A comparison of visual analog scale and categorical ratings of headache pain in a randomized controlled clinical trial with migraine patients.

abstract：:The present study observed the expression of the 5-hydroxytryptamine (5-HT) (1A) receptor mRNA in the lumbar spinal dorsal horn neurons following carrageenan inflammation using in situ hybridization (ISH). We also studied the co-localization of 5-HT(1A) receptor mRNA and gamma-amino butyric acid (GABA) or enkephalin (...

journal_title：Pain

authors： Zhang YQ,Gao X,Ji GC,Huang YL,Wu GC,Zhao ZQ

更新日期：2002-08-01 00:00:00

abstract：:Fibromyalgia (FM) syndrome represents a great challenge for clinicians and researchers because the efficacy of currently available treatments is limited. This study examined the efficacy of mindfulness-based stress reduction (MBSR) for reducing functional impairment as well as the role of mindfulness-related construct...

journal_title：Pain

authors： Pérez-Aranda A,Feliu-Soler A,Montero-Marín J,García-Campayo J,Andrés-Rodríguez L,Borràs X,Rozadilla-Sacanell A,Peñarrubia-Maria MT,Angarita-Osorio N,McCracken LM,Luciano JV

更新日期：2019-11-01 00:00:00

abstract：:Plastic changes in the anterior cingulate cortex (ACC) are critical in pain hypersensitivity caused by peripheral nerves injury. The Notch signaling pathway has been shown to regulate synaptic differentiation and transmission. Therefore, this study was to investigate the function of the Notch signaling pathway in the ...

journal_title：Pain

authors： Duan H,Shen F,Li L,Tu Z,Chen P,Chen P,Wang Z,Liang W,Wang Y

更新日期：2021-01-01 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide found primarily in the C and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the central nervous system. Calcitonin gene-related peptide was found to play important roles in cardiovascular, digestive, and sensory functi...

journal_title：Pain

authors： Iyengar S,Ossipov MH,Johnson KW

更新日期：2017-04-01 00:00:00

abstract：:We previously reported that morphine fails to produce analgesic tolerance when administered in the presence of formalin-induced pain. The hypothalamic-pituitary-adrenal (HPA) axis is known to respond to stressful stimuli, including pain. To examine whether the blockade of tolerance by pain is related to HPA activity, ...

journal_title：Pain

authors： Vaccarino AL,Couret LC Jr

更新日期：1995-12-01 00:00:00

abstract：:Ketanserin, a selective S2 serotonergic antagonist, was assessed against placebo in a double-blind cross-over study of 16 patients with chronic peripheral burning pain. Nine of these had signs of reflex sympathetic dystrophy (RSD). All patients underwent 4 intravenous regional treatments, 2 with ketanserin (10 mg for ...

journal_title：Pain

authors： Hanna MH,Peat SJ

更新日期：1989-08-01 00:00:00

abstract：:This research was designed to identify and validate facial expressions of pain occurring in a clinical chronic pain condition. Facial expressions of 28 patients with chronic temporomandibular disorder pain were videotaped during a painful clinical examination procedure and coded using an anatomically based system. Cha...

journal_title：Pain

authors： LeResche L,Dworkin SF

更新日期：1988-10-01 00:00:00

abstract：:We propose a blade as a noninjurious nociceptive stimulus modeling sharp mechanical pain and yielding acute pain and hyperalgesia responses with closer proximity to incision-induced pain/hyperalgesia than punctate or blunt pressure mechanical pain models. Twenty-six healthy men and women were investigated to compare a...

journal_title：Pain

authors： Shabes P,Schloss N,Magerl W,Schmahl C,Treede RD,Baumgärtner U

更新日期：2016-01-01 00:00:00

abstract：:Catechol-O-methyltransferase (COMT) regulates extracellular catecholamines. A widely studied COMT single nucleotide polymorphism (rs4680) changes the translated amino acid from valine to methionine (Val158Met); the polymorphism has been shown to influence opioid use. The aims of this study were to investigate the infl...

journal_title：Pain

authors： Hooten WM,Biernacka JM,O'Brien TG,Cunningham JM,Black JL

更新日期：2019-01-01 00:00:00

abstract：:In several pain models, tricyclic antidepressants (TCAs) have been shown to reduce nociception. In the present study, we evaluated the antinociceptive effect of metapramine (META) in 4 nociception tests: (1) the hot plate test; (2) the phenylbenzoquinone-induced writhing; (3) the tail flick test; and (4) the test of e...

