Regulation of the second-messenger systems in the rat spinal cord during prolonged peripheral inflammation.

abstract：:Nociception was studied in male mice, mostly of the C57BL/6 strain, during continuous or prolonged restriction of caloric intake (60% of ad-libitum) from midlife to senescence (up to 105 weeks). Restricted mice showed fewer licking or biting responses 20-60 min after hind paw injection of 5% formalin at 46 and 70 week...

journal_title：Pain

authors： Hargraves WA,Hentall ID

更新日期：2005-04-01 00:00:00

abstract：:The use of long-term opioid therapy for chronic pain remains common, yet data on long-term outcomes, especially after dose escalation, are sparse. This study examined potential benefits and harms associated with prescription opioid dose escalation. Participants from 2 institutions were enrolled in a 2-year prospective...

journal_title：Pain

authors： Morasco BJ,Smith N,Dobscha SK,Deyo RA,Hyde S,Yarborough BJH

更新日期：2020-06-01 00:00:00

abstract：:Mechanisms of hypnotic analgesia were investigated by examining changes in the R-III, a nociceptive spinal reflex, during hypnotic reduction of pain sensation and unpleasantness. The R-III was measured in 15 healthy volunteers who gave VAS-sensory and VAS-affective ratings of an electrical stimulus during conditions o...

journal_title：Pain

authors： Kiernan BD,Dane JR,Phillips LH,Price DD

更新日期：1995-01-01 00:00:00

abstract：:Coeliac plexus block (CPB) is one of the few neurolytic procedures that is still considered very useful in managing chronic cancer pain. We describe what we believe to be the fifth case in the literature of paraplegia following coeliac plexus block with ethyl alcohol. Clinical and neurophysiological examination confir...

journal_title：Pain

authors： De Conno F,Caraceni A,Aldrighetti L,Magnani G,Ferla G,Comi G,Ventafridda V

更新日期：1993-12-01 00:00:00

abstract：:Microglia-neuron signalling in the spinal cord is a key mediator of mechanical allodynia caused by peripheral nerve injury. We recently reported sex differences in microglia in pain signalling in mice: spinal mechanisms underlying nerve injury-induced allodynia are microglial dependent in male but not female mice. Whe...

journal_title：Pain

authors： Mapplebeck JCS,Dalgarno R,Tu Y,Moriarty O,Beggs S,Kwok CHT,Halievski K,Assi S,Mogil JS,Trang T,Salter MW

更新日期：2018-09-01 00:00:00

abstract：:Anecdotal reports suggest that the general anaesthetic drug ketamine, taken orally in low doses, can give rise to some extra analgesia in patients with refractory neuropathic pain. This study was designed to determine the proportion of patients with chronic neuropathic pain responding to oral ketamine, and then to sep...

journal_title：Pain

authors： Haines DR,Gaines SP

更新日期：1999-11-01 00:00:00

abstract：:Non-invasive, movement-based models were used to investigate muscle pain. In rats, the masseter muscle was rapidly stretched or electrically stimulated during forced lengthening to produce eccentric muscle contractions (EC). Both EC and stretching disrupted scattered myofibers and produced intramuscular plasma extrava...

journal_title：Pain

authors： Dessem D,Ambalavanar R,Evancho M,Moutanni A,Yallampalli C,Bai G

更新日期：2010-05-01 00:00:00

abstract：:Fourteen patients whose post-herpetic neuralgia could not be alleviated by conventional methods were treated with cryocautery using a stick of solid carbon dioxide (dry ice) applied directly to the hyperesthetic skin areas of the cutaneous scars. Follow-up evaluation revealed that 5 of 14 subjects maintained excellent...

journal_title：Pain

authors： Suzuki H,Ogawa S,Nakagawa H,Kanayama T,Taj K,Saitoh H,Ohshima Y

更新日期：1980-12-01 00:00:00

abstract：:Recently, Bennett and Xie reported that when the sciatic nerve of the rat is ligated loosely, the rat develops a pain syndrome with many features similar to those observed in neuropathic pain states in man. Anatomical and physiological studies to date indicate that the major pathology is a loss of large diameter myeli...

journal_title：Pain

authors： Basbaum AI,Gautron M,Jazat F,Mayes M,Guilbaud G

更新日期：1991-12-01 00:00:00

abstract：:The present study sought to discover whether information clarifying how the analgesic/sedative drug nitrous oxide (N2O) works would result in increased analgesic responses to painful stimuli when various concentrations of N2O were administered. Subjects were provided with high and low levels of information regarding t...

