Abstract:
:This study investigated the role of TRPA1 in the development and maintenance of mechanical and cold hyperalgesia in persistent inflammation induced by Complete Freund's Adjuvant (CFA) in mice. The intraplantar (i.pl.) injection of CFA induced a long lasting (28 days) hyperalgesia for both mechanical and thermal (cold) stimuli. The intraperitoneal (i.p., 30-300 mg/kg), intraplantar (i.pl., 100 microg/site) or intrathecal (i.t., 10 microg/site) injection of the TRPA1 selective antagonist HC-030031 significantly reduced the mechanical hyperalgesia evaluated by the von Frey hair test. The effect of HC-030031 was evidenced on the day after CFA injection and was kept throughout the test. However, the intracerebroventricular (i.c.v., 10 microg/site) injection of HC-030031 did not interfere with CFA-induced hyperalgesia. Treatment with HC-030031 (300 mg/kg, i.p.) completely inhibited the noxious cold hyperalgesia induced by tetrafluoroethane in mice that received CFA. The pre-treatment with the TRPA1 oligonucleotide antisense (AS-ODN, i.t.) consistently prevented both mechanical and cold hyperalgesia. Interestingly, both TRPA1 protein expression and mRNA were over-expressed in spinal cord and dorsal root ganglia (DRG) of mice treated with CFA, an effect that was fully prevented by the pre-treatment with the TRPA1 antagonist HC-030031. Collectively, the present results showed that TRPA1 present at either peripheral or spinal sites play a relevant role in the development and maintenance of both mechanical and cold hyperalgesia during CFA-induced inflammation. Thus, TRPA1 selective antagonists represent promising candidates to treat hyperalgesia in persistent inflammatory states.
journal_name
Painjournal_title
Painauthors
da Costa DSM,Meotti FC,Andrade EL,Leal PC,Motta EM,Calixto JBdoi
10.1016/j.pain.2009.12.002subject
Has Abstractpub_date
2010-03-01 00:00:00pages
431-437issue
3eissn
0304-3959issn
1872-6623pii
00006396-201003000-00014journal_volume
148pub_type
杂志文章相关文献
PAIN文献大全abstract::Thirty subjects were given a placebo (intravenous saline), which was described as a known pain killer, once a week for 3 consecutive weeks. Experimental ischemic arm pain was produced prior to the placebo and again 1 h later. In a double blind procedure, half of the subjects received 10 mg of naloxone after placebo; t...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(83)90203-8
更新日期:1983-06-01 00:00:00
abstract::Accurate pain assessment is the foundation for effective pain management in children. At present, there is no clear consensus regarding the age at which young children are able to appropriately use self-report scales for pain. This study examined young children's ability to use the Faces Pain Scale-Revised; (FPS-R; [H...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2005.10.004
更新日期:2006-01-01 00:00:00
abstract::Cyclin-dependent kinase 5 (Cdk5) is a unique member of the CDK family. It is predominantly expressed in postmitotic neurons and has been implicated in neuronal plasticity. The present study showed that Cdk5 and p35 were expressed in primary sensory and dorsal horn neurons, while p25, an N-terminal truncated derivative...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.08.008
更新日期:2007-01-01 00:00:00
abstract::To determine the incidence of pain related sexual dysfunction 1 year after inguinal herniorrhaphy and to assess the impact pain has on sexual function. In contrast to the well-described about 10% risk of chronic wound related pain after inguinal herniorrhaphy, chronic genital pain, dysejaculation, and sexual dysfuncti...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.01.035
更新日期:2006-06-01 00:00:00
abstract::The spinal ascending pathways responsible for neuronal ventrobasal (VB) thalamic responses elicited by joint stimulation of the posterior paw were determined in arthritic rats used as a model of experimental pain. Responses of a same neurone to mechanical (movement--pressure--brushing) or thermal stimulation (50 degre...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(86)90059-X
更新日期:1986-09-01 00:00:00
abstract::Patients with chronic low back pain (LBP) frequently demonstrate high scores for fear-avoidance beliefs and distress. We need better knowledge about fear-avoidance beliefs and distress in early stages of LBP. The objectives of this study were to compare the level of fear-avoidance beliefs and distress in patients with...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.09.020
更新日期:2004-12-01 00:00:00
abstract::We report the case of bilateral hand swelling following acupuncture therapy for chronic low back pain. Despite thorough history, examination and laboratory testing no systemic cause for the swelling could be elicited. This case highlights the incomplete knowledge of acupuncture mechanisms and that limited acupuncture ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(99)00244-4
