Nerve constriction in the rat: model of neuropathic, surgical and central pain.

abstract：:Anti-nerve growth factor (anti-NGF) therapy has shown significant promise in attenuating several types of skeletal pain. However, whether anti-NGF therapy changes the level of physical activity in individuals with or without skeletal pain is largely unknown. Here, automated day/night activity boxes monitored the effec...

journal_title：Pain

authors： Majuta LA,Mitchell SAT,Kuskowski MA,Mantyh PW

更新日期：2018-11-01 00:00:00

abstract：:The present study observed the expression of the 5-hydroxytryptamine (5-HT) (1A) receptor mRNA in the lumbar spinal dorsal horn neurons following carrageenan inflammation using in situ hybridization (ISH). We also studied the co-localization of 5-HT(1A) receptor mRNA and gamma-amino butyric acid (GABA) or enkephalin (...

journal_title：Pain

authors： Zhang YQ,Gao X,Ji GC,Huang YL,Wu GC,Zhao ZQ

更新日期：2002-08-01 00:00:00

abstract：:No research to date has descriptively catalogued what parents of healthy infants are naturalistically doing to manage their infant's pain over immunization appointments during the first year of life. This knowledge, in conjunction with an understanding of the relationships different parental techniques have with infan...

journal_title：Pain

authors： Lisi D,Campbell L,Pillai Riddell R,Garfield H,Greenberg S

更新日期：2013-08-01 00:00:00

abstract：:Patients with schizophrenia report reduced pain sensitivity in clinical studies, but experimental studies are required to establish pain sensitivity as a potential endophenotype. We conducted a systematic review of electronic databases from database inception until April 15, 2015, including experimental studies invest...

journal_title：Pain

authors： Stubbs B,Thompson T,Acaster S,Vancampfort D,Gaughran F,Correll CU

更新日期：2015-11-01 00:00:00

abstract：:We have previously reported a novel method for producing chronic nociceptive behavior in rats following compression of the trigeminal ganglion. In the present study, we have further studied the role of demyelination in the development of prolonged nociceptive behavior in the trigeminal territory. For this purpose, lys...

journal_title：Pain

authors： Ahn DK,Lee SY,Han SR,Ju JS,Yang GY,Lee MK,Youn DH,Bae YC

更新日期：2009-11-01 00:00:00

abstract：:Experimental muscle pain was elicited by bolus injection of 0.15 ml of 5% hypertonic saline into the human masseter muscle. The sensory experience was described using 10-cm visual analogue scales (VAS) and the McGill Pain Questionnaires (MPQ) on 10 subjects. Effects of pain on deliberately unilateral mastication were ...

journal_title：Pain

authors： Svensson P,Arendt-Nielsen L,Houe L

更新日期：1996-02-01 00:00:00

abstract：:A 1-year follow-up of two preadolescent age cohorts with musculoskeletal pain at least once a week was conducted to analyze predictive factors for the persistence of musculoskeletal pain. Of the 564 children with pain at baseline, representing one third of the sample studied, 515 (91.3%) could be followed and 452 (80....

journal_title：Pain

authors： Mikkelsson M,Salminen JJ,Sourander A,Kautiainen H

更新日期：1998-07-01 00:00:00

abstract：:Clinical diagnosis of complex regional pain syndrome (CRPS) is a dichotomous (yes/no) categorization, a format necessary for clinical decision making. Such dichotomous diagnostic categories do not convey an individual's subtle gradations in the severity of the condition over time and have poor statistical power when u...

journal_title：Pain

authors： Harden RN,Maihofner C,Abousaad E,Vatine JJ,Kirsling A,Perez RSGM,Kuroda M,Brunner F,Stanton-Hicks M,Marinus J,van Hilten JJ,Mackey S,Birklein F,Schlereth T,Mailis-Gagnon A,Graciosa J,Connoly SB,Dayanim D,Massey M,Fr

更新日期：2017-08-01 00:00:00

abstract：:Epidural administration of opiates as a long-term treatment of cancer pain, even for out-patients, is now well established. Most reports describe intermittent injections given several times a day, which may have technical and personal disadvantages. Continuous epidural infusion may be preferable. This report describes...

journal_title：Pain

authors： Ingemar F,Ahlgren H,Ahlgren MBE

更新日期：1987-12-01 00:00:00

abstract：:Pediatric chronic pain is associated with numerous negative outcomes including increased physical disability, increased rates of depression and anxiety, and decreased quality of life (QOL). Pain catastrophizing-broadly conceptualized as including rumination, magnification, and helplessness cognitions surrounding one's...

