Abstract:
:Mental stress induces endothelial dysfunction, that is a reduction of the post-occlusion brachial artery flow-mediated vasodilation (FMD). This does not occur in subjects highly susceptible to hypnosis (Highs) in either the waking or hypnotic state. The aim of the present experiment was to assess whether endothelial dysfunction is also induced by acute nociceptive stimulation and whether high hypnotisability and/or the specific instruction of analgesia prevent its occurrence in awake highly hypnotizable individuals. Thus, nine Highs and nine subjects with low susceptibility to hypnosis (Lows) underwent an experimental session including the administration of pressor pain and of pressor pain associated with the instruction of analgesia. Heart rate, basal artery diameters and brachial artery flow-mediated vasodilation were measured during stimulation and rest conditions. Heart rate exhibited slight changes not modulated by hypnotisability. During painful stimulation both Highs and Lows showed a decrease of FMD, but it was significantly less pronounced in Highs. During the administration of painful stimulation together with the instruction of analgesia, only Highs reported analgesia and their FMD no longer decreased. This study provides the first evidence of pain-related endothelial dysfunction and extends previous findings concerning a sort of natural protection of Highs against the vascular effects of mental stress to acute pain.
journal_name
Painjournal_title
Painauthors
Jambrik Z,Santarcangelo EL,Rudisch T,Varga A,Forster T,Carli Gdoi
10.1016/j.pain.2005.03.041keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
181-186issue
3eissn
0304-3959issn
1872-6623pii
00006396-200508000-00004journal_volume
116pub_type
临床试验,杂志文章,随机对照试验相关文献
PAIN文献大全abstract::Acute zoster infection may be followed by a chronic pain syndrome, i.e., postherpetic neuralgia (PHN). Besides older age, the intensity of pain and neuronal damage within the acutely affected body region are regarded as predictors or risk factors for PHN. As an alternative approach an underlying peripheral polyneuropa...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/S0304-3959(97)00105-X
更新日期:1997-11-01 00:00:00
abstract::This experiment had three goals: 1. To identify the basis of sucking-induced analgesia in healthy, term, newborn humans undergoing the painful, routine, procedure of heel lance and blood collection. 2. To evaluate how taste-induced and sucking-induced analgesias combine to combat pain. 3. To determine whether facial g...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0304-3959(99)00166-9
更新日期:1999-12-01 00:00:00
abstract::Late-life depression and pain more often co-occur than can be explained by chance. Determinants of pain in late-life depression are unknown, even though knowledge on possible determinants of pain in depression is important for clinical practice. Therefore, the objectives of the present study were 1) to describe pain c...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.07.019
更新日期:2014-10-01 00:00:00
abstract::Bipolar intrapulpal stimulation was applied to human teeth using the same procedure as in animal experiments. The effects of variation of stimulus parameters on the quality of sensation were studied. A prepain sensation exists which cannot be explained by diffusion of the stimulus to periodontal tissues. When the inte...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(77)90128-2
更新日期:1977-12-01 00:00:00
abstract::To clarify the relationships between physical, and psychosocial components of chronic pain, a path analytic model was tested conceptualizing self efficacy as a mediator of disability. In turn, disability was hypothesized to mediate depression. This model could help explain the circumstances under which disability deve...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(98)00220-6
更新日期:1999-04-01 00:00:00
abstract::Nocebo hyperalgesia refers to increases in perceived pain that putatively result from negative expectations regarding a nocebo stimulus (eg, an inert treatment, compared with no treatment). The precise cognitive-emotional factors contributing to the origins of nocebo effects are poorly understood. We aimed to test the...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002017
更新日期:2021-01-01 00:00:00
abstract::Histamine, substance P, serotonin and bradykinin were applied by iontophoresis to lesional and visually non-lesional skin of 14 patients with atopic dermatitis, and normal skin of 15 healthy volunteers. Itch could be evoked by light stroking of skin with a cotton swab (alloknesis) in all lesional skin sites, but not i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.06.003
更新日期:2006-12-15 00:00:00
abstract::Internet-delivered interventions are emerging as a strategy to address barriers to care for individuals with chronic pain. This is the first large multicenter randomized controlled trial of Internet-delivered cognitive-behavioral therapy (CBT) for pediatric chronic pain. Participants included were 273 adolescents (205...
