Abstract:
:Tramadol hydrochloride is a synthetic mu-opioid agonist with additional monoaminergic activity. Tramadol's analgesic effect has been equated with that of pethidine, with a more favourable side-effect profile. Tramadol has been the most-selling prescription analgesic in Germany for several years, and it is now available in many other European countries, but still there is a lack of adequately controlled clinical studies of its analgesic properties. The purpose of this study was to compare the analgesic efficacy of 50 and 100 mg oral tramadol with our standard analgesic for postoperative pain treatment, 1000 mg paracetamol + 60 mg codeine, and placebo. A single-dose, parallel group, double-blind design was used. One hundred forty-four patients were enrolled the day after total hip replacement if they had a pain intensity of 60 mm or more on a 0-100 mm visual analogue scale. Treatments were compared on the basis of pain intensity and derived variables (pain intensity difference, and summed pain intensity differences), the need of rescue medication, and a global evaluation. Serum concentrations confirmed rapid and good absorption comparable with that reported in healthy volunteers. The active drug control, paracetamol+codeine, was significantly superior to placebo for all efficacy variable (P = 0.0002-0.004), confirming good assay sensitivity. Paracetamol+codeine was also significantly superior to both 50 mg tramadol (P = 0.002-0.03) and 100 mg tramadol (P = 0.002-0.02). There was no difference between placebo and 50 and 100 mg tramadol for any of the efficacy variables.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Painjournal_title
Painauthors
Stubhaug A,Grimstad J,Breivik Hdoi
10.1016/0304-3959(95)00056-Xsubject
Has Abstractpub_date
1995-07-01 00:00:00pages
111-118issue
1eissn
0304-3959issn
1872-6623pii
00006396-199507000-00013journal_volume
62pub_type
临床试验,杂志文章,随机对照试验相关文献
PAIN文献大全abstract::The purpose of this study was to describe and quantify changes in the movement and EMG patterns caused by tonic noxious pressure on the periosteum of the zygoma during electrically induced rhythmic jaw movements in the decerebrate rabbit. Eight New Zealand rabbits were anesthetized with urethane. EMG electrodes were p...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(95)00028-Q
更新日期:1995-11-01 00:00:00
abstract::Preliminary reports have shown that hyperbaric oxygen (HBO) interrupts cluster headache (CH) attacks. In the present study, 6 of 7 patients with episodic cluster headache who were treated with hyperbaric oxygen experienced an interruption of the attack. In 3 of 6 responders the florid period of the cluster headache wa...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(93)90137-E
更新日期:1993-02-01 00:00:00
abstract::Injection of a dilute solution of formalin into a rat hindpaw produces a biphasic nociceptive response consisting of an early phase during the first 5 min after formalin injection and a later phase starting after 15 min and lasting for 40-50 min. The period between the two phases of nociceptive responding is generally...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(99)00033-0
更新日期:1999-07-01 00:00:00
abstract::A 78-year-old male patient had chronic, unrelieved abdominal pain due to mesenteric ischaemia. Unsuccessful pharmacological approaches included oral morphine plus coadjuvants as well as a sympathetic celiac plexus block which gave pain relief that lasted for 72 h. In order to obtain long-lasting relief, a trial epidur...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(00)00266-9
更新日期:2000-07-01 00:00:00
abstract::The present paper describes the effect of vibratory stimulation on pain of dental origin in 36 patients. The patients were from a clinic for dental surgery and all had suffered pain from pulpal inflammation, apical periodontitis or postoperative pain following extraction of an impacted wisdom tooth for more than 2 day...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(81)90043-9
更新日期:1981-02-01 00:00:00
abstract::In superficial layers of the lumbar spinal dorsal horn, N-methyl-D-aspartate-dependent long-term potentiation (LTP) of C fibre-evoked field potentials, a synaptic model of central sensitisation and hyperalgesia, ensues the application of electrical high-frequency, high-intensity conditioning stimulation to the sciatic...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2003.08.007
更新日期:2003-12-01 00:00:00
abstract::Recent meta-analyses have shown mindfulness-based interventions (MBIs) to be effective for chronic pain, but no pooled estimates of the effect of MBIs on acute pain are available. This meta-analysis was conducted to fill that gap. A literature search was conducted in 4 databases. Articles were eligible if they reporte...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001877
更新日期:2020-08-01 00:00:00
