Epidural administration of opiates by a new device.

abstract：:In inflammatory neuropathy, immune activation near intact peripheral nerves induces mechanical allodynia. The identity of the peripheral immune product(s) that lead to these changes in pain behavior is unknown. The present series of studies utilized the sciatic inflammatory neuropathy (SIN) model to examine this quest...

journal_title：Pain

authors： Twining CM,Sloane EM,Milligan ED,Chacur M,Martin D,Poole S,Marsh H,Maier SF,Watkins LR

更新日期：2004-07-01 00:00:00

abstract：:Many malignant cancers, including breast cancer, have a propensity to invade bones, leading to excruciating bone pain. Opioids are the primary analgesics used to alleviate this cancer-induced bone pain (CIBP) but are associated with numerous severe side effects, including enhanced bone degradation, which significantly...

journal_title：Pain

authors： Zhang H,Lund DM,Ciccone HA,Staatz WD,Ibrahim MM,Largent-Milnes TM,Seltzman HH,Spigelman I,Vanderah TW

更新日期：2018-09-01 00:00:00

abstract：:Intraoral somatosensory sensitivity in patients with atypical odontalgia (AO) has not been investigated systematically according to the most recent guidelines. The aims of this study were to examine intraoral somatosensory disturbances in AO patients using healthy subjects as reference, and to evaluate the percent agr...

journal_title：Pain

authors： Baad-Hansen L,Pigg M,Ivanovic SE,Faris H,List T,Drangsholt M,Svensson P

更新日期：2013-08-01 00:00:00

abstract：:Patients with chronic pain often report being sensitive to pain at night before falling asleep, a time when the synchronization of cortical activity is initiated. However, how cortical activity relates to pain sensitivity is still unclear. Because sleep is characterized by enhanced cortical delta power, we hypothesize...

journal_title：Pain

authors： Li YD,Ge J,Luo YJ,Xu W,Wang J,Lazarus M,Hong ZY,Qu WM,Huang ZL

更新日期：2020-02-01 00:00:00

abstract：:This study examined the effects of intravenous administration of sodium amytal (SA), a medium action barbiturate, on cutaneous limb temperatures and sympathetic skin responses (SSR) to electrical stimulation. Eight normal volunteers and 13 patients with musculoskeletal pain, somatoform pain disorders or nerve/root inj...

journal_title：Pain

authors： Mailis A,Plapler P,Ashby P,Shoichet R,Roe S

更新日期：1997-03-01 00:00:00

abstract：:Primary afferent sensory neurons are incredibly long cells, often traversing distances of over 1 m in humans. Cutaneous sensory stimuli are transduced in the periphery by specialised end organs or free nerve endings, which code the stimulus into electrical action potentials that propagate towards the central nervous s...

journal_title：Pain

authors： Clark AJ,Menendez G,AlQatari M,Patel N,Arstad E,Schiavo G,Koltzenburg M

更新日期：2018-07-01 00:00:00

abstract：:Patients suffering from postherpetic neuralgia often complain about hypo- or hypersensation in the affected dermatome. The loss of thermal sensitivity has been demonstrated by quantitative sensory testing as being associated with small-fiber (Aδ- and C-fiber) deafferentation. We aimed to compare laser stimulation (rad...

journal_title：Pain

authors： Franz M,Spohn D,Ritter A,Rolke R,Miltner WHR,Weiss T

更新日期：2012-08-01 00:00:00

abstract：:A large sample of staff physicians and residents (n = 193) responded to a questionnaire in which they were asked to rate 10 pain descriptors for level of applicability to 4 common acute and chronic pain syndromes. The purpose of the study was to examine the extent to which physicians would agree on the ratings, and wh...

journal_title：Pain

authors： Tearnan BH,Dar R

更新日期：1986-07-01 00:00:00

abstract：:Although pediatric functional abdominal pain (FAP) has been linked to abdominal pain later in life, childhood predictors of long-term outcomes have not been identified. This study evaluated whether distinct FAP profiles based on patterns of pain and adaptation in childhood could be identified and whether these profile...

journal_title：Pain

authors： Walker LS,Sherman AL,Bruehl S,Garber J,Smith CA

更新日期：2012-09-01 00:00:00

abstract：:Evidence has shown that electrical stimulation at the dorsal columns attenuated the "wind-up" phenomenon in dorsal horn neurons in nerve-injured rats. This study was aimed to test the effect of spinal cord stimulation (SCS) on temporal summation (TS), the clinical correlate of the wind-up phenomenon in patients with r...