journal_title:Pain
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/j.pain.0000000000000348
更新日期:2016-01-01 00:00:00
abstract::Painful neuromas can cause severe loss of function and have great impact on the daily life of patients. Surgical management remains challenging; despite improving techniques, success rates are low. To accurately study the success of surgical neuroma treatment and factors predictive of outcome, a prospective follow-up ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.09.032
更新日期:2010-12-01 00:00:00
abstract::The antinociception induced by the intraperitoneal coadministration of combinations of paracetamol with the nonsteroidal anti-inflammatory drugs (NSAIDs) diclofenac, ibuprofen, ketoprofen, meloxicam, metamizol, naproxen, nimesulide, parecoxib and piroxicam was studied by isobolographic analysis in the acetic acid abdo...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2005.11.012
更新日期:2006-03-01 00:00:00
abstract::Return of sensory nerve function in rat molars following cut or crush injury to the inferior alveolar nerve (IAN) was measured by observing the jaw opening reflex (JOR) response of the digastric muscle to electrical stimulation of individual molars or the gingiva. The IAN was injured from a lateral approach to the man...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(83)90071-4
更新日期:1983-04-01 00:00:00
abstract::The analgesic efficacy of single doses of oral morphine sulphate solution (10 mg) and ibuprofen 600 mg was compared in 12 volunteers using a double-blind, double-dummy, placebo-controlled design on the cold pressor experimental pain model. Measurement of pain intensity was made before medication and then at 30, 60, 90...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(88)90156-X
更新日期:1988-08-01 00:00:00
abstract::Treatment of neuropathic pain is a major clinical challenge that has been met with minimal success. After peripheral nerve injury, a decrease in the expression of the K-Cl cotransporter KCC2, a major neuronal Cl(-) extruder, leads to pathologic alterations in GABA(A) and glycine receptor function in the spinal cord. T...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.11.015
更新日期:2010-02-01 00:00:00
abstract::Recent studies into the common complaint of chronic neck pain have focused on its anatomical origin, identifying especially the cervical zygapophysial joints. However the pathophysiology of chronic neck pain remains poorly understood. In this psychophysical study, responses to electrocutaneous stimulation in subjects ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(98)00013-x
更新日期:1998-04-01 00:00:00
abstract::Salmon calcitonin (s-CT) has been shown to be a valuable analgesic in phantom limb pain (PLP) in several case reports. To evaluate these findings a double-blind crossover comparison of s-CT treatment versus placebo was initiated. Twenty-one out of 161 patients who had undergone major amputations and developed severe P...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(92)90127-W
更新日期:1992-01-01 00:00:00
abstract::Multimodal neuroimaging studies provide support for a role of alterations in sensory processing circuits and endogenous pain modulatory systems in provoked vestibulodynia (PVD). In this study, we tested the hypotheses that PVD compared with healthy controls (HCs) would demonstrate gray matter volume (GMV) alterations ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001532
更新日期:2019-07-01 00:00:00
abstract::The effect of the central grey matter (CG) on pain sensitivity has been investigated in rats. It has been demonstrated that baseline pain thresholds, tested by the hot plate method (HPM) after surgical operation, were significantly greater in CG-lesioned rats than in controls. Baseline tail flick latencies did not dif...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(83)90083-0
更新日期:1983-05-01 00:00:00
abstract:ABSTRACT:High mobility group box 1 protein (HMGB1) is increasingly regarded as an important player in the spinal regulation of chronic pain. Although it has been reported that HMGB1 induces spinal glial activation in a Toll-like receptor (TLR)4-dependent fashion, the aspect of sexual dimorphisms has not been thoroughly...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002033
更新日期:2021-02-01 00:00:00
abstract::Although both a loss of spinal inhibitory neurotransmission and the involvement of oxidative stress have been regarded as important mechanisms in the pathogenesis of pain, the relationship between these 2 mechanisms has not been studied. To determine whether reactive oxygen species (ROS) involvement in pain mechanisms...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.12.034
