Abstract：
:Pregnant women may take nonsteroidal antiinflammatory drugs (NSAIDs), selective cyclooxygenase (COX)-2 inhibitors, or biological agents to relieve symptoms or manage disease flares in late pregnancy. We aimed to quantify the risk of prematurity associated with late pregnancy exposure to nonselective NSAIDs, selective COX-2 inhibitors, and biological agents. Using data from Quebec Pregnancy Cohort, we performed a population-based cohort study. We included all women who were covered by the Quebec Drug Plan and had a singleton live birth between January 1, 1998 and December 31, 2009. Late pregnancy exposure was defined as having filled at least 1 prescription for nonselective NSAIDs, selective COX-2 inhibitors, or biological agents in the 3 months before delivery. Prematurity was defined as <37 weeks of gestation. Crude and adjusted odds ratios (OR) were obtained using generalized estimation equation models. Covariates included maternal autoimmune diseases, demographics, concomitant drug use, history of pregnancy complications, and other comorbidities. A total of 156,531 pregnancies met inclusion criteria and were considered for analyses. In the 3 months before delivery, 391 pregnancies were exposed to nonselective NSAIDs, 55 to COX-2 inhibitors, and 12 to biological agents. After adjustment for maternal autoimmune diseases, concomitant medication use, and other risk factors, COX-2 inhibitor use in late pregnancy was associated with a 2.46-fold increased risk of prematurity (adjusted OR, 2.46; 95% confidence interval, 1.28-4.72) compared to nonuse; only late pregnancy exposure to celecoxib was found to increase the risk (adjusted OR, 3.41; 95% confidence interval, 1.29-9.02). In conclusion, celecoxib use during late pregnancy may increase the risk of prematurity.
journal_name
Painjournal_title
Painauthors
Bérard A,Sheehy O,Girard S,Zhao JP,Bernatsky Sdoi
10.1097/j.pain.0000000000001163subject
Has Abstractpub_date
2018-05-01 00:00:00pages
948-955issue
5eissn
0304-3959issn
1872-6623pii
00006396-201805000-00014journal_volume
159pub_type
杂志文章相关文献
PAIN文献大全abstract：:Migraine headache is one of the most common neurological disorders. The pathological conditions that directly initiate afferent pain signaling are poorly understood. In trigeminal neurons retrogradely labeled from the cranial meninges, we have recorded pH-evoked currents using whole-cell patch-clamp electrophysiology....
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2010.09.036
更新日期：2011-01-01 00:00:00
abstract：:Tanezumab is a humanized monoclonal antibody that specifically inhibits nerve growth factor as a treatment for chronic pain. This phase IIB study investigated the efficacy and safety of tanezumab for chronic low back pain vs placebo and naproxen. Patients (N=1347) received intravenous tanezumab (5, 10, or 20mg every 8...
journal_title：Pain
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.pain.2013.03.006
更新日期：2013-07-01 00:00:00
abstract：:Tanezumab is a humanized monoclonal antinerve growth factor antibody in development for treatment of chronic pain. In a phase III, placebo- and active-controlled study, we investigated the efficacy and safety of tanezumab for osteoarthritis (OA) hip or knee pain. Patients (N=610) received up to 2 doses of intravenous ...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2013.04.035
更新日期：2013-09-01 00:00:00
abstract：:Pain has the capacity to interfere with daily tasks. Although task interference by pain is largely unintentional, it can be controlled to a certain extent. Such top-down control over pain has been believed to be reduced in patients with fibromyalgia (FM). In this study, we investigated task interference and distractio...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001196
更新日期：2018-06-01 00:00:00
abstract：:The spinal gray matter region around the central canal, lamina X, is critically involved in somatosensory processing and visceral nociception. Although several classes of primary afferent fibers terminate or decussate in this area, little is known about organization and functional significance of the afferent supply o...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001586
更新日期：2019-09-01 00:00:00
abstract：:Intraperitoneal administration of the serotonin 5-HT1A agonist, buspirone (1-5 mg/kg), produced dose- and time-related core hypothermia that was coincident with analgesia against a thermally noxious stimulus. Surface body temperature was not altered by buspirone. The 5-HT1A antagonist, NAN-190 (2 mg/kg, s.c.), blocked...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(92)90042-A
更新日期：1992-09-01 00:00:00
abstract：:Quantitative sensory testing (QST) in accordance with the DFNS (German Research Network on Neuropathic Pain) protocol assesses the function of afferent nerve fibers on the basis of 13 parameters. Within the consortia IMI (Innovative Medicines Initiative) Europain and Neuropain, QST results from pain research units exp...
