Abstract：
:Laser-evoked potentials (LEPs) are acknowledged as the most reliable laboratory tool for assessing thermal and pain pathways. Electrical stimulation with a newly developed planar concentric electrode, delivering stimuli limited to the superficial skin layers, has been suggested to provide selective activation of Aδ fibres without the inconveniences linked to laser stimulation. The aim of our study was to compare the scalp and intracranial responses to planar concentric electrode stimulation (CE-SEPs) with those of LEPs and standard somatosensory-evoked potentials (SEPs). Sixteen healthy subjects, 6 patients with intracortical electrodes, and 2 patients with selective lesions of the spinothalamic pathway were submitted to Neodymium:Yttrium-Aluminium-Perovskite laser stimulations, and electrical stimulations using standard electrodes or planar concentric electrodes (CE). In both healthy controls and epileptic implanted patients, CE- and standard SEPs showed significantly shorter latencies than LEPs. This is consistent with Aβ-fibre activation, peripheral activation time being unable to account for longer LEP latencies. In the patients with spinothalamic lesions, LEPs were absent after stimulation of the affected territory, while CE-SEPs were still present. For these 2 reasons, we conclude that the planar CE does not selectively activate the Aδ and C fibers, but coexcites a significant proportion of large myelinated Aβ fibres that dominate the ensuing cortical response. The use of CE-SEPs for the detection of spinothalamic system lesions is therefore not warranted; the planar electrode can, however, represent a useful tool to study nociceptive reflexes, which can be reliably elicited even in the presence of Aβ coactivation.
journal_name
Painjournal_title
Painauthors
Perchet C,Frot M,Charmarty A,Flores C,Mazza S,Magnin M,Garcia-Larrea Ldoi
10.1016/j.pain.2012.03.004subject
Has Abstractpub_date
2012-06-01 00:00:00pages
1244-1252issue
6eissn
0304-3959issn
1872-6623pii
00006396-201206000-00020journal_volume
153pub_type
临床试验,杂志文章相关文献
PAIN文献大全abstract：:Visceral inflammation is thought to play an important role in the sensitization of low and high threshold mechanosensory and polymodal afferents and to recruit silent nociceptors. Yet, little is known about the potential role of the mediators involved in nociceptor sensitization to mechanical stimulation as compared t...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(01)00318-9
更新日期：2001-09-01 00:00:00
abstract：:Previous work has suggested an attenuated sensitivity to painful stimulation in hypertensive men. We recently reported that, compared with persons with negative parental history, men, but not women, with a positive history for hypertension showed attenuated pain perception. This study specifically addressed factors th...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(00)00306-7
更新日期：2000-10-01 00:00:00
abstract：:Nociceptive long-term potentiation, a use dependent increase in synaptic efficacy in the dorsal horn of the spinal cord is thought to contribute to the development of persistent pain states. So far, no study has analyzed the effects of high-frequency stimulation (HFS) of afferents from deep tissues (muscle and fascia)...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000649
更新日期：2016-10-01 00:00:00
abstract：:A wide range of environmental stimuli have been shown to induce antinociception. Investigation of the brain regions contributing to environmentally induced antinociception (EIA) has focused primarily on the effect of disrupting neural transmission at various CNS sites. In contrast, the present study analyzed changes i...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(93)90108-2
更新日期：1993-01-01 00:00:00
abstract：:Nociceptive impulse activity was recorded extracellularly from single A delta and C primary afferents of the guinea pig's medial articular nerve after induction of an experimental osteoarthritis in the knee joint by partial medial menisectomy and transection of the anterior cruciate ligament (PMM+TACL). Also, the anal...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2006.11.012
更新日期：2007-07-01 00:00:00
abstract：:Venoms peptides have produced exceptional sources for drug development to treat pain. In this study we examined the antinociceptive and side effects of Tx3-3, a peptide toxin isolated from Phoneutria nigriventer venom, which inhibits high-voltage-dependent calcium channels (VDCC), preferentially P/Q and R-type VDCC. W...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2011.04.015
更新日期：2011-10-01 00:00:00
abstract：:According to fear-avoidance models, a catastrophic interpretation of a painful experience may give rise to pain-related fear and avoidance, leading to the development and maintenance of chronic pain problems in the long term. However, little is known about how exactly motivation and goal prioritization play a role in ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000116
