5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice.

abstract：:Alterations in sensory processing have been demonstrated in chronic low back and neck pain. However, it has not been yet systematically summarized how early these changes occur in spinal pain. This systematic review examines the available literature measuring somatosensory function in acute (<6 weeks) and subacute (6-...

journal_title：Pain

authors： Marcuzzi A,Dean CM,Wrigley PJ,Hush JM

更新日期：2015-02-01 00:00:00

abstract：:The primary purpose of this study was to examine the extent to which specific patient attitudes and beliefs about medical care and self-care for back pain predict future healthcare use. An automated database allowed examination of the predictive relationships in two primary care patient samples. In general, beliefs th...

journal_title：Pain

authors： Saunders KW,Von Korff M,Pruitt SD,Moore JE

更新日期：1999-11-01 00:00:00

abstract：:Although trigeminal neuralgia and atypical facial pain can usually be distinguished on the basis of several well-established criteria, differential diagnosis is difficult in a small number of patients. The purpose of this study was to determine whether the McGill Pain Questionnaire (MPQ) is capable of discriminating b...

journal_title：Pain

authors： Melzack R,Terrence C,Fromm G,Amsel R

更新日期：1986-12-01 00:00:00

abstract：:Chronic pain not only interferes with daily activities, it may also have a negative impact on the perceived integrity of one's self through self-discrepancies. Self-discrepancies are experienced distances between the actual self and self-guides that can exist from 2 perspectives (ie, own and other). Self-discrepancies...

journal_title：Pain

authors： Kindermans HPJ,Huijnen IPJ,Goossens MEJB,Roelofs J,Verbunt JA,Vlaeyen JWS

更新日期：2011-02-01 00:00:00

abstract：:Anecdotal reports suggest that the general anaesthetic drug ketamine, taken orally in low doses, can give rise to some extra analgesia in patients with refractory neuropathic pain. This study was designed to determine the proportion of patients with chronic neuropathic pain responding to oral ketamine, and then to sep...

journal_title：Pain

authors： Haines DR,Gaines SP

更新日期：1999-11-01 00:00:00

abstract：:Epidural administration of opiates as a long-term treatment of cancer pain, even for out-patients, is now well established. Most reports describe intermittent injections given several times a day, which may have technical and personal disadvantages. Continuous epidural infusion may be preferable. This report describes...

journal_title：Pain

authors： Ingemar F,Ahlgren H,Ahlgren MBE

更新日期：1987-12-01 00:00:00

abstract：:Despite decades of research, hundreds of studies, and a number of recent reviews, the effects of aging on the experience of pain remain poorly understood. Many prior investigators have reported increases in persistent pain conditions and diminished tolerance for certain types of laboratory-induced pain among the elder...

journal_title：Pain

authors： Edwards RR,Fillingim RB,Ness TJ

更新日期：2003-01-01 00:00:00

abstract：:In superficial layers of the lumbar spinal dorsal horn, N-methyl-D-aspartate-dependent long-term potentiation (LTP) of C fibre-evoked field potentials, a synaptic model of central sensitisation and hyperalgesia, ensues the application of electrical high-frequency, high-intensity conditioning stimulation to the sciatic...

journal_title：Pain

authors： Azkue JJ,Liu XG,Zimmermann M,Sandkühler J

更新日期：2003-12-01 00:00:00

abstract：:The experiments determined the ventilatory effects of epidurally injected morphine and sufentanil in rats in the absence and in the presence of chlordiazepoxide, a drug that may alleviate the effects of stress. Soon after administration of morphine as well as of sufentanil, ventilation was more profoundly depressed wh...

journal_title：Pain

authors： Van den Hoogen RHWM,Bervoets KJW,Colpaert FC

更新日期：1989-04-01 00:00:00

abstract：:Mental stress induces endothelial dysfunction, that is a reduction of the post-occlusion brachial artery flow-mediated vasodilation (FMD). This does not occur in subjects highly susceptible to hypnosis (Highs) in either the waking or hypnotic state. The aim of the present experiment was to assess whether endothelial d...

journal_title：Pain

authors： Jambrik Z,Santarcangelo EL,Rudisch T,Varga A,Forster T,Carli G

更新日期：2005-08-01 00:00:00

abstract：:Sciatica is a common pain problem and current pharmacologic therapies have proven inadequate for many patients. The objective of this sham-controlled investigation was to compare a novel non-pharmacologic technique, percutaneous electrical nerve stimulation (PENS), to transcutaneous electrical nerve stimulation (TENS)...