journal_title：Pain
pub_type： 杂志文章,多中心研究
doi：10.1097/j.pain.0000000000000433
更新日期：2016-03-01 00:00:00
abstract：:Laser-evoked potentials (LEPs) are acknowledged as the most reliable laboratory tool for assessing thermal and pain pathways. Electrical stimulation with a newly developed planar concentric electrode, delivering stimuli limited to the superficial skin layers, has been suggested to provide selective activation of Aδ fi...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/j.pain.2012.03.004
更新日期：2012-06-01 00:00:00
abstract：:Functional magnetic resonance imaging (fMRI) using the blood oxygen level-dependent (BOLD) contrast was used to study sensory processing in the brain of isoflurane-anesthetized mice. The use of a cryogenic surface coil in a small animal 9.4T system provided the sensitivity required for detection and quantitative analy...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2010.08.025
更新日期：2010-12-01 00:00:00
abstract：:Thirty subjects were given a placebo (intravenous saline), which was described as a known pain killer, once a week for 3 consecutive weeks. Experimental ischemic arm pain was produced prior to the placebo and again 1 h later. In a double blind procedure, half of the subjects received 10 mg of naloxone after placebo; t...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(83)90203-8
更新日期：1983-06-01 00:00:00
abstract：:Two classes of neurons with distinct responses to opioids have been identified in the rostral ventromedial medulla (RVM), a region with a well-documented role in nociceptive modulation. 'On-cells' are directly inhibited by opioids, and opioids can thus gain access to the modulatory circuitry of the RVM by an action on...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(97)00226-1
更新日期：1998-04-01 00:00:00
abstract：:In recent years, oxytocin has been implicated in a wide diversity of functions. The role of oxytocin in analgesia and pain modulation represents an important new function of an endogenous system controlling sensorial information. The paraventricular (PV) nucleus of the hypothalamus is one of the most important sources...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2006.01.029
更新日期：2006-05-01 00:00:00
abstract：:Sex differences for chronic back pain (cBP) have been reported, with females usually exhibiting greater morbidity, severity, and poorer response to treatment. Genetic factors acting in an age-specific manner have been implicated but never comprehensively explored. We performed sex- and age-stratified genome-wide assoc...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000002100
更新日期：2020-09-30 00:00:00
abstract：:Age-related changes in the facial expression of pain during the first 18 months of life have important implications for our understanding of pain and pain assessment. We examined facial reactions video recorded during routine immunization injections in 75 infants stratified into 2-, 4-, 6-, 12-, and 18-month age group...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/s0304-3959(97)00034-1
更新日期：1997-08-01 00:00:00
abstract：:Omega-3 and n-6 fatty acids are biosynthetic precursors to lipid mediators with antinociceptive and pronociceptive properties. We conducted a randomized, single-blinded, parallel-group clinical trial to assess clinical and biochemical effects of targeted alteration in dietary n-3 and n-6 fatty acids for treatment of c...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2013.07.028
更新日期：2013-11-01 00:00:00
abstract：:Primary burning mouth syndrome (BMS) is defined as an "intraoral burning or dysaesthetic sensation, recurring daily… more than 3 months, without clinically evident causative lesions" (IHS 2013). In addition to pain, taste alterations are frequent (dysgeusia, xerostomia). Although lacking clinical signs of neuropathy, ...
journal_title：Pain
pub_type： 杂志文章,评审
doi：10.1097/j.pain.0000000000001090
更新日期：2018-03-01 00:00:00
abstract：:Disabling neuropathic pain (NeuP) is a common sequel of diabetic peripheral neuropathy (DPN). We aimed to characterise the sensory phenotype of patients with and without NeuP, assess screening tools for NeuP, and relate DPN severity to NeuP. The Pain in Neuropathy Study (PiNS) is an observational cross-sectional multi...
