Abstract：
:Neuropathic pain may be effectively relieved by electric stimulation of the spinal cord (SCS). However, the underlying mechanisms for the ensuing pain relief are poorly understood. In a rat model of neuropathy displaying hypersensitivity to innocuous tactile stimuli, (allodynia), we have earlier demonstrated that SCS may normalise withdrawal response thresholds. In the present study, using microdialysis, it is shown that SCS induces a decreased release of the dorsal horn excitatory amino acids (EAA), glutamate and aspartate, concomitant with an increase of the GABA release. Local perfusion with a GABA(B)-receptor antagonist in the dorsal horn transiently abolishes the SCS-induced suppression of the EAA release. Thus, the effect of SCS on neuropathic pain and allodynia may be due to an activation of local GABAergic mechanisms inhibiting the EAA release which is chronically elevated in such conditions.
journal_name
Painjournal_title
Painauthors
Cui JG,O'Connor WT,Ungerstedt U,Linderoth B,Meyerson BAdoi
10.1016/s0304-3959(97)00077-8subject
Has Abstractpub_date
1997-10-01 00:00:00pages
87-95issue
1eissn
0304-3959issn
1872-6623pii
S0304395997000778journal_volume
73pub_type
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