更新日期:2000-02-01 00:00:00
abstract::Orexins are neuropeptides that are mostly expressed in the posterior and lateral hypothalamus, and related to the central control of appetite, arousal, and antinociception. Orexin neurons projected to the tuberomammillary nucleus and orexins may release histamine from the histamine neurons in this nucleus. Histamine i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2005.08.024
更新日期:2005-11-01 00:00:00
abstract::Chronic pain is associated with large societal costs, but few studies have investigated the total costs of chronic pain with respect to elderly subjects. The elderly usually require informal care, care performed by municipalities, and care for chronic diseases, all factors that can result in extensive financial burden...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/01.j.pain.0000460336.31600.01
更新日期:2015-03-01 00:00:00
abstract::A study was undertaken to investigate if the concepts pain, ache and hurt differ from each other in intensity and quality and to identify discriminating semantic correlates for each of these concepts. Forty-one nurses with different backgrounds in nursing and 12 patients with chronic pain syndrome were included in the...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90812-1
更新日期:1984-09-01 00:00:00
abstract::Chronic postsurgical pain impacts most amputees, with more than half experiencing neuralgic residual limb pain. The transition from normal acute postamputation pain to chronic residual limb pain likely involves both peripheral and central inflammatory mechanisms. As part of the Veterans Integrated Pain Evaluation Rese...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000728
更新日期:2017-01-01 00:00:00
abstract::Numerous medications prolong the rate-corrected QT (QTc) interval and induce arrhythmias by blocking ionic current through cardiac potassium channels composed of subunits expressed by the human ether-a-go-go-related gene (HERG). Recent reports suggest that high doses of methadone cause torsades de pointes. To date, no...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(03)00205-7
更新日期:2003-10-01 00:00:00
abstract::The effects of lateral reticular nucleus (LRN) stimulation on the responses to tooth pulp (TP) stimulation of neurons located in the trigeminal (V) sensory (39 units) and motor (33 units) nuclei were assessed in anesthetized rats. Only neurons which responded to TP stimulation with bursts of spikes that were in a cons...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90035-V
更新日期:1991-07-01 00:00:00
abstract::A systematic review and meta-analysis of population-based epidemiological studies was undertaken to determine the prevalence of foot and ankle pain in middle and old age. Searches were conducted in the following electronic databases from inception to October 2010: PubMed, EMBASE, AMED, CINAHL, Cochrane, PEDro, and Spo...
journal_title:Pain
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.pain.2011.09.019
更新日期:2011-12-01 00:00:00
abstract::The behavioural response of infant rats to intraplantar injection of formalin consists of specific directed behaviours (limb flexion, shaking and licking the injected paw) and non-specific behaviours that are also induced by non-nociceptive stimulation (squirming, hind limb kicks and whole body jerks), with specific i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)00277-L
更新日期:1995-09-01 00:00:00
abstract::Migraine is a common and disabling neurologic disorder, with important psychiatric comorbidities. Its pathophysiology involves activation of neurons in the trigeminocervical complex (TCC). Kainate receptors carrying the glutamate receptor subunit 5 (GluK1) are present in key brain areas involved in migraine pathophysi...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/01.j.pain.0000460325.25762.c0
更新日期:2015-03-01 00:00:00
abstract::Acute microinjection of mu-, delta-, or kappa-opioid receptor (MOPr, DOPr, KOPr) agonists into the rostral ventromedial medulla (RVM) produces antinociception. Thermal antinociception produced by MOPr and DOPr agonists is potentiated during inflammation [Hurley RW, Hammond DL. The analgesic effects of supraspinal mu a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.07.010
更新日期:2008-06-01 00:00:00
abstract::Formalin injection into the hindpaw of rats produces many neurons with c-fos protein-like immunoreactivity (fos-neurons) in the medial 3/4 of the ipsilateral dorsal horn laminae I and II at the junction of 4th and 5th lumbar segments (the sciatic territory). The tibial nerve transection 2 or 3 days earlier resulted in...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(95)00014-J
更新日期:1995-10-01 00:00:00