journal_title：Pain

authors： Miller MM,Meints SM,Hirsh AT

更新日期：2018-12-01 00:00:00

abstract：:The physiological properties of joint capsule mechanoreceptors in the ankle joint of the chicken were studied in the 3-h period immediately after intra-articular injection of microcrystal sodium urate. The electrical activity was recorded from single C- and A-delta sensory fibres dissected from the parafibular nerve. ...

journal_title：Pain

authors： Gentle MJ

更新日期：1997-04-01 00:00:00

abstract：:Although known primarily for its role in neuronal development, brain-derived neurotrophic factor (BDNF) has also recently been implicated in processes mediated by the adult nervous system, such as spinal nociception. Peripheral inflammation increases expression of BDNF preferentially in dorsal root ganglion cells that...

journal_title：Pain

authors： Groth R,Aanonsen L

更新日期：2002-11-01 00:00:00

abstract：:Hip disorder patients typically present with extensive pain referral and hyperalgesia. To better understand underlying mechanisms, an experimental hip pain model was established in which pain referrals and hyperalgesia could be studied under standardized conditions. In 16 healthy subjects, pain was induced by hyperton...

journal_title：Pain

authors： Izumi M,Petersen KK,Arendt-Nielsen L,Graven-Nielsen T

更新日期：2014-04-01 00:00:00

abstract：:Recent research has focused on identification of clinically meaningful subgroupings within the chronic pain population in contrast to prior emphasis on the homogeneity of these patients. The present study investigates site of pain as a potentially useful classification variable for identification of differences among ...

journal_title：Pain

authors： Toomey TC,Gover VF,Jones BN

更新日期：1984-08-01 00:00:00

abstract：ABSTRACT:While knee and hip replacements are intended to relieve pain and improve function, up to 44% of knee replacement patients and 27% of hip replacement patients report persistent postoperative joint pain. Improving surgical pain management is essential. We conducted a single-site, three-arm, parallel-group random...

journal_title：Pain

authors： Hanley AW,Gililland J,Erickson J,Pelt C,Peters C,Rojas J,Garland EL

更新日期：2021-01-12 00:00:00

abstract：:The present paper describes the effect of vibratory stimulation on pain of dental origin in 36 patients. The patients were from a clinic for dental surgery and all had suffered pain from pulpal inflammation, apical periodontitis or postoperative pain following extraction of an impacted wisdom tooth for more than 2 day...

journal_title：Pain

authors： Ottoson D,Ekblom A,Hansson P

更新日期：1981-02-01 00:00:00

abstract：:The aim of this study was to test the capacity of the Fear Avoidance Model to explain the relationship between pain and disability in patients with whiplash-associated disorders. Using the method of Baron and Kenny, we assessed the mediating effect of fear of movement on the cross-sectional and longitudinal relationsh...

journal_title：Pain

authors： Kamper SJ,Maher CG,Menezes Costa LDC,McAuley JH,Hush JM,Sterling M

更新日期：2012-01-01 00:00:00

abstract：:The habituation to sensory stimuli of different modalities is reduced in migraine patients. However, the habituation to pain has never been evaluated. Our aim was to assess the nociceptive pathway function and the habituation to experimental pain in patients with migraine. Scalp potentials were evoked by CO(2) laser s...

journal_title：Pain

authors： Valeriani M,de Tommaso M,Restuccia D,Le Pera D,Guido M,Iannetti GD,Libro G,Truini A,Di Trapani G,Puca F,Tonali P,Cruccu G

更新日期：2003-09-01 00:00:00

abstract：:The associative network theory of memory [2] is outlined along with the concepts of mood congruity and state dependent learning. Two experiments are reported which investigate the occurrence of these effects where memory for pain is concerned. In experiment 1 the performance of 25 chronic pain patients was compared wi...

journal_title：Pain

authors： Pearce SA,Isherwood S,Hrouda D,Richardson PH,Erskine A,Skinner J

更新日期：1990-11-01 00:00:00

abstract：:Substance P (SP) is released from primary afferent fibers in response to nociceptive stimuli. Capsaicin, which produces an initial hyperalgesic response followed by persistent antinociception, also elicits release of SP from primary afferent fibers. Capsaicin pretreatment decreases the content and release of SP from p...

