncan DT,Zhang J

更新日期：2017-04-01 00:00:00

abstract：:The present study investigated whether the level of cognitive impairment (CI) affects acute pain behavior and how it is manifested. Participants were 159 individuals (mean age 42+/-12), 121 with CI (divided into four groups according to the level of CI: mild, moderate, severe, profound) and 38 with normal cognition (c...

journal_title：Pain

authors： Defrin R,Lotan M,Pick CG

更新日期：2006-10-01 00:00:00

abstract：:Morphine is increasingly used in patients with chronic non-cancer pain, but a major concern associated with chronic use relates to possible cognitive side-effects. The aim of this long-term prospective study was to evaluate the cognitive impact of oral sustained release morphine in patients with non-cancer pain. A bat...

journal_title：Pain

authors： Tassain V,Attal N,Fletcher D,Brasseur L,Dégieux P,Chauvin M,Bouhassira D

更新日期：2003-07-01 00:00:00

abstract：:Neurotrophin-3 (NT-3) is a target-derived neurotrophic factor that regulates sensory neuronal survival and growth. Here we report that NT-3 plays a critical permissive role in cutaneous sensory nerve sprouting that contributes to pain and sensitivity following skin wounding in young animals. Sensory terminal sprouting...

journal_title：Pain

authors： Beggs S,Alvares D,Moss A,Currie G,Middleton J,Salter MW,Fitzgerald M

更新日期：2012-10-01 00:00:00

abstract：:Primary afferent sensory neurons are incredibly long cells, often traversing distances of over 1 m in humans. Cutaneous sensory stimuli are transduced in the periphery by specialised end organs or free nerve endings, which code the stimulus into electrical action potentials that propagate towards the central nervous s...

journal_title：Pain

authors： Clark AJ,Menendez G,AlQatari M,Patel N,Arstad E,Schiavo G,Koltzenburg M

更新日期：2018-07-01 00:00:00

abstract：:The heat beam dolorimeter (HBD) was developed to evaluate cutaneous pain thresholds in humans. In the present study, the hypothesis that a patient's underlying pain status affects his pain tolerance to an incident HBD stimulus was tested. Twenty-seven chronic pain patients with a variety of clinical problems unrespons...

journal_title：Pain

authors： Lipman JJ,Blumenkopf B,Parris WCV

更新日期：1987-07-01 00:00:00

abstract：:In the spinal nerve ligation (SNL) model of neuropathic pain, synaptic plasticity shifts the excitation/inhibition balance toward excitation in the spinal dorsal horn. We investigated the deregulation of the synaptogenic neuroligin (NL) molecules, whose NL1 and NL2 isoforms are primarily encountered at excitatory and ...

journal_title：Pain

authors： Dolique T,Favereaux A,Roca-Lapirot O,Roques V,Léger C,Landry M,Nagy F

更新日期：2013-11-01 00:00:00

abstract：:We investigated the role of endogenous opioid systems in the analgesic effects induced by repetitive transcranial magnetic stimulation (rTMS). We compared the analgesic effects of motor cortex (M1) or dorsolateral prefrontal cortex (DLPFC) stimulation before and after naloxone or placebo treatment, in a randomized, do...

journal_title：Pain

authors： de Andrade DC,Mhalla A,Adam F,Texeira MJ,Bouhassira D

更新日期：2011-02-01 00:00:00

abstract：:Electron microscopy was used to study normal human extracted teeth in order to define the junctions between sensory nerve endings and other cells in external pulp and inner dentin at the crown tip. Two sets of associated cells were found: (1) Connective tissue cells. The pulpal fibroblast newtork made occasional desmo...

journal_title：Pain

authors： Byers MR,Neuhaus SJ,Gehrig JD

更新日期：1982-07-01 00:00:00

abstract：:We know little about the safety or efficacy of pharmacological medicines for children and adolescents with chronic pain, despite their common use. Our aim was to conduct an overview review of systematic reviews of pharmacological interventions that purport to reduce pain in children with chronic noncancer pain (CNCP) ...