abstract::Tricyclic antidepressants (TCAs) have been found to be useful in the management of a variety of chronic pain conditions, although there is little published regarding the potential efficacy of this class of drug as an adjunct for the control of acute postoperative pain and related symptoms. Twenty-eight patients underg...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(93)90166-M
更新日期:1993-03-01 00:00:00
abstract::To better understand the association between pain recalled over a previous week and the average of multiple momentary reports of pain taken during the same period, 68 patients with chronic pain completed both weekly recall and momentary reports over a 2-week period and assessed their change in pain over the 2 weeks. P...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2003.09.020
更新日期:2004-01-01 00:00:00
abstract::Neuropathic pain may be produced, at least in part, by the increased activity of primary afferent neurons. Studies have suggested that an accumulation of voltage-gated sodium channels at the site of peripheral nerve injury is a primary precursory event for subsequent afferent hyperexcitability. In this study, a human ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(98)00120-1
更新日期:1998-11-01 00:00:00
abstract::This work aimed to evaluate the potential role of the 5-HT(7) receptor in nociception secondary to a sensitizing stimulus in mice. For this purpose, the effects of relevant ligands (5-HT(7) receptor agonists: AS-19, MSD-5a, E-55888; 5-HT(7) receptor antagonists: SB-258719, SB-269970; 5-HT(1A) receptor agonist: F-13640...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.11.009
更新日期:2009-02-01 00:00:00
abstract::Past research has shown that pain catastrophizing contributes to heightened pain experience. The hypothesis advanced in this study was that individuals who score high on measures of pain catastrophizing would also perceive more intense pain in others. The study also examined the role of pain behaviour as a determinant...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.02.007
更新日期:2006-07-01 00:00:00
abstract::Mental stress induces endothelial dysfunction, that is a reduction of the post-occlusion brachial artery flow-mediated vasodilation (FMD). This does not occur in subjects highly susceptible to hypnosis (Highs) in either the waking or hypnotic state. The aim of the present experiment was to assess whether endothelial d...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.pain.2005.03.041
更新日期:2005-08-01 00:00:00
abstract::Although conduction failure has been observed in nociceptive C-fibers, little is known regarding its significance or therapeutic potential. In a previous study, we demonstrated that C-fiber conduction failure, which is regarded as an intrinsic self-inhibition mechanism, was reduced in circumstances of painful diabetic...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000632
更新日期:2016-10-01 00:00:00
abstract::The purpose of this study was to examine racial/ethnic-related differences in a four-stage model of the processing of chronic pain. The subjects were 1557 chronic pain patients (White=1084, African American=473) evaluated at a pain management clinic at a large southeastern university medical center. Using an analysis ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(02)00306-8
更新日期:2002-12-01 00:00:00
abstract::Activation of extracellular signal-regulated kinase (ERK), a mitogen activated-protein kinase (MAPK), in dorsal horn neurons contributes to inflammatory pain by transcription-dependent and -independent means. We have now investigated if ERK is activated in the spinal cord after a spinal nerve ligation (SNL) and if thi...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.12.022
更新日期:2005-03-01 00:00:00
abstract:ABSTRACT:While knee and hip replacements are intended to relieve pain and improve function, up to 44% of knee replacement patients and 27% of hip replacement patients report persistent postoperative joint pain. Improving surgical pain management is essential. We conducted a single-site, three-arm, parallel-group random...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002195
更新日期:2021-01-12 00:00:00
abstract::Alterations in sensory processing have been demonstrated in chronic low back and neck pain. However, it has not been yet systematically summarized how early these changes occur in spinal pain. This systematic review examines the available literature measuring somatosensory function in acute (<6 weeks) and subacute (6-...
journal_title:Pain
pub_type: 杂志文章,meta分析,评审
doi:10.1097/01.j.pain.0000460300.10583.f6
更新日期:2015-02-01 00:00:00
abstract::The effect of different formalin concentrations on the nociceptive response in the formalin test was examined in mice. Subcutaneous formalin injection induces 2 distinct periods of high licking activity: an early phase lasting the first 5 min, and a late phase lasting 20-30 min after the injection. Formalin concentrat...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)91167-H
更新日期:1990-08-01 00:00:00