更新日期:2011-04-01 00:00:00
abstract::The mechanisms of chronic pain in irritable bowel syndrome (IBS) have been widely investigated but remain unclear. The present study investigated the relation between visceral hypersensitivity, cutaneous thermal sensitivity, and central pain mechanisms. Rectal sensitivity was assessed with a barostat, and forearm and ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.10.005
更新日期:2010-01-01 00:00:00
abstract::In the spinal nerve ligation (SNL) model of neuropathic pain, synaptic plasticity shifts the excitation/inhibition balance toward excitation in the spinal dorsal horn. We investigated the deregulation of the synaptogenic neuroligin (NL) molecules, whose NL1 and NL2 isoforms are primarily encountered at excitatory and ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2013.07.035
更新日期:2013-11-01 00:00:00
abstract::Slow-release strong opioids (SRSO) are indicated in patients with severe chronic pain. Side effects, lack of efficacy and risk of dependency limit their use in clinical practice. The aim of this study was to explore prescription patterns of SRSO in Swedish real-world data on patients with a diagnosis related to chroni...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.07.011
更新日期:2012-12-01 00:00:00
abstract::Activation of extracellular signal-regulated kinase (ERK), a mitogen activated-protein kinase (MAPK), in dorsal horn neurons contributes to inflammatory pain by transcription-dependent and -independent means. We have now investigated if ERK is activated in the spinal cord after a spinal nerve ligation (SNL) and if thi...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.12.022
更新日期:2005-03-01 00:00:00
abstract::In humans, chronic psychological stress is associated with increased intestinal paracellular permeability and visceral hyperalgesia, which is recapitulated in the chronic intermittent water avoidance stress (WAS) rat model. However, it is unknown whether enhanced visceral pain and permeability are intrinsically linked...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001271
更新日期:2018-09-01 00:00:00
abstract::Chronic pain is frequently accompanied by a deterioration of emotional behavior and cognitive function. A small number of studies in humans concluded that pain-associated negative affect is more pronounced when pain is localized in the left side of the body. It has been suggested that such side bias results from corti...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.07.007
更新日期:2012-11-01 00:00:00
abstract::Unilateral intraplantar injection of Freund's complete adjuvant (FCA) into 1 hind paw of rats was used as a model of peripheral inflammation and persistent pain in order to examine time course effects of a continuous barrage of nociceptive input on the second-messenger transducing systems in the spinal cord. cAMP, cGM...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)90185-6
更新日期:1994-07-01 00:00:00
abstract::Many malignant cancers, including breast cancer, have a propensity to invade bones, leading to excruciating bone pain. Opioids are the primary analgesics used to alleviate this cancer-induced bone pain (CIBP) but are associated with numerous severe side effects, including enhanced bone degradation, which significantly...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001278
更新日期:2018-09-01 00:00:00
abstract::We have examined the effects of cannabinoid agonists on hyperalgesia in a model of neuropathic pain in the rat and investigated the possible sites of action. The antihyperalgesic activity of the cannabinoids was compared with their ability to elicit behavioural effects characteristic of central cannabinoid activity. W...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(00)00474-7
更新日期:2001-05-01 00:00:00
abstract::The relationship was investigated between algogenic potential of gallbladder pathology and occurrence/extent of sensory and trophic changes in the referred area. Five groups of subjects were studied, with: symptomatic gallbladder calculosis (3-20 colics); asymptomatic calculosis; symptomatic gallbladder shape abnormal...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.12.024
更新日期:2005-03-01 00:00:00
abstract::We assessed for the first time the long-term maintenance of repetitive transcranial magnetic stimulation (rTMS)-induced analgesia in patients with chronic widespread pain due to fibromyalgia. Forty consecutive patients were randomly assigned, in a double-blind fashion, to 2 groups: one receiving active rTMS (n=20) and...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2011.01.034
更新日期:2011-07-01 00:00:00