Effects of morphine on immune response in rats with sciatic constriction injury.

abstract：:Burrowing, an ethologically relevant rodent behaviour, has been proposed as a novel outcome measure to assess the global impact of pain in rats. In a prospective multicentre study using male rats (Wistar, Sprague-Dawley), replication of suppressed burrowing behaviour in the complete Freund adjuvant (CFA)-induced model...

journal_title：Pain

authors： Wodarski R,Delaney A,Ultenius C,Morland R,Andrews N,Baastrup C,Bryden LA,Caspani O,Christoph T,Gardiner NJ,Huang W,Kennedy JD,Koyama S,Li D,Ligocki M,Lindsten A,Machin I,Pekcec A,Robens A,Rotariu SM,VoB S,Segerd

更新日期：2016-10-01 00:00:00

abstract：:Chronic dry eye disease (DE) is associated with an unstable tear film and symptoms of ocular discomfort. The characteristics of symptoms suggest a key role for central neural processing; however, little is known about central neuroplasticity and DE. We used a model for tear deficient DE and assessed effects on eye bli...

journal_title：Pain

authors： Rahman M,Okamoto K,Thompson R,Katagiri A,Bereiter DA

更新日期：2015-05-01 00:00:00

abstract：:Altogether 553 children (195 first graders, mean age 6.8 years, and 358 third graders, mean age 8.7 years) participated in the development of a self-report measure to assess the intensity of children's pain. The first step was the derivation, from children's drawings of facial expressions of pain, of 5 sets of 7 schem...

journal_title：Pain

authors： Bieri D,Reeve RA,Champion DG,Addicoat L,Ziegler JB

更新日期：1990-05-01 00:00:00

abstract：:This study investigated the role of TRPA1 in the development and maintenance of mechanical and cold hyperalgesia in persistent inflammation induced by Complete Freund's Adjuvant (CFA) in mice. The intraplantar (i.pl.) injection of CFA induced a long lasting (28 days) hyperalgesia for both mechanical and thermal (cold)...

journal_title：Pain

authors： da Costa DSM,Meotti FC,Andrade EL,Leal PC,Motta EM,Calixto JB

更新日期：2010-03-01 00:00:00

abstract：:Despite many studies, the mechanisms underlying the pathogenesis of pain in cluster headache (CH) still remain obscure. An involvement of substance P (SP) containing neurons of the Gasserian ganglion and/or of the spinal trigeminal nucleus has recently been suggested, e.g., by impairment of inhibitory descending pathw...

journal_title：Pain

authors： Sandrini G,Alfonsi E,Ruiz L,Pavesi G,Micieli G,Manzoni GC,Mancia D,Nappi G

更新日期：1991-12-01 00:00:00

abstract：:The ability of a painful stimulus to suppress pain in another, remote area (DNIC) has been intensely studied. However, the effect of the distance between the two painful stimuli and the attentional factors during the measurement of pain perception received minimal treatment. We evaluated the effect of these factors on...

journal_title：Pain

authors： Defrin R,Tsedek I,Lugasi I,Moriles I,Urca G

更新日期：2010-11-01 00:00:00

abstract：:Chronic postsurgical pain impacts most amputees, with more than half experiencing neuralgic residual limb pain. The transition from normal acute postamputation pain to chronic residual limb pain likely involves both peripheral and central inflammatory mechanisms. As part of the Veterans Integrated Pain Evaluation Rese...

journal_title：Pain

authors： Chamessian A,Van de Ven T,Buchheit T,Hsia HL,McDuffie M,Gamazon ER,Walsh C,Bruehl S,Buckenmaier C' 3rd,Shaw A

更新日期：2017-01-01 00:00:00

abstract：:Chronic pain not only interferes with daily activities, it may also have a negative impact on the perceived integrity of one's self through self-discrepancies. Self-discrepancies are experienced distances between the actual self and self-guides that can exist from 2 perspectives (ie, own and other). Self-discrepancies...

journal_title：Pain

authors： Kindermans HPJ,Huijnen IPJ,Goossens MEJB,Roelofs J,Verbunt JA,Vlaeyen JWS

更新日期：2011-02-01 00:00:00

abstract：:Chronic compression of rat dorsal root ganglion (CCD) produced tactile allodynia accompanied with hyperexcitability of the myelinated Aβ dorsal root ganglion (DRG) neurons. The Aβ DRG neuron hyperexcitability exhibits as bursting discharges in response to peripherally evoked action potentials (evoked bursting [EB]). T...

journal_title：Pain

authors： Song Y,Li HM,Xie RG,Yue ZF,Song XJ,Hu SJ,Xing JL

更新日期：2012-03-01 00:00:00

abstract：:Acrylamide was intraperitoneally administered to male Sprague-Dawley rats at four different doses (5, 10, 20 and 30 mg/kg) three times a week for 5 consecutive weeks. Because of motor dysfunction, the 30 mg/kg dose was not used for behavioral pain tests. Clinical status remained good throughout the experiment and no m...