abstract::Chronic pain after tissue trauma is frequent and may have a lasting impact on the functioning and quality of life of the affected person. Despite this, chronic postsurgical and posttraumatic pain is underrecognised and, consequently, undertreated. It is not represented in the current International Classification of Di...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1097/j.pain.0000000000001413
更新日期:2019-01-01 00:00:00
abstract::Pharmacological actions on the nociceptive flexion flexes of the hindlimb were investigated in 14 normal subjects. These reflexes were used as an index of pain and were recorded in the biceps femoris muscle, elicited by electrical stimulation of the ipsilateral sural nerve (RIII,su) and of the skin in the distal recep...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(77)90074-4
更新日期:1977-04-01 00:00:00
abstract::Little is known about patients prescribed high doses of opioids to treat chronic non-cancer pain, though these patients may be at higher risk for medication-related complications. We describe the prevalence of high-dose opioid use and associated demographic and clinical characteristics among veterans treated in a VA r...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.08.002
更新日期:2010-12-01 00:00:00
abstract::Although pediatric functional abdominal pain (FAP) has been linked to abdominal pain later in life, childhood predictors of long-term outcomes have not been identified. This study evaluated whether distinct FAP profiles based on patterns of pain and adaptation in childhood could be identified and whether these profile...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.03.026
更新日期:2012-09-01 00:00:00
abstract::The effects of pretreatment with desipramine, a selective noradrenaline (NA) uptake blocker, on spinal antinociception by 5-hydroxytryptamine (5-HT), morphine and an adenosine analog (NECA) in the rat hot-plate test were examined to determine if endogenous NA is involved in the spinal action of these agents. Desiprami...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90118-U
更新日期:1992-07-01 00:00:00
abstract::The endogenous opioid peptide dynorphin A has non-opioid effects that can damage the spinal cord when given in high doses. Dynorphin has been shown to increase the receptive field size of spinal cord neurons and facilitate C-fiber-evoked reflexes. Furthermore, endogenous dynorphin levels increase following damage to t...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(97)00046-8
更新日期:1997-08-01 00:00:00
abstract::Blockade of the noradrenergic input to the nucleus raphe magnus (NRM) by the injection of alpha-adrenergic antagonists produces hypoalgesia. Previous studies show that this hypoalgesia is blocked by the intrathecal injection of either phentolamine or methysergide. The present study demonstrates that depletion of spina...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(83)90113-6
更新日期:1983-07-01 00:00:00
abstract::Tanezumab is a humanized monoclonal antibody that specifically inhibits nerve growth factor as a treatment for chronic pain. This phase IIB study investigated the efficacy and safety of tanezumab for chronic low back pain vs placebo and naproxen. Patients (N=1347) received intravenous tanezumab (5, 10, or 20mg every 8...
journal_title:Pain
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.pain.2013.03.006
更新日期:2013-07-01 00:00:00
abstract::To characterize the contribution of interleukin-6 (IL-6) to spinal cord injury pain (SCIP), we employed a clinically relevant rat contusion model of SCIP. Using Western blots, we measured IL-6 levels in lumbar segments (L1-L5), at the lesion site (T10), and in the corresponding lumbar and thoracic dorsal root ganglia ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2013.03.026
更新日期:2013-07-01 00:00:00
abstract::Sciatica is a common pain problem and current pharmacologic therapies have proven inadequate for many patients. The objective of this sham-controlled investigation was to compare a novel non-pharmacologic technique, percutaneous electrical nerve stimulation (PENS), to transcutaneous electrical nerve stimulation (TENS)...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0304-3959(99)00097-4
更新日期:1999-11-01 00:00:00
abstract::This was a multicenter, double-blind (DB), placebo-controlled, randomized discontinuation trial to evaluate the efficacy of pregabalin monotherapy for durability of effect on fibromyalgia (FM) pain. The trial included a 6-week open-label (OL) pregabalin-treatment period followed by 26-week DB treatment with placebo or...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2008.02.027
更新日期:2008-06-01 00:00:00
abstract::A controlled clinical trial on the efficacy of a nortriptyline-fluphenazine combination was carried out in patients with painful diabetic polyneuropathy. A visual analog scale was used to evaluate the relief of pain or paresthesia. Significant relief of both pain and paresthesia was obtained with this combination. The...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(85)90010-7
