Abstract:
:The objective of this study was to examine pain as a predictor of frailty over 18 years of follow-up among older Mexican Americans who were nonfrail at baseline. Data were from a prospective cohort study of 1545 community-dwelling Mexican Americans aged ≥67 years from the Hispanic Established Populations for the Epidemiological Study of the Elderly (1995/1996-2012/2013). Frailty was defined as meeting 2 or more of the following: unintentional weight loss of >10 pounds, weakness, self-reported exhaustion, and slowness. The independent predictor was self-reported pain. Covariates included age, sex, marital status, education, comorbid conditions, body mass index, Mini-Mental State Examination, depressive symptoms, and limitation in activities of daily livings. General equation estimation was performed to estimate the odds ratio of frailty as a function of pain. A total of 538 participants (34.8%) reported pain at baseline. The prevalence of frailty among those with pain ranged from 24.4% in wave 3 to 41% in wave 8. The odds ratio of becoming frail over time as a function of pain was 1.71; 95% confidence interval: 1.41 to 2.09 after controlling for all covariates. Older age, hip fracture, high depressive symptoms, and activities of daily living disability were also associated with higher odds of becoming frail over time. Female participants and those with higher levels of education and high Mini-Mental State Examination scores were less at risk. In conclusion, pain was a significantly predictor of frailty. Early assessment and better management of pain may prevent early onset of frailty in older Mexican Americans.
journal_name
Painjournal_title
Painauthors
Sodhi JK,Karmarkar A,Raji M,Markides KS,Ottenbacher KJ,Al Snih Sdoi
10.1097/j.pain.0000000000001711subject
Has Abstractpub_date
2020-01-01 00:00:00pages
109-113issue
1eissn
0304-3959issn
1872-6623pii
00006396-202001000-00012journal_volume
161pub_type
杂志文章相关文献
PAIN文献大全abstract::Clinical observations and recent studies suggest that arthritis patients vary considerably in their involvement in self-management efforts. In the literature on health promotion, there is growing recognition that patients may be at different stages of change with respect to the adoption of self-management strategies. ...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0304-3959(00)00294-3
更新日期:2000-09-01 00:00:00
abstract::A wide range of environmental stimuli have been shown to induce antinociception. Investigation of the brain regions contributing to environmentally induced antinociception (EIA) has focused primarily on the effect of disrupting neural transmission at various CNS sites. In contrast, the present study analyzed changes i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(93)90108-2
更新日期:1993-01-01 00:00:00
abstract::In the spinal nerve ligation (SNL) model of neuropathic pain, synaptic plasticity shifts the excitation/inhibition balance toward excitation in the spinal dorsal horn. We investigated the deregulation of the synaptogenic neuroligin (NL) molecules, whose NL1 and NL2 isoforms are primarily encountered at excitatory and ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2013.07.035
更新日期:2013-11-01 00:00:00
abstract::In the skin surrounding a site of injury, hyperalgesia develops to mechanical stimuli. Two types of secondary hyperalgesia (to light touch and punctate stimuli) have recently been differentiated, based on different durations and sizes of the area involved. We studied secondary hyperalgesia in a subject who had a loss ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(93)90077-3
更新日期:1993-05-01 00:00:00
abstract::Adrenal medullary transplants in the spinal subarachnoid space, by providing a continual source of opioid peptides and catecholamines, offer a potentially important adjunct in the management of chronic pain. While previous studies have shown that this approach is effective against high-intensity phasic stimuli, adrena...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(93)90135-C
更新日期:1993-02-01 00:00:00
abstract::After 4 millennia of more or less documented history of cannabis use, the identification of cannabinoids, and of Δ(9)-tetrahydrocannabinol in particular, occurred only during the early 1960s, and the cloning of cannabinoid CB1 and CB2 receptors, as well as the discovery of endocannabinoids and their metabolic enzymes,...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/j.pain.2013.03.023
更新日期:2013-12-01 00:00:00
abstract::We know little about the safety or efficacy of pharmacological medicines for children and adolescents with chronic pain, despite their common use. Our aim was to conduct an overview review of systematic reviews of pharmacological interventions that purport to reduce pain in children with chronic noncancer pain (CNCP) ...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1097/j.pain.0000000000001609
更新日期:2019-08-01 00:00:00
abstract::Sensitization of purinergic P2X3 receptors (P2X3Rs) is a major mechanism contributing to injury-induced exaggerated pain responses. We showed in a previous study that cyclic adenosine monophosphate (cAMP)-dependent guanine nucleotide exchange factor 1 (Epac1) in rat sensory dorsal root ganglia (DRGs) is upregulated af...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000547
更新日期:2016-07-01 00:00:00
abstract:UNLABELLED:The German Randomized Acupuncture Trial for chronic shoulder pain (GRASP) comprised 424 outpatients with chronic shoulder pain (CSP) > or =6 weeks and an average pain score of VAS > or =50 mm, who were randomly assigned to receive Chinese acupuncture (verum), sham acupuncture (sham) or conventional conservat...