journal_title：Pain

authors： Michael-Titus A,Costentin J

更新日期：1987-12-01 00:00:00

abstract：:Age-related changes in the facial expression of pain during the first 18 months of life have important implications for our understanding of pain and pain assessment. We examined facial reactions video recorded during routine immunization injections in 75 infants stratified into 2-, 4-, 6-, 12-, and 18-month age group...

journal_title：Pain

authors： Lilley CM,Craig KD,Grunau RE

更新日期：1997-08-01 00:00:00

abstract：:Intrathecal (i.t.) injection of substance P (SP) results in a behavioral syndrome characterized by caudally directed biting and scratching. The present results indicate that repeated injections of 10 ng of SP, administered at 60 sec intervals, result in the rapid development of tachyphylaxis to this SP-induced behavio...

journal_title：Pain

authors： Larson AA

更新日期：1988-03-01 00:00:00

abstract：:Percutaneous radiofrequency lumbar facet denervation has been in use as a treatment for intractable, mechanical low back pain for over 2 decades. A number of case series have been reported with high rates of success in selected patients; however, there has been limited objective outcome assessment, long-term follow-up...

journal_title：Pain

authors： North RB,Han M,Zahurak M,Kidd DH

更新日期：1994-04-01 00:00:00

abstract：:Intradental nerve activity (INA) induced by cold stimulation of human teeth is regularly accompanied by pain perception. In this study a mathematical model was developed in order to quantify the relationship between INA and pain. In 5 patients (45 experiments) INA was recorded using electrodes implanted in lower incis...

journal_title：Pain

authors： Fors U,Ahlquist ML,Skagerwall R,Edwall LGA,Haegerstam GAT

更新日期：1984-04-01 00:00:00

abstract：:Combined oral administration of morphine sulfate (MS) and the over-the-counter antitussive drug and N-methyl-D-aspartate receptor antagonist dextromethorphan (DM) prevented the development of tolerance to the antinociceptive effects of MS (15, 24, or 32 mg/kg) in rats. This combined oral treatment regimen also attenua...

journal_title：Pain

authors： Mao J,Price DD,Caruso FS,Mayer DJ

更新日期：1996-10-01 00:00:00

abstract：:The effects of pretreatment with desipramine, a selective noradrenaline (NA) uptake blocker, on spinal antinociception by 5-hydroxytryptamine (5-HT), morphine and an adenosine analog (NECA) in the rat hot-plate test were examined to determine if endogenous NA is involved in the spinal action of these agents. Desiprami...

journal_title：Pain

authors： Sawynok J,Reid A

更新日期：1992-07-01 00:00:00

abstract：:Five hundred consecutive patients attending a psychiatric clinic were examined in order to ascertain the prevalence of chronic pain in various psychiatric illnesses and demographic categories. Chronic pain was found to be a frequent symptom in anxiety neurosis (60%), neurotic depression (45%) and hysteria (24.3%). Les...

journal_title：Pain

authors： Chaturvedi SK

更新日期：1987-05-01 00:00:00

abstract：:Movement is changed in pain, but the mechanisms remain unclear. Key questions are unresolved such as whether activation can be inhomogeneously distributed within a muscle in a manner that is specific to the location of noxious input. This study addressed this question using high-density electromyography (EMG) to study...

journal_title：Pain

authors： Gallina A,Salomoni SE,Hall LM,Tucker K,Garland SJ,Hodges PW

更新日期：2018-11-01 00:00:00

abstract：ABSTRACT:Spinal cord stimulation (SCS) is an approved treatment for truncal and limb neuropathic pain. However, pain relief is often suboptimal and SCS efficacy may reduce over time, requiring sometimes the addition of other pain therapies, stimulator revision, or even explantation. We designed and tested a new procedu...

journal_title：Pain

authors： Solcà M,Krishna V,Young N,Deogaonkar M,Herbelin B,Orepic P,Mange R,Rognini G,Serino A,Rezai A,Blanke O

更新日期：2020-11-30 00:00:00

abstract：:Coping with the demands of pain diminishes self-regulatory capacity and causes self-regulatory fatigue, which then leads to deteriorated executive task performance. It has been suggested that optimism can counteract the depletion of self-regulatory capacity. This study employed a 2 (optimism/no optimism)×2 (pain/no pa...