journal_title：Pain

authors： Ling B,Authier N,Balayssac D,Eschalier A,Coudore F

更新日期：2005-12-15 00:00:00

abstract：:There is evidence that serotonin may be implicated in the pathophysiology of myofascial pain (MFP). Because of this, we used oral sumatriptan (Imitrex, Glaxo), a peripherally acting agonist of 5-HT1D receptors, in a double-blind, randomized, placebo-controlled double crossover pilot study of 7 patients with episodic M...

journal_title：Pain

authors： Dao TTT,Lund JP,Rémillard G,Lavigne GJ

更新日期：1995-08-01 00:00:00

abstract：:Growth mixture modeling (GMM) identified latent groups based on treatment outcome trajectories of headache disability measures in patients in headache subspecialty treatment clinics. Using a longitudinal design, 219 patients in headache subspecialty clinics in 4 large cities throughout Ohio provided data on their head...

journal_title：Pain

authors： Lewis KN,Heckman BD,Himawan L

更新日期：2011-08-01 00:00:00

abstract：:Opioid use for chronic pain is limited by severe central adverse effects. We examined whether activating mu-opioid receptors (MORs) in the peripheral nervous system attenuates spinal cord injury (SCI) pain-like behavior in mice. We produced a contusive SCI at the T10 vertebral level and examined motor and sensory dysf...

journal_title：Pain

authors： Liu S,Huang Q,He S,Chen Z,Gao X,Ma D,Duan W,Ford N,Yang F,Chen X,Raja SN,Hao D,Guan Y

更新日期：2019-12-01 00:00:00

abstract：:Tanezumab is a humanized monoclonal antibody that specifically inhibits nerve growth factor as a treatment for chronic pain. This phase IIB study investigated the efficacy and safety of tanezumab for chronic low back pain vs placebo and naproxen. Patients (N=1347) received intravenous tanezumab (5, 10, or 20mg every 8...

journal_title：Pain

authors： Kivitz AJ,Gimbel JS,Bramson C,Nemeth MA,Keller DS,Brown MT,West CR,Verburg KM

更新日期：2013-07-01 00:00:00

abstract：:Recent studies have suggested that spouses of chronic pain patients are at risk for emotional and marital maladjustment. This study explored the role of patient and spouse gender in mediating the effects of chronic pain on the spouse's adjustment. Eight-three chronic low back pain patients and their spouses completed ...

journal_title：Pain

authors： Romano JM,Turner JA,Clancy SL

更新日期：1989-12-01 00:00:00

abstract：:A survey of the psychological characteristics of a large sample of chronic headache cases (n = 360), including classical and common migraine and tension headache sufferers, was carried out. Comparing groups defined in terms of the chronicity of their headache problems, it was found that those with a longer history of ...

journal_title：Pain

authors： Philips HC,Jahanshahi M

更新日期：1985-02-01 00:00:00

abstract：:Cyclin-dependent kinase 5 (Cdk5) is a unique member of the CDK family. It is predominantly expressed in postmitotic neurons and has been implicated in neuronal plasticity. The present study showed that Cdk5 and p35 were expressed in primary sensory and dorsal horn neurons, while p25, an N-terminal truncated derivative...

journal_title：Pain

authors： Yang YR,He Y,Zhang Y,Li Y,Li Y,Han Y,Zhu H,Wang Y

更新日期：2007-01-01 00:00:00

abstract：:Emerging lines of evidence indicate that production of reactive oxygen species (ROS) at distinct sites of the nociceptive system contributes to the processing of neuropathic pain. However, the mechanisms underlying ROS production during neuropathic pain processing are not fully understood. We here detected the ROS-gen...

journal_title：Pain

authors： Kallenborn-Gerhardt W,Hohmann SW,Syhr KM,Schröder K,Sisignano M,Weigert A,Lorenz JE,Lu R,Brüne B,Brandes RP,Geisslinger G,Schmidtko A

更新日期：2014-10-01 00:00:00

abstract：:Numerous behavioral pain measures have been validated for young children, but none is appropriate to assess pain in emergency departments (EDs), where caregivers need a simple, easily completed scale. Our objective was to elaborate and validate a tool, relevant in any painful situation, with agitation or prostration, ...

journal_title：Pain

authors： Fournier-Charrière E,Tourniaire B,Carbajal R,Cimerman P,Lassauge F,Ricard C,Reiter F,Turquin P,Lombart B,Letierce A,Falissard B

更新日期：2012-08-01 00:00:00

abstract：:Inflammatory thermal hyperalgesia is principally mediated through transient receptor potential vanilloid 1 (TRPV1) channels, as demonstrated by prior studies using models of cutaneous inflammation. Muscle pain is significantly different from cutaneous pain, and the involvement of TRPV1 in hyperalgesia induced by muscl...