journal_title：Pain

authors： Ghoname EA,White PF,Ahmed HE,Hamza MA,Craig WF,Noe CE

更新日期：1999-11-01 00:00:00

abstract：:Endometriosis, an estrogen-dependent chronic inflammatory disease, is the most common cause of chronic pelvic pain. Here, we investigated the effects of linaclotide, a Food and Drug Administration-approved treatment for IBS-C, in a rat model of endometriosis. Eight weeks after endometrium transplantation into the inte...

journal_title：Pain

authors： Ge P,Ren J,Harrington AM,Grundy L,Castro J,Brierley SM,Hannig G

更新日期：2019-11-01 00:00:00

abstract：:Genetics studies on the placebo hypoalgesic effect highlight a promising link between single nucleotide polymorphisms (SNPs) in the dopamine, opioid, and endocannabinoid genes and placebo hypoalgesia. However, epistasis and replication studies are missing. In this study, we expanded on previous findings related to the...

journal_title：Pain

authors： Colloca L,Wang Y,Martinez PE,Chang YC,Ryan KA,Hodgkinson C,Goldman D,Dorsey SG

更新日期：2019-08-01 00:00:00

abstract：:Dynorphin A is an endogenous opioid peptide, which has previously been shown to produce a long-lasting allodynia and hyperalgesia in mice, behavioral states consistent with signs of clinically observed neuropathic pain. This dynorphin-induced allodynia was used as a pharmacological, central model of neuropathic pain. ...

journal_title：Pain

authors： Laughlin TM,Bethea JR,Yezierski RP,Wilcox GL

更新日期：2000-02-01 00:00:00

abstract：:In preparation for a series of electrophysiological experiments in a model of neuropathic pain, the present spinal reflex study was done to determine the optimal time after sciatic nerve constriction in the rat for tactile allodynia and to determine also the appropriate 'control' for the nerve constriction model. Ther...

journal_title：Pain

authors： Pitcher GM,Ritchie J,Henry JL

更新日期：1999-10-01 00:00:00

abstract：:We know little about the safety or efficacy of pharmacological medicines for children and adolescents with chronic pain, despite their common use. Our aim was to conduct an overview review of systematic reviews of pharmacological interventions that purport to reduce pain in children with chronic noncancer pain (CNCP) ...

journal_title：Pain

authors： Eccleston C,Fisher E,Cooper TE,Grégoire MC,Heathcote LC,Krane E,Lord SM,Sethna NF,Anderson AK,Anderson B,Clinch J,Gray AL,Gold JI,Howard RF,Ljungman G,Moore RA,Schechter N,Wiffen PJ,Wilkinson NMR,Williams DG,Wood

更新日期：2019-08-01 00:00:00

abstract：:Capsaicin elicits burning pain via the activation of the vanilloid receptor (TRPV1). Intriguingly, several reports showed that capsaicin also inhibits Na+ currents but the mechanisms remain unclear. To explore this non-TRPV1 action we applied capsaicin to HEK293 cells stably expressing inactivation-deficient rat skele...

journal_title：Pain

authors： Wang SY,Mitchell J,Wang GK

更新日期：2007-01-01 00:00:00

abstract：:Central pain following traumatic brain injury (TBI) has not been studied in depth. Our purpose was to conduct a systematic study of patients with TBI suffering from chronic central pain, and to describe the characteristics of the central pain. Groups were TBI patients with (TBIP) and without central pain (TBINP) and h...

journal_title：Pain

authors： Ofek H,Defrin R

更新日期：2007-10-01 00:00:00

abstract：:Surgery and trauma are recognised as important causes of chronic pain, although their overall contribution has not been systematically studied. This paper reports on the contribution of surgery and trauma to chronic pain among 5130 patients attending 10 outpatient clinics located throughout North Britain. Surgery cont...

journal_title：Pain

authors： Crombie IK,Davies HT,Macrae WA

更新日期：1998-05-01 00:00:00

abstract：:There is evidence of greater opioid prescription to individuals in the United States with mental health conditions. Whether these associations generalize beyond the US prescription environment and to familial mental health and socioeconomic status (SES) has not been examined comprehensively. This study estimated assoc...

journal_title：Pain

authors： Quinn PD,Rickert ME,Franck J,Sariaslan A,Boersma K,Lichtenstein P,Larsson H,D'Onofrio BM