journal_title：Pain

authors： Eisenberg E,Burstein Y,Suzan E,Treister R,Aviram J

更新日期：2015-03-01 00:00:00

abstract：:Sendide is a selective and extremely potent antagonist of neurokinin-1 (NK1) receptors in the mouse spinal cord. The antinociceptive activities of sendide, an antagonist of NK1 receptors, and its analogue, [D-Trp7]sendide have been examined after intrathecal (i.t.) administrations in the mouse paw formalin test. Intra...

journal_title：Pain

authors： Sakurada T,Katsumata K,Yogo H,Tan-No K,Sakurada S,Ohba M,Kisara K

更新日期：1995-02-01 00:00:00

abstract：:Since many people with chronic fatigue present with pain and many people with chronic pain present with fatigue, we tested if fatigue would enhance the response to pain in male and female mice. We further tested for the activation of brainstem nuclei by the fatigue task using c-fos as a marker. Fatigue was induced by ...

journal_title：Pain

authors： Sluka KA,Rasmussen LA

更新日期：2010-02-01 00:00:00

abstract：:Nociceptive long-term potentiation, a use dependent increase in synaptic efficacy in the dorsal horn of the spinal cord is thought to contribute to the development of persistent pain states. So far, no study has analyzed the effects of high-frequency stimulation (HFS) of afferents from deep tissues (muscle and fascia)...

journal_title：Pain

authors： Schilder A,Magerl W,Hoheisel U,Klein T,Treede RD

更新日期：2016-10-01 00:00:00

abstract：:Genetics studies on the placebo hypoalgesic effect highlight a promising link between single nucleotide polymorphisms (SNPs) in the dopamine, opioid, and endocannabinoid genes and placebo hypoalgesia. However, epistasis and replication studies are missing. In this study, we expanded on previous findings related to the...

journal_title：Pain

authors： Colloca L,Wang Y,Martinez PE,Chang YC,Ryan KA,Hodgkinson C,Goldman D,Dorsey SG

更新日期：2019-08-01 00:00:00

abstract：:Acute zoster infection may be followed by a chronic pain syndrome, i.e., postherpetic neuralgia (PHN). Besides older age, the intensity of pain and neuronal damage within the acutely affected body region are regarded as predictors or risk factors for PHN. As an alternative approach an underlying peripheral polyneuropa...

journal_title：Pain

authors： Baron R,Haendler G,Schulte H

更新日期：1997-11-01 00:00:00

abstract：:The localization of sodium channels (NaChs) change following nerve lesions and this change may contribute to the development of increased pain states. Here we examine the change in distribution of NaChs within the rat infraorbital nerve (ION) two weeks after a combined inflammatory/partial axotomy lesion that results ...

journal_title：Pain

authors： Henry MA,Freking AR,Johnson LR,Levinson SR

更新日期：2006-09-01 00:00:00

abstract：:The purpose of this study was to investigate the mechanisms of referred pain observed in female patients with pain from the reproductive organs. We developed a model of inflammatory uterine pain in the rat. Inflammation of the uterus in rats pretreated with Evans Blue Dye resulted in dye extravasation in the skin over...

journal_title：Pain

authors： Wesselmann U,Lai J

更新日期：1997-12-01 00:00:00

abstract：:Our previous studies in the Sprague-Dawley rat showed that the intrinsic antinociceptive effects of oxycodone are naloxone reversible in a manner analogous to morphine but that in contrast to morphine, oxycodone's antinociceptive effects have a rapid onset of maximum effect (approximately 5-7 min compared to 30-45 min...

journal_title：Pain

authors： Ross FB,Smith MT

更新日期：1997-11-01 00:00:00

abstract：:Chronic low back pain (CLBP) and obesity are interrelated, but the physiological mechanisms linking the 2 conditions remain to be determined. Functional brain imaging data from CLBP patients show functional and structural alterations in areas mediating the attribution of hedonic value to food. Accordingly, we hypothes...

journal_title：Pain

authors： Geha P,deAraujo I,Green B,Small DM

更新日期：2014-04-01 00:00:00

abstract：:The chronic pain syndrome inherited erythromelalgia (IEM) is attributed to mutations in the voltage-gated sodium channel (NaV) 1.7. Still, recent studies targeting NaV1.7 in clinical trials have provided conflicting results. Here, we differentiated induced pluripotent stem cells from IEM patients with the NaV1.7/I848T...

journal_title：Pain

authors： Meents JE,Bressan E,Sontag S,Foerster A,Hautvast P,Rösseler C,Hampl M,Schüler H,Goetzke R,Le TKC,Kleggetveit IP,Le Cann K,Kerth C,Rush AM,Rogers M,Kohl Z,Schmelz M,Wagner W,Jørum E,Namer B,Winner B,Zenke M,Lam