journal_title：Pain

authors： Walder RY,Radhakrishnan R,Loo L,Rasmussen LA,Mohapatra DP,Wilson SP,Sluka KA

更新日期：2012-08-01 00:00:00

abstract：:Several studies have implicated a potential role for histamine H(3) receptors in pain processing, although the data are somewhat conflicting. In the present study we investigated the effects of the novel potent and highly selective H(3) receptor antagonists GSK189254 (6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepi...

journal_title：Pain

authors： Medhurst SJ,Collins SD,Billinton A,Bingham S,Dalziel RG,Brass A,Roberts JC,Medhurst AD,Chessell IP

更新日期：2008-08-15 00:00:00

abstract：:The characteristics and impact of pain were evaluated in a prospective cross-sectional survey of 438 ambulatory AIDS patients recruited from health care facilities in New York City. More than 60% of the patients reported 'frequent or persistent pain' during the 2 wks preceding the study. Patients with pain reported an...

journal_title：Pain

authors： Breitbart W,McDonald MV,Rosenfeld B,Passik SD,Hewitt D,Thaler H,Portenoy RK

更新日期：1996-12-01 00:00:00

abstract：:Chronic pain after laparoscopic cholecystectomy is related to postoperative pain during the first postoperative week, but it is unknown which components of the early pain response is important. In this prospective study, 100 consecutive patients were examined preoperatively, 1 week postoperatively, and 3, 6, and 12 mo...

journal_title：Pain

authors： Blichfeldt-Eckhardt MR,Ording H,Andersen C,Licht PB,Toft P

更新日期：2014-11-01 00:00:00

abstract：:The N-methyl-D-aspartic acid (NMDA) receptor antagonist D, L-2-amino-5-phosphonopentanoic acid (AP5) caused a stronger inhibition of wind-up in single wide dynamic range (WDR) neurons after carrageenan inflammation compared with control neurons without inflammation in the receptive field. This indicates that even a sh...

journal_title：Pain

authors： Svendsen F,Rygh LJ,Hole K,Tjølsen A

更新日期：1999-12-01 00:00:00

abstract：:An abundance of animal research suggests that fear inhibits pain whereas anxiety increases it. Human studies on this topic are more scarce, and the existing evidence seems rather inconsistent. Therefore, we aimed to investigate the divergent effects of both negative emotional states-that is, pain-related fear and anxi...

journal_title：Pain

authors： Meulders A,Vansteenwegen D,Vlaeyen JWS

更新日期：2012-05-01 00:00:00

abstract：:Phantom urinary phenomena are a relatively rare disease entity. Literature search has revealed only one case following cystectomy, seven cases following spinal cord injury and several other cases in hemodialysis patients. This report presents a case of painful phantom bladder following cystectomy for chronic kidney an...

journal_title：Pain

authors： Brena SF,Sammons EE

更新日期：1979-10-01 00:00:00

abstract：:This open prospective study evaluated the combination of initial dose titration with patient-controlled analgesia (PCA) and long-term treatment with transdermal fentanyl in 50 cancer patients requiring opioids for severe pain. The delivery rate of the first transdermal therapeutic system (TTS) was calculated from the ...

journal_title：Pain

authors： Grond S,Zech D,Lehmann KA,Radbruch L,Breitenbach H,Hertel D

更新日期：1997-01-01 00:00:00

abstract：:Chronic pain in adults has been associated with early-life stress. To examine the pronociceptive effect of early-life stress, we evaluated cutaneous and muscle nociception and activity in muscle nociceptors in an animal model of neonatal stress, limited bedding, in the rat. In this neonatal limited bedding (NLB) model...

journal_title：Pain

authors： Green PG,Chen X,Alvarez P,Ferrari LF,Levine JD

更新日期：2011-11-01 00:00:00

abstract：ABSTRACT:High mobility group box 1 protein (HMGB1) is increasingly regarded as an important player in the spinal regulation of chronic pain. Although it has been reported that HMGB1 induces spinal glial activation in a Toll-like receptor (TLR)4-dependent fashion, the aspect of sexual dimorphisms has not been thoroughly...

journal_title：Pain

authors： Agalave NM,Rudjito R,Farinotti AB,Khoonsari PE,Sandor K,Nomura Y,Szabo-Pardi TA,Urbina CM,Palada V,Price TJ,Erlandsson Harris H,Burton MD,Kultima K,Svensson CI

更新日期：2021-02-01 00:00:00

abstract：:Chronic pain is more common in the elderly and impairs functioning and quality of life. Though obesity, defined by body mass index (BMI), has been associated with pain prevalence among older adults, the mechanism of this association remains unclear. We examined components of the metabolic syndrome, insulin resistance,...

journal_title：Pain

authors： Ray L,Lipton RB,Zimmerman ME,Katz MJ,Derby CA

更新日期：2011-01-01 00:00:00