更新日期：2015-08-01 00:00:00
abstract：:This study characterized the pain reported in a selected group of obstetrical patients in labor and compared the pain experienced at 2 stages of dilation, dilation of 2-5 cm and of 6-10 cm. Pain was defined as the perception of an unpleasant sensory and emotional experience with multidimensional factors that evoke beh...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(89)90215-7
更新日期：1989-09-01 00:00:00
abstract：:Chronic low back pain (CLBP) and obesity are interrelated, but the physiological mechanisms linking the 2 conditions remain to be determined. Functional brain imaging data from CLBP patients show functional and structural alterations in areas mediating the attribution of hedonic value to food. Accordingly, we hypothes...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2013.12.027
更新日期：2014-04-01 00:00:00
abstract：:Inflammation enhances release of neuropeptides from sensory nerve terminals in the spinal cord, and this may contribute to the development of hyperalgesia. In a similar manner, proinflammatory prostaglandins also augment peptide release from sensory neurons. To ascertain whether the inflammation-induced increase in pe...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(98)00113-4
更新日期：1998-10-01 00:00:00
abstract：:We investigated the effects of acute and of chronic morphine treatment on T-lymphocyte function and natural killer (NK) cell activity in rats receiving chronic constriction injury (CCI) of the sciatic nerve. T-Lymphocyte function was evaluated based on concanavalin-A (ConA)- and phytohemagglutinin (PHA)-induced spleno...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(00)00323-7
更新日期：2000-11-01 00:00:00
abstract：:In this review, the effectiveness of behavioral and pharmacological treatments for pediatric migraine was quantitatively summarized following the meta-analytic approach outlined by Hedges and Olkin (1985). A first meta-analysis based on treatment outcome within treatment conditions revealed that thermal biofeedback an...
journal_title：Pain
pub_type： 杂志文章,meta分析
doi：10.1016/0304-3959(94)00210-6
更新日期：1995-03-01 00:00:00
abstract：:Combined oral administration of morphine sulfate (MS) and the over-the-counter antitussive drug and N-methyl-D-aspartate receptor antagonist dextromethorphan (DM) prevented the development of tolerance to the antinociceptive effects of MS (15, 24, or 32 mg/kg) in rats. This combined oral treatment regimen also attenua...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(96)03120-x
更新日期：1996-10-01 00:00:00
abstract：:The perception of pain is highly variable. It depends on bottom-up-mediated factors like stimulus intensity and top-down-mediated factors like expectations. In the brain, pain is associated with a complex pattern of neuronal responses including evoked potentials and induced responses at alpha and gamma frequencies. Al...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1097/01.j.pain.0000460309.94442.44
更新日期：2015-02-01 00:00:00
abstract：:Formalin injection into the hindpaw of rats produces many neurons with c-fos protein-like immunoreactivity (fos-neurons) in the medial 3/4 of the ipsilateral dorsal horn laminae I and II at the junction of 4th and 5th lumbar segments (the sciatic territory). The tibial nerve transection 2 or 3 days earlier resulted in...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(95)00014-J
更新日期：1995-10-01 00:00:00
abstract：:Many aspects of bilateral presentation or recurrence of reflex sympathetic dystrophy (RSD) are unknown. For this reason 1183 consecutive patients with RSD were analyzed. In 10 patients RSD started in symmetrical limbs. In 34 patients RSD recurred in the same limb after a period of no or few complaints and in 76 patien...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/0304-3959(95)00160-3
更新日期：1996-03-01 00:00:00
abstract：:Is a person's response to one noxious stimulus similar to his/her responses to other noxious stimuli? This long-investigated topic in pain research has provided inconclusive results. In the present study, 2 samples were studied: one using 60 healthy volunteers and the other using 29 patients with coronary artery disea...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(94)90135-X
更新日期：1994-09-01 00:00:00
abstract：:The processing of pain in the central nervous system is now known to have an important immune component, including T cells of the adaptive immune system. T cells have been shown to release endogenous opioids, and although it is well known that opioids have effects on T-cell populations, very little attention has been ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001420
更新日期：2019-02-01 00:00:00