journal_title：Pain

authors： Goettl VM,Larson DL,Portoghese PS,Larson AA

更新日期：1997-07-01 00:00:00

abstract：:A number of investigators have suggested that the generic classification temporomandibular disorders (TMD) may consist of several subsets of patients. Two primary factors are to be significant in discriminating subgroups, namely, presence or absence of TM joint abnormalities and psychological characteristics such as t...

journal_title：Pain

authors： Rudy TE,Turk DC,Zaki HS,Curtin HD

更新日期：1989-03-01 00:00:00

abstract：:Total hip replacement (THR) and total knee replacement (TKR) are usually effective at relieving pain; however, 7% to 23% of patients experience chronic postsurgical pain. These trials aimed to investigate the effect of local anaesthetic wound infiltration on pain severity at 12 months after primary THR or TKR for oste...

journal_title：Pain

authors： Wylde V,Lenguerrand E,Gooberman-Hill R,Beswick AD,Marques E,Noble S,Horwood J,Pyke M,Dieppe P,Blom AW

更新日期：2015-06-01 00:00:00

abstract：:The localization of sodium channels (NaChs) change following nerve lesions and this change may contribute to the development of increased pain states. Here we examine the change in distribution of NaChs within the rat infraorbital nerve (ION) two weeks after a combined inflammatory/partial axotomy lesion that results ...

journal_title：Pain

authors： Henry MA,Freking AR,Johnson LR,Levinson SR

更新日期：2006-09-01 00:00:00

abstract：:Studies on the efficacy of ketamine in the treatment of chronic pain indicate that prolonged or repetitive infusions are required to ensure prolonged pain relief. Few studies address ketamine-induced toxicity. Here we present data on the occurrence of ketamine-induced liver injury during repeated administrations of S(...

journal_title：Pain

authors： Noppers IM,Niesters M,Aarts LPHJ,Bauer MCR,Drewes AM,Dahan A,Sarton EY

更新日期：2011-09-01 00:00:00

abstract：:In primary care and physical therapy settings, we evaluated an intervention for chronic back pain patients which incorporated fear reducing and activating techniques. Primary care patients seen for back pain in primary care were screened to identify persons with significant activity limitations 8-10 weeks after their ...

journal_title：Pain

authors： Von Korff M,Balderson BHK,Saunders K,Miglioretti DL,Lin EHB,Berry S,Moore JE,Turner JA

更新日期：2005-02-01 00:00:00

abstract：:The present study examined antinociception produced by systemic administration of caffeine in the rat hot-plate (HP) and formalin tests and addressed several aspects of the mechanism of action of caffeine. Locomotor activity was monitored throughout. Caffeine produced a dose-related antinociception the HP (50-100 mg/k...

journal_title：Pain

authors： Sawynok J,Reid AR,Doak GJ

更新日期：1995-05-01 00:00:00

abstract：:The treatment of neuropathic pain by neuromodulation is an objective for more than 40 years in modern clinical practice. With respect to spinal cord and deep brain structures, the cerebral cortex is the most recently evaluated target of invasive neuromodulation therapy for pain. In the early 90s, the first successes o...

journal_title：Pain

authors： Lefaucheur JP

更新日期：2016-02-01 00:00:00

abstract：:Osteoarthritis (OA) is a major healthcare burden of increasing prevalence. It has been demonstrated that the relationship between pain and sleep produces changes in sleep patterns and pain perception. However, electrophysiological studies in animal models of pain are limited. The current study examined the effect of c...

journal_title：Pain

authors： Silva A,Andersen ML,Tufik S

更新日期：2008-12-01 00:00:00

abstract：:The use of long-term opioid therapy for chronic pain remains common, yet data on long-term outcomes, especially after dose escalation, are sparse. This study examined potential benefits and harms associated with prescription opioid dose escalation. Participants from 2 institutions were enrolled in a 2-year prospective...

journal_title：Pain

authors： Morasco BJ,Smith N,Dobscha SK,Deyo RA,Hyde S,Yarborough BJH

更新日期：2020-06-01 00:00:00

abstract：:The aim of this paper is to study the synergistic anti-analgesic effect of angiotensin II (Ang II) plus cholecystokinin octapeptide (CCK-8). Our previous studies have shown that both CCK-8 and Ang II are potent anti-opioid substances. Intracerebroventricular (i.c.v.) injection of CCK-8 or Ang II dose-dependently antag...

journal_title：Pain

authors： Han NL,Luo F,Bian ZP,Han JS

更新日期：2000-04-01 00:00:00