journal_title：Pain
pub_type： 杂志文章,多中心研究
doi：10.1097/j.pain.0000000000000491
更新日期：2016-05-01 00:00:00
abstract：:Locus of control (LOC) beliefs, long thought important in adjustment to persistent pain, were studied among 160 subjects (67 males and 93 females) referred to a comprehensive pain rehabilitation program. The subscale structure of the Multidimensional Health Locus of Control (MHLC) was factorially replicated in our sam...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(90)91141-5
更新日期：1990-09-01 00:00:00
abstract：:The present study examined the role of catastrophizing in predicting levels of pain and disability in a sample of individuals who had sustained soft-tissue injuries to the neck, shoulders or back following work or motor vehicle accidents. Participants were 86 (27 men, 59 women) consecutive referrals to the Atlantic Pa...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(98)00097-9
更新日期：1998-09-01 00:00:00
abstract：:We have previously reported that the level of 5-HT in the masseter muscle is increased in patients with fibromyalgia as compared with healthy subjects and that high intramuscular level of 5-HT is associated with muscle pain. We have also reported that injection of the 5-HT(3) receptor antagonist granisetron (GRA) into...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/S0304-3959(02)00334-2
更新日期：2003-02-01 00:00:00
abstract：:This laboratory-based study examined lagged associations between child pain behavior and maternal responses as a function of maternal catastrophizing (CAT). Mothers completed the parent version of the Pain Catastrophizing Scale. Children participated in a validated water ingestion procedure to induce abdominal discomf...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000963
更新日期：2017-09-01 00:00:00
abstract：:The present study examined antinociception produced by systemic administration of caffeine in the rat hot-plate (HP) and formalin tests and addressed several aspects of the mechanism of action of caffeine. Locomotor activity was monitored throughout. Caffeine produced a dose-related antinociception the HP (50-100 mg/k...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(94)00169-F
更新日期：1995-05-01 00:00:00
abstract：:The endogenous opioid peptide dynorphin A has non-opioid effects that can damage the spinal cord when given in high doses. Dynorphin has been shown to increase the receptive field size of spinal cord neurons and facilitate C-fiber-evoked reflexes. Furthermore, endogenous dynorphin levels increase following damage to t...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(97)00046-8
更新日期：1997-08-01 00:00:00
abstract：:In the present study the question was addressed whether sensitivity to experimental pain stimuli differs between families, which are previously characterized by the degree of cold tolerance (very insensitive or very sensitive) of one family member. A total of 232 healthy medical students were screened for cold pain to...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2007.11.012
更新日期：2008-08-15 00:00:00
abstract：:Somatovisceral convergence was demonstrated in recordings from 15 of 16 spinothalamic tract cells in the lower thoracic spinal cords of anesthetized monkeys. Inputs were produced by mechanical (or sometimes electrical) stimulation of the skin over the lower trunk and by electrical stimulation of the greater splanchnic...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(81)90002-6
更新日期：1981-10-01 00:00:00
abstract：:Individuals diagnosed with fibromyalgia syndrome (FMS) report chronic pain that is frequently worsened by physical activity and improved by rest. Palpation of muscle and tendinous structures suggests that nociceptors in deep tissues are abnormally sensitive in FMS, but methods of controlled mechanical stimulation of m...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(02)00344-5
更新日期：2003-03-01 00:00:00
abstract：:In 1864, W. Mitchell and colleagues first described the clinical syndrome which came to be known as 'causalgia'. Since that time, the concept of sympathetically related pain has evolved. There is general agreement that profound emotional and behavioural changes can follow these types of pain. Opinions have varied wide...
journal_title：Pain
pub_type： 杂志文章,评审
doi：10.1016/0304-3959(92)90241-3
更新日期：1992-06-01 00:00:00
abstract：:To inform case definition for neck/shoulder pain in epidemiological research, we compared levels of disability, patterns of association, and prognosis for pain that was limited to the neck or shoulders (LNSP) and more generalised musculoskeletal pain that involved the neck or shoulder(s) (GPNS). Baseline data on muscu...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000477
更新日期：2016-05-01 00:00:00
abstract：:It is well known that acupuncture has pain-relieving effects, but the contribution of specific and especially nonspecific factors to acupuncture analgesia is less clear. One hundred one patients who developed pain of ≥ 3 on a visual analog scale (VAS, 0 to 10) after third molar surgery were randomized to receive activ...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2013.05.008
更新日期：2013-09-01 00:00:00
abstract：:Intradermal injection of capsaicin induces primary hyperalgesia at the injection site and secondary hyperalgesia in the surrounding undamaged skin. The secondary hyperalgesia is thought to be due to central sensitization of the dorsal horn neurons while primary hyperalgesia is caused by sensitization of nociceptors in...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(01)00351-7
更新日期：2001-11-01 00:00:00
