Abstract:
:With increasing concerns about the potential harm of long-term opioid therapy, there is a need for the development and implementation of alternative treatment strategies for patients with chronic pain who have been using opioids for a prolonged period of time. Based on the findings from a recent qualitative investigation that suggested there may be a bidirectional association between opioid reliance and habitual overactivity behaviour (activity engagement that significantly exacerbates pain), this study was designed to quantitatively investigate the association between opioid use and habitual overactivity over a 5-day period in a group of chronic pain patients. Participants provided a list of their prescribed pain medication, completed a self-report measure of habitual overactivity, and then commenced 5 days of data collection. Data collection required participants to wear an activity monitor and to complete a diary that detailed their daily activities and the time at which they took medication. Individuals reporting higher levels of habitual overactivity were more likely to be prescribed opioids. In addition, higher levels of habitual overactivity were associated with more frequent pro re nata ("as needed") opioid use over the 5 days, and with a discrepancy between the prescribed and actual oral morphine-equivalent daily dose, where more medication was taken than was prescribed. There was no predominant context for pro re nata use. The results of this study support the idea that habitual overactivity behaviour may play a role in the development of reliance on opioid medication and that such an association may provide a potential treatment target for opioid therapy rationalisation.
journal_name
Painjournal_title
Painauthors
Andrews NE,Strong J,Meredith PJ,Fleming JAdoi
10.1097/j.pain.0000000000000384subject
Has Abstractpub_date
2016-02-01 00:00:00pages
466-474issue
2eissn
0304-3959issn
1872-6623pii
00006396-201602000-00022journal_volume
157pub_type
杂志文章相关文献
PAIN文献大全abstract::Serotonin is critically involved in neuropathic pain. However, its role is far from being understood owing to the number of cellular targets and receptor subtypes involved. In a rat model of neuropathic pain evoked by chronic constriction injury (CCI) of the sciatic nerve, we studied the role of 5-HT(2B) receptor in d...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.03.024
更新日期:2012-06-01 00:00:00
abstract::The objective of this study was to examine pain as a predictor of frailty over 18 years of follow-up among older Mexican Americans who were nonfrail at baseline. Data were from a prospective cohort study of 1545 community-dwelling Mexican Americans aged ≥67 years from the Hispanic Established Populations for the Epide...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001711
更新日期:2020-01-01 00:00:00
abstract::The purpose of this study was to assess the hypothesis that pain and depression negatively impact the cognitive functioning of individuals with rheumatoid arthritis (RA). One hundred twenty-one community-dwelling RA patients (ages 34-84) completed a battery of cognitive tasks and multiple measures of pain and depressi...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(01)00457-2
更新日期:2002-04-01 00:00:00
abstract::Plastic changes in the anterior cingulate cortex (ACC) are critical in pain hypersensitivity caused by peripheral nerves injury. The Notch signaling pathway has been shown to regulate synaptic differentiation and transmission. Therefore, this study was to investigate the function of the Notch signaling pathway in the ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002014
更新日期:2021-01-01 00:00:00
abstract::The effects of lateral reticular nucleus (LRN) stimulation on the responses to tooth pulp (TP) stimulation of neurons located in the trigeminal (V) sensory (39 units) and motor (33 units) nuclei were assessed in anesthetized rats. Only neurons which responded to TP stimulation with bursts of spikes that were in a cons...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90035-V
更新日期:1991-07-01 00:00:00
abstract::Multimodal neuroimaging studies provide support for a role of alterations in sensory processing circuits and endogenous pain modulatory systems in provoked vestibulodynia (PVD). In this study, we tested the hypotheses that PVD compared with healthy controls (HCs) would demonstrate gray matter volume (GMV) alterations ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001532
更新日期:2019-07-01 00:00:00
abstract::To address the lack of appropriate patient-defined quality indicators (QIs) for assessment of pain clinic care in the Netherlands, we developed the "Quality Indicators Pain Patients' Perspective" (QiPPP) questionnaire. Quality indicators are widely used to measure the quality of the structure, process, and outcome of ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001371