更新日期：2019-06-01 00:00:00

abstract：:Neuropathic pain may be effectively relieved by electric stimulation of the spinal cord (SCS). However, the underlying mechanisms for the ensuing pain relief are poorly understood. In a rat model of neuropathy displaying hypersensitivity to innocuous tactile stimuli, (allodynia), we have earlier demonstrated that SCS ...

journal_title：Pain

authors： Cui JG,O'Connor WT,Ungerstedt U,Linderoth B,Meyerson BA

更新日期：1997-10-01 00:00:00

abstract：:Burrowing, an ethologically relevant rodent behaviour, has been proposed as a novel outcome measure to assess the global impact of pain in rats. In a prospective multicentre study using male rats (Wistar, Sprague-Dawley), replication of suppressed burrowing behaviour in the complete Freund adjuvant (CFA)-induced model...

journal_title：Pain

authors： Wodarski R,Delaney A,Ultenius C,Morland R,Andrews N,Baastrup C,Bryden LA,Caspani O,Christoph T,Gardiner NJ,Huang W,Kennedy JD,Koyama S,Li D,Ligocki M,Lindsten A,Machin I,Pekcec A,Robens A,Rotariu SM,VoB S,Segerd

更新日期：2016-10-01 00:00:00

abstract：:This study evaluated movement velocity, frequency, and amplitude, as well as the number of arrests in three different subject groups, by kinematic analysis of repetitive movements during a finger tapping (FT) task. The most affected hands of 80 patients with complex regional pain syndrome (CRPS) were compared with the...

journal_title：Pain

authors： Schilder JCM,Schouten AC,Perez RSGM,Huygen FJPM,Dahan A,Noldus LPJJ,van Hilten JJ,Marinus J

更新日期：2012-04-01 00:00:00

abstract：:A visual analog scale (VAS) method of assessing headache pain was compared with a standard categorical four-grade scale (4GS) in a randomized, placebo-controlled, double-blind, clinical trial involving 792 treated migraine outpatients who received oral rizatriptan 5 mg, sumatriptan 50 mg, or placebo for a moderate or ...

journal_title：Pain

authors： Lines CR,Vandormael K,Malbecq W

更新日期：2001-08-01 00:00:00

abstract：:Injection of bee venom into one hindpaw of rat can elicit acute inflammation together with spontaneous pain, heat hyperalgesia and mechanical hyperalgesia/allodynia in the injected paw. 5-hydroxytryptamine (5-HT)1A receptor is the predominant receptor subtype in the spinal dorsal horn mediating the function of 5-HT in...

journal_title：Pain

authors： Wang W,Wu SX,Wang YY,Liu XY,Li YQ

更新日期：2003-11-01 00:00:00

abstract：:Antinociceptive effects of the 2 (each 1000 mg, orally) non-steroidal anti-inflammatory drugs (NSAIDs) acetaminophen (paracetamol) and antipyrine (phenazone) were investigated with a non-inflammatory experimental pain model in 32 healthy volunteers. Phasic pain was induced by intracutaneously applied brief electrical ...

journal_title：Pain

authors： Bromm B,Forth W,Richter E,Scharein E

更新日期：1992-08-01 00:00:00

abstract：:Age-related changes in the facial expression of pain during the first 18 months of life have important implications for our understanding of pain and pain assessment. We examined facial reactions video recorded during routine immunization injections in 75 infants stratified into 2-, 4-, 6-, 12-, and 18-month age group...

journal_title：Pain

authors： Lilley CM,Craig KD,Grunau RE

更新日期：1997-08-01 00:00:00

abstract：:The present paper describes the effect of vibratory stimulation on pain of dental origin in 36 patients. The patients were from a clinic for dental surgery and all had suffered pain from pulpal inflammation, apical periodontitis or postoperative pain following extraction of an impacted wisdom tooth for more than 2 day...

journal_title：Pain

authors： Ottoson D,Ekblom A,Hansson P

更新日期：1981-02-01 00:00:00

abstract：:The responses of primate spinothalamic tract (STT) neurons to innocuous and noxious mechanical stimuli applied to the skin can be enhanced for more than an hour following prolonged noxious stimulation. This increased responsiveness is thought to reflect sensitization of dorsal horn neurons and may help account for sec...

journal_title：Pain

authors： Paleček J,Palečková V,Dougherty PM,Willis WD

更新日期：1994-03-01 00:00:00

abstract：:This paper presents the results of a detailed study of the pain epidemiology and health related quality of life (HRQL) in 150 chronic non-malignant pain patients consecutively referred to a Danish multidisciplinary pain center. Mean pain severity was 71.6 (SD = 18.5) on the VAS scale. Forty-two percent reported poor q...

journal_title：Pain

authors： Becker N,Thomsen AB,Olsen AK,Sjøgren P,Bech P,Eriksen J

更新日期：1997-12-01 00:00:00