更新日期:1985-12-01 00:00:00
abstract::The results of a considerable number of recent prospective studies have demonstrated that greater acute pain severity in herpes zoster patients is associated with a significantly greater risk of developing postherpetic neuralgia (PHN). Only a few studies have examined the relationships between acute pain severity and ...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1016/S0304-3959(01)00347-5
更新日期:2001-10-01 00:00:00
abstract::The experience of anger (i.e. trait anger) and anger management style (i.e. anger-in, anger-out) are related to sensitivity to acute and chronic pain stimuli, although underlying mechanisms are unknown. This study tested whether anger variables are associated with impaired endogenous opioid antinociceptive activity, a...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0304-3959(02)00104-5
更新日期:2002-09-01 00:00:00
abstract::Our aim was to assess the discriminative capacity of the McGill Pain Questionnaire (MPQ) in patients with temporomandibular joint (TMJ) disorders or with myogenous facial pain (MP). The MPQ was administered to 57 TMJ and 28 MP patients who were also asked to assess the level of pain using the Visual Analog Scale (VAS)...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(00)00461-9
更新日期:2001-04-01 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) using the blood oxygen level-dependent (BOLD) contrast was used to study sensory processing in the brain of isoflurane-anesthetized mice. The use of a cryogenic surface coil in a small animal 9.4T system provided the sensitivity required for detection and quantitative analy...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.08.025
更新日期:2010-12-01 00:00:00
abstract::Fifty-seven patients (74%) who had completed a multidisciplinary pain program returned mailed questionnaires assessing both outcome and compliance measures. Significant treatment gains were observed at follow-up. Compliance with prescribed therapeutic regimens was low, averaging around 42% for individual regimens. Com...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(83)90102-1
更新日期:1983-11-01 00:00:00
abstract::This study was designed to investigate the relative efficacy of cognitive-behavioral group treatment, including relaxation training, in comparison with a control condition in a sample of 20 outpatients with chronic low back pain. Subjects in both conditions also received the same physiotherapy back-education and exerc...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90082-M
更新日期:1992-03-01 00:00:00
abstract::Pregnant women may take nonsteroidal antiinflammatory drugs (NSAIDs), selective cyclooxygenase (COX)-2 inhibitors, or biological agents to relieve symptoms or manage disease flares in late pregnancy. We aimed to quantify the risk of prematurity associated with late pregnancy exposure to nonselective NSAIDs, selective ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001163
更新日期:2018-05-01 00:00:00
abstract::Total hip replacement (THR) and total knee replacement (TKR) are usually effective at relieving pain; however, 7% to 23% of patients experience chronic postsurgical pain. These trials aimed to investigate the effect of local anaesthetic wound infiltration on pain severity at 12 months after primary THR or TKR for oste...
journal_title:Pain
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/j.pain.0000000000000114
更新日期:2015-06-01 00:00:00
abstract::The present report describes a nation-wide survey on the incidence, the indications and the efficacy of spinal cord stimulation (SCS), as assessed by the Belgian health authorities. The direct motive for this survey was the rapidly growing expenditures resulting from the increasing use of SCS. Between 1983 and 1992, n...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)90096-5
更新日期:1994-02-01 00:00:00
abstract::Anti-nerve growth factor (anti-NGF) therapy has shown significant promise in attenuating several types of skeletal pain. However, whether anti-NGF therapy changes the level of physical activity in individuals with or without skeletal pain is largely unknown. Here, automated day/night activity boxes monitored the effec...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001330
更新日期:2018-11-01 00:00:00
abstract::Although classical trigeminal neuralgia (CTN) is frequently caused by neurovascular contact (NVC) at the trigeminal root entry zone (REZ), both anatomical and MRI studies have shown that NVC of the trigeminal nerve frequently occurs in individuals without CTN. To assess the accuracy of MRI in distinguishing symptomati...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1016/j.pain.2014.04.020
更新日期:2014-08-01 00:00:00