abstract：:Clinical trial participants often require additional instruction to prevent idiosyncratic interpretations regarding completion of patient-reported outcomes. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership developed a tr...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1097/j.pain.0000000000000502
更新日期：2016-05-01 00:00:00
abstract：:The aim of the present study was to test (1) whether muscle pain is influenced by temporal and spatial summation, and (2) whether sequential noxious muscle stimuli applied at hourly interstimulus-intervals could produce an increased sensation of pain due to central hyperexcitability. In the study eleven healthy men we...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/s0304-3959(96)03243-5
更新日期：1997-01-01 00:00:00
abstract：:To better understand the association between pain recalled over a previous week and the average of multiple momentary reports of pain taken during the same period, 68 patients with chronic pain completed both weekly recall and momentary reports over a 2-week period and assessed their change in pain over the 2 weeks. P...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2003.09.020
更新日期：2004-01-01 00:00:00
abstract：:Reports of pain during mammography show that there is great variability in both the incidence of reported pain (0.2-62%) and the intensity of that pain. Much of that variability may be due to the measures used to rate mammography pain. This is the first study that has examined the incidence, quality and intensity of m...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/0304-3959(96)03057-6
更新日期：1996-08-01 00:00:00
abstract：:This study compared individuals with fibromyalgia (FM) and individuals with chronic low back pain (CLBP) on repetition-induced summation of activity-related pain (RISP). Fear of movement, pain catastrophizing and depression were examined as potential mediators of group differences. The sample consisted of 50 women wit...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2011.02.030
更新日期：2011-06-01 00:00:00
abstract：:Although known primarily for its role in neuronal development, brain-derived neurotrophic factor (BDNF) has also recently been implicated in processes mediated by the adult nervous system, such as spinal nociception. Peripheral inflammation increases expression of BDNF preferentially in dorsal root ganglion cells that...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(02)00264-6
更新日期：2002-11-01 00:00:00
abstract：:A cold pressor task (CPT) was used with 203 college students (112 women and 91 men) in a study of sex differences in pain response. Physiological measures were taken before and after pain induction, and sex-differentiating personality traits were assessed with the Personal Attributes Questionnaire (PAQ). The Pain Cata...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2004.08.017
更新日期：2004-11-01 00:00:00
abstract：:Features of somatisation have been shown to predict the onset of widespread body pain. This study aims to determine to what extent persons with orofacial pain syndromes share these features and to what extent they are uniquely related to oral mechanical factors. We have conducted a population-based cross-sectional sur...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(02)00181-1
更新日期：2002-10-01 00:00:00
abstract：:Ten patients with organic nerve injury causing chronic neuropathic pain were tested for the effects of intravenous lidocaine versus saline upon psychophysical somatosensory variables. The variables assessed were the subjective magnitude of pain, area of mechanical hyperalgesia and presence and magnitude of thermal hea...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/0304-3959(92)90087-R
更新日期：1992-03-01 00:00:00
abstract：:Two different modes of cutaneous sensory reinnervation are thought to be engaged following nerve injury: regenerative growth of the injured nerve and 'collateral sprouting' of neighboring intact nerves. Although both processes are well known from experimental preparations, there is little unequivocal documentation of ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(87)90112-6
更新日期：1987-02-01 00:00:00
abstract：:With increasing concerns about the potential harm of long-term opioid therapy, there is a need for the development and implementation of alternative treatment strategies for patients with chronic pain who have been using opioids for a prolonged period of time. Based on the findings from a recent qualitative investigat...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000384
更新日期：2016-02-01 00:00:00
abstract：:Human and animal imaging studies demonstrated that chronic pain profoundly alters the structure and the functionality of several brain regions. In this article, we conducted a longitudinal and multimodal study to assess how chronic pain affects the brain. Using the spared nerve injury model which promotes both long-la...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001610
更新日期：2019-10-01 00:00:00