journal_title：Pain

authors： Eccleston C,Fisher E,Cooper TE,Grégoire MC,Heathcote LC,Krane E,Lord SM,Sethna NF,Anderson AK,Anderson B,Clinch J,Gray AL,Gold JI,Howard RF,Ljungman G,Moore RA,Schechter N,Wiffen PJ,Wilkinson NMR,Williams DG,Wood

更新日期：2019-08-01 00:00:00

abstract：:Based on concepts that endogenous opioids participate in neural transmission of pain, the present study in central poststroke pain (CPSP) patients investigated changes in opioid receptor (OR) binding in neural structures centrally involved in the processing of pain. Five patients with central pain after lesions in the...

journal_title：Pain

authors： Willoch F,Schindler F,Wester HJ,Empl M,Straube A,Schwaiger M,Conrad B,Tölle TR

更新日期：2004-04-01 00:00:00

abstract：:Plasticity in inhibitory receptors, neurotransmission, and networks is an important mechanism for nociceptive signal amplification in the spinal dorsal horn. We studied potential changes in GABAergic pharmacology and its underlying mechanisms in hyperalgesic priming, a model of the transition from acute to chronic pai...

journal_title：Pain

authors： Kim JV,Megat S,Moy JK,Asiedu MN,Mejia GL,Vagner J,Price TJ

更新日期：2016-06-01 00:00:00

abstract：:In humans, chronic psychological stress is associated with increased intestinal paracellular permeability and visceral hyperalgesia, which is recapitulated in the chronic intermittent water avoidance stress (WAS) rat model. However, it is unknown whether enhanced visceral pain and permeability are intrinsically linked...

journal_title：Pain

authors： Creekmore AL,Hong S,Zhu S,Xue J,Wiley JW

更新日期：2018-09-01 00:00:00

abstract：:Experimental evidence is reviewed showing that brain and spinal cord serotonergic neurons are involved in nociceptive responses, as well as in the analgesic effects of opiate narcotics. This evidence, based on studies employing pharmacological, surgical, electrophysiological, and dietary manipulations of central nervo...

journal_title：Pain

authors： Messing RB,Lytle LD

更新日期：1977-10-01 00:00:00

abstract：:A portable constant current electrical stimulator with bipolar felt disk electrodes was developed for quantitative assessment of cutaneous sensibility. The new method was used in the measurement of thresholds for perception and pain in healthy volunteers. The mean values of the threshold for perception in different ar...

journal_title：Pain

authors： Laitinen LV,Eriksson TA

更新日期：1985-06-01 00:00:00

abstract：:Spasticity is a major clinical manifestation of spinal cord injury and upper motor neuron syndrome. ...

journal_title：Pain

authors： Ridgeway B,Wallace M,Gerayli A

更新日期：2000-03-01 00:00:00

abstract：:Movement is changed in pain, but the mechanisms remain unclear. Key questions are unresolved such as whether activation can be inhomogeneously distributed within a muscle in a manner that is specific to the location of noxious input. This study addressed this question using high-density electromyography (EMG) to study...

journal_title：Pain

authors： Gallina A,Salomoni SE,Hall LM,Tucker K,Garland SJ,Hodges PW

更新日期：2018-11-01 00:00:00

abstract：:The present paper describes the effect of vibratory stimulation on pain of dental origin in 36 patients. The patients were from a clinic for dental surgery and all had suffered pain from pulpal inflammation, apical periodontitis or postoperative pain following extraction of an impacted wisdom tooth for more than 2 day...

journal_title：Pain

authors： Ottoson D,Ekblom A,Hansson P

更新日期：1981-02-01 00:00:00

abstract：:No research to date has descriptively catalogued what parents of healthy infants are naturalistically doing to manage their infant's pain over immunization appointments during the first year of life. This knowledge, in conjunction with an understanding of the relationships different parental techniques have with infan...

journal_title：Pain

authors： Lisi D,Campbell L,Pillai Riddell R,Garfield H,Greenberg S

更新日期：2013-08-01 00:00:00

abstract：:Using a number of complementary anatomical and molecular techniques, we studied the effects of chronic constriction injury (CCI), a model of partial nerve injury that elicits behavioral hyperalgesia, on primary sensory neurons in the rat. Dorsal root ganglia taken from animals with CCI were analyzed for alterations in...