journal_title:Pain
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.pain.2010.06.036
更新日期:2010-10-01 00:00:00
abstract::In the present study the question was addressed whether sensitivity to experimental pain stimuli differs between families, which are previously characterized by the degree of cold tolerance (very insensitive or very sensitive) of one family member. A total of 232 healthy medical students were screened for cold pain to...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.11.012
更新日期:2008-08-15 00:00:00
abstract::Capsaicin-containing plant extracts have been used as topical treatments for a variety of pain syndromes for many centuries. Current products containing capsaicin in low concentrations (usually 0.025-0.075% w/w) have shown efficacy against a variety of pain conditions in clinical studies. However, in order to produce ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.07.017
更新日期:2004-10-01 00:00:00
abstract::The use of long-term opioid therapy for chronic pain remains common, yet data on long-term outcomes, especially after dose escalation, are sparse. This study examined potential benefits and harms associated with prescription opioid dose escalation. Participants from 2 institutions were enrolled in a 2-year prospective...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001817
更新日期:2020-06-01 00:00:00
abstract::Thirty subjects were given a placebo (intravenous saline), which was described as a known pain killer, once a week for 3 consecutive weeks. Experimental ischemic arm pain was produced prior to the placebo and again 1 h later. In a double blind procedure, half of the subjects received 10 mg of naloxone after placebo; t...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(83)90203-8
更新日期:1983-06-01 00:00:00
abstract::Experimental C-fiber pain caused by radiant heat was applied to the skin area supplied by the left sural nerve of 20 subjects. Percutaneous electrical stimulation (PNS) was performed on the left sural nerve, the left superficial peroneal nerve and the right superficial radial nerve. Stimulation frequencies were: 3, 50...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(79)90004-6
更新日期:1979-10-01 00:00:00
abstract::In a double-blind, cross-over study, ibuprofen (600 mg), a peripherally-acting selective kappa-opioid receptor agonist (7.5 mg), or placebo were given orally in experiments on healthy volunteers 1 h before assessment of pain thresholds to radiant heat and of pain ratings to controlled mechanical impact stimuli. Mechan...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0304-3959(98)00062-1
更新日期:1998-06-01 00:00:00
abstract::This study examined the effects of intravenous administration of sodium amytal (SA), a medium action barbiturate, on cutaneous limb temperatures and sympathetic skin responses (SSR) to electrical stimulation. Eight normal volunteers and 13 patients with musculoskeletal pain, somatoform pain disorders or nerve/root inj...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(96)03301-5
更新日期:1997-03-01 00:00:00
abstract::Effect of weight bearing of the hindlimbs on the assessment of mechanically-induced hindlimb withdrawal threshold was determined in intact rats and in rats with various pathophysiological conditions causing allodynia or hyperalgesia. Hindlimb withdrawal was elicited by applying a series of calibrated monofilaments to ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(97)00143-7
更新日期:1998-01-01 00:00:00
abstract::The molecular/genetic era has seen the discovery of a staggering number of molecules implicated in pain mechanisms [18,35,61,69,96,133,150,202,224]. This has stimulated pharmaceutical and biotechnology companies to invest billions of dollars to develop drugs that enhance or inhibit the function of many these molecules...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/j.pain.2013.05.037
更新日期:2013-12-01 00:00:00
abstract::Aquaporin 1 (AQP1) is the archetypal member of a family of water channel proteins that contribute to water homeostasis in kidney, lung, and other tissues. Although there is limited evidence that aquaporins are expressed in the nervous system, AQP4 is expressed in glia and AQP9 is present on some neuronal and glial mit...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.11.018
更新日期:2007-09-01 00:00:00