更新日期:2018-12-01 00:00:00
abstract::Clinical pain syndromes, and experimental assays of nociception, are differentially affected by manipulations such as drug administration and exposure to environmental stress. This suggests that there are different 'types' of pain. We exploited genetic differences among inbred strains of mice in an attempt to define t...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(98)00196-1
更新日期:1999-03-01 00:00:00
abstract::A study of the extent of sympathetic blockade after stellate ganglion block was assessed using liquid crystal thermography. Two volumes (10 and 20 ml) of bupivacaine 0.5% plain were used. Irrespective of the volume used cranial sympathetic block always occurred and thoracic sympathetic block never occurred. While uppe...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(89)90023-7
更新日期:1989-02-01 00:00:00
abstract::Approximately 70-80% of women meeting criteria for borderline personality disorder (BPD) report attenuated pain perception or analgesia during non-suicidal, intentional self-mutilation. The aim of this study was to use laser-evoked potentials (LEPs) and psychophysical methods to differentiate the factors that may unde...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.04.035
更新日期:2004-07-01 00:00:00
abstract::In a group of 30 subjects suffering from sympathetic reflex dystrophies of the limbs, the sympathetic ganglia of the affected side were blocked with a local anesthetic. Using an original method, we measured the cutaneous pain threshold before the block and at prefixed intervals after the block during a period of 2 day...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(75)90100-1
更新日期:1975-06-01 00:00:00
abstract::A cohort of 243 female sewing machine operators were studied by questionnaire and clinical examinations with the purpose to study the efficiency of a screening questionnaire-based method to identify prevalent and incident cases of neck-shoulder disorders. The cross-sectional correlation between self-reported neck-shou...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(00)00261-X
更新日期:2000-06-01 00:00:00
abstract::Morphine is increasingly used in patients with chronic non-cancer pain, but a major concern associated with chronic use relates to possible cognitive side-effects. The aim of this long-term prospective study was to evaluate the cognitive impact of oral sustained release morphine in patients with non-cancer pain. A bat...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(03)00047-2
更新日期:2003-07-01 00:00:00
abstract::Self-hypnosis was taught to 5 highly hypnotisable patients referred to Auckland Hospital Pain Clinic. Evaluation included the Illness Self-Concept Repertory Grid (ISCRG) and follow-up was at 1 and 6 months post treatment. Consensus grids indicated the subjects initially identified with physical illness but this associ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(88)90223-0
更新日期:1988-11-01 00:00:00
abstract::Chronic low back pain (CLBP) patients with pain and symptomatology incongruent with physical pathology have been found to have a poorer outcome to medical treatment and rehabilitation, and to use health care resources excessively. To examine possible psychological and behavioral bases for this pattern, this investigat...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(88)90021-8
更新日期:1988-01-01 00:00:00
abstract::Neuropathic pain behaviour is not observed in neonatal rats and tactile allodynia does not develop in the spared nerve injury (SNI) model until rats are 4 weeks of age at the time of surgery. Since activated spinal microglia are known to play a key role in neuropathic pain, we have investigated whether the microglial ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.09.018
更新日期:2007-04-01 00:00:00
abstract::Anti-nerve growth factor (anti-NGF) therapy has shown significant promise in attenuating several types of skeletal pain. However, whether anti-NGF therapy changes the level of physical activity in individuals with or without skeletal pain is largely unknown. Here, automated day/night activity boxes monitored the effec...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001330
更新日期:2018-11-01 00:00:00
abstract::In the present study 366 patients suffering acute or chronic musculoskeletal pain of different origin were given vibratory stimulation for the pain. Many of the patients had previously had treatments of various kinds without satisfactory relief. The effect of vibratory stimulation was assessed during and after stimula...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90808-X
更新日期:1984-09-01 00:00:00