journal_title：Pain

authors： Boselie JJLM,Vancleef LMG,Smeets T,Peters ML

更新日期：2014-02-01 00:00:00

abstract：:This open prospective study evaluated the combination of initial dose titration with patient-controlled analgesia (PCA) and long-term treatment with transdermal fentanyl in 50 cancer patients requiring opioids for severe pain. The delivery rate of the first transdermal therapeutic system (TTS) was calculated from the ...

journal_title：Pain

authors： Grond S,Zech D,Lehmann KA,Radbruch L,Breitenbach H,Hertel D

更新日期：1997-01-01 00:00:00

abstract：:Pain behaviors are shaped by social demands and learning processes, and chronic pain has been previously suggested to affect their meaning. In this study, we combined functional magnetic resonance imaging with in-scanner video recording during thermal pain stimulations and use multilevel mediation analyses to study th...

journal_title：Pain

authors： Vachon-Presseau E,Roy M,Woo CW,Kunz M,Martel MO,Sullivan MJ,Jackson PL,Wager TD,Rainville P

更新日期：2016-08-01 00:00:00

abstract：:Plasticity in inhibitory receptors, neurotransmission, and networks is an important mechanism for nociceptive signal amplification in the spinal dorsal horn. We studied potential changes in GABAergic pharmacology and its underlying mechanisms in hyperalgesic priming, a model of the transition from acute to chronic pai...

journal_title：Pain

authors： Kim JV,Megat S,Moy JK,Asiedu MN,Mejia GL,Vagner J,Price TJ

更新日期：2016-06-01 00:00:00

abstract：:Previous studies indicate that descending modulation of nociception is progressively increased following persistent inflammation. The present study was designed to further examine the role of supraspinal neurons in descending modulation following persistent inflammation. Constant levels of paw withdrawal (PW) and tail...

journal_title：Pain

authors： Terayama R,Dubner R,Ren K

更新日期：2002-05-01 00:00:00

abstract：:The perception of pain is highly variable. It depends on bottom-up-mediated factors like stimulus intensity and top-down-mediated factors like expectations. In the brain, pain is associated with a complex pattern of neuronal responses including evoked potentials and induced responses at alpha and gamma frequencies. Al...

journal_title：Pain

authors： Tiemann L,May ES,Postorino M,Schulz E,Nickel MM,Bingel U,Ploner M

更新日期：2015-02-01 00:00:00

abstract：:Fear-avoidance beliefs have been identified as an important psychosocial variable in patients with chronic disability doe to low back pain. The importance of fear-avoidance beliefs for individuals with acute low back pain has not been explored. Seventy-eight subjects with work-related low back pain of less than 3 week...

journal_title：Pain

authors： Fritz JM,George SZ,Delitto A

更新日期：2001-10-01 00:00:00

abstract：:Chronic severe cervico-facial pain syndrome associated with a whiplash-type injury was successfully treated with epidural spinal cord stimulation. The patient had been in pain for 9 years, responding temporarily only to stellate ganglion blocks. The patient has now been painless for 18 months. We have been unable to f...

journal_title：Pain

authors： Kirvelä OA,Kotilainen E

更新日期：1999-03-01 00:00:00

abstract：:This preliminary study examined the self-efficacy of family caregivers with regard to helping cancer patients manage pain at end of life. A sample of 63 family caregivers of hospice-eligible cancer patients with pain provided ratings of their self-efficacy in assisting the patient in pain management and rated their ow...

journal_title：Pain

authors： Keefe FJ,Ahles TA,Porter LS,Sutton LM,McBride CM,Pope MS,McKinstry ET,Furstenberg CP,Dalton J,Baucom DH

更新日期：2003-05-01 00:00:00

abstract：:Features of somatisation have been shown to predict the onset of widespread body pain. This study aims to determine to what extent persons with orofacial pain syndromes share these features and to what extent they are uniquely related to oral mechanical factors. We have conducted a population-based cross-sectional sur...

journal_title：Pain

authors： Macfarlane TV,Blinkhorn AS,Davies RM,Ryan P,Worthington HV,Macfarlane GJ

更新日期：2002-10-01 00:00:00

abstract：:Gait abnormalities have been suggested to provide an objective measure for joint pain in animal models. Here, we aimed to assess whether parameters of gait analysis correlate with measures of pain-related behavior in experimental monoarthritis. For this purpose, antigen-induced arthritis was induced in the left knee j...

journal_title：Pain

authors： Boettger MK,Weber K,Schmidt M,Gajda M,Bräuer R,Schaible HG

更新日期：2009-09-01 00:00:00