journal_title：Pain

authors： Nahin RL,Ren K,De León M,Ruda M

更新日期：1994-07-01 00:00:00

abstract：:Genetic polymorphisms result in absent enzyme activity of CYP2D6 (poor metabolizers, PM) in about 10% of the Caucasian population. This study investigates whether the PM genotype has an impact on the response to tramadol analgesia in postoperative patients. A prospective study design was used and 300 patients recoveri...

journal_title：Pain

authors： Stamer UM,Lehnen K,Höthker F,Bayerer B,Wolf S,Hoeft A,Stuber F

更新日期：2003-09-01 00:00:00

abstract：:Pain catastrophizing is a significant risk factor for patients with knee osteoarthritis (KOA) and thus is a target for many psychological interventions for pain. This study examined if interventions targeting sleep found to be effective in improving sleep in KOA also reduce pain catastrophizing measured as a trait thr...

journal_title：Pain

authors： Lerman SF,Finan PH,Smith MT,Haythornthwaite JA

更新日期：2017-11-01 00:00:00

abstract：:Hydromorphone is an alternative to morphine for intrathecal drug delivery system to treat refractory cancer pain; however, there is not enough clinical evidence to prove it. In our study, 233 patients from 12 different pain management centers across China were enrolled, 121 and 112 in the intrathecal hydromorphone (IT...

journal_title：Pain

authors： Ma K,Jin Y,Wang L,Feng ZY,Song T,Yang XQ,Chen FQ,Duan BL,Huang YQ,Xie GL,Bao HG,Wang K,Xu JT,Lu Y,Liu YQ

更新日期：2020-11-01 00:00:00

abstract：:Snakebites are a relevant public health problem in Central and South America. Snake bite envenomations cause intense pain, not relieved by anti-venom. The fangs of many species are short, causing subcutaneous injection. Fangs of larger species inflict subcutaneous or intramuscular envenomation. To understand pain indu...

journal_title：Pain

authors： Chacur M,Gutiérrez JM,Milligan ED,Wieseler-Frank J,Britto LR,Maier SF,Watkins LR,Cury Y

更新日期：2004-09-01 00:00:00

abstract：:Ketanserin, a selective S2 serotonergic antagonist, was assessed against placebo in a double-blind cross-over study of 16 patients with chronic peripheral burning pain. Nine of these had signs of reflex sympathetic dystrophy (RSD). All patients underwent 4 intravenous regional treatments, 2 with ketanserin (10 mg for ...

journal_title：Pain

authors： Hanna MH,Peat SJ

更新日期：1989-08-01 00:00:00

abstract：:The present study examined the relationship between depression and a constellation of pain-related variables that describe the experience of chronic pain patients. Thirty-seven depressed and 32 non-depressed heterogeneous chronic pain patients were identified through structured interviews, use of standardized criteria...

journal_title：Pain

authors： Haythornthwaite JA,Sieber WJ,Kerns RD

更新日期：1991-08-01 00:00:00

abstract：:Questions concerning stump, phantom and other pain problems as well as demographic data were mailed to 5000 Americans whose amputations were connected with military service. Fifty-five percent responded and of these, 78% reported phantom pain. No predisposing factors, other than presence of stump pain, correlated with...

journal_title：Pain

authors： Sherman RA,Sherman CJ,Parker L

更新日期：1984-01-01 00:00:00

abstract：:Clinical evidence suggests that cutaneous and visceral pain differ in sensory, affective, and motivational realms, yet there has been little comparative characterization of these types of pain. This study uses psychophysical measures to compare directly visceral and cutaneous pain and sensitivity. Healthy subjects (10...

journal_title：Pain

authors： Strigo IA,Bushnell CM,Boivin M,Duncan GH

更新日期：2002-06-01 00:00:00

abstract：:Tetrodotoxin-resistant (TTX-R) Na(+) channels play a key role in the generation of action potentials in nociceptive dorsal root ganglion (DRG) neurons and are an important target for the proinflammatory mediator prostaglandin E(2), which augments these currents. Prostaglandin D(2) (PGD(2)) is released in the tissue to...

journal_title：Pain

authors： Ebersberger A,Natura G,Eitner A,Halbhuber KJ,Rost R,Schaible HG

更新日期：2011-05-01 00:00:00