abstract::This double-blind, within-subjects experiment examined the effects of ingesting two doses of caffeine on perceptions of leg muscle pain and blood pressure during moderate intensity cycling exercise. Low caffeine consuming college-aged males (N=12) ingested one of two doses of caffeine (5 or 10 mg.kg(-1) body weight) o...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/j.pain.2004.01.017
更新日期:2004-06-01 00:00:00
abstract::The presence of a trigger point is essential to the myofascial pain syndrome. This study centres on identifying clearer criteria for the presence of trigger points in the quadratus lumborum and gluteus medius muscle by investigating the occurrence and inter-rater reliability of trigger point symptoms. Using the sympto...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(94)90125-2
更新日期:1994-09-01 00:00:00
abstract::(1) Quantitative measurements of somatosensory thresholds and skin temperature were made before (24 cases), 3-5 days after (12 cases), and 6 months after (11 cases) successful radiofrequency thermocoagulation of the proximal root and gasserian ganglion in 24 cases of idiopathic trigeminal neuralgia (TGN), 18 of whom h...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)91121-X
更新日期:1990-03-01 00:00:00
abstract::Mental stress induces endothelial dysfunction, that is a reduction of the post-occlusion brachial artery flow-mediated vasodilation (FMD). This does not occur in subjects highly susceptible to hypnosis (Highs) in either the waking or hypnotic state. The aim of the present experiment was to assess whether endothelial d...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.pain.2005.03.041
更新日期:2005-08-01 00:00:00
abstract::Injection of a dilute solution of formalin into a rat hindpaw produces a biphasic nociceptive response consisting of an early phase during the first 5 min after formalin injection and a later phase starting after 15 min and lasting for 40-50 min. The period between the two phases of nociceptive responding is generally...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(99)00033-0
更新日期:1999-07-01 00:00:00
abstract::The opiate antagonist naloxone has been reported to cause pain relief. Therefore, the effect was determined of naloxone, injected intravenously, on the activity in single neurones of the dorsomedial part of the ventral nucleus (VDM) in the thalamus of rats under urethane anaesthesia elicited by electrical stimulation ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(88)90144-3
更新日期:1988-12-01 00:00:00
abstract::The heat beam dolorimeter (HBD) was developed to evaluate cutaneous pain thresholds in humans. In the present study, the hypothesis that a patient's underlying pain status affects his pain tolerance to an incident HBD stimulus was tested. Twenty-seven chronic pain patients with a variety of clinical problems unrespons...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(87)90083-2
更新日期:1987-07-01 00:00:00
abstract::Neuropathic pain may be effectively relieved by electric stimulation of the spinal cord (SCS). However, the underlying mechanisms for the ensuing pain relief are poorly understood. In a rat model of neuropathy displaying hypersensitivity to innocuous tactile stimuli, (allodynia), we have earlier demonstrated that SCS ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(97)00077-8
更新日期:1997-10-01 00:00:00
abstract::Ten patients with myofascial trigger point pain were entered into a double-blind cross-over study of the reversibility of myofascial trigger point injection (TPI) effects with naloxone versus placebo in order to test the hypothesis that the benefits of TPI are mediated, at least in part, through activation of an endog...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(88)90018-8
更新日期:1988-01-01 00:00:00
abstract::Evidence has been accumulated suggesting that a dysfunction in pain inhibitory systems, i.e. in 'diffuse noxious inhibitory controls' (DNIC)-like mechanisms, might be-amongst other factors-responsible for the development of anatomically generalized chronic pain like fibromyalgia. The aim of the present study was to lo...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2005.08.019
更新日期:2005-11-01 00:00:00
abstract::The assessment and development of pain in children is reviewed in the first part of a two-part series. Assessment of pain in children has relied on self-report measures that have included visual analogue procedures using concrete stimuli for ratings. Behavioral assessment procedures are more sophisticated, but researc...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/0304-3959(86)90206-X
更新日期:1986-11-01 00:00:00
abstract::Migraine headache is an episodic phenomenon, and patients with episodic migraine have ictal (headache), peri-ictal (premonitory, aura, and postdrome), and interictal (asymptomatic) phases. We aimed to find the functional characteristics of the migraine brain regardless of headache phase using dynamic functional connec...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001676
更新日期:2019-12-01 00:00:00