journal_title：Pain

authors： Dworkin SF,Chen ACN,Schubert MM,Clark DW

更新日期：1984-08-01 00:00:00

abstract：:Genetic influence on the sensory, motor and histopathological outcome of transient spinal cord ischemia was studied in Sprague-Dawley (SD), spontaneously hypertensive (SH) and Wistar-Kyoto (WKY) rats. Ischemia caused minor motor deficits and no identifiable morphological damage in the spinal cord of the majority of SD...

journal_title：Pain

authors： Wiesenfeld-Hallin Z,Hao JX,Xu XJ,Aldskogius H,Seiger Å

更新日期：1993-11-01 00:00:00

abstract：:The effects of lateral reticular nucleus (LRN) stimulation on the responses to tooth pulp (TP) stimulation of neurons located in the trigeminal (V) sensory (39 units) and motor (33 units) nuclei were assessed in anesthetized rats. Only neurons which responded to TP stimulation with bursts of spikes that were in a cons...

journal_title：Pain

authors： Sotgiu ML,Bellinzona M

更新日期：1991-07-01 00:00:00

abstract：:The relationship was investigated between algogenic potential of gallbladder pathology and occurrence/extent of sensory and trophic changes in the referred area. Five groups of subjects were studied, with: symptomatic gallbladder calculosis (3-20 colics); asymptomatic calculosis; symptomatic gallbladder shape abnormal...

journal_title：Pain

authors： Giamberardino MA,Affaitati G,Lerza R,Lapenna D,Costantini R,Vecchiet L

更新日期：2005-03-01 00:00:00

abstract：:Intradermal injection of capsaicin induces primary hyperalgesia at the injection site and secondary hyperalgesia in the surrounding undamaged skin. The secondary hyperalgesia is thought to be due to central sensitization of the dorsal horn neurons while primary hyperalgesia is caused by sensitization of nociceptors in...

journal_title：Pain

authors： Kim HT,Park SK,Lee SE,Chung JM,Lee DH

更新日期：2001-11-01 00:00:00

abstract：:Tramadol hydrochloride is a synthetic mu-opioid agonist with additional monoaminergic activity. Tramadol's analgesic effect has been equated with that of pethidine, with a more favourable side-effect profile. Tramadol has been the most-selling prescription analgesic in Germany for several years, and it is now availabl...

journal_title：Pain

authors： Stubhaug A,Grimstad J,Breivik H

更新日期：1995-07-01 00:00:00

abstract：:Facial expressions of pain and emotions provide powerful social signals, which impart information about a person's state. Unfortunately, research on pain and emotion expression has been conducted largely in parallel with few bridges allowing for direct comparison of the expressive displays and their impact on observer...

journal_title：Pain

authors： Simon D,Craig KD,Gosselin F,Belin P,Rainville P

更新日期：2008-03-01 00:00:00

abstract：:The role of proinflammatory cytokines in neuropathic and inflammatory pain is well established. Recent studies suggest that cytokines such as tumor necrosis factor-alpha (TNF) may also be involved in the development of muscle pain. To investigate the pathophysiology of intramuscular TNF, exogenous TNF (0.1-10 microg),...

journal_title：Pain

authors： Schäfers M,Sorkin LS,Sommer C

更新日期：2003-08-01 00:00:00

abstract：:Neurotrophin-3 (NT-3) is a target-derived neurotrophic factor that regulates sensory neuronal survival and growth. Here we report that NT-3 plays a critical permissive role in cutaneous sensory nerve sprouting that contributes to pain and sensitivity following skin wounding in young animals. Sensory terminal sprouting...

journal_title：Pain

authors： Beggs S,Alvares D,Moss A,Currie G,Middleton J,Salter MW,Fitzgerald M

更新日期：2012-10-01 00:00:00

abstract：:Transient receptor potential ion channel melastatin subtype 8 (TRPM8) is activated by cold temperatures and cooling agents, such as menthol and icilin. Compounds containing peppermint are reported to reduce symptoms of bowel hypersensitivity; however, the underlying mechanisms of action are unclear. Here we determined...

journal_title：Pain

authors： Harrington AM,Hughes PA,Martin CM,Yang J,Castro J,Isaacs NJ,Blackshaw AL,Brierley SM

更新日期：2011-07-01 00:00:00

abstract：:Patients suffering from postherpetic neuralgia often complain about hypo- or hypersensation in the affected dermatome. The loss of thermal sensitivity has been demonstrated by quantitative sensory testing as being associated with small-fiber (Aδ- and C-fiber) deafferentation. We aimed to compare laser stimulation (rad...