更新日期：2019-11-01 00:00:00

abstract：:The nationwide multicenter trials of the German Research Network on Neuropathic Pain (DFNS) aim to characterize the somatosensory phenotype of patients with neuropathic pain. For this purpose, we have implemented a standardized quantitative sensory testing (QST) protocol giving a complete profile for one region within...

journal_title：Pain

authors： Rolke R,Baron R,Maier C,Tölle TR,Treede -DR,Beyer A,Binder A,Birbaumer N,Birklein F,Bötefür IC,Braune S,Flor H,Huge V,Klug R,Landwehrmeyer GB,Magerl W,Maihöfner C,Rolko C,Schaub C,Scherens A,Sprenger T,Valet M,

更新日期：2006-08-01 00:00:00

abstract：:The aim of this paper is to study the synergistic anti-analgesic effect of angiotensin II (Ang II) plus cholecystokinin octapeptide (CCK-8). Our previous studies have shown that both CCK-8 and Ang II are potent anti-opioid substances. Intracerebroventricular (i.c.v.) injection of CCK-8 or Ang II dose-dependently antag...

journal_title：Pain

authors： Han NL,Luo F,Bian ZP,Han JS

更新日期：2000-04-01 00:00:00

abstract：:Distinct developmental trajectories for neck disability and posttraumatic stress disorder (PTSD) symptoms after whiplash injury have recently been identified. This study aimed to identify baseline predictors of membership to these trajectories and to explore their dual development. In a prospective study, 155 individu...

journal_title：Pain

authors： Sterling M,Hendrikz J,Kenardy J

更新日期：2011-06-01 00:00:00

abstract：:Migraine encompasses a broader spectrum of sensory symptoms than just headache. These "other" symptoms, eg, sensory phobias, cognitive and mood changes, allodynia, and many others indicate an altered sensitivity to sensory input which can be measured, in principle, by quantifying sensory threshold changes longitudinal...

journal_title：Pain

authors： Peng KP,May A

更新日期：2019-07-01 00:00:00

abstract：:As part of a comprehensive study of the natural history of herpes zoster (HZ), 57 of 94 subjects in a cohort at elevated risk for post-herpetic neuralgia (PHN) consented to collection of 3-mm skin punch biopsies from affected, mirror-image, and distant control skin at baseline and followup visits. As cutaneous innerva...

journal_title：Pain

authors： Petersen KL,Rice FL,Farhadi M,Reda H,Rowbotham MC

更新日期：2010-07-01 00:00:00

abstract：:Dysfunction in the motor system is a feature of persistent whiplash associated disorders. Little is known about motor dysfunction in the early stages following injury and of its progress in those persons who recover and those who develop persistent symptoms. This study measured prospectively, motor system function (ce...

journal_title：Pain

authors： Sterling M,Jull G,Vicenzino B,Kenardy J,Darnell R

更新日期：2003-05-01 00:00:00

abstract：:We report the case of bilateral hand swelling following acupuncture therapy for chronic low back pain. Despite thorough history, examination and laboratory testing no systemic cause for the swelling could be elicited. This case highlights the incomplete knowledge of acupuncture mechanisms and that limited acupuncture ...

journal_title：Pain

authors： McCartney CJ,Herriot R,Chambers WA

更新日期：2000-02-01 00:00:00

abstract：:Acute microinjection of mu-, delta-, or kappa-opioid receptor (MOPr, DOPr, KOPr) agonists into the rostral ventromedial medulla (RVM) produces antinociception. Thermal antinociception produced by MOPr and DOPr agonists is potentiated during inflammation [Hurley RW, Hammond DL. The analgesic effects of supraspinal mu a...

journal_title：Pain

authors： Schepers RJ,Mahoney JL,Shippenberg TS

更新日期：2008-06-01 00:00:00

abstract：:Compared with other European countries, French laws and restrictions concerning the use of opioids are of medium severity only. Still, together with Germany, Belgium and Spain, France belongs to the group of countries with a low national consumption of morphine, calculated by the International Narcotics Control Board ...

journal_title：Pain

authors： Vainio A

更新日期：1995-08-01 00:00:00

abstract：:The objective of this preliminary study was to examine the extent to which affective marital interaction related to depressive symptoms in persons with chronic pain and their spouses and to pain severity in persons with pain. Couples from the community completed self-report surveys and engaged in a videotaped conversa...

journal_title：Pain

authors： Johansen AB,Cano A

更新日期：2007-11-01 00:00:00