abstract::Long-term potentiation (LTP) in wide dynamic range (WDR) neurons in the dorsal horn has been suggested to contribute to central sensitization and the development of chronic pain. Indirect experimental evidence indicates an involvement of substance P (SP), in this respect. The aim of the present study was to monitor th...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(01)00414-6
更新日期:2002-03-01 00:00:00
abstract::The main goal of current pain management approaches is to increase the patients' quality of life by improving pain coping skills and by reducing the levels of disability in daily life, often despite persistent pain. Direct measurement of quality of life is of crucial importance in economic evaluation research, in whic...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0304-3959(98)00232-2
更新日期:1999-03-01 00:00:00
abstract::Spinal long-term potentiation (LTP) elicited by noxious stimulation enhances the responsiveness of dorsal horn nociceptive neurons to their normal input, and may represent a key mechanism of central sensitization by which acute pain could turn into a chronic pain state. This study investigated the electrophysiological...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.05.002
更新日期:2009-08-01 00:00:00
abstract::Cognitive factors are thought to play an important mediational role between pain and consequent levels of suffering, yet there has been little investigation of these issues in older chronic pain patients. The present study sought to examine the reliability and validity of the Pain Locus of Control (PLOC) scale when us...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/S0304-3959(99)00284-5
更新日期:2000-04-01 00:00:00
abstract::Attenuation of neuropathic manifestations in experimental animals, by lidocaine injection in the rostral ventro-medial medulla (RVM), has been traditionally attributed to selective block of a descending pain facilitatory system. However, the presence of descending fibers carrying this effect and the selective action o...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.01.014
更新日期:2010-04-01 00:00:00
abstract::In primary care and physical therapy settings, we evaluated an intervention for chronic back pain patients which incorporated fear reducing and activating techniques. Primary care patients seen for back pain in primary care were screened to identify persons with significant activity limitations 8-10 weeks after their ...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.pain.2004.11.007
更新日期:2005-02-01 00:00:00
abstract::Despite decades of research, hundreds of studies, and a number of recent reviews, the effects of aging on the experience of pain remain poorly understood. Many prior investigators have reported increases in persistent pain conditions and diminished tolerance for certain types of laboratory-induced pain among the elder...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(02)00324-x
更新日期:2003-01-01 00:00:00
abstract::Conditioned pain modulation (CPM) is a phenomenon that may be tested with a dynamic quantitative sensory test that assesses the inhibitory aspect of this pain modulatory network. Although CPM has been adopted as a clinical assessment tool in recent years, the stability of the measure has not been determined over long ...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/j.pain.2013.06.038
更新日期:2013-12-01 00:00:00
abstract::Studies in healthy human subjects and patients with irritable bowel syndrome suggest sex differences in cerebral nociceptive processing. Here we examine sex differences in functional brain activation in the rat during colorectal distention (CRD), a preclinical model of acute visceral pain. [(14)C]-iodoantipyrine was i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.05.025
更新日期:2009-09-01 00:00:00
abstract::Amitriptyline, a non-selective noradrenaline (NA) and 5-hydroxytryptamine (5-HT) reuptake inhibitor, has recently been demonstrated to produce a peripheral antinociceptive action in an inflammatory (formalin test) and a neuropathic pain model (spinal nerve ligation). In the present study, we determined whether desipra...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(99)00043-3
更新日期:1999-08-01 00:00:00
abstract::Extracellular nucleosides and nucleotides have widespread functions in responding to physiological stress. The "purinome" encompasses 4 G-protein-coupled receptors (GPCRs) for adenosine, 8 GPCRs activated by nucleotides, 7 adenosine 5'-triphosphate-gated P2X ion channels, as well as the associated enzymes and transpor...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001857
更新日期:2020-07-01 00:00:00