journal_title：Pain

authors： Franz M,Spohn D,Ritter A,Rolke R,Miltner WHR,Weiss T

更新日期：2012-08-01 00:00:00

abstract：:Neuropathic pain behaviour is not observed in neonatal rats and tactile allodynia does not develop in the spared nerve injury (SNI) model until rats are 4 weeks of age at the time of surgery. Since activated spinal microglia are known to play a key role in neuropathic pain, we have investigated whether the microglial ...

journal_title：Pain

authors： Moss A,Beggs S,Vega-Avelaira D,Costigan M,Hathway GJ,Salter MW,Fitzgerald M

更新日期：2007-04-01 00:00:00

abstract：:Despite many studies, the mechanisms underlying the pathogenesis of pain in cluster headache (CH) still remain obscure. An involvement of substance P (SP) containing neurons of the Gasserian ganglion and/or of the spinal trigeminal nucleus has recently been suggested, e.g., by impairment of inhibitory descending pathw...

journal_title：Pain

authors： Sandrini G,Alfonsi E,Ruiz L,Pavesi G,Micieli G,Manzoni GC,Mancia D,Nappi G

更新日期：1991-12-01 00:00:00

abstract：:In the last decade, there has been burgeoning interest in the effectiveness of third-generation psychological therapies for managing fibromyalgia (FM) symptoms. The present study examined the effectiveness of acceptance and commitment therapy (ACT) on functional status as well as the role of pain acceptance as a media...

journal_title：Pain

authors： Luciano JV,Guallar JA,Aguado J,López-Del-Hoyo Y,Olivan B,Magallón R,Alda M,Serrano-Blanco A,Gili M,Garcia-Campayo J

更新日期：2014-04-01 00:00:00

abstract：:Biopsychosocial models of chronic pain that recognize psychological and environmental factors as important aspects of adjustment to pain have been proposed for understanding chronic pain and related suffering in persons with multiple sclerosis (MS), but such models have not been empirically tested. The objective of th...

journal_title：Pain

authors： Osborne TL,Jensen MP,Ehde DM,Hanley MA,Kraft G

更新日期：2007-01-01 00:00:00

abstract：:Intense stress and fear have long been known to give rise to a suppression of pain termed "stress-induced analgesia", mediated by brainstem pain-modulating circuitry, including pain-inhibiting neurons of the rostral ventromedial medulla. However, stress does not invariably suppress pain, and indeed, may exacerbate it....

journal_title：Pain

authors： Martenson ME,Cetas JS,Heinricher MM

更新日期：2009-04-01 00:00:00

abstract：:The facial expression of pain plays a crucial role in pain communication and pain diagnostics. Despite its importance, it has remained unknown which dimensions of pain (sensory and/or affective) are encoded in the face. To answer this question, we used a well-established cognitive strategy (suggestions) to differentia...

journal_title：Pain

authors： Kunz M,Lautenbacher S,LeBlanc N,Rainville P

更新日期：2012-02-01 00:00:00

abstract：:The physiological properties of joint capsule mechanoreceptors in the ankle joint of the chicken were studied in the 3-h period immediately after intra-articular injection of microcrystal sodium urate. The electrical activity was recorded from single C- and A-delta sensory fibres dissected from the parafibular nerve. ...

journal_title：Pain

authors： Gentle MJ

更新日期：1997-04-01 00:00:00

abstract：:Anxiety has been described as an important comorbidity in patients suffering from chronic pain. However, in animals the connection between persistent pain and anxiety has hardly been investigated. Therefore, in the current study it was assessed whether chronic pain also causes anxiety-like behaviour in animals and if ...

journal_title：Pain

authors： Roeska K,Doods H,Arndt K,Treede RD,Ceci A

更新日期：2008-10-15 00:00:00

abstract：:Anti-nociceptive tolerance to opioids is a well-described phenomenon, which severely limits the clinical efficacy of opioids for the treatment of chronic pain syndromes. The mechanisms that drive anti-nociceptive tolerance, however, are less well understood. We have previously shown that glia have a central role in th...

journal_title：Pain

authors： Horvath RJ,Romero-Sandoval AE,De Leo JA

更新日期：2010-09-01 00:00:00

abstract：:The perception of pain is highly variable. It depends on bottom-up-mediated factors like stimulus intensity and top-down-mediated factors like expectations. In the brain, pain is associated with a complex pattern of neuronal responses including evoked potentials and induced responses at alpha and gamma frequencies. Al...

journal_title：Pain

authors： Tiemann L,May ES,Postorino M,Schulz E,Nickel MM,Bingel U,Ploner M

更新日期：2015-02-01 00:00:00